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PREDICTED: Drosophila takahashii Hecw ubiquitin protein ligase


LOCUS       XM_017157427            6009 bp    mRNA    linear   INV 09-DEC-2024
            (Hecw), transcript variant X1, mRNA.
ACCESSION   XM_017157427
VERSION     XM_017157427.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017157427.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6009
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..6009
                     /gene="Hecw"
                     /note="Hecw ubiquitin protein ligase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 22
                     Proteins"
                     /db_xref="GeneID:108068051"
     CDS             332..4465
                     /gene="Hecw"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HECW2 isoform X1"
                     /protein_id="XP_017012916.2"
                     /db_xref="GeneID:108068051"
                     /translation="MELLDRSPVEPIAVSLQQEGEQEEEEEDEEEEDDANKEEEAFYD
                     SRNGNESDELEQAFQSALTLTNDVQVSVSEVEVEQEKEEQLPEHQEHLGACALASPKE
                     EEKPPRHQTLLSTKSCETNPANSATLSPTNSYNGSIGSDGGSSSVGVGGGARRKSWTL
                     SPQSGGSTPLSGAKKKTKATASNSLANGEGFNLWVARECFETVPAEMVDSLSMAEVEE
                     EQEEEEQQEQEEEEDEEDEEAAAVESLLGAAAALQASTHVQRRQQQQKQEQQHHHHHH
                     HLQPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEMEMAQCGSSNNSPLAT
                     PPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSSGVGSSSQFPHLRQHR
                     PLTRALSNGKASSSEDQASPRLLLSPKRPRSPPSGCSTRSASPLDLSLSPEQHSPTRG
                     RGVGGIQDAGTPQRPQQRLLKRVGGGAGGGATGSPLVCPPTPTHHARRHARLQAVTAN
                     SSGAGEPSVVAPSQLEPPPDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGT
                     GVAMSSGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH
                     RQQLDRRYQSIRRTITNESRAAQLYNLPSSGNPPVAAPGAPTAPPPPPAAHPAILMLC
                     RPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPQCFQRYQYNKDLVALVNTFAQIS
                     RELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQQQQTQQPTSGV
                     GYYYPDLVDGNCLSATSGHINASPGSSVSGVPPLPPPRPSSSSSSAASSSAARSSHGH
                     GHNCTTTAAIACALSMDRSAGGAAGMGATGMAAGYEDVPIAYNEKVIAFLRQPNILEI
                     LRERQGQHTMSRPLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMSYVPIEER
                     SPQGSPVLSSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLE
                     DAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSA
                     NDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVAL
                     SDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGRVVERELKPGGKNIIVNE
                     KNKKEYLERMIKWRLERGVQEQTESLVRGFYEVVDSRLVSVFDARELELVIAGTAEID
                     TNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALR
                     GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE"
     misc_feature    2069..2158
                     /gene="Hecw"
                     /note="WW domain; Region: WW; pfam00397"
                     /db_xref="CDD:459800"
     misc_feature    2372..2542
                     /gene="Hecw"
                     /note="Helical box domain of E3 ubiquitin-protein ligase
                     HECW1; Region: HECW1_helix; pfam18436"
                     /db_xref="CDD:465766"
     misc_feature    3386..4456
                     /gene="Hecw"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; Region: HECTc;
                     cd00078"
                     /db_xref="CDD:238033"
     misc_feature    order(3404..3406,3497..3499,3530..3532,3713..3715,
                     4241..4243,4346..4351,4358..4372,4430..4432,4451..4453)
                     /gene="Hecw"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     misc_feature    order(3797..3799,3806..3811,3815..3820,3827..3829,
                     3851..3853,3857..3859,3869..3871,3875..3877,3893..3895,
                     3908..3910,3959..3961,3971..3973)
                     /gene="Hecw"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     polyA_site      6009
                     /gene="Hecw"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 aggcgctctc ctctagctta ttgcaccatt gccatctggt agcactgttt tgcgataaaa
       61 aactattctt tagctttgca actttaatta acaattaaac aattgataaa attaaaaggc
      121 gaaaatatag aacggccgga ctaatggcag tgagcgggga aatgcgcggg tcgaagggca
      181 gccaaggtca caacgcggaa gtagagcaat tgcagctgta actgtaaccg ttaaccctgg
      241 gcagggcgcg ggggttgggt tggctagggg aagaagagga ggcagagtgg aagaggaaga
      301 gcacatcttg agttccggag gcggaggaga aatggagctg ctggacagga gccccgtgga
      361 acccatagca gtcagcttgc agcaggaggg ggagcaagag gaggaggagg aagacgaaga
      421 ggaggaggat gatgccaaca aggaggagga ggccttctac gattcgcgca atggcaacga
      481 aagcgatgaa ctggaacagg ccttccaaag cgccctcacc ctgaccaacg atgtccaggt
      541 gagtgtgagt gaggtggagg tggagcagga gaaggaggag cagcttcctg agcatcagga
      601 gcacctgggc gcctgcgcac tggcatcccc caaggaggag gagaagccac cccgccacca
      661 gacgctgctc tccacgaaat cctgcgagac caatccagcc aacagtgcca ccctttcgcc
      721 cacaaattcc tacaacggca gcatcggcag cgatggcggc agcagcagcg tgggcgtggg
      781 cggcggtgcc cgtcgcaaat cctggacgct gtcgcctcaa agcggcggct ccacgcccct
      841 cagcggcgcc aagaagaaaa ccaaggccac cgctagcaac tccctggcca atggagaggg
      901 ttttaaccta tgggtggctc gcgaatgctt tgaaacagtg cccgccgaaa tggtggatag
      961 cctgagcatg gctgaggtgg aggaggagca agaggaggag gagcagcagg agcaggagga
     1021 ggaggaggat gaggaggacg aggaggcggc tgccgtggag agtctcctgg gagcagccgc
     1081 tgccctccag gctagcacac atgtgcagcg ccgtcagcag cagcagaagc aagagcaaca
     1141 gcatcatcat catcatcacc atctgcagcc gcagcatcgt ccgctggaac gctcctggcc
     1201 gccgcgtgcc gtgggtcgcg atctcaagct gcagggcgat gtctttcagt tcgacattct
     1261 ggacacggac gagcggctgg ccgagatgga gatggcccag tgcggcagct cgaacaactc
     1321 accactggcc acgcctcccg tgcgtttcaa gccgctgctg aagaagaaaa tcggtccgga
     1381 tagctacatc aatacgatta gcacgcagaa agtgcccgtg catcagagct atgagtttcc
     1441 caccttcccc agctcctcct cgggtgtcgg atcctcgtcg caatttcccc atctccgcca
     1501 gcaccgtcca ctcacccgag ctctgtccaa tggcaaggct agctcctcgg aggatcaggc
     1561 ctcgccgcga ctcctgctct cgccaaagcg tccccgaagt ccgccctccg gctgctccac
     1621 gcgcagtgcc tcgccgctgg atctcagcct cagtcccgag cagcattcgc ccaccagagg
     1681 aaggggcgtg ggtggcatcc aggatgctgg gacgccgcag cgaccgcagc agcggctgct
     1741 caagcgcgtg ggcggaggag ccggaggagg agccactggt tcgcctctgg tgtgtcctcc
     1801 cacgccaact catcatgcaa ggcgacatgc ccgcctgcaa gccgtcactg ccaactccag
     1861 cggagcagga gaacccagtg tagtcgcccc tagtcaattg gagccgccgc ccgatgaggt
     1921 ggtgcatatt agtagcaccc gtttgccctc cattcccgaa cgcagtgcag ctgcggcagc
     1981 ggcggcggcg gcagcagcag cgggagcagc tctcatggaa cccggaacag gtgttgcaat
     2041 gtccagcgga gcagcgggag agccaccact gccgccggcg tgggaggcac gcatggatag
     2101 ccacgggcgc atcttctaca ttgatcacac gacgcggaca acctcctggc agcgaccagg
     2161 agcggcacca agtggcggac cagccgggcg ggagcagcat catcgccagc agctggacag
     2221 aaggtatcag agcatccggc gcaccataac caatgagagc agagccgctc agctgtacaa
     2281 tctgccttcg tcgggtaatc ctccagttgc tgctccaggt gctcctactg ctcctcctcc
     2341 tccccccgcc gctcatcccg ccatcctgat gctctgccgc ccggatttct actccctgct
     2401 gcacaccaac gaagctgcgc tggccattta caatcgcaat gccgccttga aacacatggt
     2461 catgcgcatc cgacgggatc cgcagtgctt ccagcggtat cagtacaaca aggatctggt
     2521 ggcgctggtc aacaccttcg cacagataag cagggaactg ccgtcgtgct gggaaacgaa
     2581 gctggatcag tcgggcaagc agttcttcat tgaccaccag catcgacgca cctccttcat
     2641 ggatccccgc ctgccggtgg agtgtcctcg ggtggtgcga catcgccagc agcagcagca
     2701 aacgcagcag ccgacaagtg gcgtgggcta ctattatccc gatctggtgg atggcaactg
     2761 cctgtcggcc accagtgggc atataaatgc cagtccggga tcctcggtct ctggagtgcc
     2821 gcccctgccg ccgcccaggc cctcctcctc ctcctcctcc gccgcctcct catccgccgc
     2881 ccggagcagc catggtcatg gccacaactg caccaccacg gcggccattg cctgtgcctt
     2941 gagcatggat cgctcggcgg gcggagcagc cggaatggga gctaccggaa tggccgctgg
     3001 gtacgaggat gtgcccattg cctacaacga aaaggtcatt gccttcctgc gccagccaaa
     3061 catcctggag attctgagag aacgccaggg acagcacacc atgtcccggc cgctgcgcga
     3121 gaaaatcaat atactgcgag tggagggagt tcccgctctc gagagattgg gccacgacct
     3181 acaactgacc attttgctga gcctgtttga gcaggagatc atgagctatg ttcctattga
     3241 agagcgcagt ccccagggat cgccggtgct cagttcccgg atgccgcagc gggcgccgcc
     3301 gccgtttcgc agggatttcg aggccaagct gcgcagcttc taccgcaagc tggagtccaa
     3361 gggctatggc caggggccgc acaagctaaa actccacatc cgacgcagcc atttgctgga
     3421 ggacgccttc cgtcgcatca tgtcggcgaa caagaaggac ctgcagcgcg gccgcctcgc
     3481 cgtcctgtgg gacacggagg agggcctgga ctacggcgga ccctcccgcg agttcttctt
     3541 cctgctctcc cgcgaactgt ttaaccccta ctacggcctg ttcgagtatt cggcaaatga
     3601 tacgtacacg gttcaagtgt cgccgctgtc ggcgttcgtg gacaactgcc acgattggtt
     3661 ccgcttcagt ggtcgtgttt tgggtctggc cctcgtccat caatatctgc tggacgcctt
     3721 cttcacgcgg cccttctaca aggctctcct gcgactgccc gtcgccttga gtgatctgga
     3781 gtcgctggac aatgagttcc atcagtcgct gcagtggata cgcgacaatg acattggaac
     3841 gggcgtggat ctcggtctga ccttctgcgt caccgaggag ctgcttggtc gggtggtgga
     3901 gcgtgaactg aagccgggcg gcaagaacat cattgtgaac gagaagaaca agaaggagta
     3961 tctggagcgg atgatcaagt ggcggctgga gcgaggcgtt caggagcaga cggagtcgct
     4021 ggtgcgcggc ttctacgagg tggtcgactc gcggctcgtc tccgtcttcg atgcccgtga
     4081 attagagctg gtgatagcag gaaccgccga gatcgacacg aacgattggc gcctgaacac
     4141 agagtatcgg tcggggtatc acgacaacca ccaggtgatc gtgtggttct ggcaggtcat
     4201 cgagcggttt agcaacgagc agcgtttgcg tctgctgcag tttgtcaccg gcacctcgag
     4261 cattccgtac gaaggtttct ccgcgctgcg cggatcgacg ggaccgcggc gtttttgcat
     4321 cgagaagtgg ggcaaaccga atgccctgcc ccgcgcacac acctgcttca atcggttgga
     4381 tctgccgccc tatcccacgc ccgagctgct ctacgagaag ctgctgctgg ccgtcgagga
     4441 gaccaacacg ttcggcatcg agtaggcagc acgtgatatt attgcacctc agccgccgca
     4501 ctttgttgca cccaaaaaaa aaaaacgctt tatttcgatt ttagaagttt tttttagaac
     4561 ttgcctaagt ctaggaattc ggggtgatgc agaaatctct gagaaaacta tttaaaatca
     4621 attgaattta attttttgaa tgctaatccc tagatataat aaacgaaatt tgaagtttac
     4681 ttcgtttccc ttgagaaaaa attagttgtt agctatttct aggcgcctaa attatactgg
     4741 gatttctgca acaccccacc ccgattgtac tgtagttatt tatatacgta ggttacccgt
     4801 ccccttcaaa agaaaacaaa aaagagaaga agcctagcca tagacagact cgctacttta
     4861 ggcatcccac acactagttc gtagacaatt tgccttcgcc ttcgtttgcc gttcactgaa
     4921 tggaagttac ctcaagagca aaacggcttg ccagcgccgc cagtcattag tcctaagatc
     4981 ttaaaaccca aaccttataa gacccccata aacttataaa ctgtaagcct aaggatcctt
     5041 cgcttgactc tgcctgattt acaatcgaaa cgatgccaac tgcctctaga gaaattttca
     5101 acgcctaatc gctgctccag attcagaagt tcaacggggg ccccaaagaa aaaaaggaga
     5161 gcagagcaac tctacgccaa tacttaacta gcttataatg ttgtcttagc cttaactcga
     5221 attccaactc aaatttgaac actccctaga tgtgtgcatt ccaaataagc gtattgtgga
     5281 tgtcagttat tatatagcat ataatatata tacccctatt tacccctctc tcctttaacc
     5341 caaacaaaaa aagtatgtaa actgtttttg aatttacaaa accccttaac tatccgtgcg
     5401 gaggctgccg tgtgcttcct gcggcctgcc acttgaccaa atctctggcc aggacacagg
     5461 actccacatg gcggctccga tcgggtctat atggtatatt atatatacac attttggctg
     5521 ctgttttgcc aacgattaca aattggtcca gtgcgttgct tcggctttat tggttatttc
     5581 ggcgcataaa attaatatgg attatattta acgaaaacat acaaaaattc gaaacgtagc
     5641 taaataatta taaaaaaaag aaaagaaaaa aataaaaaaa caaatttttt aatattagta
     5701 ttgatcgaaa gcgagagcga aacgaaacga aaagataact aaatggtgat ttgtttacat
     5761 gtatttttgg cattagttaa tacggaaagc gaaagagacg gaaggccaga gatggagaga
     5821 gatagagcga tagacagagc tggagacagt gtcagtgaaa gagacagaga tagaaagata
     5881 aaaagcgctt tttgaactac ttattgataa atgaattgtt ttaatgaatt attaatgtgc
     5941 gtgtatttat gaacaaatta actataatta taaacaaata aatgtgagcc ttttacttca
     6001 aaagcaaaa