5'-AMP-activated protein kinase catalytic subunit alpha-2

LOCUS       XP_016998598             588 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016998598
VERSION     XP_016998598.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017143109.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016998598.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..588
                     /product="5'-AMP-activated protein kinase catalytic
                     subunit alpha-2"
                     /calculated_mol_wt=65402
     Region          25..280
                     /region_name="STKc_AMPK_alpha"
                     /note="Catalytic domain of the Alpha subunit of the
                     Serine/Threonine Kinase, AMP-activated protein kinase;
                     cd14079"
                     /db_xref="CDD:270981"
     Site            order(34..38,42,55,57,89,105..108,112,114..115,117,
                     150..151,153,155..156,158,168..169,172,186..190,192,
                     222..225)
                     /site_type="active"
                     /db_xref="CDD:270981"
     Site            order(34..37,42,55,57,89,105..108,112,155..156,158,
                     168..169)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270981"
     Site            order(112,114..115,117,151,153,155,172,186..190,192,
                     222..225)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270981"
     Site            168..190
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270981"
     Site            order(176..181,200..201,203,206,266)
                     /site_type="other"
                     /note="heterotrimer interface [polypeptide binding]"
                     /db_xref="CDD:270981"
     Region          297..360
                     /region_name="UBA_AID_AMPKalpha"
                     /note="UBA-like autoinhibitory domain (AID) found in
                     vertebrate 5'-AMP-activated protein kinase catalytic alpha
                     (AMPKalpha) subunits; cd14336"
                     /db_xref="CDD:270521"
     Region          463..586
                     /region_name="AMPKA_C"
                     /note="C-terminal regulatory domain of 5'-AMP-activated
                     protein kinase (AMPK) alpha catalytic subunit; cd12122"
                     /db_xref="CDD:213378"
     Site            order(464..469,476..477,481,484..485,488,492..494,
                     496..500,503..505,516,520..524,529..530,532..535,570,
                     572..573,575..577,579..580,583..584)
                     /site_type="other"
                     /note="beta subunit interface [polypeptide binding]"
                     /db_xref="CDD:213378"
     Site            order(508,510,570..571,573..574,577)
                     /site_type="other"
                     /note="gamma subunit interface [polypeptide binding]"
                     /db_xref="CDD:213378"
     CDS             1..588
                     /gene="AMPKalpha"
                     /coded_by="XM_017143109.3:171..1937"
                     /db_xref="GeneID:108058407"
ORIGIN      
        1 mpqlraaaae avaagssngq plvkighyll gatlgtgtfg kvkigehqit rvkvavkiln
       61 rqkiksldvv gkirreiqnl klfrhphiik lyqvistpsd ifmimeyvsg gelfdyivkh
      121 gklqehqarr ffqqiisgvd ychrhmivhr dlkpenllld hnmhvkiadf glsnmmldge
      181 flrtscgspn yaapevisgk lyagpevdiw scgvilyall cgtlpfddeh vptlfrkiks
      241 gifpipeyln kqvvnlvcqm lqvdplkran ieeikkhewf qkdlpaylfp ssieqdsnvi
      301 dtyavaevct kfgvketevh nsllsgdphd qlaiayhlii dnkrfaddaa nqineinnff
      361 vagspppppp plpqstmqqq qqqqqqdnha platvtvggt aassgtstpv ppasssgtps
      421 stirphperi apmrerqlam svqnsgggaf pektarggtp ikrakwhlgi rsqskpndim
      481 levyramkal syewkiinpy hvrvrrqnvk tgkfskmslq lyqvdaksyl ldfksltnde
      541 veqgddvime sltppplsvs gvmplqptgh htmeffemca aliiqlar