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LOCUS XP_070074427 917 aa linear INV 09-DEC-2024 ACCESSION XP_070074427 VERSION XP_070074427.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070218326.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..917 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..917 /product="alpha-actinin, sarcomeric isoform X1" /calculated_mol_wt=106242 Region 31..135 /region_name="CH_ACTN_rpt1" /note="first calponin homology (CH) domain found in the alpha-actinin family; cd21214" /db_xref="CDD:409063" Site order(36,40,84,88..90,93..94,109..117,125,127..128, 131..132,134..135) /site_type="other" /note="actin binding site [polypeptide binding]" /db_xref="CDD:409063" Site order(51,53,77..79) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:409063" Region 139..252 /region_name="CH_ACTN_rpt2" /note="second calponin homology (CH) domain found in the alpha-actinin family; cd21216" /db_xref="CDD:409065" Site order(149,153,200..202,205..206,221..229,240,242..243, 246..247,249..250) /site_type="other" /note="putative actin binding site [polypeptide binding]" /db_xref="CDD:409065" Region 302..525 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Region 420..647 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 420..425 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Site 525..530 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 538..760 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 646..651 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 775..842 /region_name="EFh" /note="EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051" /db_xref="CDD:238008" Site order(784,786,788,795,825,827,829,836) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238008" Region 847..913 /region_name="EFhand_Ca_insen" /note="Ca2+ insensitive EF hand; pfam08726" /db_xref="CDD:430177" CDS 1..917 /gene="Actn" /coded_by="XM_070218326.1:220..2973" /db_xref="GeneID:108056774" ORIGIN 1 mmmenglsme ygdgymeqee ewereglldp awekqqkktf tawcnshlrk agtaidniee 61 dfrnglklml llevisgetl pkpdrgkmrf hkianvnkal dfiaskgvhl vsigaeeivd 121 gnlkmtlgmi wtiilrfaiq disveemtak eglllwcqrk tapyknvnvq nfhlsfkdgl 181 afcalihrhr pdlidyakls kdnplenlnt afdvaekyld iprmldpddl intpkpdera 241 imtyvscyyh afqgaqqvgn vthvpeptrq ytyvpnnyna etaanrickv lkvnqenerl 301 meeyerlasd llewirrtmp wlnsrqadns lagvqkklee yrtyrrkhkp prveqkakle 361 tnfntlqtkl rlsnrpaylp tegktvsdis nswkglelae kafeewllae tmrlerlehl 421 aqkfkhkada hedwtrgkee mlqsqdfrqc klnelkalkk kheafesdla ahqdrveqia 481 aiaqelntle yhdcvsvnar cqricdqwdr lgaltqrrrt aldeaerile kidilhlefa 541 kraapfnnwl dgtredlvdm fivhtmeeiq gliqahdqfk atlgeadkef nlivnlvrev 601 esivkqhqip gglenpyttl tandmtrkws dvrqlvpqrd qtlanelrkq qnnemlrrqf 661 aekanivgpw ierqmdavta igmglqgsle dqlhrlkeye qavyaykpni eelekihqav 721 qesmifenry tnytmetlrv gweqlltsin rninevenqi ltrdskgisq eqlnefrssf 781 nhfdknrtgr lspeefkscl vslgysigkd rqgdldfqri lavvdpnntg yvhfdafldf 841 mtrestdtdt aeqvidsfri laadkpyilp delrrelppd qaeyciqrmp pykgpngvpg 901 aldymsfsta lygetdl