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PREDICTED: Drosophila takahashii topoisomerase 1 (Top1), transcript


LOCUS       XM_070218192            4679 bp    mRNA    linear   INV 09-DEC-2024
            variant X1, mRNA.
ACCESSION   XM_070218192
VERSION     XM_070218192.1
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4679
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..4679
                     /gene="Top1"
                     /note="topoisomerase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 Protein"
                     /db_xref="GeneID:108060319"
     CDS             597..3686
                     /gene="Top1"
                     /codon_start=1
                     /product="DNA topoisomerase 1 isoform X1"
                     /protein_id="XP_070074293.1"
                     /db_xref="GeneID:108060319"
                     /translation="MTDAQLLHCPQLYLTPSLTLSPSLSNQNIHIQNGGSCGEVVQSN
                     GVTTNGHGHHHHHSSSGSSGSSKHKSSSKDKHRDKDREHKSSGSSSSSKDHKSSSRDK
                     DRHKSSSSSSSSSKHRDKDKDKEHRSSSSSSHRDKDGSSSSSSSKHKSSSSSSSSSGH
                     HKSSSKDKERRDKDKDRSSSSSSSSSSRHKSSSSSSSSRDKERSSSSSHKSSSSSSSS
                     SSKSKHSSSRHSSSQSSSSKEPPSYDGVFVKPEPVSQPLMQQQQEHSGPIDPFHMQQL
                     INCNGNGNGNDYKNGYEESIVDIKKEDESFNNLSQASSCDYSMSQFRADEPAFEVKHE
                     QSYAEEDSTMNDNDQDEEADNEPEEMDNDNEEEDDDEEDVPLAMRKRKQEAPDQADGG
                     MDDDDDDIPLLARKKVKKEPKEKSKKNKRVKEEPDDEYGSVKPKKKKIKKEHEIKTEV
                     VSSSPTKRQKVKEEEEEVWRWWEEEKRADGVKWTTLEHKGPVFAPPYERVPRNVRFYY
                     DGKPLELSEETEEAATFYAKMLNHDYCTKDVFNNNFFKDFRKSMTSKEKEIIKDFRKC
                     NFQEMFNFFQAESEKRKAATKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPP
                     GLFRGRGEHPKMGMIKRRIQSSDVSINCGKDSKVPSPPYGSRWKEVRHDNTVTWLASW
                     IENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQ
                     RAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKD
                     SIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMDGLTAKVFRT
                     YNASKTLQSQLDLLTDPGATVPEKLLAYNRANRAVAILCNHQRSVPKGHEKSMENLKE
                     KIKTKRDAIDDCEAEYHDLKKAAKRGSVKEKVNADKKGKQLERLKDQLKKLELQETDR
                     DENKTIALGTSKLNYLDPRISVAWCKKNGVPIEKIFNKTQRTKFLWAIHMADEHYRF"
     misc_feature    2040..2684
                     /gene="Top1"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); Region:
                     Topoisomer_IB_N_htopoI_like; cd03488"
                     /db_xref="CDD:239570"
     misc_feature    order(2040..2042,2190..2192,2460..2465,2478..2480,
                     2484..2486,2493..2495,2514..2516,2622..2630,2667..2672,
                     2676..2678)
                     /gene="Top1"
                     /note="DNA binding site"
                     /db_xref="CDD:239570"
     misc_feature    2472..3593
                     /gene="Top1"
                     /note="DNA Topoisomerase I (eukaryota); Region: TOPEUc;
                     smart00435"
                     /db_xref="CDD:214661"
     misc_feature    2484..2486
                     /gene="Top1"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     polyA_site      4679
                     /gene="Top1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 caagtgtccc agtcccattt tgcaattaca tttatatgtg cacatacaaa cgtacagagg
       61 tgtttttttt ttttgtatat gcttgtgtgt cgtctgataa gacagatgtg ccaccccgaa
      121 aaaaaaacac acttactaaa taatatgctg caacaacaac aaccccgtgt gtgtgtgtgc
      181 aagtgtgtgc gtgtgtagcc ttgatgcagc gcccacgttg aaaaaaaaga agaatatatg
      241 cagttaaaaa aaaaaatacg attttctgta ttctccaatt tgcgcgtgtg tgtgcgtgtg
      301 tgttccattg tttggcagcg gtgtttttgt atttccattt catttaacct attcttccaa
      361 cgggaagaat atcgggaacg atatttccaa tttcctgtcg ccatcgctct tcggctcctc
      421 ttcttcttcc tgctcatcgc atttaaccca ttgctgcccg tttcaagtga attttcctac
      481 gcggcatttg tgttagggtt gatttttcac cacgtggtga gcggatagac acgagataat
      541 catagtaaat ccatcaaaag gcccaggaaa tcgtgaggaa gcgaacgaga gaagctatga
      601 cggatgcaca gctgctccat tgcccacaac tctatctcac tccctctctc acgctctccc
      661 cttctctctc taaccagaac atccacatac aaaatggtgg cagctgcggc gaggtggttc
      721 aatccaacgg ggtgaccacc aacggacacg gacaccacca ccaccacagc agcagtggga
      781 gcagcgggag cagcaagcat aaatcctcca gcaaggacaa gcaccgtgat aaggacaggg
      841 agcacaagag ctccggatcc tccagctcgt cgaaggatca caagagcagc agtcgcgaca
      901 aggatcgcca caaaagcagc agcagcagca gctcgtcgtc gaagcatcgg gacaaggaca
      961 aggacaagga gcatcgcagc agctcttcgt ctagccacag ggacaaggat gggagcagca
     1021 gcagtagcag cagcaagcac aagtcctcgt cgtcatcatc gtcctcgtcc ggccaccaca
     1081 agagctcctc gaaggacaag gagcgacgcg acaaggacaa ggatcgcagc agcagcagca
     1141 gcagcagctc ctccagccgg cacaagtcat cctcatcctc gtccagttcc cgtgataagg
     1201 agcgcagcag cagcagcagt cacaagagct cctcctcatc gtcatcctcg tcatcgaaga
     1261 gcaaacattc cagttcgcgg cacagcagct cgcagtcctc ctcctcgaag gagccgccat
     1321 cgtacgatgg agtgtttgtc aagccggagc ccgtttcgca gccgctgatg cagcagcagc
     1381 aggagcactc tggccccatc gatcccttcc acatgcagca gctcatcaat tgcaatggca
     1441 atggcaatgg caacgactac aagaacggct acgaggaatc gattgtggac atcaagaagg
     1501 aggacgagag cttcaacaat ctatcgcagg cgagctcctg cgactactcc atgtcccagt
     1561 ttcgagccga tgagccggca ttcgaggtga agcacgagca gagctacgcc gaggaggata
     1621 gcaccatgaa cgacaatgat caggacgagg aggctgataa cgaacccgag gaaatggaca
     1681 acgacaacga ggaggaggac gacgatgagg aggatgtgcc gctggccatg cgtaagcgca
     1741 agcaggaggc acccgatcag gccgatggcg gcatggatga cgacgacgac gacattccgc
     1801 tgctggcgcg caagaaggtc aagaaggagc ccaaggagaa gtcgaagaag aacaagcggg
     1861 tcaaggagga gcccgacgac gagtacggca gtgttaagcc caagaagaaa aagatcaaaa
     1921 aggaacacga aattaagacc gaggtcgtat catcatcgcc caccaaacgt cagaaggtca
     1981 aggaggagga ggaggaggtg tggagatggt gggaggagga gaagcgcgca gatggcgtca
     2041 agtggacaac gctggagcac aagggacccg ttttcgcacc gccctacgag cgggtgcccc
     2101 gcaatgtgcg gttctactac gacggcaagc cactggaact ctccgaggag acggaggagg
     2161 cggccacctt ctatgcgaag atgttgaatc atgactactg caccaaggat gtgttcaaca
     2221 acaacttctt caaggacttc cgcaagtcga tgacgtccaa ggagaaggag atcatcaagg
     2281 atttccgcaa gtgcaacttc caggagatgt tcaacttctt ccaggcggag tccgagaagc
     2341 gcaaggcggc caccaaggag gagaagctga tcaagaagaa cgagaacgag gcgctgatga
     2401 aggagtttgg cttctgtatg atcgacggcc acaaggagaa gattggcaac tttcgcctgg
     2461 agcctcccgg ccttttccgt ggccgtggcg agcatcccaa aatgggcatg atcaagcgtc
     2521 gcattcagtc cagcgatgtg tccattaact gcggcaagga ctccaaggtc ccctcgcccc
     2581 catacggatc gcggtggaag gaggtgcgcc acgacaacac ggtcacctgg ctggcctcct
     2641 ggatcgagaa cgtgcagggc caggtcaagt acatcatgct gaatccctcc tcgaagctca
     2701 agggcgagaa ggatcacatt aagtacgaga cggcacggcg actggacaag gtgatcgaca
     2761 agattcgggc cacctatcgc gacgaatgga agtcgaagga gatgcgagtg cgccagcggg
     2821 cggttgccct ctactttatc gacaagctgg cgctgagagc gggcaacgaa aaggacgagg
     2881 atcaggcgga caccgtcggc tgttgctcgc tgcgcgtcga gcacgtccag ctgcacaagg
     2941 agctcaacgg caaggagaac gtggtggtgt tcgacttccc cggtaaggat tccattcgct
     3001 actacaacga ggtcgaggtg gagaagcgcg tcttcaagaa cctcgagctg tttatggagc
     3061 acaagaagga gggcgacgat ctcttcgatc gcctcaacac tcaggtgctc aacgagcatc
     3121 tcaaggagct gatggatgga ctcacggcca aggtattccg tacgtacaac gcttcgaaaa
     3181 cactgcaaag ccagctggat ctgctcaccg atccgggtgc cacggtaccg gagaagctct
     3241 tggcctacaa tcgggccaat cgcgccgtgg ccatcctgtg taaccatcag cgttccgtgc
     3301 ccaagggcca cgagaagtcg atggagaatc tgaaggagaa gatcaagacc aagcgggatg
     3361 ccatcgatga ttgcgaggct gaatatcatg atttaaagaa ggccgccaaa cggggatccg
     3421 tgaaggagaa ggtcaatgcc gacaagaagg gcaaacagct ggagcgcctg aaggatcagc
     3481 tgaagaaact agaattacaa gagactgata gagacgagaa taagaccatt gccctgggca
     3541 catctaagct aaactatctc gatccacgca tatcggtggc ttggtgtaaa aagaacggag
     3601 tgccgatcga gaagatattt aacaaaacgc aaagaaccaa atttctgtgg gccattcaca
     3661 tggccgatga gcattatcgt ttttaaattg ggttgttatc ctcacaggca cgcccaccca
     3721 cacacacaga tacgcccccc tctcacacac acaaagaagc atagacagcg caggttgaaa
     3781 gactaggaac ccgaagacac tttgccccga aaagtttatg caaacagtag tgcatatgtt
     3841 cagcttttcg gttttcggta aaggcatttc gggatgatta tactgctcct cccccagaaa
     3901 agaaagggac ggatgtattc tagggatagg gatctggatc tgcgtctgtt ttgtctgctt
     3961 tggaaaaaca aaaacgtttg attgtttcaa gtgcgcgcac tacgctgaag tctaacttgc
     4021 gaaatgtaca caccaaaaac atgccacaca cgcgttcaca cttctatatt gatatatata
     4081 tatggatata tatattttaa acacaatata tatatatata tattatatac gagacaacaa
     4141 tttaaataaa caccaagaga agaagagaaa cctgtgcaag acgtcgccgc cacctaaaaa
     4201 caaaataaga gcataatttt ctatgtttta ccgtctacaa aagaagcaac aaattttttc
     4261 tttttttttt gtcgtcaaaa ctctgctgac ttctcttata tatttttaat taattaattt
     4321 ttatatataa actataaaca aaaaagaaag agaaagaaag taaaagctaa aaaaaaaagg
     4381 aaaagaacct acaagcaaac gaaaaatgat aaaattaacg gtttttttat gtttacctat
     4441 agttgatttt tgtttagcga aaaaatgtct ttcactatta attaatatta attatacaat
     4501 tactacgatt acgtatttaa gtgctaaatg aacagagaaa ccttgtagcc caactttttt
     4561 agcatagcat aatttattca attcaaaaaa actctgatcc agcgcaattt acccaacacg
     4621 atttatgatt ttagttaaaa ttaaaaaata aacgaatgct aaattcattt gcaaacaaa