DNA topoisomerase 1 isoform X4 [Drosophila takahashii].

LOCUS       XP_017001465             608 aa            linear   INV 09-DEC-2024
ACCESSION   XP_017001465
VERSION     XP_017001465.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017145976.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017001465.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..608
                     /product="DNA topoisomerase 1 isoform X4"
                     /calculated_mol_wt=71021
     Region          61..275
                     /region_name="Topoisomer_IB_N_htopoI_like"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); cd03488"
                     /db_xref="CDD:239570"
     Site            order(61,111,201..202,207,209,212,219,255..257,270..271,
                     273)
                     /site_type="DNA binding"
                     /db_xref="CDD:239570"
     Region          205..578
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     Site            209
                     /site_type="active"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     CDS             1..608
                     /gene="Top1"
                     /coded_by="XM_017145976.3:16..1842"
                     /db_xref="GeneID:108060319"
ORIGIN      
        1 mlrplaavrl fgdrsacwvf geqivatvat vagkkrrvrr ksvqeeqirw weeekradgv
       61 kwttlehkgp vfappyervp rnvrfyydgk plelseetee aatfyakmln hdyctkdvfn
      121 nnffkdfrks mtskekeiik dfrkcnfqem fnffqaesek rkaatkeekl ikknenealm
      181 kefgfcmidg hkekignfrl eppglfrgrg ehpkmgmikr riqssdvsin cgkdskvpsp
      241 pygsrwkevr hdntvtwlas wienvqgqvk yimlnpsskl kgekdhikye tarrldkvid
      301 kiratyrdew kskemrvrqr avalyfidkl alragnekde dqadtvgccs lrvehvqlhk
      361 elngkenvvv fdfpgkdsir yynevevekr vfknlelfme hkkegddlfd rlntqvlneh
      421 lkelmdglta kvfrtynask tlqsqldllt dpgatvpekl laynranrav ailcnhqrsv
      481 pkgheksmen lkekiktkrd aiddceaeyh dlkkaakrgs vkekvnadkk gkqlerlkdq
      541 lkklelqetd rdenktialg tsklnyldpr isvawckkng vpiekifnkt qrtkflwaih
      601 madehyrf