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LOCUS XP_017009148 2707 aa linear INV 09-DEC-2024 ACCESSION XP_017009148 VERSION XP_017009148.2 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_017153659.3 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Oct 18, 2021 this sequence version replaced XP_017009148.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..2707 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..2707 /product="neurogenic locus Notch protein" /calculated_mol_wt=289322 Region 179..214 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 217..252 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(217,220,234) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 260..291 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 293..329 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(293,296,310) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 331..369 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(331,334,351) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 449..486 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(449,452,467) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 488..524 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(488,491,505) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 526..562 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(526,529,543) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 564..600 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(564,567,581) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 602..637 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(602,605,618) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 640..675 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 677..713 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(677,680,694) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 715..750 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(715,718,732) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 753..789 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(753,756,770) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 791..827 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(791,794,808) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 829..865 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(829,832,846) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 907..943 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(907,910,925) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 946..982 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(946,949,963) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 984..1020 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(984,987,1001) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1027..1058 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1064..1094 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 1184..1219 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1221..1257 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1221,1224,1238) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1259..1295 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1259,1262,1276) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1297..1335 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1297,1300,1316) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1338..1373 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1417..1450 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1472..1508 /region_name="NL" /note="Domain found in Notch and Lin-12; smart00004" /db_xref="CDD:197463" Region 1515..1549 /region_name="Notch" /note="LNR domain; pfam00066" /db_xref="CDD:459658" Region 1561..1589 /region_name="Notch" /note="LNR domain; pfam00066" /db_xref="CDD:459658" Region 1594..1648 /region_name="NOD" /note="NOTCH protein; pfam06816" /db_xref="CDD:462014" Region 1715..1802 /region_name="JMTM_dNotch" /note="juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; cd21706" /db_xref="CDD:411989" Site order(1716..1718,1721..1723,1743..1744,1746,1748..1756, 1759..1760,1763..1765) /site_type="other" /note="putative polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:411989" Region 1896..1988 /region_name="Ank_2" /note="Ankyrin repeats (3 copies); pfam12796" /db_xref="CDD:463710" Region 1908..1955 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 1943..2146 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 1958..1988 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 1991..2022 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(2024,2026,2030..2031,2034..2036,2038..2039,2043, 2046,2055,2057,2059,2063..2064,2067..2069,2071..2072,2076, 2079,2088,2090,2092,2096..2097,2100..2102,2104..2105,2109, 2112,2121) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 2024..2055 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 2057..2088 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 2090..2121 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..2707 /gene="N" /coded_by="XM_017153659.3:697..8820" /db_xref="GeneID:108065618" ORIGIN 1 mqsprsrrrs rapntwiccw inkmhavasl saslpllllt lafanlpstv rgtdtalvpl 61 sctsvvcqng gtcvtqlngk iycacdshyv gdycqhrnpc nsmrcqnggt cqvtfrngrp 121 gisckcplgf deslceiavp nacdhvtchn ggtcqlktlq eytcacangy tgercetknl 181 casspcrngg tctalagsss ftcscppgfn gdtcsfdiee clsnpckygg tcvnthgsyq 241 cmcptgytgk dcdtkykpcs pspcqnggvc rsnglsydck cpkgfegknc eqnfddclgh 301 lcqnggtcvd gisdyscrcp pnftgkfcqd dvdecaqrdh pvcqngatct nthgsyscic 361 vngwagldcs nntddckqaa cfygatcidg vgsfycqctk gktgllchld dactsnpcha 421 daicdtspin gsyacscatg ykgvdcsedi decdqgspce hngicvntpg syrcncsqgf 481 tgprcetnin eceshpcqne gsclddpgtf rcvcmpgftg tqceididec qsnpclndgt 541 chdkingfkc scalgftgar cqiniddcqs qpcrnrgich dsiagyscec ppgytgtsce 601 inindcdsnp chrgkciddv nsfkclcdpg ytgyicqkqi necesnpcqf dghcqdrvgs 661 yycqcqagts gkncevnvne chsnpcnnga tcidginsyk cqcvpgftgv hceknvdeci 721 sspcanngvc idqvngykce cprgfydahc lsdvdecasn pcvnegrced sinefichcp 781 pgytgkrcel didecssnpc qhggtcydkl nafscqcmpg ytgqkcetni ddcvqnpcgn 841 ggtcidkvng ykcvckvpft grdceskmdp casnrcknea kctpssnfld fsctcklgyt 901 grycdedide cslsspcrng asclnvpgsy rclctkgyeg rdcaintddc asfpcqnggt 961 cldgigdysc lcvdgfdgkh cetdinecls qpcqngatcs qyvnsytctc plgfsgincq 1021 tndedctess clnggscidg ingyncscla gfsgancqyk lnkcdsnpcl nggtcheqrd 1081 eytchcpsgf tgkqcseyvd wcgqspceng atcsqmkhqf sckcsagwtg klcdvqtisc 1141 qdaadrkgls lrqlcnngtc kdygnshvcy csqgyagsyc qkeidecqsq pcqnggtcld 1201 ligayeckcr qgfqgqncel niddcapnpc qnggtchdrv mnfscscppg tvgiiceink 1261 ddckpgachn ngscidrvgg fecvcqpgfv garcegdine clsnpcsnag tldcvqlvnn 1321 yhcncrpghm grhcehkvdf caqspcqngg ncnirqsghh cicnngfygk ncelsgqdcd 1381 snpcrvgncv vadegfgyrc ecprgtlgeh ceidtldecs pnpcaqgaac edllgdfecf 1441 cpskwkgkrc diydvsypgw nggndryaad leqqramcek rgcnekqtng icdsecntya 1501 cnfdgndcsl ginpwancta necwnkfkng kcneecnnaa chydghdcer klkscdslfd 1561 aycqkhygdg fcdygcnnae cswdgldcen ktqspvlaeg aisvvmlmne eqfreiqaqf 1621 lrnmshmlrt tvrlkkdafg rdmitkwrdn qpvaeidntd farknkilyt qqvyqtgiqi 1681 qieidnrkct ecfthaveaa eflaataakh qlrndfqihs vgvvknpgdd dsgeppanvk 1741 yvitgiilvi ialafagmvl stqrkrahgv twfpegfrap aavmsrrrrd phgqemrnln 1801 kqvglqsqgv gqtgahwsdd esdmplpkrq rsapisvinq qglgnnggya sdhtmvseye 1861 eadqrvwsqa hldvadvrai mtppahqdgg iglsgisnkh dvdargphgq tplmiavrgg 1921 ggldtgedie nnedstaqvi sdllaqgael natmdktget slhlaarfar adaakrllda 1981 gadancqdnt grtplhaava adamgvfqil lrnratnlna rmhdgttpli laarlaiegm 2041 vedlitadad inaadnsgkt alhwaaavnn teavnillmh hanrdaqddk detplflaar 2101 egsyeackal ldnfanreit dhmdrlprdv aserlhhdiv rlldehvprs pqmlsmtpqa 2161 migspppgqq qqqqqlitqp tvisagngng ngnasgkqss qsakqkaakk akliegspdn 2221 gldatgggsl rrkasskkts aaskkaatln gqltgaaqaq aqaaqaaaaa aaaaaaaaam 2281 tmshelegsp vgvgmggnlp spydtssmys namaaplang npntgakqpp syedciknaq 2341 slqslqgngl dmikldnygy smgspfqqel lngqglgmng ngqrngvvgg vlpgglcgmg 2401 gltgagngns heqglsppys nqspphsvqs slalsphayl gspspaksrp slptspthiq 2461 amrhatqqkq fggsnlnsll ggangggvvg ggggnggqgp qnspvslgii sptgsdmgim 2521 lappqsskgs aimqtlspqq qqqqqqqqqq qqqhqqqqqq qqqqqqqqqq qqlgglefgs 2581 agldlngfcg spdsfhsgqm nppsiqssms gsspstnmls pssqhnqqaf yqyltppsqh 2641 sgghtpqhlv qtldsyptps pespghwsss sprsnsdwse gvqspaannl yisgghqank 2701 gseaiyi