E3 ubiquitin-protein ligase HECW2 isoform X1 [Drosophila

LOCUS       XP_017012916            1377 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017012916
VERSION     XP_017012916.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017157427.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017012916.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1377
                     /product="E3 ubiquitin-protein ligase HECW2 isoform X1"
                     /calculated_mol_wt=152297
     Region          580..609
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          681..737
                     /region_name="HECW1_helix"
                     /note="Helical box domain of E3 ubiquitin-protein ligase
                     HECW1; pfam18436"
                     /db_xref="CDD:465766"
     Region          1019..1375
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(1025,1056,1067,1128,1304,1339..1340,1343..1347,1367,
                     1374)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(1156,1159..1160,1162..1163,1166,1174,1176,1180,1182,
                     1188,1193,1210,1214)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..1377
                     /gene="Hecw"
                     /coded_by="XM_017157427.3:332..4465"
                     /db_xref="GeneID:108068051"
ORIGIN      
        1 melldrspve piavslqqeg eqeeeeedee eeddankeee afydsrngne sdeleqafqs
       61 altltndvqv svseveveqe keeqlpehqe hlgacalasp keeekpprhq tllstkscet
      121 npansatlsp tnsyngsigs dggsssvgvg ggarrkswtl spqsggstpl sgakkktkat
      181 asnslangeg fnlwvarecf etvpaemvds lsmaeveeeq eeeeqqeqee eedeedeeaa
      241 avesllgaaa alqasthvqr rqqqqkqeqq hhhhhhhlqp qhrplerswp pravgrdlkl
      301 qgdvfqfdil dtderlaeme maqcgssnns platppvrfk pllkkkigpd syintistqk
      361 vpvhqsyefp tfpssssgvg sssqfphlrq hrpltralsn gkasssedqa sprlllspkr
      421 prsppsgcst rsaspldlsl speqhsptrg rgvggiqdag tpqrpqqrll krvgggaggg
      481 atgsplvcpp tpthharrha rlqavtanss gagepsvvap sqlepppdev vhisstrlps
      541 ipersaaaaa aaaaaaagaa lmepgtgvam ssgaageppl ppawearmds hgrifyidht
      601 trttswqrpg aapsggpagr eqhhrqqldr ryqsirrtit nesraaqlyn lpssgnppva
      661 apgaptappp ppaahpailm lcrpdfysll htneaalaiy nrnaalkhmv mrirrdpqcf
      721 qryqynkdlv alvntfaqis relpscwetk ldqsgkqffi dhqhrrtsfm dprlpvecpr
      781 vvrhrqqqqq tqqptsgvgy yypdlvdgnc lsatsghina spgssvsgvp plppprpsss
      841 sssaasssaa rsshghghnc tttaaiacal smdrsaggaa gmgatgmaag yedvpiayne
      901 kviaflrqpn ileilrerqg qhtmsrplre kinilrvegv palerlghdl qltillslfe
      961 qeimsyvpie erspqgspvl ssrmpqrapp pfrrdfeakl rsfyrklesk gygqgphklk
     1021 lhirrshlle dafrrimsan kkdlqrgrla vlwdteegld yggpsrefff llsrelfnpy
     1081 yglfeysand tytvqvspls afvdnchdwf rfsgrvlgla lvhqylldaf ftrpfykall
     1141 rlpvalsdle sldnefhqsl qwirdndigt gvdlgltfcv teellgrvve relkpggkni
     1201 ivneknkkey lermikwrle rgvqeqtesl vrgfyevvds rlvsvfdare lelviagtae
     1261 idtndwrlnt eyrsgyhdnh qvivwfwqvi erfsneqrlr llqfvtgtss ipyegfsalr
     1321 gstgprrfci ekwgkpnalp rahtcfnrld lppyptpell yeklllavee tntfgie