DNA topoisomerase 1 isoform X2 [Drosophila takahashii].

LOCUS       XP_017001462            1011 aa            linear   INV 09-DEC-2024
ACCESSION   XP_017001462
VERSION     XP_017001462.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017145973.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_017001462.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1011
                     /product="DNA topoisomerase 1 isoform X2"
                     /calculated_mol_wt=115383
     Region          464..678
                     /region_name="Topoisomer_IB_N_htopoI_like"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); cd03488"
                     /db_xref="CDD:239570"
     Site            order(464,514,604..605,610,612,615,622,658..660,673..674,
                     676)
                     /site_type="DNA binding"
                     /db_xref="CDD:239570"
     Region          608..981
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     Site            612
                     /site_type="active"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     CDS             1..1011
                     /gene="Top1"
                     /coded_by="XM_017145973.3:323..3358"
                     /db_xref="GeneID:108060319"
ORIGIN      
        1 msgdvaaenn ihiqnggscg evvqsngvtt nghghhhhhs ssgssgsskh kssskdkhrd
       61 kdrehkssgs sssskdhkss srdkdrhkss ssssssskhr dkdkdkehrs ssssshrdkd
      121 gssssssskh ksssssssss ghhkssskdk errdkdkdrs sssssssssr hkssssssss
      181 rdkersssss hkssssssss sskskhsssr hsssqssssk eppsydgvfv kpepvsqplm
      241 qqqqehsgpi dpfhmqqlin cngngngndy kngyeesivd ikkedesfnn lsqasscdys
      301 msqfradepa fevkheqsya eedstmndnd qdeeadnepe emdndneeed ddeedvplam
      361 rkrkqeapdq adggmddddd dipllarkkv kkepkekskk nkrvkeepdd eygsvkpkkk
      421 kikkeheikt evvsssptkr qkvkeeeeev wrwweeekra dgvkwttleh kgpvfappye
      481 rvprnvrfyy dgkplelsee teeaatfyak mlnhdyctkd vfnnnffkdf rksmtskeke
      541 iikdfrkcnf qemfnffqae sekrkaatke eklikknene almkefgfcm idghkekign
      601 frleppglfr grgehpkmgm ikrriqssdv sincgkdskv psppygsrwk evrhdntvtw
      661 laswienvqg qvkyimlnps sklkgekdhi kyetarrldk vidkiratyr dewkskemrv
      721 rqravalyfi dklalragne kdedqadtvg ccslrvehvq lhkelngken vvvfdfpgkd
      781 siryynevev ekrvfknlel fmehkkegdd lfdrlntqvl nehlkelmdg ltakvfrtyn
      841 asktlqsqld lltdpgatvp ekllaynran ravailcnhq rsvpkgheks menlkekikt
      901 krdaiddcea eyhdlkkaak rgsvkekvna dkkgkqlerl kdqlkklelq etdrdenkti
      961 algtsklnyl dprisvawck kngvpiekif nktqrtkflw aihmadehyr f