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PREDICTED: Drosophila takahashii topoisomerase 1 (Top1), transcript


LOCUS       XM_017145976            2835 bp    mRNA    linear   INV 09-DEC-2024
            variant X4, mRNA.
ACCESSION   XM_017145976
VERSION     XM_017145976.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017145976.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..2835
                     /gene="Top1"
                     /note="topoisomerase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 Protein"
                     /db_xref="GeneID:108060319"
     CDS             16..1842
                     /gene="Top1"
                     /codon_start=1
                     /product="DNA topoisomerase 1 isoform X4"
                     /protein_id="XP_017001465.2"
                     /db_xref="GeneID:108060319"
                     /translation="MLRPLAAVRLFGDRSACWVFGEQIVATVATVAGKKRRVRRKSVQ
                     EEQIRWWEEEKRADGVKWTTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAA
                     TFYAKMLNHDYCTKDVFNNNFFKDFRKSMTSKEKEIIKDFRKCNFQEMFNFFQAESEK
                     RKAATKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMI
                     KRRIQSSDVSINCGKDSKVPSPPYGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNP
                     SSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRA
                     GNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVF
                     KNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMDGLTAKVFRTYNASKTLQSQLDLLT
                     DPGATVPEKLLAYNRANRAVAILCNHQRSVPKGHEKSMENLKEKIKTKRDAIDDCEAE
                     YHDLKKAAKRGSVKEKVNADKKGKQLERLKDQLKKLELQETDRDENKTIALGTSKLNY
                     LDPRISVAWCKKNGVPIEKIFNKTQRTKFLWAIHMADEHYRF"
     misc_feature    196..840
                     /gene="Top1"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); Region:
                     Topoisomer_IB_N_htopoI_like; cd03488"
                     /db_xref="CDD:239570"
     misc_feature    order(196..198,346..348,616..621,634..636,640..642,
                     649..651,670..672,778..786,823..828,832..834)
                     /gene="Top1"
                     /note="DNA binding site"
                     /db_xref="CDD:239570"
     misc_feature    628..1749
                     /gene="Top1"
                     /note="DNA Topoisomerase I (eukaryota); Region: TOPEUc;
                     smart00435"
                     /db_xref="CDD:214661"
     misc_feature    640..642
                     /gene="Top1"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     polyA_site      2835
                     /gene="Top1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 tcgtacacat atattatgtt gcgccccttg gcggcagtac gtctattcgg agatcggagt
       61 gcttgctggg ttttcgggga gcagatcgta gccaccgtag ccaccgttgc gggcaaaaag
      121 agaagagtgc gacggaagag cgtccaggaa gagcaaattc gatggtggga ggaggagaag
      181 cgcgcagatg gcgtcaagtg gacaacgctg gagcacaagg gacccgtttt cgcaccgccc
      241 tacgagcggg tgccccgcaa tgtgcggttc tactacgacg gcaagccact ggaactctcc
      301 gaggagacgg aggaggcggc caccttctat gcgaagatgt tgaatcatga ctactgcacc
      361 aaggatgtgt tcaacaacaa cttcttcaag gacttccgca agtcgatgac gtccaaggag
      421 aaggagatca tcaaggattt ccgcaagtgc aacttccagg agatgttcaa cttcttccag
      481 gcggagtccg agaagcgcaa ggcggccacc aaggaggaga agctgatcaa gaagaacgag
      541 aacgaggcgc tgatgaagga gtttggcttc tgtatgatcg acggccacaa ggagaagatt
      601 ggcaactttc gcctggagcc tcccggcctt ttccgtggcc gtggcgagca tcccaaaatg
      661 ggcatgatca agcgtcgcat tcagtccagc gatgtgtcca ttaactgcgg caaggactcc
      721 aaggtcccct cgcccccata cggatcgcgg tggaaggagg tgcgccacga caacacggtc
      781 acctggctgg cctcctggat cgagaacgtg cagggccagg tcaagtacat catgctgaat
      841 ccctcctcga agctcaaggg cgagaaggat cacattaagt acgagacggc acggcgactg
      901 gacaaggtga tcgacaagat tcgggccacc tatcgcgacg aatggaagtc gaaggagatg
      961 cgagtgcgcc agcgggcggt tgccctctac tttatcgaca agctggcgct gagagcgggc
     1021 aacgaaaagg acgaggatca ggcggacacc gtcggctgtt gctcgctgcg cgtcgagcac
     1081 gtccagctgc acaaggagct caacggcaag gagaacgtgg tggtgttcga cttccccggt
     1141 aaggattcca ttcgctacta caacgaggtc gaggtggaga agcgcgtctt caagaacctc
     1201 gagctgttta tggagcacaa gaaggagggc gacgatctct tcgatcgcct caacactcag
     1261 gtgctcaacg agcatctcaa ggagctgatg gatggactca cggccaaggt attccgtacg
     1321 tacaacgctt cgaaaacact gcaaagccag ctggatctgc tcaccgatcc gggtgccacg
     1381 gtaccggaga agctcttggc ctacaatcgg gccaatcgcg ccgtggccat cctgtgtaac
     1441 catcagcgtt ccgtgcccaa gggccacgag aagtcgatgg agaatctgaa ggagaagatc
     1501 aagaccaagc gggatgccat cgatgattgc gaggctgaat atcatgattt aaagaaggcc
     1561 gccaaacggg gatccgtgaa ggagaaggtc aatgccgaca agaagggcaa acagctggag
     1621 cgcctgaagg atcagctgaa gaaactagaa ttacaagaga ctgatagaga cgagaataag
     1681 accattgccc tgggcacatc taagctaaac tatctcgatc cacgcatatc ggtggcttgg
     1741 tgtaaaaaga acggagtgcc gatcgagaag atatttaaca aaacgcaaag aaccaaattt
     1801 ctgtgggcca ttcacatggc cgatgagcat tatcgttttt aaattgggtt gttatcctca
     1861 caggcacgcc cacccacaca cacagatacg cccccctctc acacacacaa agaagcatag
     1921 acagcgcagg ttgaaagact aggaacccga agacactttg ccccgaaaag tttatgcaaa
     1981 cagtagtgca tatgttcagc ttttcggttt tcggtaaagg catttcggga tgattatact
     2041 gctcctcccc cagaaaagaa agggacggat gtattctagg gatagggatc tggatctgcg
     2101 tctgttttgt ctgctttgga aaaacaaaaa cgtttgattg tttcaagtgc gcgcactacg
     2161 ctgaagtcta acttgcgaaa tgtacacacc aaaaacatgc cacacacgcg ttcacacttc
     2221 tatattgata tatatatatg gatatatata ttttaaacac aatatatata tatatatatt
     2281 atatacgaga caacaattta aataaacacc aagagaagaa gagaaacctg tgcaagacgt
     2341 cgccgccacc taaaaacaaa ataagagcat aattttctat gttttaccgt ctacaaaaga
     2401 agcaacaaat tttttctttt ttttttgtcg tcaaaactct gctgacttct cttatatatt
     2461 tttaattaat taatttttat atataaacta taaacaaaaa agaaagagaa agaaagtaaa
     2521 agctaaaaaa aaaaggaaaa gaacctacaa gcaaacgaaa aatgataaaa ttaacggttt
     2581 ttttatgttt acctatagtt gatttttgtt tagcgaaaaa atgtctttca ctattaatta
     2641 atattaatta tacaattact acgattacgt atttaagtgc taaatgaaca gagaaacctt
     2701 gtagcccaac ttttttagca tagcataatt tattcaattc aaaaaaactc tgatccagcg
     2761 caatttaccc aacacgattt atgattttag ttaaaattaa aaaataaacg aatgctaaat
     2821 tcatttgcaa acaaa