DNA topoisomerase 1 isoform X1 [Drosophila takahashii].

LOCUS       XP_070074293            1029 aa            linear   INV 09-DEC-2024
ACCESSION   XP_070074293
VERSION     XP_070074293.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218192.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1029
                     /product="DNA topoisomerase 1 isoform X1"
                     /calculated_mol_wt=117463
     Region          482..696
                     /region_name="Topoisomer_IB_N_htopoI_like"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); cd03488"
                     /db_xref="CDD:239570"
     Site            order(482,532,622..623,628,630,633,640,676..678,691..692,
                     694)
                     /site_type="DNA binding"
                     /db_xref="CDD:239570"
     Region          626..999
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     Site            630
                     /site_type="active"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     CDS             1..1029
                     /gene="Top1"
                     /coded_by="XM_070218192.1:597..3686"
                     /db_xref="GeneID:108060319"
ORIGIN      
        1 mtdaqllhcp qlyltpsltl spslsnqnih iqnggscgev vqsngvttng hghhhhhsss
       61 gssgsskhks sskdkhrdkd rehkssgsss sskdhksssr dkdrhkssss ssssskhrdk
      121 dkdkehrsss ssshrdkdgs sssssskhks ssssssssgh hkssskdker rdkdkdrsss
      181 sssssssrhk ssssssssrd kerssssshk ssssssssss kskhsssrhs ssqsssskep
      241 psydgvfvkp epvsqplmqq qqehsgpidp fhmqqlincn gngngndykn gyeesivdik
      301 kedesfnnls qasscdysms qfradepafe vkheqsyaee dstmndndqd eeadnepeem
      361 dndneeeddd eedvplamrk rkqeapdqad ggmddddddi pllarkkvkk epkekskknk
      421 rvkeepddey gsvkpkkkki kkeheiktev vsssptkrqk vkeeeeevwr wweeekradg
      481 vkwttlehkg pvfappyerv prnvrfyydg kplelseete eaatfyakml nhdyctkdvf
      541 nnnffkdfrk smtskekeii kdfrkcnfqe mfnffqaese krkaatkeek likkneneal
      601 mkefgfcmid ghkekignfr leppglfrgr gehpkmgmik rriqssdvsi ncgkdskvps
      661 ppygsrwkev rhdntvtwla swienvqgqv kyimlnpssk lkgekdhiky etarrldkvi
      721 dkiratyrde wkskemrvrq ravalyfidk lalragnekd edqadtvgcc slrvehvqlh
      781 kelngkenvv vfdfpgkdsi ryynevevek rvfknlelfm ehkkegddlf drlntqvlne
      841 hlkelmdglt akvfrtynas ktlqsqldll tdpgatvpek llaynranra vailcnhqrs
      901 vpkgheksme nlkekiktkr daiddceaey hdlkkaakrg svkekvnadk kgkqlerlkd
      961 qlkklelqet drdenktial gtsklnyldp risvawckkn gvpiekifnk tqrtkflwai
     1021 hmadehyrf