LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase highwire

LOCUS       XP_041447872            5491 aa            linear   INV 14-MAY-2021
            [Drosophila obscura].
ACCESSION   XP_041447872
VERSION     XP_041447872.1
DBLINK      BioProject: PRJNA728747
DBSOURCE    REFSEQ: accession XM_041591938.1
KEYWORDS    RefSeq; corrected model.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 2 indels
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Drosophila obscura"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     Protein         1..5491
                     /product="LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase
                     highwire"
                     /calculated_mol_wt=590549
     Region          <589..784
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          <960..1049
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1453..1603
                     /region_name="PHR"
                     /note="PHR domain; pfam08005"
                     /db_xref="CDD:462339"
     Region          2039..2192
                     /region_name="PHR"
                     /note="PHR domain; pfam08005"
                     /db_xref="CDD:462339"
     Region          3107..>3149
                     /region_name="SH3_3"
                     /note="Bacterial SH3 domain; pfam08239"
                     /db_xref="CDD:462405"
     Region          4433..4547
                     /region_name="APC10-like"
                     /note="APC10-like DOC1 domains in E3 ubiquitin ligases
                     that mediate substrate ubiquitination; cl02148"
                     /db_xref="CDD:382862"
     Site            order(4443,4470,4477,4539)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176484"
     Region          5067..5115
                     /region_name="Bbox2_MYCBP2"
                     /note="B-box-type 2 zinc finger found in Myc-binding
                     protein 2 (MYCBP2) and similar proteins; cd19799"
                     /db_xref="CDD:380857"
     Region          5246..5300
                     /region_name="RING-H2_PHR"
                     /note="RING finger, H2 subclass, found in the PHR
                     (Pam/Highwire/RPM-1) protein family; cd16463"
                     /db_xref="CDD:438126"
     CDS             1..5491
                     /gene="LOC111076890"
                     /coded_by="XM_041591938.1:27..16502"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: inserted 1 base in 1 codon;
                     deleted 1 base in 1 codon"
                     /db_xref="GeneID:111076890"
ORIGIN      
        1 mpanmvglln pmkygdhfye lftnqtrrrt hnerrtltkr ksrkeksaaa maaaaaaavl
       61 dgnpggivnp ldpplvkeql mimpsfpagh ielepnaskf avfsairttv leaetryall
      121 qeggggreag mglkkwaanl dssccllcaa sclasnildc tchaqlalaa galgggpgpg
      181 iapggaaiag ligvvigpgg pggsndkrnr rdsansdads dteepterep vyatvplivg
      241 aglrslfeli adarhiqpll ctkalkalld viqgqqpesf kmepeelinp lydllldlat
      301 mpaalnsttg aeanwsamac aallglciar gdtgkmlkai aamlmsprql saqivqlpav
      361 laalqhtvis aalnkptrpd fhshgvphns lidefplklp evgpggaeta pamacdgvfl
      421 yllydgyllk igtgfggsyk ghvyaqnddf trernawlgy saghlyfrrn crrntgdqlq
      481 lvgldtlalk smsplnmlam reginyvlft dddslhaics nrddtlvvkk lnlyhnsyss
      541 epqpfelplq larkkfrtlg yaafeddlln qhqvqriqss hnsfepklpa tcrdadvdvl
      601 gmacgkefgl vrasngrvyy ygkstalglk cvgrtpslkl teliiskaah ivhvavghdg
      661 ihallvnddg tvffagtarr gedgdtsknr rqpkavkpkk mtkidghvvv haacnngtsa
      721 fvtkagklim ygkdtahcda mgfvtelldq hvtkvalgka hcvalnakgq lfsfglnnkg
      781 qcgrifnklq pvkdvassss aascfaallp pdkrykldls alcdyddhsl vqgqcrvciv
      841 crectgynvs cvsalnvple qrlagsicpc ghgdagcakc glcatcialq dndndanrel
      901 ktlstemqqr qqrsktllmr rkekkpcele tgaagggaat ptdldkdppr vaplapqllq
      961 lpsaspvvqv acglhhtvvl tlagevytfg snqygqlgsg dlqpvsgpvr vqvqgaisqv
     1021 aagsnhsvll thkgmvytfg nyqkgqlgrl psdfgpnidk nqrpgqspgq gqaqpqpqph
     1081 tqdeelpnst tggasgssda aaaaalessv lpscskelpp lmpnfscpvl tqrqkflwnc
     1141 spaavfglgp sfgkkvtwig angdqtfiki deslitaqml pkmhvvanrk tillvpsipl
     1201 sfhtlsinrr dgsctahyrg qsnfiqlmqa qpqpqanesq rqtdattpvm aspalaepva
     1261 ghassallta lagtatagvp ineqmsrsmh earnqifeep eggvavvasg sggciprprr
     1321 flrqrldmga pgspsdqqqs pqqlafamdp synvlwvfdg vsrrirchnv vasdisesde
     1381 naanyralls pelslptkae arvsrsqgsl nllacldilt saqdnipycf eqtlpkaihp
     1441 ttetpggdyq vvnrfdnfgg gwgysghsve airfasdtdi vlcgfgmfgg rgeysckvkl
     1501 fdlgsdgggy ekegvllset kevpyecaar skhhillpkp vsaaagrwyl vwariagpss
     1561 dcgscgqasv ttedqvvfsf ksskkanngt dvnsgqipai lyrlvtqdck qtaapmdadp
     1621 vqrisrafan svsrecfesl vvllswswes fktqlreqsd rsrplqlqqs lqylgyvnks
     1681 clrllrkytn eiypqratnt atgaaagagr nnkggssgpa aggggssmva aalsklesks
     1741 skdkhlprvv pnpitvskyf gehpstsgag ggagggsrgg gadgsaagtg tpitrkanle
     1801 niqlaecvgn vralligifc ddifkdiatd egyaltleil dechlsfvac fdafyptssl
     1861 kwsclcdlla qmdrgalhsr llsailaglc sptvklratf sllsapgndr qsiispsdns
     1921 glpmlsstda hqypilveqm iyrtqqeksd flisswtfkd vlvrlldiia spirqriesi
     1981 ysrslegsyp gkewinqgli dncchllarv laeivyqtam geydklflpp rtlhstgarf
     2041 arcdlsrtwn tgnfgpdaia fsvdrsgiai agamvytgsg sydyqlellf dntvdlqpqh
     2101 kwetlesvsg sydqeavhnd laeikfehpv qikeharyal rlcsqgartc sgdsglptvr
     2161 gpcgtnfhfy acdlsfngtt pargqlpcil yystpvklea gvvgsgstam aaadavsmla
     2221 assqliahev strdtalqia sditkkctel limarnamaa scspsdnsss nhtqtidseh
     2281 nitpieehmd inwannsrta aqpraadpqn stardlgrri esfskgimqt ltfdkrstnp
     2341 femeiemgat eigeedsddl angqipsqsq gqgqgqgqmq svvpingner vdfelaeqpq
     2401 qqqqlqsllv hsdseeaapi dagaagcsgf avgggvglgv gvssvlgeaa rgvplggala
     2461 gggcpvaalq llevfnlaas nmfhtllplv yahmsnlacs dpkssvqilg likeilphia
     2521 alnqlhvske qrqpeaaaaa aaanfphppe aappeqaeaa gagappaags ysssnsggss
     2581 sttsnhycmv esehpyrsas iscyrvefpp cvqwmtiefd gqsgtaqled ylllsipmrp
     2641 aeqagepasq tddyydmldn nlpsvpesrr tviptasemg tatgagsknr sanaqllmas
     2701 ccrtpgtssg sgattasspl raqdandrew ivvkkfntas nwlmsvlvvp gncvefslet
     2761 sslyaqdphn nrygfkclvv gydnptaing snsclirleq elsylggmcc anlmkkelnm
     2821 pedkdvedms gveetimahh sllskgfals dphlnvhqal epylpigsqs nerqflkdfi
     2881 sgapgssgar laawlqpesr ldpnkcemnp iteplrygwp tqvtitirdq ygdavlvpel
     2941 kveikaiptg pgphgpggvg aanilrmrra scastvtdac lggmappprf nyevttkerm
     3001 cfkaitfmkp ftnysfeelr ysspvqtrst dtlsardmed gtfsvqwtpn svggyclavi
     3061 idgihleevy rvevkegvlp pptqrssttr rpqapsklrr fqvrhsaglr irshptlqse
     3121 qvgvvrlggi isfideiend dgiwlrlste sirqhctmgw ypteawclqf nqhlakvllq
     3181 pvldakdaga vapaspttgg gcsgepspep epehspppsp vlpkspvvqr rflggpvntn
     3241 pflfptkrer qrerererer emerererer ereqrervqq mepepdqdve veaelqpela
     3301 gaaaaasasa savapppvpv pesgpepela gaaassssss savaatellp anlgsaiagv
     3361 vgggairlqa lqkwfkgdai egaqpqaqaq ahepshmdas fsqsppppha gvsvremvra
     3421 mgqepapsps gspcpsmrgn gnrsssqqqe qqqeqqqeqe pepefnlasm rrpnytasqt
     3481 aallstpkht prrtvagvaa aaaaaavqev vsgleddlsl lqitttttgt eqqselqlas
     3541 tsaaatasas aaaarntmgp ikramppsfa esiravfaal lwhegvvhda macasflkfh
     3601 pglpkegatv vtrrgetgda rlqlsreqka qqrhsvevan aghylnirps tletltksgn
     3661 sslhnrskhr knmsppagge dqqqqpprdg qqqqklqalp evvsvlppal rclvylweqi
     3721 csgcvqivqt ngleqprqpr llspihhmdg hghghghepk eggkmgaghh mdqggagasd
     3781 kegkktkrkk kddgswceic elflpmpvty hmriahpgcg ksakgkgyns vgifcegwag
     3841 ncgeggkgas swflmcdtcr drylascrst nninsvargq eansaednvl nlfgvrstli
     3901 anaevyttmr enatfllelc ssfssasssn sssnsilakr spqsmampvv iehqhhhhpl
     3961 gvadlkpsts rnsrmarlsg gpkfcpagig gafrksfvgg pptapdnlwl apdsfaclec
     4021 lgtagheepp yemfglgpne nafdrplsei syescdpnny dmgmapgtsa aaagavskfh
     4081 rsysmgqgwa slvqqatqap qqqhxqqqqq apqqqdtppk vvyrrrnnls sesegarlic
     4141 ypsehlrrlv phkllasvtv lqtstsaaaa aaaegdapai spgpeqggag gasssllsrp
     4201 amafitqkhe lerlraamrr slrisvcrsy slqalnwllr svtqgvclhd lmwwfvssle
     4261 tavthlpdgr yeespdmale hpaaytqisg rfahlitqsl hvllqsvadl tlhlppgspl
     4321 qrvaiqcfgi rfrqadhqfl hsshvfgnis kilsksdeqn damavstlll lkseshcdve
     4381 hnqlqlnats ggsgagsgsg tgagagpggr vvcytdlagm fdiavssrpa maesltdnst
     4441 etfwesdeed rnkvkiievs lirltyacrf llvhidnsrd iqnkvlnvgf yagqslgdtn
     4501 liksvdvdsk actwisakin desythfrle lhgpentlrv rqikllglpi qnqqgqpgpa
     4561 qfqtlgesmr lgmgmgmglg lglgldepfg selkpylrhs yaphiqqqic eaetlrvfrl
     4621 itgqvfgkli snvnavrsse epppevpgpa gvsgggagga ggsslladsl dlrehmvgil
     4681 fsrsklshlq kqvivhivha irrealrake dwelanlahd lrnpmeaaaa alpgpplqqq
     4741 qqqqaaagss esssersrap dtycfemlsm vlalsgsavg rsylsqqhgl lrdllgllht
     4801 gsdrvqrqvt allrrilpei spesfadllg vqrlppadys iahqsgsdfd msrlglldif
     4861 laviakslql qikvkttaat agggaaggss gsggsgqaqq kqgqqektpa fvrlcssldl
     4921 svqqlrsrpp tgeaqlpgts agagagsvgd pfqfelaapp rkeskrnlnq rwflngiist
     4981 kqaesiigli rdlasgklse kwsqttkaai aesvlnltrl eeiyrtpehc tktatlwlal
     5041 aslcvlerdh veklssgqws kvcdtrpmct nhddgetaai iqcetcgslc gdcdrflhln
     5101 rktrahkrtv ckeeeeairv elhescgrtk lfwllalads ktlkamvefr dgshtiisgp
     5161 qeavgrcrfc gltgnsglle ignvcadaqc qeyaansclk tkpcghacgg vvgeekclpc
     5221 lqhvcharen elaeeqhdpk ltqdaddmcm icfveavsca psihlecghv fhfhcckavl
     5281 ekrwsgprit fgfslcpick adihhpllad ilkpinalkq dvkrkalmri kyegvvkdte
     5341 skdvnvtqla mdryayyvcf kcqkayygge arcdaeigek fdpeelvcgg csdvaraqmc
     5401 pkhgtdfley kcryccsvav ffcfgtthfc dtchddfqrl tnipkiklpq cpagpkakql
     5461 lgdecplhvm hpptgeefal gcgvcrnaqt f