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probable E3 ubiquitin-protein ligase HERC2 [Drosophila takahashii].


LOCUS       XP_016996929            4804 aa            linear   INV 09-DEC-2024
ACCESSION   XP_016996929
VERSION     XP_016996929.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017141440.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016996929.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4804
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..4804
                     /product="probable E3 ubiquitin-protein ligase HERC2"
                     /calculated_mol_wt=520306
     Region          582..>851
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1252..1324
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1881..1941
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2464..2508
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2562..2637
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2700..2863
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2760,2789,2795,2797,2856)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2911..3244
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3226..3274
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          3942..4281
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4401..4772
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4407,4454,4465,4532,4703,4736..4737,4740..4744,4764,
                     4771)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4560,4563..4564,4566..4567,4570,4574,4576,
                     4580..4581,4583,4589,4594,4611,4615)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4804
                     /gene="HERC2"
                     /coded_by="XM_017141440.3:380..14794"
                     /db_xref="GeneID:108057265"
ORIGIN      
        1 mfnrqasgga apaqttatas sggggfglgg gaaaspdlyl rplpfldakw lradliaslr
       61 nsangavlwn hliqdcelvs sptppllnar gqlsylgddg khycgaqqlk csccqpdycg
      121 plsacncdgc rpldsdtaik kltsqaaaqq atdavlsgwl wslpptqqar lecqrsmiae
      181 lqelalraag nclsaqhlrq qlfvyeryfv alkrererer qpsnstpava sssstttive
      241 pqppaeqpse hgalglarva traalnfsfa flrrawrsge dtemcsells ealaslqelp
      301 eatlfeaavv sslwlevmer sikflrlval gdpmggrcta plndrhtalc lllelgvqkg
      361 tlaatlecvv lllmlwekdr agndnrdmpr ktgaplqril lryqriganv kgagmaggep
      421 apvasatetf lrflslpkss aaivdlrraa vviishldrl vqplmprcll rngggqatas
      481 stasssapqq riyalgwpsl skdqqgfsae ptlswsgeat svpllscrfq vkqvaccesq
      541 llilsqegkl htwrlakpea eplpleevah evfisiaghc egrhflaids nhnayswgtg
      601 edhrlghgdt haravptkia aleqhcvqsv ycgcsysaai tcggnlltwg rgtyarlghg
      661 nsddrclptl vaalaehmvv dvalgsgdah slaltskglv fawgdgdygk lgngncngsl
      721 qpilveslpr vqrifagsqf svalssegql ftwgkatclg hqlversvqg csvprlvssl
      781 qhkrivdvav gvahclalss sgevfgwgrn dsqqicpasv ssepllrtpi lvalptlpas
      841 giactsaqsl vwtqssqqgv plrapfvidl geptfrlldq llsmcssqdn rqtpnqesec
      901 iavaclnlir lqllaliang veprqvglas gsrllgslkt rvlglaggsq vlrtiqvaaq
      961 qalqdgwsvl lptaaeraqt ltsllpsepg qassaghrfm tdllvsslma egglesalqh
     1021 airlessscs adcgdgvhlp llqlitrllg nnaalsqtrl sptlgkqqek eeeeqrdqqq
     1081 hhqepstsps lsllhrfqrl llahihqaep eeettgaeal llqylhalip acvgtlqkah
     1141 elalqcrepg dhslshqvgh lgrvlqadis dallhellvg lvllkrdrpq clgglrwarl
     1201 flpllrvldr lnralgegel rdgddmgwpg iicrggpkgg pppadpethy vrradmenll
     1261 ldgsrciila gyvcdlsgyn cesetlrtll dsglgkdlta emsgqvhrsa mehilqhhkl
     1321 gkymaqasne ektsspgpsr lthfssecvl aqllglvanl mcsgpalqpa elqcrqldks
     1381 sllsgglqll qpsnpfdeek gearsshsch stagntpteq ppplplqqql npgrgksqlq
     1441 qradafiasl aeariteppv aawlsltery ckahnlmwhq efatehpvqe lerllsavli
     1501 rhqylgglvl saletteslp prqlgeiirl vhqakwsvvr trqqlnrsyk evcapilerl
     1561 rfllyevrpa ispqqrglrr lpilqrpprf rllvrrllqe lrssrqpakp edlvnasiqq
     1621 eqekkplakq leleeeetll rrlnerqlhg egeldavlmq divdfalqds cdvetarram
     1681 ycqmqryqlr laglqlvqql lelhglldaa qysllngflg lhlksggsvn sgsslhvlgq
     1741 lnmisayqka rlllaqarvl dwavrelrrl vnqeqqghar gkdstnlgty vllkrlprar
     1801 fllsvfglla kelgpnelgl linsgllgtv lgllaqtgge gasggqmhge lsilyedsvl
     1861 kqksskaqls gpdlaklmki gtrivrgadw kwgdqdgnpp gegriisevg edgwvrvewy
     1921 tgatnsyrmg kegqydlqla dsalnvaspt eperedvags esspssdshp skllrhcaak
     1981 llqilavgtg lhgaqldkha lrgmtsmfra iiypkptmsn ishslgwlnl gfiraisgdc
     2041 prlclelstp nwlshylsll eqpagseagv yrqlhclrll qfilamwgve eeprmpalvh
     2101 qlfatlgria lhcpgdasll ptsegkarvl ltashsgsva eelvallrrl htlptwnpvi
     2161 nsflaqklcv aaellaeqsp ldseqvfvlg vlgamgghdl rprvglhcfh egshmviasf
     2221 tpkgrcllap ggvgssglgf vkvplpalmp hldhsvfsls rlpmnemlln awtvllygpa
     2281 qelrdlpssp dgrldltllr aqqlqlavlh tngvlyrhqv alrrilkqra pgmiyaagee
     2341 qqksesqeqe pqeqqlsaaq esqlliqcil lratqaspvk acysymdlat aalnciqsla
     2401 tqahqeiseg scnlpsnphp matppqptmv hgvpvynvak keqkpldppa etkskwpaaa
     2461 tdaqlinqim emgftrrtve falkqlslqa eimptpeqiv qwilehpdvc antieedaps
     2521 hdpeadsdcd cpssesssss sassdtvega pvatppvkfe srkdfqtadl yalyvrglvr
     2581 pgmtvrccrd feeikqgdmg tvlivdtegl hdlnvqvdwr nhgstywvcf vhielveaaq
     2641 aahqprpppi avgarvklrt sslrygmlcq mrrnqgaatg vvtsvrskql tvdfpellnw
     2701 qghinevelv tplmatnlap lgaaespsdl iedwsrcirs ltvssneaaa khllngsnqp
     2761 wqscstgpcr hwirlelhdr ilvhsltlkv spedhshmps lleirvgecv dslkeytwip
     2821 vpagaskvll mqqvptyypw vevvvkqcqn ngiqckihgl kfvgrrqqpd lqhilanaqf
     2881 laseysggaa gtagslsnhn lepaeqdlpc tvmvwglndk eqlgglkgsk vkvptfsqti
     2941 srlrpihiag gskslfivsq dgkvyacgeg tngrlglgvt hnvplphqlp vlhqyvvkkv
     3001 avhsggkhal altldgkvfs wgegedgklg hgnrttldkp rlveslrakk irdvacgssh
     3061 saaissqgel ytwglgeygr lghgdnatql kpklvaalag rrviqvacgs rdaqtlalte
     3121 dgavyswgdg dfgklgrggs egsdtpheie rlsgigvvqi ecgaqfslal tragevwtwg
     3181 kgdyyrlghg gdqhvrkpqp igglrgrrvi hvavgalhcl avtdagqvya wgdndhgqqg
     3241 sgntfvnkkp alvigldavf vnrvacgssh siawglpnas ldeekrgpvp fgstrdplgg
     3301 sslgiyeaet vqavkqegkp lnlcslsesl aletpaarqa alghvlrams ilqarqliva
     3361 altshskvny kerggggvpg aeedqlggga aivggaalqe gggeapadaa daalqeqspe
     3421 aaieapglpt lpagplsafq sltgslsisg slsssalpqh khsrmsasam svmaatmtqq
     3481 eemlshhchg lddfggllge peakslvell klavcgrcgp pstaqtigdt lislgagapp
     3541 vaamlletci teledlctsr hclgklpkpv mqesshpyvd nvnvtgvvri pgaemlrlef
     3601 dsqcstekrn dplvimdgtg rvlamrsgre fahwapeirv pgdelrwkfs sdssvngwgw
     3661 rfwvhaimpa atlgesgsdr avlsqpsmal vmslldsrla prqpsvllrl asalaacsql
     3721 galttaqriw slrklhgvll leqaprpqdp alssllqpli pellrqyeye epqvrggihl
     3781 mhsdyfktla alacdmqldv glpnsssaga tgdvhkwawf kryciavrva qslirrtdlp
     3841 rafclevrkk faemlpnhnp htggqspgas mlnsatslss stasnvsppp sdqqelhcql
     3901 esastllhed hslfqaphda qllqwlnrrp ddwalswgga stiygwghnh rgqlgglegs
     3961 riktptpcea lsllrpvqla ggeqslfavt pdgklfatgy gsggrlgvgg sdswaiptll
     4021 gslqhvfvkk vavnsggkhc lalttegevy awgegedgkl ghgnrmsydr pklvehlngm
     4081 svadiacgsa hsaaitasgh vltwgkgryg rlghgdsedq lrpklveall gyraidiacg
     4141 sgdaqtlcit dddnvwswgd gdygklgrgg sdgcklpyki eslaglgvvk vecgsqfsva
     4201 ltksgavytw gkgdfhrlgh gsvdhvrrpk kvaalqgkki isiatgslhc vacsdsgevy
     4261 twgdndegql gdgtvtaiqr prlvaalqgk hivkvtcgsa htlalstsql serlrplpnp
     4321 pleydlvrdl apealharli llhhfselvc pclamlpiag dlslgalkdv lvynikeaaf
     4381 rkviqttmvr dkqhgpviel nriqvkrsrs rcnglagvdg mksvfgqmvq klplltqeal
     4441 alphrvwkvk fvgesvddcg ggysesiaem cdelqngsvp llintpngrg eaganrdcfl
     4501 ldptlssvlq mnmfrflgvl mgiavrtgsp lsinlaepvw rqltgeilrp tdltevdrdy
     4561 vagllcirnm dddpklfntl elpfstssar ghevplstry thisprnrse yvrlalgfrl
     4621 hefdeqvkav rdgmskvipv pllslfsaae lqamvcgspd iplgllksva tykgfdpssa
     4681 lvtwfwevme eftnqerslf lrfvwgrtrl prtiadfrgr dfvlqvlekn ppdhflpesy
     4741 tcffllkmpr yscklvllek lkyaihfcks idtdeyarva mgepteatgs ednsdlesva
     4801 sheg