probable pyruvate dehydrogenase E1 component subunit alpha,

LOCUS       XP_017013821             500 aa            linear   INV 09-DEC-2024
            mitochondrial [Drosophila takahashii].
ACCESSION   XP_017013821
VERSION     XP_017013821.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017158332.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017013821.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..500
                     /product="probable pyruvate dehydrogenase E1 component
                     subunit alpha, mitochondrial"
                     /calculated_mol_wt=55360
     Region          36..382
                     /region_name="TPP_enzymes"
                     /note="Thiamine pyrophosphate (TPP) enzyme family,
                     TPP-binding module; found in many key metabolic enzymes
                     which use TPP (also known as thiamine diphosphate) as a
                     cofactor. These enzymes include, among others, the E1
                     components of the pyruvate, the acetoin and...; cl01629"
                     /db_xref="CDD:470272"
     Site            order(89,141,166..167,198,200..203,206,210,214,229..232,
                     246,249,296,300)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(119..120,166,168,196..199,226,228,292)
                     /site_type="other"
                     /note="TPP-binding site [chemical binding]"
                     /db_xref="CDD:238958"
     Site            order(161,163,165,170,173..174,177..178,180..181,184,
                     203..204,210..211,214)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(287..293,295..305,314..316)
                     /site_type="phosphorylation"
                     /note="phosphorylation loop region [posttranslational
                     modification]"
                     /db_xref="CDD:238958"
     CDS             1..500
                     /gene="LOC108068641"
                     /coded_by="XM_017158332.3:123..1625"
                     /db_xref="GeneID:108068641"
ORIGIN      
        1 mkpnrirlvv grsgarsllh rnilssiigr hkcscltlen tfkcydletg ptmdvelsre
       61 dalsmytrml elrrfetvag nsykqrlirg fchlytgqea vavgmkerlr rcdsvitayr
      121 chawtylmgv slyeimaell glrtgcsrgk ggsmhmygen fyggngivga qvpvgtgigl
      181 ahsyrkdngv cvilygdgaa nqgqvfesfn maklwclpci fvcennhygm gthekrasam
      241 tefymrgqyi pglwvdgnqv lavrsatqfa vdyalkegpi vlemstyryv ghsmsdpgts
      301 yrsrkevqav resrdpitsf rsqiltlcla deeelkalee rtkkqvdaec kraakdkeve
      361 lqelhtdiya knvdgkirgv srfdlehirl sevcfgkprk tpaseikdvp vgaavdaaka
      421 kerkaaqeak eakegqkkkk edskdlknsk epkdpkpvdp kpptaaaapp aktppskapp
      481 skappakktp ptkaptdpkk