dual specificity mitogen-activated protein kinase kinase

LOCUS       XP_017013192            1185 aa            linear   INV 09-DEC-2024
            hemipterous isoform X1 [Drosophila takahashii].
ACCESSION   XP_017013192
VERSION     XP_017013192.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017157703.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017013192.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1185
                     /product="dual specificity mitogen-activated protein
                     kinase kinase hemipterous isoform X1"
                     /calculated_mol_wt=125362
     Region          182..477
                     /region_name="PKc_MKK7"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinase, Mitogen-activated protein Kinase Kinase 7;
                     cd06618"
                     /db_xref="CDD:270791"
     Site            order(204..208,212,225,227,258,274..277,279..280,283,321,
                     323..326,328,338..339,342,355..358,360,389,398)
                     /site_type="active"
                     /db_xref="CDD:270791"
     Site            order(204..208,210,212,225,227,258,274..277,279..280,
                     282..283,323,325..326,328,339)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270791"
     Site            order(207..208,321,323..325,342,355..358,360,389,398)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270791"
     Site            338..360
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270791"
     CDS             1..1185
                     /gene="hep"
                     /coded_by="XM_017157703.3:641..4198"
                     /db_xref="GeneID:108068245"
ORIGIN      
        1 mstiefetig srlqsleakl qaqneshdqi vssarvppla tsasasatts asshgmgigs
       61 gisiaqrpap pvphatpias anatassssa sasafafasa stsasassas aapstgafgg
      121 tytppttrvp ratptlplls sgpgggggfn rtrpvilplp tpphppvset dkklkiimeq
      181 tgklningrq yptdindlkh lgdlgngtsg nvvkmmhlss nmiiavkqmr rtgnaeenkr
      241 ilmdldvvlk shdckyivkc lgcfvrdpdv wicmelmsmc fdkllklskk pvpeqilgkv
      301 tvatvnalsy lkdkhgvihr dvkpsnilid ergniklcdf gisgrlvdsk antrsagcaa
      361 ymaperidpk kpkydiradv wslgitlvel atarspyegc ntdfevltkv ldseppclpy
      421 gegfnftqqf rdfvikcltk nhqdrpkype llaqpfirty eitkvdvpnw fqsikdsrlr
      481 angdpnplqr atatgsgggs gcgslagsgs aggsgaikyg rtmaqsptnp qktikptqip
      541 syqqqqqsqy fmqsatqlpq tttptattnc fggsgngrgn gngsgsgsss sasplsppsg
      601 gggvgdlnrl yrkspfmqrk lsngshhphy kyndespkke smfssigqsi lrnlttspfs
      661 qkkhnsaaat aitiplphnn qttlftdaat atanaiatat attppniaaa aaaaaptttp
      721 tatptwrlpa dnsqaydscd sssnatttln lalsspspsl prkqfatesp tlqlasqqqq
      781 qqpqrlqpgn qspivlqrfy hqqnqlreke aaeryqqqrq qpqtigvtst npfhsnyvpp
      841 ppsthstssq sstqstcsqi avnpaslsps tgsggdaaag hfgaggngep lqyqplpiaa
      901 eatatsptll prspdpqqsd ygaggssmva sklsklyarr qllgqssssg assssldgcs
      961 reqhdagwfn tlagamkrqf atyvktqlns tatspvaasa asasmdrdqe pvhpqppayr
     1021 sivsnngsgg ksyyyrtlsa assssntsqs tsptteplpg ggtssflrry assgpgmtss
     1081 ggggsistpp sphilagldr rhrspdpppr ynrgqsplll rknllelsgq ppgspllhrr
     1141 yvsaspplpp prrgsesvpg spqhfrtrih ytpepqrriy rtidq