LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha

LOCUS       XP_022219959            2161 aa            linear   INV 14-MAY-2021
            [Drosophila obscura].
ACCESSION   XP_022219959
VERSION     XP_022219959.2
DBLINK      BioProject: PRJNA728747
DBSOURCE    REFSEQ: accession XM_022364267.2
KEYWORDS    RefSeq; corrected model.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XP_022219959.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 1 indel
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Drosophila obscura"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     Protein         1..2161
                     /product="LOW QUALITY PROTEIN: phosphatidylinositol
                     4-kinase alpha"
                     /calculated_mol_wt=243155
     Region          619..1578
                     /region_name="PI4K_N"
                     /note="PI4-kinase N-terminal region; pfam19274"
                     /db_xref="CDD:437106"
     Region          1607..1782
                     /region_name="PI4Ka"
                     /note="Phosphoinositide 4-kinase(PI4K), accessory domain
                     (PIK domain); PIK domain is conserved in PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. PI4K
                     phosphorylates hydroxylgroup at position 4 on the...;
                     cd00871"
                     /db_xref="CDD:238443"
     Region          1843..2160
                     /region_name="PI4Kc_III_alpha"
                     /note="Catalytic domain of Type III Phosphoinositide
                     4-kinase alpha; cd05167"
                     /db_xref="CDD:270711"
     Site            order(1855,1857..1858,1860,1862,1907,1909,1912,1943,
                     1955..1958,1963,1966,2021,2023,2033..2034)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270711"
     Site            2013..2021
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270711"
     Site            order(2034..2044,2047..2050,2051..2056)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270711"
     CDS             1..2161
                     /gene="LOC111072420"
                     /coded_by="XM_022364267.2:203..6688"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: deleted 1 base in 1 codon"
                     /db_xref="GeneID:111072420"
ORIGIN      
        1 mtmtasdkyt yqravlclar vlagiqptpw ekvqtlfryc pqenaagvfc ldtraqdavi
       61 algiyflesg cqhesqivpy llrlakclpk avwiddarss kiervripsa ekfsfclntl
      121 lsdiaakcpd sreeiilnqv etlgaltniv kssrdsssap ppiilckatv pllfglarsm
      181 gryasndppl lcrifppell piqrvggrdg tasssasgtc ggsfssserl aatanhqfrp
      241 iiprsmsgsl aahqhhhqly ddnrqrhlgy gfysnasnan nskqkpslns ycsvpydprt
      301 hfftrygssf nqfpnmrvce sptkggprpl yrvppfpiqh lqtifavskk lltkdtlehl
      361 deqasdifsl hqikgycyks fsetlnlvlv tllrellqhq vdlptpftkd vqefvkrlfl
      421 ngqtelqnkq qdqererree ngiavvnkyk vnvmanaacv dllvwairde tvdvdytvps
      481 lqnglqfllk keadklcgrl sqklnlvlsh kivmdhmpll mvcleglgkl aqkfpniagt
      541 sisylrdflv dpspilgklh ahamqslalq kkekeltpfk ivvqhsdsra vvdilndnqk
      601 haaaaggpga sgrsghvafe alrdaaienl sialraahtl dqfcvpalva nvsnrlftae
      661 khesesnlvs lniivmlghv avalkdtskt tqnilqffiq rfckvpseqn alivdqlgcm
      721 iisqcethvf deimkmfsrv tvqsaslayt sdpehrkqfh hvsdavvnal gniaaniqgd
      781 aemlellgkl lelfvqigld gersydntpg aqkassragn lgmlipviav lvrrlppikn
      841 prqrlhklfk dfwaycvvmg ftnarlwpad wyqgvqqiaa kspllisqta hksdmrelny
      901 tlaiksdsvn elrsqilmll ehssdnvata inkltfaqct yllsvywlem lrvenadeps
      961 lepimsylcd talqrdktgi wqcvkcvadq vfekfrnvly ahdeirekvl esqatlllvy
     1021 fnhihkqiql vadqylsqlv drfphllwnr rvlwcmldil qllaysltld pneetptlrv
     1081 vstpytlqlm dslparelrl kdfadrcqgi vneamkwapr strshlqeyp nqiptpvlah
     1141 hsglalaids vvnssylhpg nalgtlskrp scvnsdtprf vsvlclrsky ageisgllsv
     1201 lseqdkagla erlvsdvwea crdksdarhr galwratayl iicaevdrkl lhavassqle
     1261 lftesvmeta vecwqwvlta rqdlelcfiq emvsawqttf ekrmglfale kevthplaaf
     1321 egcklvsspi liaphliwlq llsemvdtak ycnrdkvemf clllhrclpi lkssrqnrqv
     1381 atvgcrfkll qcglsllqgn tipkslarni lreriysnal dyfcgpptcp iqsrdqlldd
     1441 ilillkfwqt mrsekkhlvt sevgdydmaa anasgssnqm lgvkanpeta slisggpdys
     1501 mrsmsasgnv tggssgwynt iphststlsk rsnrskrlqy qkdsydkdym kkrnlilell
     1561 aveleflitw ynpnclpdli vpgeeqitew rnrpykanvw rdyarlawcy npslavflpq
     1621 riknaeiide evsrlvcsdp iavchipeal kylcttknll qespdlvyil swspvtpiqa
     1681 lsyfsrqyps hpltaqyavk slssfpaesv lpyipqlvqa lrhdtmgyvv efikniskrs
     1741 qivahqliwn mqtnmymded qmhrdpnlye aldllsqnii asfsgaakrf yerefdffgk
     1801 itavsgeirs fakgierkna claalsrikv qsgcylpsnp eamvldidys sgtpmqsaak
     1861 apylarfrvy rcgiteletr amevsnnpns qedakitlgv eswqaaifkv gddvrqdmla
     1921 lqvitifkni fqqvgldlfl fpyrvvatap gcgviecvpn aksrdqlgrq tdsglseyfq
     1981 hqygdesske fqaaranfvk smaaysligy llqikdrhng nimidkdghi ihidfgfmfe
     2041 sspggnigfe pdmkltdemv mimggkmdsp afkwfcelcv qaflavrpyq daivslvslm
     2101 ldtglpcfrg qtinllkqrf vatknnkeaa ahmlsvirns yqnfrtrtyd miqyyqnqip
     2161 y