E3 ubiquitin-protein ligase HECW2 isoform X2 [Drosophila

LOCUS       XP_017012917             436 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017012917
VERSION     XP_017012917.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017157428.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..436
                     /product="E3 ubiquitin-protein ligase HECW2 isoform X2"
                     /calculated_mol_wt=50898
     Region          78..434
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(84,115,126,187,363,398..399,402..406,426,433)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(215,218..219,221..222,225,233,235,239,241,247,252,
                     269,273)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..436
                     /gene="Hecw"
                     /coded_by="XM_017157428.3:200..1510"
                     /db_xref="GeneID:108068051"
ORIGIN      
        1 mglfskfvyt fhmwenlfeq eimsyvpiee rspqgspvls srmpqrappp frrdfeaklr
       61 sfyrkleskg ygqgphklkl hirrshlled afrrimsank kdlqrgrlav lwdteegldy
      121 ggpsrefffl lsrelfnpyy glfeysandt ytvqvsplsa fvdnchdwfr fsgrvlglal
      181 vhqylldaff trpfykallr lpvalsdles ldnefhqslq wirdndigtg vdlgltfcvt
      241 eellgrvver elkpggknii vneknkkeyl ermikwrler gvqeqteslv rgfyevvdsr
      301 lvsvfdarel elviagtaei dtndwrlnte yrsgyhdnhq vivwfwqvie rfsneqrlrl
      361 lqfvtgtssi pyegfsalrg stgprrfcie kwgkpnalpr ahtcfnrldl ppyptpelly
      421 eklllaveet ntfgie