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PREDICTED: Drosophila takahashii topoisomerase 1 (Top1), transcript


LOCUS       XM_017145973            4351 bp    mRNA    linear   INV 09-DEC-2024
            variant X2, mRNA.
ACCESSION   XM_017145973
VERSION     XM_017145973.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017145973.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4351
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..4351
                     /gene="Top1"
                     /note="topoisomerase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 Proteins"
                     /db_xref="GeneID:108060319"
     CDS             323..3358
                     /gene="Top1"
                     /codon_start=1
                     /product="DNA topoisomerase 1 isoform X2"
                     /protein_id="XP_017001462.2"
                     /db_xref="GeneID:108060319"
                     /translation="MSGDVAAENNIHIQNGGSCGEVVQSNGVTTNGHGHHHHHSSSGS
                     SGSSKHKSSSKDKHRDKDREHKSSGSSSSSKDHKSSSRDKDRHKSSSSSSSSSKHRDK
                     DKDKEHRSSSSSSHRDKDGSSSSSSSKHKSSSSSSSSSGHHKSSSKDKERRDKDKDRS
                     SSSSSSSSSRHKSSSSSSSSRDKERSSSSSHKSSSSSSSSSSKSKHSSSRHSSSQSSS
                     SKEPPSYDGVFVKPEPVSQPLMQQQQEHSGPIDPFHMQQLINCNGNGNGNDYKNGYEE
                     SIVDIKKEDESFNNLSQASSCDYSMSQFRADEPAFEVKHEQSYAEEDSTMNDNDQDEE
                     ADNEPEEMDNDNEEEDDDEEDVPLAMRKRKQEAPDQADGGMDDDDDDIPLLARKKVKK
                     EPKEKSKKNKRVKEEPDDEYGSVKPKKKKIKKEHEIKTEVVSSSPTKRQKVKEEEEEV
                     WRWWEEEKRADGVKWTTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFY
                     AKMLNHDYCTKDVFNNNFFKDFRKSMTSKEKEIIKDFRKCNFQEMFNFFQAESEKRKA
                     ATKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRR
                     IQSSDVSINCGKDSKVPSPPYGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSK
                     LKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNE
                     KDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNL
                     ELFMEHKKEGDDLFDRLNTQVLNEHLKELMDGLTAKVFRTYNASKTLQSQLDLLTDPG
                     ATVPEKLLAYNRANRAVAILCNHQRSVPKGHEKSMENLKEKIKTKRDAIDDCEAEYHD
                     LKKAAKRGSVKEKVNADKKGKQLERLKDQLKKLELQETDRDENKTIALGTSKLNYLDP
                     RISVAWCKKNGVPIEKIFNKTQRTKFLWAIHMADEHYRF"
     misc_feature    1712..2356
                     /gene="Top1"
                     /note="Topoisomer_IB_N_htopoI_like : N-terminal DNA
                     binding fragment found in eukaryotic DNA topoisomerase
                     (topo) IB proteins similar to the monomeric yeast and
                     human topo I. Topo I enzymes are divided into: topo type
                     IA (bacterial) and type IB (eukaryotic); Region:
                     Topoisomer_IB_N_htopoI_like; cd03488"
                     /db_xref="CDD:239570"
     misc_feature    order(1712..1714,1862..1864,2132..2137,2150..2152,
                     2156..2158,2165..2167,2186..2188,2294..2302,2339..2344,
                     2348..2350)
                     /gene="Top1"
                     /note="DNA binding site"
                     /db_xref="CDD:239570"
     misc_feature    2144..3265
                     /gene="Top1"
                     /note="DNA Topoisomerase I (eukaryota); Region: TOPEUc;
                     smart00435"
                     /db_xref="CDD:214661"
     misc_feature    2156..2158
                     /gene="Top1"
                     /note="topo1 poison binding [active]"
                     /db_xref="CDD:239570"
     polyA_site      4351
                     /gene="Top1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 cttgagtgaa aagcaaaaaa aagcaaaggg ttttcgattc gcgtggctgc tgcgcgctgt
       61 gaaaagcaaa gaattgcatc gccagaagca ccaaacgctg ctccatttcg gaaacggaaa
      121 gcggaaaacc ccagtgcgct cactttccaa ccgccgccgc cgcaagaact gctcagaaaa
      181 tatagaatag caaagaaaaa aaaaacgaac tgaaagagtg aacaattttt taaccaagtg
      241 cggatgcaga gagagtaaaa agtaaaaagt caaaggaccg acaagtagaa agaaaaataa
      301 gaaaaacgcc gagcgccgca aaatgagtgg ggatgtggct gccgagaata acatccacat
      361 acaaaatggt ggcagctgcg gcgaggtggt tcaatccaac ggggtgacca ccaacggaca
      421 cggacaccac caccaccaca gcagcagtgg gagcagcggg agcagcaagc ataaatcctc
      481 cagcaaggac aagcaccgtg ataaggacag ggagcacaag agctccggat cctccagctc
      541 gtcgaaggat cacaagagca gcagtcgcga caaggatcgc cacaaaagca gcagcagcag
      601 cagctcgtcg tcgaagcatc gggacaagga caaggacaag gagcatcgca gcagctcttc
      661 gtctagccac agggacaagg atgggagcag cagcagtagc agcagcaagc acaagtcctc
      721 gtcgtcatca tcgtcctcgt ccggccacca caagagctcc tcgaaggaca aggagcgacg
      781 cgacaaggac aaggatcgca gcagcagcag cagcagcagc tcctccagcc ggcacaagtc
      841 atcctcatcc tcgtccagtt cccgtgataa ggagcgcagc agcagcagca gtcacaagag
      901 ctcctcctca tcgtcatcct cgtcatcgaa gagcaaacat tccagttcgc ggcacagcag
      961 ctcgcagtcc tcctcctcga aggagccgcc atcgtacgat ggagtgtttg tcaagccgga
     1021 gcccgtttcg cagccgctga tgcagcagca gcaggagcac tctggcccca tcgatccctt
     1081 ccacatgcag cagctcatca attgcaatgg caatggcaat ggcaacgact acaagaacgg
     1141 ctacgaggaa tcgattgtgg acatcaagaa ggaggacgag agcttcaaca atctatcgca
     1201 ggcgagctcc tgcgactact ccatgtccca gtttcgagcc gatgagccgg cattcgaggt
     1261 gaagcacgag cagagctacg ccgaggagga tagcaccatg aacgacaatg atcaggacga
     1321 ggaggctgat aacgaacccg aggaaatgga caacgacaac gaggaggagg acgacgatga
     1381 ggaggatgtg ccgctggcca tgcgtaagcg caagcaggag gcacccgatc aggccgatgg
     1441 cggcatggat gacgacgacg acgacattcc gctgctggcg cgcaagaagg tcaagaagga
     1501 gcccaaggag aagtcgaaga agaacaagcg ggtcaaggag gagcccgacg acgagtacgg
     1561 cagtgttaag cccaagaaga aaaagatcaa aaaggaacac gaaattaaga ccgaggtcgt
     1621 atcatcatcg cccaccaaac gtcagaaggt caaggaggag gaggaggagg tgtggagatg
     1681 gtgggaggag gagaagcgcg cagatggcgt caagtggaca acgctggagc acaagggacc
     1741 cgttttcgca ccgccctacg agcgggtgcc ccgcaatgtg cggttctact acgacggcaa
     1801 gccactggaa ctctccgagg agacggagga ggcggccacc ttctatgcga agatgttgaa
     1861 tcatgactac tgcaccaagg atgtgttcaa caacaacttc ttcaaggact tccgcaagtc
     1921 gatgacgtcc aaggagaagg agatcatcaa ggatttccgc aagtgcaact tccaggagat
     1981 gttcaacttc ttccaggcgg agtccgagaa gcgcaaggcg gccaccaagg aggagaagct
     2041 gatcaagaag aacgagaacg aggcgctgat gaaggagttt ggcttctgta tgatcgacgg
     2101 ccacaaggag aagattggca actttcgcct ggagcctccc ggccttttcc gtggccgtgg
     2161 cgagcatccc aaaatgggca tgatcaagcg tcgcattcag tccagcgatg tgtccattaa
     2221 ctgcggcaag gactccaagg tcccctcgcc cccatacgga tcgcggtgga aggaggtgcg
     2281 ccacgacaac acggtcacct ggctggcctc ctggatcgag aacgtgcagg gccaggtcaa
     2341 gtacatcatg ctgaatccct cctcgaagct caagggcgag aaggatcaca ttaagtacga
     2401 gacggcacgg cgactggaca aggtgatcga caagattcgg gccacctatc gcgacgaatg
     2461 gaagtcgaag gagatgcgag tgcgccagcg ggcggttgcc ctctacttta tcgacaagct
     2521 ggcgctgaga gcgggcaacg aaaaggacga ggatcaggcg gacaccgtcg gctgttgctc
     2581 gctgcgcgtc gagcacgtcc agctgcacaa ggagctcaac ggcaaggaga acgtggtggt
     2641 gttcgacttc cccggtaagg attccattcg ctactacaac gaggtcgagg tggagaagcg
     2701 cgtcttcaag aacctcgagc tgtttatgga gcacaagaag gagggcgacg atctcttcga
     2761 tcgcctcaac actcaggtgc tcaacgagca tctcaaggag ctgatggatg gactcacggc
     2821 caaggtattc cgtacgtaca acgcttcgaa aacactgcaa agccagctgg atctgctcac
     2881 cgatccgggt gccacggtac cggagaagct cttggcctac aatcgggcca atcgcgccgt
     2941 ggccatcctg tgtaaccatc agcgttccgt gcccaagggc cacgagaagt cgatggagaa
     3001 tctgaaggag aagatcaaga ccaagcggga tgccatcgat gattgcgagg ctgaatatca
     3061 tgatttaaag aaggccgcca aacggggatc cgtgaaggag aaggtcaatg ccgacaagaa
     3121 gggcaaacag ctggagcgcc tgaaggatca gctgaagaaa ctagaattac aagagactga
     3181 tagagacgag aataagacca ttgccctggg cacatctaag ctaaactatc tcgatccacg
     3241 catatcggtg gcttggtgta aaaagaacgg agtgccgatc gagaagatat ttaacaaaac
     3301 gcaaagaacc aaatttctgt gggccattca catggccgat gagcattatc gtttttaaat
     3361 tgggttgtta tcctcacagg cacgcccacc cacacacaca gatacgcccc cctctcacac
     3421 acacaaagaa gcatagacag cgcaggttga aagactagga acccgaagac actttgcccc
     3481 gaaaagttta tgcaaacagt agtgcatatg ttcagctttt cggttttcgg taaaggcatt
     3541 tcgggatgat tatactgctc ctcccccaga aaagaaaggg acggatgtat tctagggata
     3601 gggatctgga tctgcgtctg ttttgtctgc tttggaaaaa caaaaacgtt tgattgtttc
     3661 aagtgcgcgc actacgctga agtctaactt gcgaaatgta cacaccaaaa acatgccaca
     3721 cacgcgttca cacttctata ttgatatata tatatggata tatatatttt aaacacaata
     3781 tatatatata tatattatat acgagacaac aatttaaata aacaccaaga gaagaagaga
     3841 aacctgtgca agacgtcgcc gccacctaaa aacaaaataa gagcataatt ttctatgttt
     3901 taccgtctac aaaagaagca acaaattttt tctttttttt ttgtcgtcaa aactctgctg
     3961 acttctctta tatattttta attaattaat ttttatatat aaactataaa caaaaaagaa
     4021 agagaaagaa agtaaaagct aaaaaaaaaa ggaaaagaac ctacaagcaa acgaaaaatg
     4081 ataaaattaa cggttttttt atgtttacct atagttgatt tttgtttagc gaaaaaatgt
     4141 ctttcactat taattaatat taattataca attactacga ttacgtattt aagtgctaaa
     4201 tgaacagaga aaccttgtag cccaactttt ttagcatagc ataatttatt caattcaaaa
     4261 aaactctgat ccagcgcaat ttacccaaca cgatttatga ttttagttaa aattaaaaaa
     4321 taaacgaatg ctaaattcat ttgcaaacaa a