E3 ubiquitin-protein ligase HECW2 isoform X3 [Drosophila

LOCUS       XP_017012918             434 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017012918
VERSION     XP_017012918.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017157429.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..434
                     /product="E3 ubiquitin-protein ligase HECW2 isoform X3"
                     /calculated_mol_wt=50417
     Region          76..432
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(82,113,124,185,361,396..397,400..404,424,431)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(213,216..217,219..220,223,231,233,237,239,245,250,
                     267,271)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..434
                     /gene="Hecw"
                     /coded_by="XM_017157429.3:268..1572"
                     /db_xref="GeneID:108068051"
ORIGIN      
        1 mgflskaayi vwavlfeqei msyvpieers pqgspvlssr mpqrapppfr rdfeaklrsf
       61 yrkleskgyg qgphklklhi rrshlledaf rrimsankkd lqrgrlavlw dteegldygg
      121 psreffflls relfnpyygl feysandtyt vqvsplsafv dnchdwfrfs grvlglalvh
      181 qylldafftr pfykallrlp valsdlesld nefhqslqwi rdndigtgvd lgltfcvtee
      241 llgrvverel kpggkniivn eknkkeyler mikwrlergv qeqteslvrg fyevvdsrlv
      301 svfdarelel viagtaeidt ndwrlnteyr sgyhdnhqvi vwfwqvierf sneqrlrllq
      361 fvtgtssipy egfsalrgst gprrfciekw gkpnalprah tcfnrldlpp yptpellyek
      421 lllaveetnt fgie