phosphatidylinositol 4-kinase alpha isoform X2 [Drosophila

LOCUS       XP_017006612            2128 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_017006612
VERSION     XP_017006612.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017151123.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017006612.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..2128
                     /product="phosphatidylinositol 4-kinase alpha isoform X2"
                     /calculated_mol_wt=239691
     Region          393..1545
                     /region_name="PI4K_N"
                     /note="PI4-kinase N-terminal region; pfam19274"
                     /db_xref="CDD:437106"
     Region          1574..1749
                     /region_name="PI4Ka"
                     /note="Phosphoinositide 4-kinase(PI4K), accessory domain
                     (PIK domain); PIK domain is conserved in PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. PI4K
                     phosphorylates hydroxylgroup at position 4 on the...;
                     cd00871"
                     /db_xref="CDD:238443"
     Region          1810..2127
                     /region_name="PI4Kc_III_alpha"
                     /note="Catalytic domain of Type III Phosphoinositide
                     4-kinase alpha; cd05167"
                     /db_xref="CDD:270711"
     Site            order(1822,1824..1825,1827,1829,1874,1876,1879,1910,
                     1922..1925,1930,1933,1988,1990,2000..2001)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270711"
     Site            1980..1988
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270711"
     Site            order(2001..2011,2014..2017,2018..2023)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270711"
     CDS             1..2128
                     /gene="Pi4KIIIalpha"
                     /coded_by="XM_017151123.3:365..6751"
                     /db_xref="GeneID:108063860"
ORIGIN      
        1 mtmtasdkyt yqrtvlclar vlagiqptpw ekvqtlfryc pqenaagvfc ldtraqdavi
       61 algiyylegg cqhegqivpy llrlakclpk avwiddarsn kveriripsa ekfsfclntl
      121 lsdiaakcpd sreeiilnqv etlsalaniv kssrdsssap ppiilckatv pllfglarsm
      181 gryasndppl lcrifppell piqkgggrdg tggssssasg tcggsfssse rlagathqfr
      241 piiprsmsgs laqaqaqanq nhedarqgkc hqgskhqkps lhsyfsvpyd prthfftryg
      301 ssfnqfpnmr vcesptkggp rplyrvppfp iqhlqtifav skklltkdtl ehldeqasdi
      361 fslhqikgyc yksfsetlnl vlvtllrell qhqvdlptpf tkdvqefvkr lflngqtelq
      421 nkqqdqerer reengiavvn kykvnvmana acvdllvwai rdeteadklc grlsqklnle
      481 lshkivmdhm pllmvclegl gklahkfpni agtsisylrd flvapspiln klhdhamqsl
      541 aqqkkekelt pfkiavqhsd srtavviygd nqkqpssgtg rsghaafeal rdaaienlsi
      601 alraahtldq fcvpalvanv snrlftaeks gsesqgechk snlvslniiv mlghvavalk
      661 dtskttqnil qffiqrfckv pseqnalivd qlgcmiisqc ethvfdeimk mfsrvtvqsa
      721 slaytsdpeh rkqfhhvsda vvnalgniaa niqgdaemle llgkllelfv qigldgersy
      781 dntpgaqkas sragnlgmli pviavlvrrl ppiknprqrl hklfkdfway cvvmgftnar
      841 lwpadwyqgv qqiaakspll isqtahksdm relnytlaik sdsvnelrsq ilvllehssd
      901 nvatainkls faqctyllsv ywlemlrven adepslepim sylcdtalqr dktgiwqcvk
      961 cvadqvfekf rnvlyahdei rekvlesqat lllvyfnhih kpiqvvadqy lsflvdrfph
     1021 llwnrrvlwc mldilqllay slsldpneet ptlrvvstpy tlqlmdslpa relrlkdfad
     1081 rcqgivneam kwaprstrsh lqeypnqipt pvlahhsgla lafdsvisss sslqtkrpsc
     1141 vnsdtprfvs vlclrskyag eisgllsvls ekdkagladr lvsdvweacg eksdarhrga
     1201 lwrataylii cseidrkllh avassqlelf tesametave cwqwvltarq dlelcfiqem
     1261 vsawqttfek rmglfqwete vtnplaayeg cklvskpili tphliwlqll semvdtakyc
     1321 nrdkvemfcl llhrclpilk ssrqnrqvst vgcrfkllqc glsllqgnti pkslarnilr
     1381 eriysnaldy fcgpptcpnq sreqllediq illkfwqtmr sekkhlvtse vgdydltnas
     1441 vsstqmlavr hnpetaslis gsglvndytr smsasgnavg ssgwyntiph ststlskrsn
     1501 rskrlqyqkd sydkdymkkr nlilellave leflltwynp nclpdliipg eeqitewrnr
     1561 pykpnvwrdy arlawcynps lavflpqrik naeiideevs rlvcsdpiav chipealkyl
     1621 cttknllqes pdlvyilsws pvtpiqalay fsrqypshpl taqyavktls sypaesvlpy
     1681 ipqlvqalrh dtmgyvvefi rnisrrsqiv ahqliwnmqt nmymdedqqh rdpnlyeald
     1741 qlslsiiasf sgaakrfyer efdffgkita vsgeirsfak gierknacla alsrikvqgg
     1801 cylpsnpeam vldidyssgt pmqsaakapy larfrvyrcg iteletrame vsnnpnsqed
     1861 akmtlgvesw qaaifkvgdd vrqdmlalqv itifksifqq vgldlflfpy rvvatapgcg
     1921 viecvpnaks rdqlgrqtds glseyfqhqy gdesskefqa aranfvksma aysligyllq
     1981 ikdrhngnim idkdghiihi dfgfmfessp ggnigfepdm kltdemvmim ggkmdspafk
     2041 wfcelcvqaf lavrpyqdai vslvslmldt glpcfrgqti nllkqrfvat knnkeaaahm
     2101 lavirnsyqn frtrtydmiq yyqnqipy