serine/threonine-protein kinase PAK mbt [Drosophila obscura].

LOCUS       XP_022220036             643 aa            linear   INV 14-MAY-2021
ACCESSION   XP_022220036
VERSION     XP_022220036.2
DBLINK      BioProject: PRJNA728747
DBSOURCE    REFSEQ: accession XM_022364344.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XP_022220036.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Drosophila obscura"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     Protein         1..643
                     /product="serine/threonine-protein kinase PAK mbt"
                     /calculated_mol_wt=69570
     Region          9..54
                     /region_name="CRIB_PAK_like"
                     /note="PAK (p21 activated kinase) Binding Domain (PBD),
                     binds Cdc42p- and/or Rho-like small GTPases; also known as
                     the Cdc42/Rac interactive binding (CRIB) motif; has been
                     shown to inhibit transcriptional activation and cell
                     transformation mediated by the...; cd01093"
                     /db_xref="CDD:238526"
     Site            order(11,14,17,19,22,39,43)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238526"
     Region          364..624
                     /region_name="STKc_PAK_II"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Group II p21-activated kinase; cd06648"
                     /db_xref="CDD:270815"
     Site            order(378..382,386,399,401,430,446..450,452..453,456,491,
                     493..496,498,508..509,512,525..529,531,558,567..569)
                     /site_type="active"
                     /db_xref="CDD:270815"
     Site            order(378..382,386,399,401,430,446..450,452..453,456,
                     495..496,498,508..509)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270815"
     Site            order(381..382,410,491,493..495,512,525..529,531,558,
                     567..569)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270815"
     Site            508..531
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270815"
     CDS             1..643
                     /gene="LOC111072457"
                     /coded_by="XM_022364344.2:411..2342"
                     /db_xref="GeneID:111072457"
ORIGIN      
        1 mftkkkkkpl ismpsnfehr vhtgfdkren kyvglplqwa sivgnnqilk stnrplplvd
       61 pseitpteil dlktivrphh nnnkadttsl nssstmmmas vggpgggsip gtpggvhgsm
      121 gmlgaggqhh lmdpmtasgi vlpktshvar snslrssspp rvrrvanvpp svpeeessst
      181 aatttttpat gfkpqpplgh pmlyssqnah vngaatgpla vrtdqganmq yramggvgpp
      241 gaipqqtspv gsvasgtrst hshtnngnst gfplyppasq ahqpksvgvg dqnqnplhsh
      301 aqthphphqh phnhaksasr assssggass atlaasqasa qqqpkqdqrl theqfraalq
      361 mvvsagdpre nldhfnkige gstgtvciat dkstgrqvav kkmdlrkqqr rellfnevvi
      421 mrdyhhpniv etyssflvnd elwvvmeyle ggaltdivth srmdeeqiat vckqclkala
      481 ylhsqgvihr diksdsilla adgrvklsdf gfcaqvsqel pkrkslvgtp ywmspevisr
      541 lpygpevdiw slgimviemv dgeppffnep plqamrrird mqppnlknah kvsprlqsfl
      601 drmlvrdpaq rataaellah pflrqagpps llvplmrnar hhs