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LOCUS XM_041591938 16550 bp mRNA linear INV 14-MAY-2021 (LOC111076890), mRNA. ACCESSION XM_041591938 VERSION XM_041591938.1 DBLINK BioProject: PRJNA728747 KEYWORDS RefSeq; corrected model. SOURCE Drosophila obscura ORGANISM Drosophila obscura Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_024542752.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Drosophila obscura Annotation Release 101 Annotation Version :: 101 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.6 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## frameshifts :: corrected 2 indels ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-109 JAECWW010000165.1 874129-874237 c 110-1208 JAECWW010000165.1 872469-873567 c 1209-1595 JAECWW010000165.1 872018-872404 c 1596-2709 JAECWW010000165.1 870835-871948 c 2710-3463 JAECWW010000165.1 870004-870757 c 3464-3603 JAECWW010000165.1 869781-869920 c 3604-4166 JAECWW010000165.1 869153-869715 c 4167-5253 JAECWW010000165.1 867997-869083 c 5254-5520 JAECWW010000165.1 867666-867932 c 5521-6455 JAECWW010000165.1 866665-867599 c 6456-6936 JAECWW010000165.1 866183-866663 c 6937-7223 JAECWW010000165.1 865835-866121 c 7224-8239 JAECWW010000165.1 864765-865780 c 8240-8387 JAECWW010000165.1 864557-864704 c 8388-8490 JAECWW010000165.1 864372-864474 c 8491-8626 JAECWW010000165.1 864160-864295 c 8627-8740 JAECWW010000165.1 839479-839592 c 8741-10687 JAECWW010000165.1 837464-839410 c 10688-11685 JAECWW010000165.1 836391-837388 c 11686-12161 JAECWW010000165.1 835834-836309 c 12162-12338 JAECWW010000165.1 835553-835729 c 12339-12339 "N" 1-1 12340-13472 JAECWW010000165.1 834420-835552 c 13473-15011 JAECWW010000165.1 832777-834315 c 15012-15353 JAECWW010000165.1 832355-832696 c 15354-15818 JAECWW010000165.1 831826-832290 c 15819-16012 JAECWW010000165.1 831565-831758 c 16013-16550 JAECWW010000165.1 830955-831492 c FEATURES Location/Qualifiers source 1..16550 /organism="Drosophila obscura" /mol_type="mRNA" /isolate="BZ-5 IFL" /db_xref="taxon:7282" /chromosome="Unknown" /sex="male" /tissue_type="whole fly" /dev_stage="Adult fly" /geo_loc_name="Serbia: Babin Zub" /collection_date="2017" gene 1..16550 /gene="LOC111076890" /note="The sequence of the model RefSeq transcript was modified relative to its source genomic sequence to represent the inferred CDS: inserted 1 base in 1 codon; deleted 1 base in 1 codon; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins, and 98% coverage of the annotated genomic feature by RNAseq alignments" /db_xref="GeneID:111076890" CDS 27..16502 /gene="LOC111076890" /note="The sequence of the model RefSeq protein was modified relative to its source genomic sequence to represent the inferred CDS: inserted 1 base in 1 codon; deleted 1 base in 1 codon" /codon_start=1 /product="LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase highwire" /protein_id="XP_041447872.1" /db_xref="GeneID:111076890" /translation="MPANMVGLLNPMKYGDHFYELFTNQTRRRTHNERRTLTKRKSRK EKSAAAMAAAAAAAVLDGNPGGIVNPLDPPLVKEQLMIMPSFPAGHIELEPNASKFAV FSAIRTTVLEAETRYALLQEGGGGREAGMGLKKWAANLDSSCCLLCAASCLASNILDC TCHAQLALAAGALGGGPGPGIAPGGAAIAGLIGVVIGPGGPGGSNDKRNRRDSANSDA DSDTEEPTEREPVYATVPLIVGAGLRSLFELIADARHIQPLLCTKALKALLDVIQGQQ PESFKMEPEELINPLYDLLLDLATMPAALNSTTGAEANWSAMACAALLGLCIARGDTG KMLKAIAAMLMSPRQLSAQIVQLPAVLAALQHTVISAALNKPTRPDFHSHGVPHNSLI DEFPLKLPEVGPGGAETAPAMACDGVFLYLLYDGYLLKIGTGFGGSYKGHVYAQNDDF TRERNAWLGYSAGHLYFRRNCRRNTGDQLQLVGLDTLALKSMSPLNMLAMREGINYVL FTDDDSLHAICSNRDDTLVVKKLNLYHNSYSSEPQPFELPLQLARKKFRTLGYAAFED DLLNQHQVQRIQSSHNSFEPKLPATCRDADVDVLGMACGKEFGLVRASNGRVYYYGKS TALGLKCVGRTPSLKLTELIISKAAHIVHVAVGHDGIHALLVNDDGTVFFAGTARRGE DGDTSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSAFVTKAGKLIMYGKDTAHCDA MGFVTELLDQHVTKVALGKAHCVALNAKGQLFSFGLNNKGQCGRIFNKLQPVKDVASS SSAASCFAALLPPDKRYKLDLSALCDYDDHSLVQGQCRVCIVCRECTGYNVSCVSALN VPLEQRLAGSICPCGHGDAGCAKCGLCATCIALQDNDNDANRELKTLSTEMQQRQQRS KTLLMRRKEKKPCELETGAAGGGAATPTDLDKDPPRVAPLAPQLLQLPSASPVVQVAC GLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVQGAISQVAAGSNHSVLL THKGMVYTFGNYQKGQLGRLPSDFGPNIDKNQRPGQSPGQGQAQPQPQPHTQDEELPN STTGGASGSSDAAAAAALESSVLPSCSKELPPLMPNFSCPVLTQRQKFLWNCSPAAVF GLGPSFGKKVTWIGANGDQTFIKIDESLITAQMLPKMHVVANRKTILLVPSIPLSFHT LSINRRDGSCTAHYRGQSNFIQLMQAQPQPQANESQRQTDATTPVMASPALAEPVAGH ASSALLTALAGTATAGVPINEQMSRSMHEARNQIFEEPEGGVAVVASGSGGCIPRPRR FLRQRLDMGAPGSPSDQQQSPQQLAFAMDPSYNVLWVFDGVSRRIRCHNVVASDISES DENAANYRALLSPELSLPTKAEARVSRSQGSLNLLACLDILTSAQDNIPYCFEQTLPK AIHPTTETPGGDYQVVNRFDNFGGGWGYSGHSVEAIRFASDTDIVLCGFGMFGGRGEY SCKVKLFDLGSDGGGYEKEGVLLSETKEVPYECAARSKHHILLPKPVSAAAGRWYLVW ARIAGPSSDCGSCGQASVTTEDQVVFSFKSSKKANNGTDVNSGQIPAILYRLVTQDCK QTAAPMDADPVQRISRAFANSVSRECFESLVVLLSWSWESFKTQLREQSDRSRPLQLQ QSLQYLGYVNKSCLRLLRKYTNEIYPQRATNTATGAAAGAGRNNKGGSSGPAAGGGGS SMVAAALSKLESKSSKDKHLPRVVPNPITVSKYFGEHPSTSGAGGGAGGGSRGGGADG SAAGTGTPITRKANLENIQLAECVGNVRALLIGIFCDDIFKDIATDEGYALTLEILDE CHLSFVACFDAFYPTSSLKWSCLCDLLAQMDRGALHSRLLSAILAGLCSPTVKLRATF SLLSAPGNDRQSIISPSDNSGLPMLSSTDAHQYPILVEQMIYRTQQEKSDFLISSWTF KDVLVRLLDIIASPIRQRIESIYSRSLEGSYPGKEWINQGLIDNCCHLLARVLAEIVY QTAMGEYDKLFLPPRTLHSTGARFARCDLSRTWNTGNFGPDAIAFSVDRSGIAIAGAM VYTGSGSYDYQLELLFDNTVDLQPQHKWETLESVSGSYDQEAVHNDLAEIKFEHPVQI KEHARYALRLCSQGARTCSGDSGLPTVRGPCGTNFHFYACDLSFNGTTPARGQLPCIL YYSTPVKLEAGVVGSGSTAMAAADAVSMLAASSQLIAHEVSTRDTALQIASDITKKCT ELLIMARNAMAASCSPSDNSSSNHTQTIDSEHNITPIEEHMDINWANNSRTAAQPRAA DPQNSTARDLGRRIESFSKGIMQTLTFDKRSTNPFEMEIEMGATEIGEEDSDDLANGQ IPSQSQGQGQGQGQMQSVVPINGNERVDFELAEQPQQQQQLQSLLVHSDSEEAAPIDA GAAGCSGFAVGGGVGLGVGVSSVLGEAARGVPLGGALAGGGCPVAALQLLEVFNLAAS NMFHTLLPLVYAHMSNLACSDPKSSVQILGLIKEILPHIAALNQLHVSKEQRQPEAAA AAAAANFPHPPEAAPPEQAEAAGAGAPPAAGSYSSSNSGGSSSTTSNHYCMVESEHPY RSASISCYRVEFPPCVQWMTIEFDGQSGTAQLEDYLLLSIPMRPAEQAGEPASQTDDY YDMLDNNLPSVPESRRTVIPTASEMGTATGAGSKNRSANAQLLMASCCRTPGTSSGSG ATTASSPLRAQDANDREWIVVKKFNTASNWLMSVLVVPGNCVEFSLETSSLYAQDPHN NRYGFKCLVVGYDNPTAINGSNSCLIRLEQELSYLGGMCCANLMKKELNMPEDKDVED MSGVEETIMAHHSLLSKGFALSDPHLNVHQALEPYLPIGSQSNERQFLKDFISGAPGS SGARLAAWLQPESRLDPNKCEMNPITEPLRYGWPTQVTITIRDQYGDAVLVPELKVEI KAIPTGPGPHGPGGVGAANILRMRRASCASTVTDACLGGMAPPPRFNYEVTTKERMCF KAITFMKPFTNYSFEELRYSSPVQTRSTDTLSARDMEDGTFSVQWTPNSVGGYCLAVI IDGIHLEEVYRVEVKEGVLPPPTQRSSTTRRPQAPSKLRRFQVRHSAGLRIRSHPTLQ SEQVGVVRLGGIISFIDEIENDDGIWLRLSTESIRQHCTMGWYPTEAWCLQFNQHLAK VLLQPVLDAKDAGAVAPASPTTGGGCSGEPSPEPEPEHSPPPSPVLPKSPVVQRRFLG GPVNTNPFLFPTKRERQREREREREREMEREREREREREQRERVQQMEPEPDQDVEVE AELQPELAGAAAAASASASAVAPPPVPVPESGPEPELAGAAASSSSSSSAVAATELLP ANLGSAIAGVVGGGAIRLQALQKWFKGDAIEGAQPQAQAQAHEPSHMDASFSQSPPPP HAGVSVREMVRAMGQEPAPSPSGSPCPSMRGNGNRSSSQQQEQQQEQQQEQEPEPEFN LASMRRPNYTASQTAALLSTPKHTPRRTVAGVAAAAAAAAVQEVVSGLEDDLSLLQIT TTTTGTEQQSELQLASTSAAATASASAAAARNTMGPIKRAMPPSFAESIRAVFAALLW HEGVVHDAMACASFLKFHPGLPKEGATVVTRRGETGDARLQLSREQKAQQRHSVEVAN AGHYLNIRPSTLETLTKSGNSSLHNRSKHRKNMSPPAGGEDQQQQPPRDGQQQQKLQA LPEVVSVLPPALRCLVYLWEQICSGCVQIVQTNGLEQPRQPRLLSPIHHMDGHGHGHG HEPKEGGKMGAGHHMDQGGAGASDKEGKKTKRKKKDDGSWCEICELFLPMPVTYHMRI AHPGCGKSAKGKGYNSVGIFCEGWAGNCGEGGKGASSWFLMCDTCRDRYLASCRSTNN INSVARGQEANSAEDNVLNLFGVRSTLIANAEVYTTMRENATFLLELCSSFSSASSSN SSSNSILAKRSPQSMAMPVVIEHQHHHHPLGVADLKPSTSRNSRMARLSGGPKFCPAG IGGAFRKSFVGGPPTAPDNLWLAPDSFACLECLGTAGHEEPPYEMFGLGPNENAFDRP LSEISYESCDPNNYDMGMAPGTSAAAAGAVSKFHRSYSMGQGWASLVQQATQAPQQQH XQQQQQAPQQQDTPPKVVYRRRNNLSSESEGARLICYPSEHLRRLVPHKLLASVTVLQ TSTSAAAAAAAEGDAPAISPGPEQGGAGGASSSLLSRPAMAFITQKHELERLRAAMRR SLRISVCRSYSLQALNWLLRSVTQGVCLHDLMWWFVSSLETAVTHLPDGRYEESPDMA LEHPAAYTQISGRFAHLITQSLHVLLQSVADLTLHLPPGSPLQRVAIQCFGIRFRQAD HQFLHSSHVFGNISKILSKSDEQNDAMAVSTLLLLKSESHCDVEHNQLQLNATSGGSG AGSGSGTGAGAGPGGRVVCYTDLAGMFDIAVSSRPAMAESLTDNSTETFWESDEEDRN KVKIIEVSLIRLTYACRFLLVHIDNSRDIQNKVLNVGFYAGQSLGDTNLIKSVDVDSK ACTWISAKINDESYTHFRLELHGPENTLRVRQIKLLGLPIQNQQGQPGPAQFQTLGES MRLGMGMGMGLGLGLGLDEPFGSELKPYLRHSYAPHIQQQICEAETLRVFRLITGQVF GKLISNVNAVRSSEEPPPEVPGPAGVSGGGAGGAGGSSLLADSLDLREHMVGILFSRS KLSHLQKQVIVHIVHAIRREALRAKEDWELANLAHDLRNPMEAAAAALPGPPLQQQQQ QQAAAGSSESSSERSRAPDTYCFEMLSMVLALSGSAVGRSYLSQQHGLLRDLLGLLHT GSDRVQRQVTALLRRILPEISPESFADLLGVQRLPPADYSIAHQSGSDFDMSRLGLLD IFLAVIAKSLQLQIKVKTTAATAGGGAAGGSSGSGGSGQAQQKQGQQEKTPAFVRLCS SLDLSVQQLRSRPPTGEAQLPGTSAGAGAGSVGDPFQFELAAPPRKESKRNLNQRWFL NGIISTKQAESIIGLIRDLASGKLSEKWSQTTKAAIAESVLNLTRLEEIYRTPEHCTK TATLWLALASLCVLERDHVEKLSSGQWSKVCDTRPMCTNHDDGETAAIIQCETCGSLC GDCDRFLHLNRKTRAHKRTVCKEEEEAIRVELHESCGRTKLFWLLALADSKTLKAMVE FRDGSHTIISGPQEAVGRCRFCGLTGNSGLLEIGNVCADAQCQEYAANSCLKTKPCGH ACGGVVGEEKCLPCLQHVCHARENELAEEQHDPKLTQDADDMCMICFVEAVSCAPSIH LECGHVFHFHCCKAVLEKRWSGPRITFGFSLCPICKADIHHPLLADILKPINALKQDV KRKALMRIKYEGVVKDTESKDVNVTQLAMDRYAYYVCFKCQKAYYGGEARCDAEIGEK FDPEELVCGGCSDVARAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCDTCHDDFQ RLTNIPKIKLPQCPAGPKAKQLLGDECPLHVMHPPTGEEFALGCGVCRNAQTF" misc_feature <1791..2378 /gene="LOC111076890" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Region: ATS1; COG5184" /db_xref="CDD:444065" misc_feature <2904..3173 /gene="LOC111076890" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Region: ATS1; COG5184" /db_xref="CDD:444065" misc_feature 4383..4835 /gene="LOC111076890" /note="PHR domain; Region: PHR; pfam08005" /db_xref="CDD:462339" misc_feature 6141..6602 /gene="LOC111076890" /note="PHR domain; Region: PHR; pfam08005" /db_xref="CDD:462339" misc_feature 9345..>9473 /gene="LOC111076890" /note="Bacterial SH3 domain; Region: SH3_3; pfam08239" /db_xref="CDD:462405" misc_feature 13323..13667 /gene="LOC111076890" /note="APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148" /db_xref="CDD:382862" misc_feature order(13353..13355,13434..13436,13455..13457,13641..13643) /gene="LOC111076890" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:176484" misc_feature 15225..15371 /gene="LOC111076890" /note="B-box-type 2 zinc finger found in Myc-binding protein 2 (MYCBP2) and similar proteins; Region: Bbox2_MYCBP2; cd19799" /db_xref="CDD:380857" misc_feature 15762..15926 /gene="LOC111076890" /note="RING finger, H2 subclass, found in the PHR (Pam/Highwire/RPM-1) protein family; Region: RING-H2_PHR; cd16463" /db_xref="CDD:438126" ORIGIN 1 atcgatttga ccgctctgaa ggaaagatgc ccgctaatat ggtgggacta ttgaatccca 61 tgaaatatgg tgatcatttc tacgagttgt ttacaaacca aacacgcagg cgaacccaca 121 atgagaggag aaccctcacc aagcgcaaaa gccgcaagga gaagtcggcg gcagcgatgg 181 cggccgctgc tgccgccgcc gtgctggatg ggaatcccgg tggcattgtg aatcccctgg 241 atccgccact ggtcaaggag cagctgatga ttatgccctc gttcccggcg ggccacatcg 301 agctagagcc aaatgcctcc aagtttgccg tcttctcggc cattcgcacc acagtcctgg 361 aagcggagac gcgctatgcc ctgctgcagg agggtggcgg cggcagggag gcggggatgg 421 gcctgaaaaa gtgggccgcc aatttggact catcctgctg cctgctgtgt gctgccagct 481 gcttggccag caacattctc gactgcacat gtcacgctca actggccctg gctgccggtg 541 cgctcggcgg tggcccaggg ccgggcatag cacctggcgg agctgccatc gctggcctta 601 ttggtgtggt gatcggaccc ggtggtccgg gcggctccaa cgacaagcgc aatcgccgcg 661 acagtgccaa cagcgatgcg gactcggaca ccgaggagcc caccgaacgg gagcccgtct 721 atgccaccgt tccgctcatc gtgggcgccg gactgcgcag tctgttcgag ctgattgccg 781 acgcccgcca cattcagccg ctgctctgca cgaaggcgct aaaggctctg ctcgacgtta 841 tccagggcca gcagcccgag tccttcaaga tggaaccgga ggagctgatc aatccgctgt 901 acgacctgtt gctcgatctg gccaccatgc cggcggccct caactcgacg accggagccg 961 aagccaattg gtcggccatg gcctgtgccg cactgctggg cctctgcatt gcccgcgggg 1021 acaccggcaa gatgctcaaa gcgattgccg ccatgctcat gtcgccacgg caactctctg 1081 cccagattgt ccaattgccg gccgtgctgg ccgccctcca gcacacggtg atcagtgcgg 1141 cgctgaacaa gccgacacgt ccggatttcc atagccacgg agtgccgcac aattccctga 1201 tcgatgagtt ccccttgaag ctgcctgaag tggggcccgg aggtgccgaa acggcaccgg 1261 ccatggcctg tgacggtgtc tttctatatc tgctgtacga tggctatctg ctgaagatcg 1321 gcactggctt tgggggctcc tacaaggggc atgtgtacgc gcagaacgat gactttacgc 1381 gcgagcggaa tgcctggctg ggctacagtg ccgggcattt gtatttcaga aggaactgca 1441 gacggaatac gggcgatcag ctgcagctgg tcggcctcga tacgctggcc ctcaagtcga 1501 tgagtcccct gaatatgctg gccatgcgtg agggcatcaa ctatgtccta tttaccgatg 1561 atgactcact ccatgccatc tgcagcaatc gcgatgacac ccttgtggtg aagaaactga 1621 atctgtacca caacagctac agcagcgaac cgcagccgtt tgagctgccg ctgcagctgg 1681 cccgcaagaa attccgcacc ctgggctatg ctgcctttga ggatgatctg ctcaaccagc 1741 atcaggtgca gcgcatccag tcatcgcaca acagctttga gcccaagctg ccggccacgt 1801 gtcgggatgc ggatgtggat gtgctgggca tggcctgcgg caaggagttc ggcctggtta 1861 gggccagcaa cggacgcgtc tactactatg gcaaatcgac ggccctgggc ctcaaatgtg 1921 tgggtcgcac gccctcgctg aagctcaccg aactgatcat atcgaaggcg gcgcacattg 1981 tccatgtggc cgtcggccac gatggcatcc atgcgctgct ggtgaacgac gatgggaccg 2041 ttttctttgc gggcacagca cgccgtggcg aggatgggga caccagcaag aatcgcaggc 2101 agccgaaggc ggtcaagccc aaaaagatga ccaaaatcga tggccatgtg gtggtgcatg 2161 cggcctgcaa caatggcacc tcggcgtttg tcaccaaggc cggcaaactg atcatgtacg 2221 gcaaggatac ggcccactgt gatgcgatgg gctttgtcac ggaactattg gatcagcatg 2281 tgacgaaggt ggccctgggc aaggcccatt gcgtggccct caatgccaag gggcagctct 2341 tctcgtttgg cctgaacaac aaaggtcagt gcggacggat cttcaacaag ctgcagcccg 2401 tcaaggatgt ggcctcgtcg tcctcggccg cctcctgctt tgccgccctg ctgccgccgg 2461 ataagcgcta caagctggac ctatcggccc tctgcgacta cgatgatcac agtctggtgc 2521 agggccagtg ccgcgtctgc attgtgtgtc gcgaatgcac cggctacaat gtcagctgtg 2581 tgtcggccct gaatgtgccg ctcgaacagc ggctggcggg cagcatctgc ccctgcggac 2641 acggggatgc gggctgtgcc aaatgcggtc tgtgtgccac ctgcattgcc ctacaggata 2701 acgataatga tgccaaccgt gagctaaaga ccctttccac tgagatgcag cagcgacagc 2761 agcgctccaa gacgctcctc atgcggcgca aagagaagaa accctgcgag ctggagacgg 2821 gcgccgctgg tggcggtgcc gcgacaccca ccgatctgga caaggatccg ccgcgtgtgg 2881 caccgctggc gccgcaactg ttgcagctgc caagcgcctc gcccgtggtc caagtggcct 2941 gtggcctgca tcacaccgtg gtgctgacgc tggccggtga ggtctacacg tttggcagca 3001 atcagtacgg acagctgggc agcggtgacc tgcagccggt cagcggtccg gtgcgcgtac 3061 aagtgcaggg tgccatcagt caggtggcgg ccggcagcaa tcattcggtg ctgctgacgc 3121 acaaaggaat ggtctataca tttggcaact atcagaaggg acagctgggt cgattgccca 3181 gcgattttgg ccccaacata gacaagaatc aaagaccagg acagagtccg ggtcagggtc 3241 aggcacagcc tcagcctcag ccacacacac aggatgaaga gctgcccaac agcacaactg 3301 gcggggcatc tggttcgagt gatgctgctg ctgctgctgc tctagagagc agtgtcctgc 3361 ccagctgcag caaggagctg ccacccttga tgccgaattt ctcctgtccc gtgctcaccc 3421 aaaggcaaaa gtttctctgg aactgctccc cggcagctgt atttggcctg ggtcccagtt 3481 ttggcaagaa agtcacctgg atcggcgcca atggggatca gacctttatc aaaatagacg 3541 agtcgctgat caccgcccaa atgctgccca aaatgcatgt ggtggccaac aggaagacca 3601 ttttgcttgt gcccagcata ccgctgtcct ttcacaccct gtccatcaat aggcgggatg 3661 gcagctgcac ggcccactat cgcggtcaga gcaactttat ccagctaatg caggcgcaac 3721 cacagccaca ggccaacgag agccaacggc aaacggacgc gacgacacct gttatggcct 3781 caccagcgct ggcagagccc gtggccggcc acgcatcatc agcgctgctg actgccctgg 3841 cgggcactgc caccgctggc gtgccgatca acgagcagat gtccaggagc atgcacgagg 3901 cacgaaatca gatcttcgaa gagcccgaag gtggtgttgc cgtggtcgcc tctggcagcg 3961 gcggttgcat accacgtccg cgtcgatttc tgaggcagcg actcgacatg ggtgcccccg 4021 gctcaccgtc ggaccaacag cagtcgccgc aacagctggc ctttgccatg gaccccagct 4081 acaatgtgct gtgggtcttc gatggcgtct cacggcgcat acgttgccac aatgttgtgg 4141 ccagcgatat atccgaaagc gatgagaatg cagccaacta tagggctttg ctctcgccgg 4201 agctgtcgct gcccactaag gcggaggcac gcgtctcccg ctcgcagggc tcactgaatc 4261 tgttggcctg cctggacata ctcacctccg cgcaggacaa tataccgtac tgcttcgagc 4321 agacgctgcc caaggccata cacccgacaa cggagacacc gggcggcgat tatcaggtgg 4381 tgaatcgctt tgacaacttt ggcggcggct ggggctattc gggacacagt gtggaggcca 4441 tacgcttcgc ctcggacacg gacattgtgc tgtgcggctt cggtatgttc ggcggacgcg 4501 gcgaatacag ctgcaaggtg aagctcttcg atctgggcag cgacggcggt ggctacgaga 4561 aggagggcgt ccttctcagc gagaccaagg aggtgccgta cgagtgtgcc gcccgcagca 4621 agcatcacat tctgctgccc aagccggtga gtgcggcagc gggacgctgg tatttggtct 4681 gggcacgcat cgcgggaccc tcatcggact gtggctcgtg cggtcaggca tcggtcacca 4741 ccgaggatca ggtggtgttc tcgttcaagt ccagcaagaa ggccaacaat ggcaccgatg 4801 tcaactcggg ccagataccc gccatcctgt accgcttggt cacccaggac tgcaagcaaa 4861 cagccgcacc gatggacgcc gatcccgtgc agcggatatc gcgcgccttt gccaatagcg 4921 ttagccgcga gtgcttcgag agtctggttg tgctgctcag ctggtcgtgg gagagcttca 4981 agacgcagct gcgcgaacag agcgatcgat cgcgtcccct gcagctgcag cagtcgctgc 5041 agtatctcgg ctacgtgaac aaatcctgtc tgcgattgct gcgcaagtac accaacgaga 5101 tctatccaca gcgcgccacc aacacggcca caggtgctgc tgctggtgcg ggtcggaaca 5161 acaagggcgg ctcctctggc ccagcggctg gtggtggtgg tagcagcatg gtggctgctg 5221 ctctgtccaa attggaatca aagtcaagca aagacaaaca tttgcctcgt gttgtgccca 5281 atccgataac agtgtcaaaa tactttggcg aacatccatc cacatcgggt gcaggcggtg 5341 gagccggtgg cggctcaaga ggtggcggcg cagatggatc ggcagctggc acgggcacac 5401 ccatcacacg gaaggcgaat ctcgagaata tccagctggc cgagtgcgtg ggcaatgtgc 5461 gagctctgct cattggcatc ttctgcgacg acatattcaa ggacatagcc acagacgagg 5521 gctatgcctt gaccctggag atcctggacg agtgccatct gagctttgtg gcctgcttcg 5581 atgccttcta tcccacctcg tcgctgaaat ggagctgcct gtgcgatctg ctggcccaaa 5641 tggatcgcgg tgcgctgcac tcccggctgc tgagcgccat tctggcgggc ctgtgctcgc 5701 ccaccgtcaa gctgcgtgcc accttttcgc tgctgagcgc ccccggcaac gatcgccagt 5761 cgataatcag tcccagcgac aattcgggcc tgcccatgct atcctcgacg gatgcccacc 5821 agtatcccat actggtcgag cagatgatct accggacgca gcaggagaag agtgactttc 5881 tgatcagctc gtggacgttc aaggatgtgc tggtgcgtct gctggacatc attgccagcc 5941 ccataaggca gcgcatcgaa tcgatatata gccgcagcct ggagggcagc tatccgggca 6001 aggagtggat caaccagggc ctcatcgaca actgttgcca tctgctggcc cgcgtgctcg 6061 ccgaaatcgt ttaccaaacg gccatgggcg agtacgacaa gctgtttctg ccgccgcgca 6121 ccctgcactc gacgggcgcc agattcgcac gctgcgacct gagccggaca tggaatacgg 6181 gcaactttgg ccccgatgcc attgcctttt cggtggaccg ttcgggcatt gccatagcgg 6241 gcgccatggt ctataccggt tcgggcagct acgactatca gctggagctg ctgttcgaca 6301 atacggtgga tctgcagccg cagcacaagt gggagacact ggaatcggtg tcgggcagct 6361 acgaccagga ggcggtgcac aacgatctgg cggagatcaa gttcgagcat cccgtacaaa 6421 tcaaggagca tgcacgctat gccctgcgcc tctgctccca gggggcacgc acctgttccg 6481 gtgactcggg cctgcccacg gtgcgtgggc cgtgtggcac gaacttccat ttctatgcct 6541 gcgatctgag cttcaatggc acgacaccgg cacggggcca gctgccgtgc atcctgtact 6601 acagcacacc cgtcaagctg gaggcaggcg tggtgggatc cggctcaacg gcgatggcag 6661 cggccgatgc ggtcagcatg ttggcggcca gcagtcaact gattgcccac gaggtgtcca 6721 cgagggacac ggccctgcag attgcctcgg atataaccaa aaagtgcacc gagctgctga 6781 tcatggcccg caatgcgatg gctgcctcgt gctcgccctc ggacaacagc agctccaatc 6841 acacgcagac aatcgactcg gagcacaaca taacgcccat cgaggagcac atggacatta 6901 attgggccaa caattcgcgc actgctgccc agccacgcgc agcagatccg cagaattcca 6961 ccgcccgtga tctgggcagg cgcattgagt ccttttcgaa gggcatcatg caaacgttga 7021 cgttcgacaa gcgctccacg aatccatttg aaatggaaat cgaaatgggc gccaccgaga 7081 ttggcgagga ggattccgat gatctggcca atggtcagat acccagccag agtcagggtc 7141 agggtcaggg acagggacag atgcagagtg ttgtgcccat caatggcaat gagcgggtgg 7201 actttgagct ggccgaacag ccacagcagc agcagcagct gcagtcgctg ctggtacact 7261 cggactcgga ggaggcggcg cccatcgatg ctggagccgc cggctgcagt ggctttgctg 7321 tgggaggagg agtaggccta ggcgtgggcg tatcctctgt actgggagag gcagcgagag 7381 gagtgccact tgggggcgca ctagcaggtg gtggctgccc agtggccgct ctccagctgc 7441 tggaagtctt caatctggcc gcctccaata tgtttcacac cctcctgccg ctggtctacg 7501 cgcacatgtc gaacttggcc tgcagcgatc ccaagagctc agtacagata ctcggcttaa 7561 tcaaggagat actgccacac attgcggccc tcaatcaatt gcatgtatcc aaggagcaac 7621 gccagccaga ggcggcagca gcagcagcag ctgccaattt tccgcatccg ccagaggcag 7681 cgccaccaga acaggcagaa gcagcaggag caggagcacc tccagcagca ggtagctaca 7741 gttcgagcaa ctctggagga tcgagcagca ccaccagcaa ccactattgc atggtggaga 7801 gcgagcatcc gtatcggagt gccagcatta gttgctaccg tgtcgagttt cccccatgcg 7861 tccagtggat gaccatcgag ttcgatgggc aatcgggcac ggcacagctg gaggattatc 7921 tgctgctatc catacccatg cgaccggccg agcaggctgg cgaacctgcc agccaaacgg 7981 acgactacta cgatatgctg gacaacaatc tgcccagtgt gccggaatca agaaggaccg 8041 tgatacccac tgcatcggaa atgggaacag caacgggagc tggcagtaaa aatcgctcgg 8101 ccaatgccca gctactgatg gccagctgtt gtcgcactcc agggacatcc agtggcagcg 8161 gtgccacaac cgcatcgtcc ccgctgcgtg cccaagatgc caatgacagg gaatggattg 8221 tggttaagaa gttcaacacc gcctccaact ggctgatgag tgtcctcgtt gtgcccggca 8281 attgtgtgga attctcgctg gagacatcat cgctgtatgc ccaggatccg cacaataatc 8341 gctatggctt caagtgtctg gtggtgggat atgacaatcc cacagctatt aacggcagca 8401 attcgtgttt gatacgactg gagcaggagc tgtcctattt gggcggcatg tgctgtgcca 8461 atctcatgaa gaaggagctc aatatgccag aggacaagga tgttgaggac atgagtggcg 8521 ttgaggagac cattatggca catcattcgc tgctttccaa gggatttgca ctctccgatc 8581 cacatctgaa tgtacatcag gctttggagc catatctgcc cattggatca caatccaatg 8641 aacggcaatt cctcaaggac tttatcagcg gtgcacccgg ctcgtcgggt gcccgactgg 8701 cggcctggct gcagccagag tcccgcctgg atcccaacaa atgcgaaatg aatccaatta 8761 cggagccact gcgctacggc tggcccaccc aggtgaccat caccatacgc gatcagtacg 8821 gagatgctgt cctcgtgccc gagctaaagg tggagatcaa ggccataccg acgggaccgg 8881 gtccccatgg accgggcggc gtgggtgctg ccaatatcct gcgcatgcgt cgcgcctcct 8941 gcgcctccac ggtgacggac gcgtgcctgg gcggcatggc gccgccgccg cgtttcaact 9001 acgaagtgac caccaaggag cggatgtgct tcaaggccat caccttcatg aagcccttca 9061 cgaactactc gttcgaggag ctgcgctact ccagccccgt gcagacgcgc tccacggaca 9121 cgctcagcgc ccgcgacatg gaggatggca ccttcagtgt ccagtggacg cccaattccg 9181 ttggcggcta ctgcctggcc gtcatcatcg acggcatcca tctggaggag gtctaccgcg 9241 tcgaggtgaa ggagggcgtt ctgcccccgc ccacccagag gagcagcacg acgcgccgcc 9301 cccaggcgcc cagcaagctg cgacgctttc aggtgcgcca cagcgccggc ctgcggatcc 9361 gctcccatcc gacgctgcag tcggagcagg tgggcgtggt gcggctgggc ggcatcatct 9421 cgttcatcga tgagatcgag aacgacgacg gcatctggct gcggctctcc acagagtcga 9481 tacggcagca ctgcaccatg ggctggtatc cgacggaggc ctggtgcctg cagttcaacc 9541 agcatctggc caaggtgctg ctgcagccgg tgctggatgc caaggatgct ggtgccgtgg 9601 cgccagccag tcccaccacc ggtggcggct gcagtggcga gcccagcccc gagccggagc 9661 ccgagcacag tcccccaccg agccccgtgc tgcccaagtc gcccgttgtc cagcgcagat 9721 tcttgggcgg tcccgtcaac acgaatccct ttctgttccc caccaagcgg gagcgtcaac 9781 gcgaacgcga gagggagcgc gagagggaaa tggaacgtga aagggagcgc gagcgagaga 9841 gagagcagcg cgaaagggtg cagcaaatgg agccagagcc agaccaggat gtggaggtgg 9901 aggctgaatt gcagccagaa ctggcaggag cggctgcggc tgcgtctgcg tctgcctctg 9961 cggttgcacc tccgcccgta cccgtacccg aatcggggcc ggagccggag ctggcgggag 10021 cggcagcgtc gtcgtcgtcc tcctcctcgg cggtggcggc cacggagctt ctgcccgcca 10081 atctcggctc cgccattgcc ggcgttgtcg gtggcggtgc catcaggctt caggccctac 10141 aaaaatggtt caaaggcgat gccatcgagg gagcccagcc ccaggcacag gcacaggccc 10201 acgagcccag ccacatggat gcatcgtttt cacagtcacc gcccccgccc catgcgggcg 10261 tctctgtacg cgagatggtg cgggccatgg gacaggagcc tgcgccctcg ccctccggtt 10321 cgccatgccc atcgatgcgg ggaaatggca atcgcagcag cagtcagcag caggagcaac 10381 agcaggagca gcagcaggag caggagccgg agccggagtt caatttggcc agcatgcggc 10441 gtcccaacta caccgccagc caaacggcgg cactgctgtc gacgcccaag cacacgcccc 10501 gtcgaacggt ggccggggtg gcggcggccg ctgcagccgc tgccgtccag gaggtggtct 10561 ccggcctgga ggatgatctc agtctgctgc agatcaccac aacgacgacg ggcacggaac 10621 agcagagcga actccagctg gcctccacat cggcagcagc cacagcatcg gcttcagcgg 10681 cagcagcgcg gaacaccatg ggacccatta agcgggccat gcccccgtcg tttgcggaga 10741 gcattcgggc cgtgttcgcg gcactgctgt ggcacgaggg cgtcgtccac gatgccatgg 10801 cctgcgccag cttcctcaag ttccatcccg gcctgcccaa ggagggggcc actgtggtga 10861 cgcgccgtgg cgagacgggc gacgcgcggc tgcagctctc ccgtgagcag aaggcccagc 10921 agcggcactc ggtggaggtg gccaatgcgg gccactacct gaacatacga ccctccacac 10981 tggagacgct caccaagagc ggcaacagct cgctgcacaa tcgcagcaag catcgcaaga 11041 acatgtcccc gcccgctggc ggcgaggatc agcagcagca gccaccccga gacgggcagc 11101 agcagcagaa gctgcaggcg ctgccggagg tggtcagcgt gctgccgccg gcactgcgct 11161 gtctggtcta tctgtgggag caaatctgct ccggctgcgt gcagatcgtc cagacgaatg 11221 gcctcgaaca gccgcgacag ccgcgcctgc tctcgcccat ccaccacatg gatgggcacg 11281 gccacgggca tggccatgag ccaaaggagg gcggcaagat gggggccgga caccacatgg 11341 atcagggggg agcgggtgcg agcgataaag agggcaagaa gacgaagcgc aagaagaagg 11401 acgacggcag ctggtgcgag atctgtgagc tgttcctgcc gatgcccgtc acgtaccaca 11461 tgcggatcgc ccatccgggc tgcggcaagt cggccaaggg caagggctac aattccgtgg 11521 gcatattctg cgagggctgg gcgggcaatt gtggcgaggg cggcaagggc gcctcctcgt 11581 ggttcctcat gtgcgacacg tgccgggaca ggtatctggc cagctgccgc agcaccaaca 11641 acatcaatag tgtggcacgc ggccaggagg ccaattccgc ggaggataat gtcctcaatc 11701 tgtttggcgt gagatccaca ttgattgcca atgcggaggt ctacaccaca atgcgtgaga 11761 atgccacctt tctgctggag ctgtgctcca gcttcagctc tgccagcagc agcaacagca 11821 gcagcaacag cattctagca aagcgttcgc cccagtccat ggccatgccg gtggtcattg 11881 agcatcagca tcatcatcat ccgttgggcg ttgccgatct gaagcccagc accagtcgca 11941 acagtcgcat ggcccgactc agtggcggcc ccaagttctg tccagcgggc attggcggtg 12001 ccttccgcaa gagctttgtg ggtggaccgc cgacggcgcc ggacaacctg tggctggcac 12061 ccgacagttt tgcgtgtctg gagtgcctcg gcacggcggg gcacgaggag ccgccctacg 12121 agatgttcgg cctgggaccc aacgagaatg ccttcgatag gccgctgtct gaaatatcgt 12181 acgagtcgtg cgatcccaac aactacgaca tgggcatggc accgggcacg agtgcagccg 12241 ccgctggcgc tgtgtccaag ttccatcgca gctactccat gggccagggc tgggcctcgc 12301 tggtacagca ggcaacgcag gcaccgcagc agcagcacna acagcagcag cagcaggcgc 12361 cacagcagca ggatacaccg ccaaaggtgg tgtacaggcg aaggaataac ttgagcagcg 12421 agagcgaagg cgccaggctc atctgctatc cgtcggagca tttgcggcgt ctggtgccgc 12481 acaagctgct ggccagcgtc actgtcctac agacctccac atcggccgcc gccgccgccg 12541 cagcagaggg cgatgccccg gcaatcagtc cggggccaga gcagggcgga gcaggcggtg 12601 caagcagctc gctgctgtcc cgaccggcca tggcattcat tacgcaaaaa cacgagctgg 12661 aacgactgcg ggcggccatg cggcgcagcc tgaggatctc cgtgtgccgc agctactcgc 12721 tgcaggcact caactggctg ctgcgcagcg tcacccaggg cgtttgtctg cacgatctga 12781 tgtggtggtt cgtcagctcg ctggagacgg ccgtcaccca tctgccggac ggccgatacg 12841 aggagtcacc ggacatggcg ctggagcacc cggcagccta cacccagatc agtggccgct 12901 ttgcccacct gatcacccag tcgctgcatg tgctgctgca gtcggtggcg gatctgacgc 12961 tccacctgcc gccaggatcg ccgctgcagc gcgtggccat ccagtgcttt ggcatacgtt 13021 tccggcaggc cgaccatcag ttcctgcaca gctcccatgt ctttggcaac atctccaaga 13081 tcctgtccaa gtcggacgag cagaacgatg cgatggccgt gtccacgctg ctgctgctca 13141 agtccgagtc ccactgcgat gtcgagcaca atcagctgca gttgaatgcc acatcgggcg 13201 gctctggtgc cggttccggt tccggtaccg gtgctggggc cggacccggt ggccgggttg 13261 tctgctacac ggatctggca ggcatgttcg acattgctgt gtcgtcgcgg ccagcgatgg 13321 ccgagtccct cacggacaac tccacggaga cgttctggga gagcgacgag gaggatcgca 13381 acaaggtgaa aatcattgaa gtgtccctca tcaggctgac atacgcctgc cgcttcctgc 13441 tcgtccacat cgacaacagt cgcgatattc agaacaaagt gctcaatgtg ggcttctatg 13501 cgggccaatc gctgggcgat acgaatctga tcaagtcggt ggatgtcgac tcgaaggcct 13561 gcacctggat ctcggcgaag atcaatgacg agagctacac ccatttccgg ctggagctgc 13621 acggacccga gaacacgctg cgcgtgcgcc agatcaagct gctgggactg cccatccaga 13681 atcagcaggg acagccgggt ccggctcagt ttcagacgct cggcgagagc atgcgcctgg 13741 gcatgggtat gggcatgggc ctgggtctgg gcctgggtct ggatgaaccg tttggtagcg 13801 aactgaagcc ctatctgcgg catagttatg cgccgcacat ccagcagcag atctgcgagg 13861 cggagaccct gcgcgtcttt cgcctgatca ccggccaggt ctttggcaag ctgatcagca 13921 atgtgaatgc ggtgcgcagc agtgaggagc cgccaccgga ggtgcctggc cccgctggcg 13981 tcagtggcgg tggcgctggc ggtgccggtg gcagctccct gctggccgat tccctcgacc 14041 tgcgcgagca catggtcggc atcctgttct cgcgcagcaa actctcgcac ctgcagaagc 14101 aggtgattgt gcacattgtg cacgccattc gccgggaggc gctgcgcgcc aaagaggact 14161 gggagctggc caatctcgcc cacgacctca ggaatcccat ggaggcggct gccgcggctc 14221 tgccggggcc cccactgcag cagcaacagc agcagcaggc tgcagctggc agcagcgaga 14281 gcagctcgga gcgtagccgg gccccggaca cctactgctt cgagatgctg agcatggtgc 14341 tggccctatc cggcagcgct gtgggtcgct cctatctgtc gcagcagcac gggctgctgc 14401 gcgacctctt gggactgctg cacaccggca gcgatcgtgt gcagcgtcag gtgacggcct 14461 tgctgcgtcg catactgccc gagatatcgc cggagagctt tgcggatctg ctgggcgtgc 14521 agcggctgcc accggccgac tacagcatcg cgcatcagag cggcagcgac ttcgatatga 14581 gccgactggg gctgctggac atattcctgg ccgtgattgc caaatccctg cagctgcaga 14641 tcaaagtgaa gaccacagcg gcaacggcag gcggcggtgc agcaggagga tcgagcggat 14701 caggcggatc aggccaagcc cagcagaagc agggacaaca ggagaagaca ccggcctttg 14761 tgaggctctg cagttccctg gacctgtccg ttcagcagct gcgctcgcgc ccacccacag 14821 gagaggcaca gctgccgggc acgtccgctg gcgctggcgc tggcagcgtg ggcgatccgt 14881 tccagttcga gctggcagcc ccgcccagaa aggagtccaa gcggaatctc aaccagcgct 14941 ggttcctcaa cggcatcatc tccaccaagc aagcggagag cattattggc ctcatccgcg 15001 atctggccag cggcaaactg agcgagaagt ggtcgcagac gaccaaggcg gccattgccg 15061 agtccgtgct gaatctgacg cgactcgagg agatctatcg cacgccggag cactgcacca 15121 aaacggctac actgtggctg gcgctggcca gcctgtgtgt gctcgagcgc gaccatgtgg 15181 agaagctgtc gtcggggcag tggtcgaagg tgtgcgacac ccgacccatg tgcaccaatc 15241 acgatgatgg cgagacggcg gccatcatac agtgcgagac atgcggctcc ctttgcggtg 15301 actgcgatcg cttcctgcat ctcaatcgca agacgcgagc gcacaagcga acggtatgca 15361 aagaggagga ggaggccata cgcgtggagc tgcatgaatc gtgtggccgc acgaaactct 15421 tttggctgct ggccctggcc gattccaaga cgctcaaggc catggtcgag ttccgcgatg 15481 gcagccacac gatcatctcg gggccgcagg aggcggtggg cagatgccgc ttctgcggcc 15541 tcaccggcaa ctcgggcctg ctggagatcg gcaatgtgtg cgcggatgcg cagtgtcagg 15601 agtatgcggc caattcatgc ctcaaaacga agccctgcgg ccatgcatgc ggcggtgtgg 15661 tgggcgagga gaagtgtctg ccctgcctgc agcacgtgtg ccatgcgcgg gagaacgagc 15721 tggccgagga gcagcacgat ccgaagctca cacaggatgc ggatgatatg tgcatgatat 15781 gcttcgtgga ggccgtctcc tgtgccccct ccatacatct ggagtgcggg cacgtgttcc 15841 actttcattg ctgcaaggcg gtgctggaga aacgctggag cggcccacgc atcacatttg 15901 gcttctcatt gtgccccatc tgtaaggcgg atatccatca tccgctgctg gccgacatac 15961 tgaagcccat caatgccctc aagcaggatg tgaagcgcaa ggcgctcatg cgcatcaagt 16021 acgagggcgt ggtcaaggac acggaaagca aggacgtgaa tgtgacacaa ctggccatgg 16081 atcgctatgc gtactacgtg tgcttcaagt gccagaaggc ctactatggc ggcgaggcac 16141 gctgcgatgc ggaaatcggc gagaagttcg atcctgagga gctggtgtgc ggcggctgtt 16201 cggatgtggc acgcgcccag atgtgcccca agcacggcac cgatttcctc gagtacaagt 16261 gccgctactg ctgctcggtg gcggtgttct tctgctttgg cacgacacac ttttgcgaca 16321 cctgtcacga cgatttccag cggctgacca acataccgaa gatcaagctg ccccagtgcc 16381 ccgccgggcc caaggccaag cagctgctgg gcgatgagtg cccgctgcac gtaatgcatc 16441 cgcccaccgg cgaggagttc gccctgggct gtggcgtttg ccgcaatgcc caaacatttt 16501 agccacggac aaatattgag tccgatccag agccagagca agagccagag