Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS XM_017158297 16582 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X5, mRNA. ACCESSION XM_017158297 VERSION XM_017158297.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017158297.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16582 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16582 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins" /db_xref="GeneID:108068620" CDS 468..15818 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X3" /protein_id="XP_017013786.2" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPS RAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLA SYEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNG LNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVA SGGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGAS AAPIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQR AALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVV TVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFE FLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADAT EAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVA GSGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQ AVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLP NLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGG SVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRW GVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTA DPLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVG SPQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLI CSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWAS MEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVP FEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHT RMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNP EASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMP SIIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQ WVDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVE AITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKA NMRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCM TQVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDEL ISLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSS SHGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCA RLTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERV LGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADD ARVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPC WHYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEEETPAPASSKKQSSGGGASAGQP QTTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLLSHIYTP ADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVA EELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYRVLLRQG VMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGGGGGGAG GANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSNAMGGEH VLRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGGSGAAVI DVVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQSEGLRL ASRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDVDVGGGG NGGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVSTSESDSD ASTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPESSETASN DADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALALVSSNN RPRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAAQAEAYL YERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTAGGSGRG SSSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNANGGEVN AFLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNGGVSGGG GANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHW WLEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNTTTPASS ASSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPPVAASAT GGTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLESQTTTR APRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQQQQQQQ NSSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQAVRSRLQ VSSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPAPTLVSM PTPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQQQEQQE AQQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVAGSSEAA NESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAEESAVGG TTATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRI RQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVD TAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSN ALSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTMGKPLAL LMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISI VQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAA QMIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAGAGAPAR NIDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPSTSKAAA AKAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQPAWEWQ ANSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEEQLPLSD QMPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAAAKRTQL PTLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQ ASNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAGATVSGA SLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTL KIFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTI SPPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQILCLDV LWHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVGSGLRAA GGLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSAATTVLS AHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKY FQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDA GGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAK AVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTF STEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYD IIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQ ADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLP MYKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 735..1445 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2334..3398 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4830..4949 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5670..5888 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11466..11558 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11613..11696 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14748..15809 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14760..14762,14850..14852,14883..14885,15066..15068, 15588..15590,15696..15701,15708..15722,15780..15782, 15804..15806) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15150..15152,15159..15164,15168..15173,15180..15182, 15201..15203,15207..15209,15219..15224,15228..15230, 15243..15245,15258..15260,15309..15311,15321..15323) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16582 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 catttgcctt caatttgcca aaaagaataa acgccagcgc ctatcgatag ccatcgatag 61 gcagagtcga ttgcaattct tcgttgccgt ggattggagc ggtgcgtggt cacactaatg 121 cttgcatttt ttttgtctgt ggaaatttca tttcacaaaa accgagatag ttaaattaac 181 caaattatag cgtttcagat cgaaataaca atagcagcaa tatgctgcag ttaaatataa 241 tttttattga acacgctgac gtatacgttt aaaccgcaac tcgatgccca acctataaac 301 aatcgacgcc cgacgccttt tcaccacgaa ccacccaatc tacacaagcc gcccactcga 361 caaacagccg gaggaagagg aggaggagga ggaggaagga ggaggagcac caccacccca 421 agtggtggcc acctgctgct ccattagctc cactagctcc acgaacaatg aaggtggaca 481 cggtgaagct gaagaagggc tcctcggagc tcaccgccga gtgccgcgag ctcatcgacg 541 agctcaccaa gcggcggacg cgggccgagc tgctcgagtt cctcgacacc atccacgtct 601 ggatctacgg caagtgcgag ctctaccact ggatcgagat cctcgaccgg ttcgacaaga 661 tcctcgagga ggcgtcgcgc catgtcaacg ccaacgagtt cgtgctgcag tgcgacacca 721 atttccagga aacggatgtc acactgctgt tgcacgttct taacttcacc acactgctga 781 tcgagcactc gttctcgcgg cacctctaca actccatcga acacctgacg gtgctgctct 841 cctcccagaa catggacatc gtcctggccg tcctcaatct gctgtacatg ttctccaagc 901 gcagcaactt cataccccgc ctgccgttcg agaagaagga actgctgatt gtcaagctgt 961 ttaacatagc cgagcgctgg ggcgatccca actacggact gtcgctcaag gactgctgca 1021 ttggcgagcc gaagctggaa ttcctttacc agctgtgcat cgactatgtg gacgagcacg 1081 gtcatgccgc ccagctggaa atcccggaca tgatggacct ctgccacacg gcgtccgcgc 1141 ccgaggtgat caagacgatt gccggacaga tctcaaagcc cagcgaggca atcaagatgc 1201 gcattgctca tcgggtgcgc ttgatctcag gcttcaacaa ctacaagctg cgcctccagt 1261 tcgtccaggc tcgcctgcag gccgtctcca ttctgatcta ctcgaatgcc ctgcaggaca 1321 acacggacaa ggtgctgtat gccggcttcg gcgaggagct gtgcgagctg atcgacaagg 1381 aggacgtgca tctcgtggag atacgggcgg cagtgctgcg cacactcacc tcgatgctgc 1441 actttgaccg caatccgaat gtgcccagca gggccggttc gcgactgatg aagatcgttc 1501 actacacagg agccgagcgg cagggcggca ctttgccact gctggtgcgc gactgcattg 1561 ataatttaac cacccatgga ctcaccgaac gctacccgct catcctggcc acgtcactct 1621 tctcgctgct ctaccatttg gccagctacg aaatgggcgg ctctgctctg gtcaaaagcg 1681 gcatgatgca gtccctcctg tgcgtcatca gctggccggg agtcgacctc gagcacatta 1741 cgttcgtgac gcgggcggtg cgggtgatcg acctgataac caacatagat atcgcacggt 1801 tccatcagaa caacggactc aacgtgttca ttgaccgtct ggagaaggag atcaagagct 1861 gctgcaaggc actggccgac attggcatca cgctgaagga gtcgacgctg cgcgatgacc 1921 acaagttgga taactcgctg gagcaagtgg acgatgatgt ggaagagacc ggagagaaca 1981 cgtccgtggc cagtggaggt ggatcgccgc gtcgcgagaa ctcgagtgac gggctcaccg 2041 gtgccgggag cagcgcctac agagcctatc acgagcacag tggaggagga gcgggctcag 2101 gagcgggact cctggacatt ggtggagcac gcagcgcagg aggaggatca tcgggtggtg 2161 cttcagccgc accgatcatt ggattaatca accgggacgg aagtgccgct cgtccgccgg 2221 ccatcatgta ccccacaaac agttactacg cccgtccgct ggccgagcgc aaggcggagc 2281 tctcctcgca gctgccgagc agcctggcgc cgaagaagcc ctcctgcgtc acccagcggg 2341 cggcgctgct caagtcgatg ctgaatttcc tgaagaagag catccaggat catgcgcact 2401 ttagcaacat gcgcaacatc atggagacca gcttaacgca gtcgcttcgc cacatcatag 2461 ccaatgcgga gtactacggg ccgtcgctct tcctgctggc caccgatgtg gtcaccgtgt 2521 acgtgttcaa cgagccctcg ctgctctcct cgctgcagga tctgggcatc acgagtgtca 2581 tgctgaaggc gctgctccag aaggatgtgc cggccacgcg ggaagtgctg ggctccctgc 2641 cgaatgtctt ttccgccctg tgcctgaatg agcgtggcct ttttgagttc ctctcctatg 2701 atccttttga caaggtgctg aaggtgctgc tctcgccgga ctatctggtg gccatgcgca 2761 ggcgccgctc ctcggatccg ctgggcgata cggccaccaa tttgggcaat gccatggacg 2821 atctgatcaa gcatcatccg tatttgcgag ccgatgccac ggaggcgatt gtgaggcttt 2881 tgaatgagct ggttcgcctt ggttccgatc ccagtttcat ttgctggcgg gccaacaagg 2941 agagcagtgg ctctggctcg ggttcaggca gccatggcgg cggcggttcg catcacgtgg 3001 cctccacacc ctcgcccatg gccgtcatgg tggctggctc gggaggatcg acgtcggtgc 3061 tccagggagc cgcggatacg aacgacagca gcggcgacga tgacgacgat gatgatgaaa 3121 tgagctcggc ttcgcagcaa cagcagcaaa gtggaggagc caccacaccc aggacgcaac 3181 aaccaggagg aggagtagcc accccgcagg ccgtcaaggt ggtgacgccc ccggaacgag 3241 aggcaatacc cctaatcgac tatatcttga atgtgatgaa gttcatcgag gcgattttca 3301 gcaacagtcc gaatggcgat cactgccggg agtttgtcct ccacggcgga ctaaagccca 3361 ttctgcaact gctgtcgctg cccaatctgc cggtggattc acccgtttcc accacctcac 3421 aggcggtggc caatgtctgc aaggccatac tcagccaggc gcaggaaacg aaggttctcg 3481 atgtggcgct caagcagctg gctgatattg tggcccagct gaagccgctg atcaagcact 3541 ttacctttcc cggcggcagt gtcctcctcg cagagctcgt ctgctgtcag cggctggagg 3601 atggcttcgc caatgccgaa tacacaccga tactgcacaa catgagcttt gtgcacggct 3661 atgtggtgat gctggtgcat ctctgtcgca acgcctccaa cgacatgcga gcgattctgc 3721 tcaagcgttg gggcgtcaat cgcgagactg gagtgcaatt gctgcagcag ctggtccagc 3781 tgtacatttc gctggtgtgg gagagcacca tactgctgaa tctctgctcg gatgagccca 3841 cccagcatcc ggatctcatt tgggacgaga ttgcggccca gatgtcggcg gcagcgggca 3901 ccgcggatcc cctgaccgaa gcggagctct cgcggaagct ggagcgtgcg gcggaattcc 3961 ggacgaagta ctcgcccgag gagcagttcc ggtacatcaa atccctgctg gcggcgagct 4021 ctcggctcgg cagggcgctc gccgagctgc tgggcacgct ggtgaagcta tcggtgggtt 4081 cgccgcagac gcgacagcga cgcatcaacg atctgatcag caatatcaac aaagttccta 4141 cgcccgaggc tcgcgaaata gcccgcatcc tcagctcgat tctggtgaat ggcttcagtc 4201 acgagagcat tctaccgaag cctgtgccca agttgaagct caccttcctc atctgctcgg 4261 tgggattcac cggtccaatg ctgttcgacg acaagcgcag cgcctttcac ctgatgatat 4321 cgcaattctg cgcagagaat ggattgaaag ccttctttga gatgttctac tgggcgctgt 4381 cgctggataa tgtctcgcag aagttcgatt tcgatcagtg ggcctcgatg gaggatctga 4441 tgcagtcgca cgaggacgac aagcgcgatt gccccgaggg cacgggcgag tttctcgacg 4501 cctggctgca gctgctcgag aagatggtga atccgcgtgc catgctcgat tcgccgtata 4561 cgatgagtcc gcggctgaat tacctgcccg attcggtgcc cttcgagccg gtcttttacc 4621 tcattcacat ccaccagctg gccatgcagg cactgcgcag gatctgggca cgtcgcccga 4681 ttcccaacta tggacccagt atgttcgaga ccatgatact gatcctgaag catctgatca 4741 agtcgcatca aacgctgctc gatcgctatc acacgcggat gaaggagatc aagttcgaga 4801 acctctacat ccgcagcacg gacgatggcc taaatgcgga tcacatcaag acgctgacgg 4861 acatgggctt catgcattac cacgttattg aggctctccg cacgaatgcc tcgctggagg 4921 aggccaccga ttatctgctg aataacccag aagccagtgc tttgtccaca acgactggtg 4981 gttctgctgc tcctccgccg ccgccaccgc caccgccttc caccatggac attgacatgg 5041 atttgccagc ggatggggga gagaaatcta gctctagttc ggcgaactcc agctatgact 5101 acaagcacct caaactgatg ccgtcgatca tcttcgatcg cttctgcgac gaggccattt 5161 cgcgggcctt tgagttcatg gaggccattc cggatacggt gaacagtgcc gcagatctga 5221 tagccgtgct gtatagacgc cacaatcacc tgaacaagca ggtctttgtg accaactttg 5281 tgcgcaacat tatccagtgg gtggacttta ccctgcagct ctttgaacca tcgaaaacgg 5341 cagcgtcgaa ggcttcgcgg ttggaggaat gcttgacggg attgacggcc acccggttgt 5401 ttgtgcggct caagacatcg acgcggctgc tcgaggagaa ctacagtgat ttgcatcgtc 5461 cgctggtgga ggcaataacc gcccaggatg ccatggtgtc gctggtcaag ctgctcgact 5521 gcatgagcca gtggatgctg gagcaatcag tggattctag ggctacggtc ccccgatggg 5581 tgcagaacct ggtggatcta atcgattcga tcgacagcat cagccacatt ctgcagcgca 5641 aggccaacat gcgggcggtg agcagcgagg tgtggcgctg gtacgacgcc tccacgggca 5701 agtggaatgc ctattcggag gccaacaatg agctcattcg gaatgcctat gccgccggcg 5761 agcggtggct gcacattaac atcggcaggc aaaggtgtac ggtgagcctg aactgcatga 5821 cgcaggtgag cgaggcatcc ggcacacatc gtcctgtttg tccggctctc aagctcagtg 5881 aagccatcac tgcgctcaac agtcccgtgt cgctgcacaa agtggagcat ctgctgaacc 5941 gcgtggtgcg aacctcaccc gatggctcgg gaaccgtgca ttccgacgaa ttgatttccc 6001 tgcgccagct gatcaacttt tcggatggtc agcagccgca ggagaacccg gcgaatgaag 6061 agggaacaaa tgaagatagt ggatctcctc tggccgccat gaccacgcgc agcaagtcgc 6121 ggcaaaagag cgccgccgct gcagccgctg cccagaagaa atcctcgtcg catggctcac 6181 cgcccatacc caaacgcacc cagaagatca tactcaacga ggagcaggtg ggactgagta 6241 aattcgactg cggtcggata attggcagca ttgtggatct cctgcagcct tcgcatctca 6301 tgctcaacga aacgaagctt tcgctgctgc ggctgtgtgc aagattaacc cgaaactacg 6361 acaatgccca ggtgttcatc cggcggggcg gcgttaagat gctgctgcat ctgcagcagg 6421 cctgcagctt catgggcttc cccacctatg cgaatatcat actgcgtcac gtgctcgagg 6481 cgccgccggt gctgcaggag gccatggaac gagtgctggg catgcgggca gccggcattg 6541 tgcccgtggg gcatcgggat ctaatctatg tactcaccca ggtatcctca gcggtttcgc 6601 gcaatccgca gatctttgtg gccgccgcca aggagatgct caagggagag tacctcctga 6661 acacgaacag cacgacgctg gcggacgatg cgcgggtgat ggtcaagtcc aagtttggtc 6721 aacaaccgac ggcagcggct ggcggagcca cgccaaattc gcagacgtcc acgccgccgg 6781 atgagcagct caaggacgat ccccaggttc agtcatcggt ggctgtgctt aaggatctac 6841 tgcatggatt ggtgcagccc tgctggcact acggcggcac gggatccttg gatcgcggcc 6901 ctggcgccgc cgagctgctg caaccggacc agccaccggg aacggccgcc cagggaggcc 6961 acgacgagga ggaaaccccc gcacctgcga gcagcaagaa gcaatcctca ggaggaggag 7021 catctgctgg gcagccacag acgacggaga agttcgagcc ctgctgctgc acgtggcaca 7081 tcccgaccag cggccacacg cacgccaagc cgaccatttc gcgggcgacg ctgctcaagc 7141 tgctggcgga ttcaacgagg gcctatcagt ctttagtgcc ccgcgtgctg ctatcccaca 7201 tttacacgcc cgccgacagt ccgctgatct cggcgccgca gcagacgttc ctgggcgtcc 7261 tcctcgatcg ctttctgccc atcacgcagc ggcatcatgt gcccgaggtg agcacgatga 7321 cgagggtgct catttgctcc ctttctgact gctaccagca gccgggagtc caggtccatg 7381 tggccgagga gctgcacgcg gcggtggcca gggctttggc ccaaccggac tcggcggaga 7441 agcacacgcg actccaggtg ctgatgagcc tgtttcccaa tctcatcgag tcgccgatgc 7501 tgtacgataa ggtgcacatg catcgcaaca acatgtaccg agtgctgctg cgccagggag 7561 tgatgaccta cctgaccaag gtggcccagt acaaggatct gtccaatcac aacacgctga 7621 gcactctggc ggccatcctg cgacccatgg agatcttgct gaggtttagt gtgtccacca 7681 caacgctcgg atcgaagagg attctctttg gcggcggcgg cggaggagct ggcggagcaa 7741 atggagcagg gagcgggaac agtgctgtcg gaggaggcag tggaactggc ccgggatcgg 7801 gcaatacata tggaaccatc atcaatcgtc ggctatatcc tcgtttggcc gcccgcaccg 7861 cagtcagtgc ggccgtggag cgatccaatg cgatgggtgg cgagcatgtg ctgcgcgaca 7921 ttatacgcaa tgtgctctcc gatcggcggc acgcctttga gtttatcttc aactcggacg 7981 agatggccgt ggactcggag gactcggctg ccccggcggt gggtggtaat ggatcgggag 8041 caggcggaat aggagcagga ggatcaggag cagccgtcat cgatgtggtg gaggagcgca 8101 gcaatggcgg ggataccagc gatcccccag gtaatgtaaa ctccggatct ggaacgggcg 8161 cagttcaatc ttcaaccagt ggaggtcccg tgcggccagt tctgaacttt gaccagctgt 8221 gggacgactt cctgcagagc gagggactgc gattggcctc gcggagcggc ggaggcgcgg 8281 gatctggagc aggatccaca ggagcaggct caacgggtca gcaaaacggt ggcaatgcca 8341 ctggtggctc tgcaaactcc ggcagcaatt cagtcagcgg agatcctcgc ctgcgcacca 8401 atcccgatgt ggatgtgggc ggcggtggaa atggcggtgg tcagtcatcc aattcgggtg 8461 tggtaaacga taatggaatt ggcggcggcg gcggcagcga tggcgcctcc acatcctcgg 8521 acactggagc tccgggcggc gaacgtcgcg atttgaatgc ctcgctgctg ggcgatgtca 8581 gcacctcgga atccgattcg gatgcctcca cggagaacga cgagcggaat gaggaggacg 8641 aggacgagga tgacgatgcc cccgatgaag atgtggacga gcatagcgaa acggatgtgg 8701 atgaggaaag gccacgtcaa tttatcgagg tctttgatca catctacgaa ccggaatcct 8761 cggaaaccgc ttccaatgat gcggatgtgg ataacgacga cgatgatgac gaggatgagg 8821 acgatgtgga cgacgacgat gatgatgacg aggataacga cgatgaggat cgcgaggagg 8881 gccagagtgt catggatgcc gagttggaga accaaataga cattgccctc gccttggttt 8941 cgtccaacaa tcgtccgcga cgcagtgcag cggttaatgc ttcgggcgat gcgtccgcca 9001 atcgagatcc caatcccgac gaggaggtgg acgacgagga cgacgatgtg gacgccgatc 9061 ccgatggaga tcccgatgtg gaccccattg gcggcccctc ggctgcccag gcggaggcct 9121 atctgtacga gcgactgggc agcggcctga tgcccacgcc accggtgggt ttccgcgtcc 9181 gcatgaacag ctcgattgcc cagcccctgg acattgatgt gaatggcgga aatggcggtg 9241 gtggatctgg tggatccgga gcaggcgtca ctggaacggc cggtggatcc ggaagaggct 9301 cctcgtcggg cggaacaacg gccagtattg gagccattgc ctccgctgcc ttgcgtccct 9361 cgtccggttc ttggatggcg ccggacttta atttcattgg agtctcgggc ggtggaggag 9421 ccagtggctc tggaggcgcc tcagggagca atgccaacgg gggcgaggtg aacgccttcc 9481 tcacgcccgc catgtcgcag ctggaacgca gtggtggcgc ctcgggcagt ggccaaaaca 9541 tgagcaatct gctggacgaa caaccgtcgg tcagtggcaa cggcggcgga ggaggaggaa 9601 gtggcggagg ttccgcctct ggtaacggcg gcgtcagcgg tggaggagga gccaatggcg 9661 gcggtaccgc aggacagcat ccgaatgcca cgctctgcgc caacggagtg cgccggcggt 9721 tgctctattt ggaccagcag tactgcgtct gcatgcccac gcatcagaat cccacggaag 9781 agacccagat ggagacgttc acccaggatg ctctgcattg gtggctggag gaggccacgg 9841 tcttggatat ggagagccag actgacgcct gcctgtacgc cgctcacttc ctgctgccgc 9901 atctcatcaa ggagctgaag acggcccacc agcagcgcaa gcaggaggag gccgcccgcc 9961 agacggccac gaacaccaca acacctgcat catcggcttc gtcttcggcc ggagctccgg 10021 cgacctccat cctatcgaac acagcggccc caacagcgac ggcctccatt gcgtccagtc 10081 tactggcgaa tgccgtggcc gcgggctcag gcggcagcag cagcagcggc agcggattgg 10141 tggtgccacc ggtggcagcc tccgccacgg gaggcacccg gcgcagctcg attcccgtgc 10201 tgattccctc gagcttcggc ggtcctggta gtgcaaccac tggcgatgcc acggccacaa 10261 cgggaggaac caccagcagc agttcctaca caaccacatc cattagcggc agtggctcct 10321 tggagtcgca gacgacgact cgagcgcctc ggcaacgcgg tggattgcgc cagcacagcc 10381 agctgccctt caacatctac gcggagatcg atctgaccaa cgaacaggat agccagggcg 10441 ccacgtcaac gggctctgct ccaaacgatg gagcggaatc acaggcacag cagccgcagc 10501 agcagcagca gcagcaaaac tcctccgctc cttcgttggc gcagggggcg gtccttcagc 10561 atcagcgtca tccaccggtg ccgctcctgc cgtccagtgg aaggccttcg cgacctcact 10621 cgcgtctcga cgaggcggag ctgcttctgt tgcagttggc cgatcgccag gctgttcgca 10681 gtcgcctgca agtgtccagc ggtcacacga attcctcgcg cacctcggga tcggcgctga 10741 tcaacgctcg gcccaatcgc gatctacccg cccgcctgca gcgcctcgtc caggcacatg 10801 gctccctttc cagtcgcatc aatgcatccg ccgccagcac gccggctccg acgctcgtct 10861 ccatgcccac gcccatgtcc agtgcggcgc tggagcagct gaatgtcacg cccgccggcc 10921 cggatgttgt gggcccagac aggaactttg cattgccacc ttccctggag gttgatgtgg 10981 atgtgctgcc tggaatactg gatcgcatac tgccgcagca gcagcaggag cagcaggaag 11041 cgcagcagca ggaggaggag gaggaacagc tgttgctacc accgccacct ccgccgccgc 11101 ccagtgaaac ggcgcccttg ctcctcaccg aggaggatat gtggcaaggg acaagagagg 11161 aggaggagga ttccacttcc acagtggcag ttgccggcag cagcgaggct gcaaacgagt 11221 caaaccaatc ggatcagacg ccggagagca gcgaatctgt ttccccgaac ccgcaggctc 11281 ctcccccagc agcagaatcc ggcgaaggag gagcaggggg agcaggagga gctgcctcgg 11341 ctagcacaca aaccccggca accgcagaag aatccgctgt aggtggaaca acagcaacag 11401 caacaacgac agcagccacc gtaacggaca tgagtcccga ggtgcgggcc gctctcgggg 11461 atctggaggt gcccgagggc gtggatccct ccttcctggc cgccctgccc agcgagatgc 11521 gcgaggaggt gatccaggag catctgcgga tgcagcgcat tcgccagcgg gcgcagcaga 11581 atgccattca gattgcgcac gattcgctcg tcgaggtgaa tcccgagttc ctcgccgccc 11641 tgccgctgaa cattcagtcc gaggtgctga tgcagcagcg gatcgagcag cagcgccagg 11701 cggcgcagac cgcgaatccc gaggatcccg tcgacacggc cgccttcttt cagaacctgc 11761 ccgagaatct gcggcaagcg atactcaccg acatggagga gtcgcagata gccagtttgc 11821 cgcccgagtt ggcggcggag gcgcagttcc tgcgtcgcga ctgggagtcc cgcaatggcg 11881 cccgcatgga cgcccatccg cccagcaatg cgttgtcccg cttccagacg acgctgcaga 11941 gcctggacga ggcccgctgg cacagctcca tttggtacga cgccagcggc aatgcccagc 12001 cgcagcacca ccagcacacc acgattgtgc accaccatgc ccacgcacat cacgccccca 12061 cgatgggcaa acccctagcc ctgctgatga tggaggacga gaacatcctg ctcgatccgg 12121 actcgctggc caccctgctg ctcttcctgt tcgtcgagga tcagaaggtg aacagcatgc 12181 ggctgcatcg tgtgattcgc aacctttgcc accacgaacc cacgcgcgat tggatcatca 12241 gcgctctgat tagcatcgtc caaaagacca acgaggataa cgccaacttt ggagctggac 12301 aggcgggcgg caaaccggag tggctgaagc tgcgcgtgga cgccgccttt ggctacaaga 12361 gcaacatctt cctcatcaat cggctgtacg agggcagtgc gcggagcatc agcatcaatc 12421 cgcaggccgc acagatgata gtgcgcaact gtctggatct gctcttcgtg ctggccaagc 12481 actatccgtc cagctttgtg cccttcaacc gcgaggtgaa ggccaggcgc atactgagtg 12541 cggtatttgg catgccatcg cccacgggtg gtgcttctac tgctggagct ggagctcctg 12601 cacgcaatat agatgacttt ccaccgcccg gcggaactct ggactttcgc tcgcgtttct 12661 gccgctacca ggtggccaat cgactgcgcg gcatactcga cgatcatccg gcggcggccc 12721 cgaaacccca aagtgcaact cccctggatg aggcaccctc cacatcgaag gcggctgctg 12781 ccaaggcagc tgccacggct aaggtttcga gtcagagcag tcagtcggtg ccgtatcaaa 12841 cgaatgcgaa gaatttctgg gatgtggtgc tcaacatcga tcgacagacc caagtgcgtt 12901 tggccaatgt ggcccagttt ccactcacct cgcagccagc ttgggaatgg caagcgaaca 12961 gcgccgactt cctgtcgttc agcgattcgc ctttcggaca gctgctggaa atgctgccct 13021 acaaggtcat ctgccggtcg ccacatctca ccgatatgct ggtcaagttg ctcgcctcgc 13081 tgagcaccga gttgcccaag gaggaggaac agttgccgct gagcgatcaa atgcccaccc 13141 tgatacccat taatcaggcg gcggcagcgg cagcagattc cccagcgaat ccatcagaga 13201 ttggtgacgg actggccgca aatgtggagc aggaagccac gccggccagc ggtaatccag 13261 cctccggtga cagcaatgcg gctgccaagc gaacacagct gcccacattg agtgtagccc 13321 tgccagttgc tccgtcgaag ccgcggcgca agatctactc gaagaacttc tcgcaactgc 13381 agctggtcat cgaggtgctg acccaccagt gcggcaccac cgagggcctg gacaacgtgg 13441 ccaagctgat tgtgaatcta acgcagtgct cgcaggcatc caatgcgatt ttcattcagt 13501 acctgaccgc tgccatcctg ggattggccg aggaggtgcg ccaggcgata cagatgctgc 13561 tgaatgagat acgcatgtac aacagtcatc atggagtgac ggcctccaca tccggagcag 13621 cggcagcggg agccaccgtt tcaggagcca gtctgctgcc taacctcgcc gttcacgagg 13681 gcatcatgca ggatcgcttc accgccgagc atgtcatcat ttcggcgccg aagaacgcca 13741 agcccacctg cgaactccag ctgccgtcga tgaagaagct tatgtccaac tcatccgccc 13801 agccgtactt cctgcgcacc ctgaagatct tcatgcaggt gcgcgacatg tacgaggcgc 13861 agaatggttt atccacgggc ggtggtttgg ctggagcagc tggcgacaac gatgacgaca 13921 tcatcgacat tgagggcgat ggcggagctt cgggcggcag cagttcggat atggcgcccg 13981 gttcggcgag cacaatatct ccgccgccgc cgccaccgat ggaaaccaat cagaacatta 14041 acgatgagga ggaggatgag gatggggagg aggaggagga cgatgatgat gcggccaggg 14101 catcgccagc ggcggcaagt gctggcaagt caagcaagcc cacgctcagc cagatcctct 14161 gcctcgacgt cctttggcac acgctcagcg aatgcctggt ggcgctggag gagtccaagg 14221 acgagttcgc cgtcctggtg ctgcagccca ccgtggaggc cttcttcctc atccacgcct 14281 cgcatcgcgc gggggctaag aagtcgggtc gcggcggagt tgtgggctcc ggactgcggg 14341 cagctggagg attgggagca gctgcgtcgg cggcccagga gcacagtcca tcgatggacg 14401 acaccagcag cgccaatacc cttagttcgg ccagtttcga agatgagccg cgaatgcagg 14461 acgcctccac aaacacgccg ctttcgagca acagctccgc cgccaccact gtgctgagcg 14521 cacacgaggc gcagctgcga caggatcgcc agaagttcct gcagttcgcc gagaaacacc 14581 gcaccgtgct caaccaaata ctgcgccagt cgcccactca tctctccgac ggacccttcg 14641 ccgttctcgt cgaccacacg cgcatcctgg actttgacgt caagcggaag tacttccaga 14701 cggagctgga gcgcctggac gagggcattc ggcgcgagga gcacacggtc agtgtgcggc 14761 gcgtgaccgt cttcgaggat tcgttccgcg tgttgtaccg cctgggaccg gaggagtgga 14821 agaaccgctt ctacattgtc ttcgaggacg aggaaggcca ggatgctggc ggcctgctgc 14881 gcgaatggta tgtgatcata tcgcgcgaga tcttcaatcc gatgtatgcc ttgttctgcg 14941 tatcgccggg cgatcgcgtc acctacatga tcaatccctc cagccatgcc aatccgaatc 15001 atctgagcta cttcaagttc gtcggccgcg taattgccaa ggccgtgcac gataacaagc 15061 tgctggagtg ctacttcacc cgatccttct acaagcacat cctgggcaag caggtgaagc 15121 acacggacat ggagtcgcag gactacgagt tctacaaggg cctcgactat ctgatgaaga 15181 acgacatctc caccctgggc tacgagctga ccttctccac ggaggtgcag gagttcggtg 15241 tcacccagat ccgtgatctc aagccaaacg gacgcgacac cgcggtgacc gaggaaaaca 15301 agttcgagta tgtgcagctg gtgtgccagc tgaagatgag cggctccatt cgacagcaat 15361 tggacgcatt cctcgagggc ttctacgaca ttattccaaa gcatttaatt tcgatattca 15421 acgaacagga actggaactt ctcatatccg gcctgccgga tattgacatt gaagatctaa 15481 aggcgaacac cgagtaccac aagtacacct ccaaatcggc ccagattcaa tggttctggc 15541 gtgcattgcg cagcttcgac caagcggacc gggccaagtt cctgcagttc gtcactggca 15601 catcgaaggt gccgctgcag ggcttcggct ccctggaggg catgaacggg attcagaagt 15661 tccaaatcca tcgggacgat cggtccactg atcgattgcc ctgtgcacac acctgcttca 15721 accaactgga tcttccgatg tacaagtcat acgacaaact gcggagctgc ttgctgaagg 15781 ccatacacga gtgctccgag ggctttggct tcgcctaagc gggaacatca gtggctttcg 15841 gtcctccagc ctccagcgag gccagccaac caagcagcca ggaacccatg gacgcaactc 15901 tattcctagt tcgcccaatt cacgggcgac acgacgagaa atgcataatt gatttgaaca 15961 gaacagaaca gccactgcta atttgcgata gcggcaacag aaactgcata catacacagt 16021 acatatagtt atatagtata tataaaaatg ttgaattaat tattaatttt cgcgcctata 16081 tatatacaat atatattttc ttaaattttc aaaagaaaac ggaaaaaagt ctaaggaaac 16141 ctacaaaaaa aaaataagat acaaacgcga aacagcatat tcgatttaaa tttgtctgcg 16201 taactcatcc ctattatata ttttctcgga atctatccct gtcgttttgc acattttcat 16261 taaaacaaaa ggatttatat aaaaaaacat acacaatttg acatattttt atttacctaa 16321 acacgaaacc gaatagcaaa ggattaaacg tagtctatag aacgcaaatg caaatgcaca 16381 taaacagatt tcttgtttac ttaagtgaat ttaccgaaga tgagacgggg aggcagcgga 16441 aataattaaa tggattaaag tatttcgatg taagagataa gtccttatgt tatgcatttt 16501 atgtttacct ttggaataat gagccgcaga tgtaacttaa agaatgtgga ataaagtaag 16561 agtaagctca tttatcaaaa ta