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PREDICTED: Drosophila takahashii topoisomerase 1 (Top1), transcript


LOCUS       XM_017145974            4612 bp    mRNA    linear   INV 09-DEC-2024
            variant X3, mRNA.
ACCESSION   XM_017145974
VERSION     XM_017145974.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017145974.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4612
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..4612
                     /gene="Top1"
                     /note="topoisomerase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 Proteins"
                     /db_xref="GeneID:108060319"
     CDS             596..3619
                     /gene="Top1"
                     /codon_start=1
                     /product="DNA topoisomerase 1 isoform X3"
                     /protein_id="XP_017001463.2"
                     /db_xref="GeneID:108060319"
                     /translation="MTDAQNIHIQNGGSCGEVVQSNGVTTNGHGHHHHHSSSGSSGSS
                     KHKSSSKDKHRDKDREHKSSGSSSSSKDHKSSSRDKDRHKSSSSSSSSSKHRDKDKDK
                     EHRSSSSSSHRDKDGSSSSSSSKHKSSSSSSSSSGHHKSSSKDKERRDKDKDRSSSSS
                     SSSSSRHKSSSSSSSSRDKERSSSSSHKSSSSSSSSSSKSKHSSSRHSSSQSSSSKEP
                     PSYDGVFVKPEPVSQPLMQQQQEHSGPIDPFHMQQLINCNGNGNGNDYKNGYEESIVD
                     IKKEDESFNNLSQASSCDYSMSQFRADEPAFEVKHEQSYAEEDSTMNDNDQDEEADNE
                     PEEMDNDNEEEDDDEEDVPLAMRKRKQEAPDQADGGMDDDDDDIPLLARKKVKKEPKE
                     KSKKNKRVKEEPDDEYGSVKPKKKKIKKEHEIKTEVVSSSPTKRQKVKEEEEEVWRWW
                     EEEKRADGVKWTTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFYAKML
                     NHDYCTKDVFNNNFFKDFRKSMTSKEKEIIKDFRKCNFQEMFNFFQAESEKRKAATKE
                     EKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQSS
                     DVSINCGKDSKVPSPPYGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGE
                     KDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDED
                     QADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFM
                     EHKKEGDDLFDRLNTQVLNEHLKELMDGLTAKVFRTYNASKTLQSQLDLLTDPGATVP
                     EKLLAYNRANRAVAILCNHQRSVPKGHEKSMENLKEKIKTKRDAIDDCEAEYHDLKKA
                     AKRGSVKEKVNADKKGKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISV
                     AWCKKNGVPIEKIFNKTQRTKFLWAIHMADEHYRF"
     misc_feature    1973..2617
                     /gene="Top1"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); Region:
                     Topoisomer_IB_N_htopoI_like; cd03488"
                     /db_xref="CDD:239570"
     misc_feature    order(1973..1975,2123..2125,2393..2398,2411..2413,
                     2417..2419,2426..2428,2447..2449,2555..2563,2600..2605,
                     2609..2611)
                     /gene="Top1"
                     /note="DNA binding site"
                     /db_xref="CDD:239570"
     misc_feature    2405..3526
                     /gene="Top1"
                     /note="DNA Topoisomerase I (eukaryota); Region: TOPEUc;
                     smart00435"
                     /db_xref="CDD:214661"
     misc_feature    2417..2419
                     /gene="Top1"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     polyA_site      4612
                     /gene="Top1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 aagtgtccca gtcccatttt gcaattacat ttatatgtgc acatacaaac gtacagaggt
       61 gttttttttt tttgtatatg cttgtgtgtc gtctgataag acagatgtgc caccccgaaa
      121 aaaaaacaca cttactaaat aatatgctgc aacaacaaca accccgtgtg tgtgtgtgca
      181 agtgtgtgcg tgtgtagcct tgatgcagcg cccacgttga aaaaaaagaa gaatatatgc
      241 agttaaaaaa aaaaatacga ttttctgtat tctccaattt gcgcgtgtgt gtgcgtgtgt
      301 gttccattgt ttggcagcgg tgtttttgta tttccatttc atttaaccta ttcttccaac
      361 gggaagaata tcgggaacga tatttccaat ttcctgtcgc catcgctctt cggctcctct
      421 tcttcttcct gctcatcgca tttaacccat tgctgcccgt ttcaagtgaa ttttcctacg
      481 cggcatttgt gttagggttg atttttcacc acgtggtgag cggatagaca cgagataatc
      541 atagtaaatc catcaaaagg cccaggaaat cgtgaggaag cgaacgagag aagctatgac
      601 ggatgcacag aacatccaca tacaaaatgg tggcagctgc ggcgaggtgg ttcaatccaa
      661 cggggtgacc accaacggac acggacacca ccaccaccac agcagcagtg ggagcagcgg
      721 gagcagcaag cataaatcct ccagcaagga caagcaccgt gataaggaca gggagcacaa
      781 gagctccgga tcctccagct cgtcgaagga tcacaagagc agcagtcgcg acaaggatcg
      841 ccacaaaagc agcagcagca gcagctcgtc gtcgaagcat cgggacaagg acaaggacaa
      901 ggagcatcgc agcagctctt cgtctagcca cagggacaag gatgggagca gcagcagtag
      961 cagcagcaag cacaagtcct cgtcgtcatc atcgtcctcg tccggccacc acaagagctc
     1021 ctcgaaggac aaggagcgac gcgacaagga caaggatcgc agcagcagca gcagcagcag
     1081 ctcctccagc cggcacaagt catcctcatc ctcgtccagt tcccgtgata aggagcgcag
     1141 cagcagcagc agtcacaaga gctcctcctc atcgtcatcc tcgtcatcga agagcaaaca
     1201 ttccagttcg cggcacagca gctcgcagtc ctcctcctcg aaggagccgc catcgtacga
     1261 tggagtgttt gtcaagccgg agcccgtttc gcagccgctg atgcagcagc agcaggagca
     1321 ctctggcccc atcgatccct tccacatgca gcagctcatc aattgcaatg gcaatggcaa
     1381 tggcaacgac tacaagaacg gctacgagga atcgattgtg gacatcaaga aggaggacga
     1441 gagcttcaac aatctatcgc aggcgagctc ctgcgactac tccatgtccc agtttcgagc
     1501 cgatgagccg gcattcgagg tgaagcacga gcagagctac gccgaggagg atagcaccat
     1561 gaacgacaat gatcaggacg aggaggctga taacgaaccc gaggaaatgg acaacgacaa
     1621 cgaggaggag gacgacgatg aggaggatgt gccgctggcc atgcgtaagc gcaagcagga
     1681 ggcacccgat caggccgatg gcggcatgga tgacgacgac gacgacattc cgctgctggc
     1741 gcgcaagaag gtcaagaagg agcccaagga gaagtcgaag aagaacaagc gggtcaagga
     1801 ggagcccgac gacgagtacg gcagtgttaa gcccaagaag aaaaagatca aaaaggaaca
     1861 cgaaattaag accgaggtcg tatcatcatc gcccaccaaa cgtcagaagg tcaaggagga
     1921 ggaggaggag gtgtggagat ggtgggagga ggagaagcgc gcagatggcg tcaagtggac
     1981 aacgctggag cacaagggac ccgttttcgc accgccctac gagcgggtgc cccgcaatgt
     2041 gcggttctac tacgacggca agccactgga actctccgag gagacggagg aggcggccac
     2101 cttctatgcg aagatgttga atcatgacta ctgcaccaag gatgtgttca acaacaactt
     2161 cttcaaggac ttccgcaagt cgatgacgtc caaggagaag gagatcatca aggatttccg
     2221 caagtgcaac ttccaggaga tgttcaactt cttccaggcg gagtccgaga agcgcaaggc
     2281 ggccaccaag gaggagaagc tgatcaagaa gaacgagaac gaggcgctga tgaaggagtt
     2341 tggcttctgt atgatcgacg gccacaagga gaagattggc aactttcgcc tggagcctcc
     2401 cggccttttc cgtggccgtg gcgagcatcc caaaatgggc atgatcaagc gtcgcattca
     2461 gtccagcgat gtgtccatta actgcggcaa ggactccaag gtcccctcgc ccccatacgg
     2521 atcgcggtgg aaggaggtgc gccacgacaa cacggtcacc tggctggcct cctggatcga
     2581 gaacgtgcag ggccaggtca agtacatcat gctgaatccc tcctcgaagc tcaagggcga
     2641 gaaggatcac attaagtacg agacggcacg gcgactggac aaggtgatcg acaagattcg
     2701 ggccacctat cgcgacgaat ggaagtcgaa ggagatgcga gtgcgccagc gggcggttgc
     2761 cctctacttt atcgacaagc tggcgctgag agcgggcaac gaaaaggacg aggatcaggc
     2821 ggacaccgtc ggctgttgct cgctgcgcgt cgagcacgtc cagctgcaca aggagctcaa
     2881 cggcaaggag aacgtggtgg tgttcgactt ccccggtaag gattccattc gctactacaa
     2941 cgaggtcgag gtggagaagc gcgtcttcaa gaacctcgag ctgtttatgg agcacaagaa
     3001 ggagggcgac gatctcttcg atcgcctcaa cactcaggtg ctcaacgagc atctcaagga
     3061 gctgatggat ggactcacgg ccaaggtatt ccgtacgtac aacgcttcga aaacactgca
     3121 aagccagctg gatctgctca ccgatccggg tgccacggta ccggagaagc tcttggccta
     3181 caatcgggcc aatcgcgccg tggccatcct gtgtaaccat cagcgttccg tgcccaaggg
     3241 ccacgagaag tcgatggaga atctgaagga gaagatcaag accaagcggg atgccatcga
     3301 tgattgcgag gctgaatatc atgatttaaa gaaggccgcc aaacggggat ccgtgaagga
     3361 gaaggtcaat gccgacaaga agggcaaaca gctggagcgc ctgaaggatc agctgaagaa
     3421 actagaatta caagagactg atagagacga gaataagacc attgccctgg gcacatctaa
     3481 gctaaactat ctcgatccac gcatatcggt ggcttggtgt aaaaagaacg gagtgccgat
     3541 cgagaagata tttaacaaaa cgcaaagaac caaatttctg tgggccattc acatggccga
     3601 tgagcattat cgtttttaaa ttgggttgtt atcctcacag gcacgcccac ccacacacac
     3661 agatacgccc ccctctcaca cacacaaaga agcatagaca gcgcaggttg aaagactagg
     3721 aacccgaaga cactttgccc cgaaaagttt atgcaaacag tagtgcatat gttcagcttt
     3781 tcggttttcg gtaaaggcat ttcgggatga ttatactgct cctcccccag aaaagaaagg
     3841 gacggatgta ttctagggat agggatctgg atctgcgtct gttttgtctg ctttggaaaa
     3901 acaaaaacgt ttgattgttt caagtgcgcg cactacgctg aagtctaact tgcgaaatgt
     3961 acacaccaaa aacatgccac acacgcgttc acacttctat attgatatat atatatggat
     4021 atatatattt taaacacaat atatatatat atatattata tacgagacaa caatttaaat
     4081 aaacaccaag agaagaagag aaacctgtgc aagacgtcgc cgccacctaa aaacaaaata
     4141 agagcataat tttctatgtt ttaccgtcta caaaagaagc aacaaatttt ttcttttttt
     4201 tttgtcgtca aaactctgct gacttctctt atatattttt aattaattaa tttttatata
     4261 taaactataa acaaaaaaga aagagaaaga aagtaaaagc taaaaaaaaa aggaaaagaa
     4321 cctacaagca aacgaaaaat gataaaatta acggtttttt tatgtttacc tatagttgat
     4381 ttttgtttag cgaaaaaatg tctttcacta ttaattaata ttaattatac aattactacg
     4441 attacgtatt taagtgctaa atgaacagag aaaccttgta gcccaacttt tttagcatag
     4501 cataatttat tcaattcaaa aaaactctga tccagcgcaa tttacccaac acgatttatg
     4561 attttagtta aaattaaaaa ataaacgaat gctaaattca tttgcaaaca aa