DNA topoisomerase 1 isoform X3 [Drosophila takahashii].

LOCUS       XP_017001463            1007 aa            linear   INV 09-DEC-2024
ACCESSION   XP_017001463
VERSION     XP_017001463.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017145974.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017001463.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1007
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1007
                     /product="DNA topoisomerase 1 isoform X3"
                     /calculated_mol_wt=115055
     Region          460..674
                     /region_name="Topoisomer_IB_N_htopoI_like"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); cd03488"
                     /db_xref="CDD:239570"
     Site            order(460,510,600..601,606,608,611,618,654..656,669..670,
                     672)
                     /site_type="DNA binding"
                     /db_xref="CDD:239570"
     Region          604..977
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     Site            608
                     /site_type="active"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     CDS             1..1007
                     /gene="Top1"
                     /coded_by="XM_017145974.3:596..3619"
                     /db_xref="GeneID:108060319"
ORIGIN      
        1 mtdaqnihiq nggscgevvq sngvttnghg hhhhhsssgs sgsskhksss kdkhrdkdre
       61 hkssgsssss kdhksssrdk drhkssssss ssskhrdkdk dkehrsssss shrdkdgsss
      121 sssskhksss ssssssghhk ssskdkerrd kdkdrsssss sssssrhkss ssssssrdke
      181 rssssshkss ssssssssks khsssrhsss qsssskepps ydgvfvkpep vsqplmqqqq
      241 ehsgpidpfh mqqlincngn gngndykngy eesivdikke desfnnlsqa sscdysmsqf
      301 radepafevk heqsyaeeds tmndndqdee adnepeemdn dneeedddee dvplamrkrk
      361 qeapdqadgg mddddddipl larkkvkkep kekskknkrv keepddeygs vkpkkkkikk
      421 eheiktevvs ssptkrqkvk eeeeevwrww eeekradgvk wttlehkgpv fappyervpr
      481 nvrfyydgkp lelseeteea atfyakmlnh dyctkdvfnn nffkdfrksm tskekeiikd
      541 frkcnfqemf nffqaesekr kaatkeekli kknenealmk efgfcmidgh kekignfrle
      601 ppglfrgrge hpkmgmikrr iqssdvsinc gkdskvpspp ygsrwkevrh dntvtwlasw
      661 ienvqgqvky imlnpssklk gekdhikyet arrldkvidk iratyrdewk skemrvrqra
      721 valyfidkla lragnekded qadtvgccsl rvehvqlhke lngkenvvvf dfpgkdsiry
      781 ynevevekrv fknlelfmeh kkegddlfdr lntqvlnehl kelmdgltak vfrtynaskt
      841 lqsqldlltd pgatvpekll aynranrava ilcnhqrsvp kgheksmenl kekiktkrda
      901 iddceaeyhd lkkaakrgsv kekvnadkkg kqlerlkdql kklelqetdr denktialgt
      961 sklnyldpri svawckkngv piekifnktq rtkflwaihm adehyrf