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E3 ubiquitin-protein ligase HUWE1 isoform X3 [Drosophila


LOCUS       XP_017013786            5116 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017013786
VERSION     XP_017013786.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017158297.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017013786.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5116
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..5116
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X3"
                     /calculated_mol_wt=552341
     Region          90..326
                     /region_name="DUF908"
                     /note="Domain of Unknown Function (DUF908); pfam06012"
                     /db_xref="CDD:428721"
     Region          623..977
                     /region_name="DUF913"
                     /note="Domain of Unknown Function (DUF913); pfam06025"
                     /db_xref="CDD:461803"
     Region          1455..1494
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          1735..1807
                     /region_name="WWE"
                     /note="Domain in Deltex and TRIP12 homologues. Possibly
                     involved in regulation of ubiquitin-mediated proteolysis;
                     smart00678"
                     /db_xref="CDD:128922"
     Region          3667..3697
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          3716..3743
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          4761..5114
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4765,4795,4806,4867,5041,5077..5078,5081..5085,5105,
                     5113)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4895,4898..4899,4901..4902,4905,4912,4914,
                     4918..4919,4921,4926,4931,4948,4952)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..5116
                     /gene="HUWE1"
                     /coded_by="XM_017158297.3:468..15818"
                     /db_xref="GeneID:108068620"
ORIGIN      
        1 mkvdtvklkk gsseltaecr elideltkrr traellefld tihvwiygkc elyhwieild
       61 rfdkileeas rhvnanefvl qcdtnfqetd vtlllhvlnf ttlliehsfs rhlynsiehl
      121 tvllssqnmd ivlavlnlly mfskrsnfip rlpfekkell ivklfniaer wgdpnyglsl
      181 kdccigepkl eflyqlcidy vdehghaaql eipdmmdlch tasapevikt iagqiskpse
      241 aikmriahrv rlisgfnnyk lrlqfvqarl qavsiliysn alqdntdkvl yagfgeelce
      301 lidkedvhlv eiraavlrtl tsmlhfdrnp nvpsragsrl mkivhytgae rqggtlpllv
      361 rdcidnltth glteryplil atslfsllyh lasyemggsa lvksgmmqsl lcviswpgvd
      421 lehitfvtra vrvidlitni diarfhqnng lnvfidrlek eikscckala digitlkest
      481 lrddhkldns leqvdddvee tgentsvasg ggsprrenss dgltgagssa yrayhehsgg
      541 gagsgaglld iggarsaggg ssggasaapi iglinrdgsa arppaimypt nsyyarplae
      601 rkaelssqlp sslapkkpsc vtqraallks mlnflkksiq dhahfsnmrn imetsltqsl
      661 rhiianaeyy gpslfllatd vvtvyvfnep sllsslqdlg itsvmlkall qkdvpatrev
      721 lgslpnvfsa lclnerglfe flsydpfdkv lkvllspdyl vamrrrrssd plgdtatnlg
      781 namddlikhh pylradatea ivrllnelvr lgsdpsficw rankessgsg sgsgshgggg
      841 shhvastpsp mavmvagsgg stsvlqgaad tndssgdddd dddemssasq qqqqsggatt
      901 prtqqpgggv atpqavkvvt ppereaipli dyilnvmkfi eaifsnspng dhcrefvlhg
      961 glkpilqlls lpnlpvdspv sttsqavanv ckailsqaqe tkvldvalkq ladivaqlkp
     1021 likhftfpgg svllaelvcc qrledgfana eytpilhnms fvhgyvvmlv hlcrnasndm
     1081 raillkrwgv nretgvqllq qlvqlyislv westillnlc sdeptqhpdl iwdeiaaqms
     1141 aaagtadplt eaelsrkler aaefrtkysp eeqfryiksl laassrlgra laellgtlvk
     1201 lsvgspqtrq rrindlisni nkvptpeare iarilssilv ngfshesilp kpvpklkltf
     1261 licsvgftgp mlfddkrsaf hlmisqfcae nglkaffemf ywalsldnvs qkfdfdqwas
     1321 medlmqshed dkrdcpegtg efldawlqll ekmvnpraml dspytmsprl nylpdsvpfe
     1381 pvfylihihq lamqalrriw arrpipnygp smfetmilil khlikshqtl ldryhtrmke
     1441 ikfenlyirs tddglnadhi ktltdmgfmh yhviealrtn asleeatdyl lnnpeasals
     1501 tttggsaapp pppppppstm didmdlpadg geksssssan ssydykhlkl mpsiifdrfc
     1561 deaisrafef meaipdtvns aadliavlyr rhnhlnkqvf vtnfvrniiq wvdftlqlfe
     1621 psktaaskas rleecltglt atrlfvrlkt strlleenys dlhrplveai taqdamvslv
     1681 klldcmsqwm leqsvdsrat vprwvqnlvd lidsidsish ilqrkanmra vssevwrwyd
     1741 astgkwnays eannelirna yaagerwlhi nigrqrctvs lncmtqvsea sgthrpvcpa
     1801 lklseaital nspvslhkve hllnrvvrts pdgsgtvhsd elislrqlin fsdgqqpqen
     1861 paneegtned sgsplaamtt rsksrqksaa aaaaaqkkss shgsppipkr tqkiilneeq
     1921 vglskfdcgr iigsivdllq pshlmlnetk lsllrlcarl trnydnaqvf irrggvkmll
     1981 hlqqacsfmg fptyaniilr hvleappvlq eamervlgmr aagivpvghr dliyvltqvs
     2041 savsrnpqif vaaakemlkg eyllntnstt laddarvmvk skfgqqptaa aggatpnsqt
     2101 stppdeqlkd dpqvqssvav lkdllhglvq pcwhyggtgs ldrgpgaael lqpdqppgta
     2161 aqgghdeeet papasskkqs sgggasagqp qttekfepcc ctwhiptsgh thakptisra
     2221 tllklladst rayqslvprv llshiytpad splisapqqt flgvlldrfl pitqrhhvpe
     2281 vstmtrvlic slsdcyqqpg vqvhvaeelh aavaralaqp dsaekhtrlq vlmslfpnli
     2341 espmlydkvh mhrnnmyrvl lrqgvmtylt kvaqykdlsn hntlstlaai lrpmeillrf
     2401 svstttlgsk rilfgggggg aggangagsg nsavgggsgt gpgsgntygt iinrrlyprl
     2461 aartavsaav ersnamggeh vlrdiirnvl sdrrhafefi fnsdemavds edsaapavgg
     2521 ngsgaggiga ggsgaavidv veersnggdt sdppgnvnsg sgtgavqsst sggpvrpvln
     2581 fdqlwddflq seglrlasrs gggagsgags tgagstgqqn ggnatggsan sgsnsvsgdp
     2641 rlrtnpdvdv ggggngggqs snsgvvndng igggggsdga stssdtgapg gerrdlnasl
     2701 lgdvstsesd sdastender needededdd apdedvdehs etdvdeerpr qfievfdhiy
     2761 epessetasn dadvdndddd dededdvddd ddddedndde dreegqsvmd aelenqidia
     2821 lalvssnnrp rrsaavnasg dasanrdpnp deevddeddd vdadpdgdpd vdpiggpsaa
     2881 qaeaylyerl gsglmptppv gfrvrmnssi aqpldidvng gnggggsggs gagvtgtagg
     2941 sgrgsssggt tasigaiasa alrpssgswm apdfnfigvs ggggasgsgg asgsnangge
     3001 vnafltpams qlersggasg sgqnmsnlld eqpsvsgngg ggggsgggsa sgnggvsggg
     3061 gangggtagq hpnatlcang vrrrllyldq qycvcmpthq npteetqmet ftqdalhwwl
     3121 eeatvldmes qtdaclyaah fllphlikel ktahqqrkqe eaarqtatnt ttpassasss
     3181 agapatsils ntaaptatas iassllanav aagsggssss gsglvvppva asatggtrrs
     3241 sipvlipssf ggpgsattgd atattggtts sssytttsis gsgslesqtt traprqrggl
     3301 rqhsqlpfni yaeidltneq dsqgatstgs apndgaesqa qqpqqqqqqq nssapslaqg
     3361 avlqhqrhpp vpllpssgrp srphsrldea ellllqladr qavrsrlqvs sghtnssrts
     3421 gsalinarpn rdlparlqrl vqahgslssr inasaastpa ptlvsmptpm ssaaleqlnv
     3481 tpagpdvvgp drnfalppsl evdvdvlpgi ldrilpqqqq eqqeaqqqee eeeqlllppp
     3541 pppppsetap lllteedmwq gtreeeedst stvavagsse aanesnqsdq tpessesvsp
     3601 npqapppaae sgeggaggag gaasastqtp ataeesavgg ttatatttaa tvtdmspevr
     3661 aalgdlevpe gvdpsflaal psemreeviq ehlrmqrirq raqqnaiqia hdslvevnpe
     3721 flaalplniq sevlmqqrie qqrqaaqtan pedpvdtaaf fqnlpenlrq ailtdmeesq
     3781 iaslppelaa eaqflrrdwe srngarmdah ppsnalsrfq ttlqsldear whssiwydas
     3841 gnaqpqhhqh ttivhhhaha hhaptmgkpl allmmedeni lldpdslatl llflfvedqk
     3901 vnsmrlhrvi rnlchheptr dwiisalisi vqktnednan fgagqaggkp ewlklrvdaa
     3961 fgyksnifli nrlyegsars isinpqaaqm ivrncldllf vlakhypssf vpfnrevkar
     4021 rilsavfgmp sptggastag agaparnidd fpppggtldf rsrfcryqva nrlrgilddh
     4081 paaapkpqsa tpldeapsts kaaaakaaat akvssqssqs vpyqtnaknf wdvvlnidrq
     4141 tqvrlanvaq fpltsqpawe wqansadfls fsdspfgqll emlpykvicr sphltdmlvk
     4201 llaslstelp keeeqlplsd qmptlipinq aaaaaadspa npseigdgla anveqeatpa
     4261 sgnpasgdsn aaakrtqlpt lsvalpvaps kprrkiyskn fsqlqlviev lthqcgtteg
     4321 ldnvaklivn ltqcsqasna ifiqyltaai lglaeevrqa iqmllneirm ynshhgvtas
     4381 tsgaaaagat vsgasllpnl avhegimqdr ftaehviisa pknakptcel qlpsmkklms
     4441 nssaqpyflr tlkifmqvrd myeaqnglst ggglagaagd ndddiidieg dggasggsss
     4501 dmapgsasti sppppppmet nqnindeeed edgeeeeddd daaraspaaa sagksskptl
     4561 sqilcldvlw htlseclval eeskdefavl vlqptveaff lihashraga kksgrggvvg
     4621 sglraagglg aaasaaqehs psmddtssan tlssasfede prmqdastnt plssnssaat
     4681 tvlsaheaql rqdrqkflqf aekhrtvlnq ilrqspthls dgpfavlvdh trildfdvkr
     4741 kyfqtelerl degirreeht vsvrrvtvfe dsfrvlyrlg peewknrfyi vfedeegqda
     4801 ggllrewyvi isreifnpmy alfcvspgdr vtyminpssh anpnhlsyfk fvgrviakav
     4861 hdnkllecyf trsfykhilg kqvkhtdmes qdyefykgld ylmkndistl gyeltfstev
     4921 qefgvtqird lkpngrdtav teenkfeyvq lvcqlkmsgs irqqldafle gfydiipkhl
     4981 isifneqele llisglpdid iedlkantey hkytsksaqi qwfwralrsf dqadrakflq
     5041 fvtgtskvpl qgfgslegmn giqkfqihrd drstdrlpca htcfnqldlp myksydklrs
     5101 cllkaihecs egfgfa