rho GTPase-activating protein Graf isoform X4 [Drosophila

LOCUS       XP_070074377             843 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_070074377
VERSION     XP_070074377.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218276.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..843
                     /product="rho GTPase-activating protein Graf isoform X4"
                     /calculated_mol_wt=94493
     Region          <1..57
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          97..214
                     /region_name="BAR-PH_GRAF_family"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; cd01249"
                     /db_xref="CDD:269953"
     Region          207..408
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(255,299,303,372,375..376,399)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:239839"
     Site            255
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239839"
     Region          785..838
                     /region_name="SH3_GRAF-like"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase and similar
                     proteins; cd11882"
                     /db_xref="CDD:212815"
     Site            order(790,792,795,799,818..819,832,834..835)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212815"
     CDS             1..843
                     /gene="Graf"
                     /coded_by="XM_070218276.1:149..2680"
                     /db_xref="GeneID:108056722"
ORIGIN      
        1 mhereyiqes lsyvlriqev qerikfefve illafisgwl vfyhtaheqa edhrdylqdl
       61 rhkvqktren feearekvte lktkymekrt kpeeiftkrg ylflmekssi lkisllepfk
      121 atwtkyyctf kkqkreftml qfnqmnhnft rpearddekl tlfscqrras efekrfcfdl
      181 tfkekpgvvy tfqalsekdh rywisamdgt eptylapgki kvseayhlde agfmfirrci
      241 qvleirgled egiyrksgvg tkiskllslg lnqketddvf vddkyrdlme sntiasalkm
      301 ylrnlneplm tyqyhsdfie aakqetlnqr vnevhklvyk lpqpnfqmld mvichltdvs
      361 rkyeknkmsv fnlgvvfgpt llrpreesva aildikfnni vinilidnye rifknkpsad
      421 vklpveaaka psimyparss pptrmprasq igkaastgam gstsstaaaa aaagnpmfln
      481 qqkiyrvvsk sncteptmss slqnipngdn yasggagcis lsppmhmlng ilsptigsin
      541 nlhtisknet tvgtttaagt rryvpndtae vatdygiiga nnggvtlqsh haipvssttn
      601 frhpeylvtq sgstnhlytn ssssvagaaa tsgnrislnn vsppntamrk erflgstgsg
      661 pqqhppvqrg lhsygqtkqq qqqhysplmp tstsssndsv cdslssnngq hlgarnsndy
      721 amltsqnssl sphlghgsac devvtattvs cggsanesse yppskmhrnr dinqikrdls
      781 tgtarvrtly acmgesegel sfepnqiitn vryshepgwl qgtlngktgl ipenyvehlk
      841 phh