type II inositol 1,4,5-trisphosphate 5-phosphatase [Drosophila

LOCUS       XP_017006668             854 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017006668
VERSION     XP_017006668.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017151179.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..854
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase"
                     /calculated_mol_wt=97681
     Region          25..162
                     /region_name="INPP5B_PH"
                     /note="Type II inositol 1,4,5-trisphosphate 5-phosphatase
                     PH domain; pfam16776"
                     /db_xref="CDD:465268"
     Region          187..480
                     /region_name="INPP5c_INPP5B"
                     /note="Catalytic inositol polyphosphate 5-phosphatase
                     (INPP5c) domain of Type II inositol polyphosphate
                     5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and
                     related proteins; cd09093"
                     /db_xref="CDD:197327"
     Site            order(195,197,228,231,233,236,300,306..307,327,330..331,
                     368,370,372,424..425,438,440,446,470..471)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197327"
     Site            order(195,228,327,368,370,446,470..471)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197327"
     Site            order(197,228,470)
                     /site_type="other"
                     /note="Mg binding site [ion binding]"
                     /db_xref="CDD:197327"
     Site            order(228,231,233,236,300,306..307,327,330..331,372,
                     424..425,438,440,470)
                     /site_type="other"
                     /note="putative PI/IP binding site [chemical binding]"
                     /db_xref="CDD:197327"
     Site            order(327,370,471)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197327"
     Region          616..825
                     /region_name="RhoGAP_OCRL1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in OCRL1-like proteins.
                     OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins
                     contain two conserved domains: a central inositol
                     polyphosphate 5-phosphatase domain and...; cd04380"
                     /db_xref="CDD:239845"
     Site            order(688,727,735,789,792..793,816)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239845"
     Site            688
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239845"
     CDS             1..854
                     /gene="Ocrl"
                     /coded_by="XM_017151179.3:695..3259"
                     /db_xref="GeneID:108063899"
ORIGIN      
        1 mdtassgdsv pngtapaatr tlkdivkerf kedetieylf eayqikgpey tnrllalvss
       61 qsggtfaiva fsylrtplts vneliinkvf aidhnfqlrq dskssittqq fdlstaedgp
      121 ikyyyyateg dhyeefvakv isfkstmtqh dpetvlnfrw lndyrqigev kqelkkrese
      181 yivykdiiiy catwnvnnkt csdsqnplra wlacseqppd iyaiglqeld tptkamlnst
      241 qvqalekhwi dmmmdsvhpd veyeilmshr lvatmltviv rkelrqhiir crpksvargi
      301 fntlgnkggv aislqlnegn icfvnshlaa hmgyveernq dynaivegir fddgrtisdh
      361 dhifwvgdln yriqeppgqq rpgplsdaqt yelllqydql rqemrrgkcf egytegdikf
      421 rptykydpgt dnydssekqr apaycdrvlw kgtrieqlay nsimeirqsd hkpvyavfrv
      481 kiktrdevky krvqeevlka vdkrendnqp qinvektvid fgtvrfneat trdfnvynnc
      541 plpvdfsfke kdihaicepw lhvdprqdsl lidsarsirl kmhanvrtia gllrkirasd
      601 nfdililhve ngrdifitvt gdyqpscfgl smetmcrtdr plsefsqeqi kqlmndespe
      661 yrvtmpreff llidylyrqg skqvgafpsy darlslgaqf navrdwldtw sdepfpanae
      721 taaqalllll dlpeqallep vvenllecsn ksqamdyisl lsppkrnvfm hlcmflragi
      781 esqyydlhqv astfgrillr steraawmdy hsrciqfmrl fidsdaetvg ngnegagtgt
      841 gtgsgsgara glqa