tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Drosophila

LOCUS       XP_017007273             476 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017007273
VERSION     XP_017007273.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017151784.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017007273.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..476
                     /product="tRNA-dihydrouridine(20) synthase [NAD(P)+]-like"
                     /calculated_mol_wt=52861
     Region          30..271
                     /region_name="DUS_like_FMN"
                     /note="Dihydrouridine synthase-like (DUS-like) FMN-binding
                     domain. Members of this family catalyze the reduction of
                     the 5,6-double bond of a uridine residue on tRNA.
                     Dihydrouridine modification of tRNA is widely observed in
                     prokaryotes and eukaryotes, and also...; cd02801"
                     /db_xref="CDD:239200"
     Site            order(34..36,60,105,131,173,201,232,234,259..260)
                     /site_type="other"
                     /note="FMN binding site [chemical binding]"
                     /db_xref="CDD:239200"
     Site            order(105,134..135,173,175,200..201,203..204,233..234,260)
                     /site_type="active"
                     /db_xref="CDD:239200"
     Site            order(134,175,201,203)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239200"
     Site            order(135,173,200,204,233..234)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:239200"
     Region          397..461
                     /region_name="DSRM_DUS2L"
                     /note="double-stranded RNA binding motif of
                     tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L)
                     and similar proteins; cd19871"
                     /db_xref="CDD:380700"
     Site            order(397,399..400,403..404,407..408,413..414,421,
                     422..423,425,443..446,449..450)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380700"
     CDS             1..476
                     /gene="Dus2"
                     /coded_by="XM_017151784.3:85..1515"
                     /db_xref="GeneID:108064304"
ORIGIN      
        1 mqsmrlpiqi larslgismk trqrldyrdk lilapmvrvg tlpmrllale mgadivytee
       61 lvdlkliksi rrpnaalgtv dfvdpsdgti vfrtcaqets rlvlqlgtsd pnralavgql
      121 lqrdiagldi nmgcpkefsi kggmgaalls dpakaalilr tlcsgldipv tckirilpdv
      181 aqtidlvqql aatgiaaigi hartrderpq hpahpevlra vaqavdipii anggsksmhc
      241 hedlrkfqad cgaasvmvar aaqinvsifr kegllpmdel ierylrlcvd ydnaphnaky
      301 cvqsilrelq etprgkrflq cqtlqqmcei wqlgdycrrr qrelrtlgns graeveppea
      361 qakrqkleei ssgdeysnvi crnmpflrst ypsdnhlpkt qlyvhaareg ksppayetqq
      421 cdklfrsics fdgqrfsssf weknkkqaeq gaalvallhl gqleaqvlrd ngslln