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LOCUS XM_017141440 15536 bp mRNA linear INV 09-DEC-2024 (HERC2), mRNA. ACCESSION XM_017141440 VERSION XM_017141440.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017141440.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..15536 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..15536 /gene="HERC2" /note="E3 ubiquitin-protein ligase HERC2; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 3 Proteins" /db_xref="GeneID:108057265" CDS 380..14794 /gene="HERC2" /codon_start=1 /product="probable E3 ubiquitin-protein ligase HERC2" /protein_id="XP_016996929.2" /db_xref="GeneID:108057265" /translation="MFNRQASGGAAPAQTTATASSGGGGFGLGGGAAASPDLYLRPLP FLDAKWLRADLIASLRNSANGAVLWNHLIQDCELVSSPTPPLLNARGQLSYLGDDGKH YCGAQQLKCSCCQPDYCGPLSACNCDGCRPLDSDTAIKKLTSQAAAQQATDAVLSGWL WSLPPTQQARLECQRSMIAELQELALRAAGNCLSAQHLRQQLFVYERYFVALKRERER ERQPSNSTPAVASSSSTTTIVEPQPPAEQPSEHGALGLARVATRAALNFSFAFLRRAW RSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPM GGRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLLMLWEKDRAGNDNRDMPRKT GAPLQRILLRYQRIGANVKGAGMAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAA VVIISHLDRLVQPLMPRCLLRNGGGQATASSTASSSAPQQRIYALGWPSLSKDQQGFS AEPTLSWSGEATSVPLLSCRFQVKQVACCESQLLILSQEGKLHTWRLAKPEAEPLPLE EVAHEVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQ HCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRCLPTLVAALAEHMVVDV ALGSGDAHSLALTSKGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRIFAGSQF SVALSSEGQLFTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVGVAHCLAL SSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVALPTLPASGIACTSAQSLVWTQSS QQGVPLRAPFVIDLGEPTFRLLDQLLSMCSSQDNRQTPNQESECIAVACLNLIRLQLL ALIANGVEPRQVGLASGSRLLGSLKTRVLGLAGGSQVLRTIQVAAQQALQDGWSVLLP TAAERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCS ADCGDGVHLPLLQLITRLLGNNAALSQTRLSPTLGKQQEKEEEEQRDQQQHHQEPSTS PSLSLLHRFQRLLLAHIHQAEPEEETTGAEALLLQYLHALIPACVGTLQKAHELALQC REPGDHSLSHQVGHLGRVLQADISDALLHELLVGLVLLKRDRPQCLGGLRWARLFLPL LRVLDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPETHYVRRADMENLLLD GSRCIILAGYVCDLSGYNCESETLRTLLDSGLGKDLTAEMSGQVHRSAMEHILQHHKL GKYMAQASNEEKTSSPGPSRLTHFSSECVLAQLLGLVANLMCSGPALQPAELQCRQLD KSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTEQPPPLPLQQQLNPGRGK SQLQQRADAFIASLAEARITEPPVAAWLSLTERYCKAHNLMWHQEFATEHPVQELERL LSAVLIRHQYLGGLVLSALETTESLPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEV CAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFRLLVRRLLQELRSSRQPAKP EDLVNASIQQEQEKKPLAKQLELEEEETLLRRLNERQLHGEGELDAVLMQDIVDFALQ DSCDVETARRAMYCQMQRYQLRLAGLQLVQQLLELHGLLDAAQYSLLNGFLGLHLKSG GSVNSGSSLHVLGQLNMISAYQKARLLLAQARVLDWAVRELRRLVNQEQQGHARGKDS TNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGLLINSGLLGTVLGLLAQTGGEGA SGGQMHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPP GEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVA GSESSPSSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKHALRGMTSMFRAIIYPKP TMSNISHSLGWLNLGFIRAISGDCPRLCLELSTPNWLSHYLSLLEQPAGSEAGVYRQL HCLRLLQFILAMWGVEEEPRMPALVHQLFATLGRIALHCPGDASLLPTSEGKARVLLT ASHSGSVAEELVALLRRLHTLPTWNPVINSFLAQKLCVAAELLAEQSPLDSEQVFVLG VLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSSGLGFVKVPLPAL MPHLDHSVFSLSRLPMNEMLLNAWTVLLYGPAQELRDLPSSPDGRLDLTLLRAQQLQL AVLHTNGVLYRHQVALRRILKQRAPGMIYAAGEEQQKSESQEQEPQEQQLSAAQESQL LIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQEISEGSCNLPSNPHPMA TPPQPTMVHGVPVYNVAKKEQKPLDPPAETKSKWPAAATDAQLINQIMEMGFTRRTVE FALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDAPSHDPEADSDCDCPSSESSS SSSASSDTVEGAPVATPPVKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQ GDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQAAHQPRPPPIAVGA RVKLRTSSLRYGMLCQMRRNQGAATGVVTSVRSKQLTVDFPELLNWQGHINEVELVTP LMATNLAPLGAAESPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSTGPCR HWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGECVDSLKEYTWIPVPAGASKV LLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGLKFVGRRQQPDLQHILANAQFLASEYS GGAAGTAGSLSNHNLEPAEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLR PIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLHQYVVKKVAV HSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVESLRAKKIRDVACGSSH SAAISSQGELYTWGLGEYGRLGHGDNATQLKPKLVAALAGRRVIQVACGSRDAQTLAL TEDGAVYSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEV WTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDN DHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASLDEEKRGPVPFG STRDPLGGSSLGIYEAETVQAVKQEGKPLNLCSLSESLALETPAARQAALGHVLRAMS ILQARQLIVAALTSHSKVNYKERGGGGVPGAEEDQLGGGAAIVGGAALQEGGGEAPAD AADAALQEQSPEAAIEAPGLPTLPAGPLSAFQSLTGSLSISGSLSSSALPQHKHSRMS ASAMSVMAATMTQQEEMLSHHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTA QTIGDTLISLGAGAPPVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNV NVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRV PGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSR LAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHGVLLLEQAPRPQDPALSSLL QPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDVGLPNSSSAGATGDV HKWAWFKRYCIAVRVAQSLIRRTDLPRAFCLEVRKKFAEMLPNHNPHTGGQSPGASML NSATSLSSSTASNVSPPPSDQQELHCQLESASTLLHEDHSLFQAPHDAQLLQWLNRRP DDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFA VTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTE GEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTW GKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGD YGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGH GSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAI QRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALH ARLILLHHFSELVCPCLAMLPIAGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQH GPVIELNRIQVKRSRSRCNGLAGVDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFV GESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQ MNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEILRPTDLTEVDRDYVAGLLCIR NMDDDPKLFNTLELPFSTSSARGHEVPLSTRYTHISPRNRSEYVRLALGFRLHEFDEQ VKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTW FWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTC FFLLKMPRYSCKLVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSEDNSDLESVA SHEG" misc_feature 2123..>2932 /gene="HERC2" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Region: ATS1; COG5184" /db_xref="CDD:444065" misc_feature 4133..4351 /gene="HERC2" /note="Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173" /db_xref="CDD:459698" misc_feature 6020..6202 /gene="HERC2" /note="Mib_herc2; Region: MIB_HERC2; pfam06701" /db_xref="CDD:461991" misc_feature 7769..7903 /gene="HERC2" /note="UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins; Region: UBA_HERC2; cd14402" /db_xref="CDD:270585" misc_feature 8063..8290 /gene="HERC2" /note="Mouse development and cellular proliferation protein Cullin-7; Region: Cul7; pfam11515" /db_xref="CDD:463286" misc_feature 8477..8968 /gene="HERC2" /note="APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2); Region: APC10-HERC2; cd08664" /db_xref="CDD:176485" misc_feature order(8657..8659,8744..8746,8762..8764,8768..8770, 8945..8947) /gene="HERC2" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:176485" misc_feature 9110..10111 /gene="HERC2" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Region: ATS1; COG5184" /db_xref="CDD:444065" misc_feature 10055..10201 /gene="HERC2" /note="Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415" /db_xref="CDD:395335" misc_feature 12203..13222 /gene="HERC2" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Region: ATS1; COG5184" /db_xref="CDD:444065" misc_feature 13580..14695 /gene="HERC2" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(13598..13600,13739..13741,13772..13774,13973..13975, 14486..14488,14585..14590,14597..14611,14669..14671, 14690..14692) /gene="HERC2" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(14057..14059,14066..14071,14075..14080,14087..14089, 14099..14101,14105..14107,14117..14122,14126..14128, 14144..14146,14159..14161,14210..14212,14222..14224) /gene="HERC2" /note="E2 interaction site [active]" /db_xref="CDD:238033" ORIGIN 1 cttgatatcg attgccagag ttttattcca tttaaaaata ttcctttgaa actcgcctta 61 tatttgcaat tgacgggtga ttattaaagg aaagtgtgat tttcggaggg ctaccaagtg 121 cgggagtcgt aactgcgggc gagggaacag aatgagcagt gcggagtgcg gataacaacg 181 gataatcctg atcctggaat tggattccca acgactgcag ttgtgcgtgt gtgtgtgtgt 241 gcgagtgacg acattgaccc gcccccaacc acccacccac ctcccactgc caccccctcg 301 cacaggggaa aatgtgccat gtttctaggc tgagtgggga aaagcaggag aaggaggagg 361 aggactagaa aaacccacta tgttcaaccg ccaggcgagc ggaggagcag ctcccgccca 421 aaccacagcc actgcatctt ccggaggagg aggattcgga ttaggaggag gagcagctgc 481 atcacccgat ctctacctgc gcccgctgcc cttcctcgac gccaagtggc tgcgcgccga 541 tctcatcgcc tccctgcgca attccgccaa tggcgccgtg ctctggaatc acctcatcca 601 ggactgcgaa ctggtctcct cgcccacgcc gcccctgctg aatgcgcggg gccaactatc 661 ctacctgggc gacgacggga agcactactg cggcgcccag cagctcaagt gctcctgctg 721 ccagccggac tactgtggcc cgctctccgc ctgcaattgc gatggctgtc gtcccctgga 781 ctcggatacg gccatcaaga agctaaccag ccaggcggca gcccagcagg ccaccgatgc 841 cgtgctcagt ggctggctct ggagtctgcc gcccacgcag caggccaggc tggagtgcca 901 gcgctccatg atcgccgagc tgcaggagct ggcgctgcgg gcggctggga actgcctgtc 961 cgcccagcat cttcgccagc agctctttgt ctacgagcgg tatttcgtgg cgctgaaaag 1021 ggagagggaa agggagcgcc aacccagcaa cagcactcca gcggtggcta gcagcagcag 1081 caccaccacc attgtggagc cacagccgcc ggcggagcag ccctcggagc acggagccct 1141 tggtttggca agggtggcca cgcgggcggc tttaaacttt agctttgcct tcctgcgacg 1201 cgcctggcgt tccggcgagg atacggaaat gtgcagcgag ctgctcagcg aggcgctggc 1261 ttctttgcag gagctgcccg aggccacgct cttcgaggcg gccgtggtct cctcgctctg 1321 gctggaggtg atggagcgct ccatcaagtt cctgcgcctg gtggcgctgg gcgatcccat 1381 gggtggaaga tgcactgctc ccctgaacga taggcacacc gctttgtgcc ttctcctcga 1441 gctcggtgtg caaaagggca cgctggccgc cactctcgag tgcgtcgtcc tgctgctgat 1501 gctctgggag aaggatcgcg cgggcaacga caatagggac atgccgcgca agacgggcgc 1561 tccgctgcag cgcatcctcc tgcgctatca gaggattgga gcgaacgtca agggagcagg 1621 catggcgggc ggagaacctg cgccggtggc cagtgccacg gagaccttcc tgcgctttct 1681 ttcgctgccc aagagcagtg cggccattgt ggatctgcgt cgcgccgccg tcgtcatcat 1741 ttcgcatttg gaccgcctgg tgcagccgct gatgccgcgc tgcctgctgc gcaatggtgg 1801 tggccaggct accgcctcct ccacagcttc gtcctcagct ccacagcagc gcatctacgc 1861 actgggctgg ccctcgctgt ccaaggatca gcagggattc agcgccgaac cgacgctcag 1921 ctggagcgga gaggctacgt ccgtgccgct gctcagctgc cgctttcagg tgaagcaggt 1981 ggcctgctgc gagagccagc tgctcatcct cagtcaggag ggcaagctgc acacctggcg 2041 actggccaag ccggaggcgg agcccctgcc cctcgaggag gtcgcccacg aggtcttcat 2101 cagcatcgcc ggccactgcg aggggcgaca cttcctggcc atcgacagca accacaacgc 2161 ctactcctgg ggcactggcg aggatcaccg tttgggccac ggcgacacgc atgcccgggc 2221 ggtgcccacc aagatcgctg ccctggagca gcactgcgtg cagtccgttt actgtggctg 2281 ctcctacagt gcggccatca cgtgcggcgg caacctgctc acctggggcc gcggcaccta 2341 cgctcgtctg ggccacggga acagcgacga tcgctgtttg cccacgctgg tggcggccct 2401 ggccgagcac atggtggtgg acgtggccct gggcagtggc gatgcccatt cgctggccct 2461 cacctccaag ggattggtgt tcgcctgggg cgatggtgac tatggcaagc tgggcaatgg 2521 caattgcaat ggaagcctgc agccaattct cgtggaatct ctgccccgcg tgcagcgcat 2581 ctttgcgggc tcccagttct cggtggcgct gagcagcgag ggtcagctat tcacctgggg 2641 caaggccacc tgcctgggcc accagctggt ggagcgcagt gtccagggct gcagtgttcc 2701 gcgtctcgtc agcagtttgc agcacaaacg cattgtggac gtggccgtgg gtgtggccca 2761 ttgtctggcg ctctccagca gcggcgaagt cttcggctgg ggacgcaacg atagccagca 2821 gatctgtcca gcctccgtgt ccagcgaacc cctgttgcgt acgcccattc tggttgccct 2881 gcccacgctc cccgccagcg gaatcgcctg caccagcgcc caaagtctag tgtggaccca 2941 gagctcccag cagggtgttc cactgcgtgc cccctttgtg attgacctgg gcgagcccac 3001 cttccgcctg ctggaccaat tgctgagcat gtgcagcagc caagacaaca ggcagactcc 3061 caaccaggag agcgaatgca tcgccgtcgc ctgccttaat ctgatccgcc tgcagctgct 3121 cgcgctcatc gccaacggag tggagccgcg ccaggtgggc ctcgccagcg ggagtcgcct 3181 cctcggcagc ctcaagacgc gtgtgctcgg tttggcaggc gggagccaag tgctgcgcac 3241 aatccaagtg gccgctcaac aggctctgca ggacggttgg agtgtcctac tgcccactgc 3301 agcggagcgc gcccagaccc tcacctcgct gctgccctcg gagcccggac aggcgtcctc 3361 cgcgggccac cgcttcatga cggacctcct ggtcagctcc ctgatggccg agggcggctt 3421 ggagtcggcc ctgcaacacg ccatccgcct ggagagcagc tcctgctcgg cggactgcgg 3481 cgacggtgtg catttgcccc tgctgcagtt gatcacgcga ctgctgggca acaatgcggc 3541 tctctcgcag acgcgactct cgcccacgtt gggcaagcag caggagaagg aggaggagga 3601 gcagcgcgac cagcagcagc atcaccagga gccgagcacc agtcccagtc tcagtctgct 3661 gcatcgcttt cagcgcctgc tgctggccca catccaccag gcggagcccg aggaggagac 3721 caccggggcg gaggctctgc tgctgcaata cctgcacgcc ctgatccccg cctgcgtcgg 3781 cacgctgcag aaggcccacg aattggcgct gcagtgccgc gagccgggcg accattccct 3841 cagccaccag gtgggccacc tgggccgcgt cctacaggcg gacatctcgg atgccctgct 3901 gcacgagctg ctcgtgggcc tggtgctgct caagcgcgat cgtccccagt gtctgggcgg 3961 cctgcgttgg gcgcgcctct tcctgcccct gctgcgcgtg ttggaccgac tcaatcgggc 4021 gctcggcgag ggagagctgc gcgacggcga cgacatgggc tggcccggca tcatctgtcg 4081 cggcgggccc aagggcggtc cgccgcccgc cgatcccgag acgcactatg tgcgccgcgc 4141 ggacatggag aatcttctgc tcgacggcag tcgctgcatc atcctggccg gctacgtgtg 4201 cgatctgagt ggatacaact gcgagtcgga gacactgcgt acccttttgg actctggatt 4261 gggcaaggat ctcaccgccg agatgagcgg ccaggtgcac aggagcgcca tggagcacat 4321 cctgcagcac cacaagctgg gcaagtacat ggctcaggcg agcaacgagg agaagacatc 4381 gtctcccgga cccagtcgcc tcacccactt cagctcggag tgcgttttgg cgcagcttct 4441 cggcctggtg gccaacctga tgtgcagcgg acccgctctt cagccggcgg agcttcagtg 4501 ccgccagttg gacaagtcca gcctgctaag cggtggctta cagctcctcc agccgagcaa 4561 tcccttcgac gaggagaagg gcgaggcgcg cagcagccac agctgccaca gcacggcggg 4621 caacacgccc acggagcagc cgcctccgct gcccctgcag cagcaattaa atccggggag 4681 agggaaatcc cagttgcagc agcgagcgga tgcgtttatc gccagcctgg cggaggcacg 4741 aatcacggag ccaccggtgg ccgcttggct ttcgcttacg gagcgctact gcaaggcgca 4801 caacttgatg tggcaccagg agttcgccac cgagcatccc gtccaggagc tggagcgcct 4861 gctgagcgct gtgctcattc gtcaccagta tctcggcggc ctggtgctga gtgctctgga 4921 gacaacggaa tccctgccgc cgcggcagct gggcgagatc attcggctgg tgcatcaggc 4981 caaatggtcg gtggttcgca cgcggcagca gctgaaccgc agctacaagg aggtctgtgc 5041 ccccatcctc gagcgactgc gctttcttct ctacgaggtg cgaccggcca tcagtccgca 5101 acagcgtggt ttgcgtcgcc tgcccatttt gcagcgtccg ccgcgctttc gcctgctggt 5161 gcgtcgtctc ctgcaggaat tgcgctcctc gcggcagcct gcgaagccgg aggatctagt 5221 gaatgcctcg attcaacagg agcaggagaa gaagccgctg gccaagcagc tggagctgga 5281 ggaggaggag acgctgctgc ggcggctcaa cgagcggcag ttgcatggcg agggggagct 5341 agatgcggtg ctcatgcagg acattgtgga ctttgccctg caggacagct gcgatgtgga 5401 gacggcgaga cgagcaatgt actgccaaat gcagcgatac cagttgcgtt tggccgggct 5461 tcagcttgtc cagcagctgc tcgagttgca tggccttttg gatgcggcgc agtacagtct 5521 gctcaatggt ttcctggggc tccacttgaa atctggagga tcagttaact ccggcagctc 5581 tctccacgtt cttggccagc taaacatgat aagtgcctac cagaaggccc ggcttttgct 5641 cgcccaggca cgcgtcctcg actgggcagt gcgggagctg cgccggctgg tcaaccagga 5701 gcagcaggga catgcccgcg gcaaggatag caccaatctg ggcacctatg tgctcctcaa 5761 gcgactgcca cgtgcccgct tccttctcag cgtctttgga ctgctcgcca aggaactggg 5821 acccaacgaa ctgggcctgc tcatcaactc cggactgctg ggcactgttt tgggattgct 5881 ggcgcaaaca ggcggcgagg gagcgagcgg cggccaaatg cacggcgaac taagcatcct 5941 gtacgaggat agcgtgctca agcaaaagtc cagcaaggcg cagctcagtg gtcccgatct 6001 ggccaagctg atgaagatcg gcacgcggat tgtgcgcgga gcggactgga agtggggcga 6061 ccaggatggc aatccgcccg gcgagggacg catcatcagc gaggtgggcg aagatggctg 6121 ggtccgcgtg gaatggtaca cgggagccac caactcgtat cgcatgggca aggagggtca 6181 gtacgatctc cagctggcgg acagtgcgct caatgtggcc tcgcccacgg aaccggaacg 6241 ggaggacgtg gccggcagtg aatcctcgcc gagcagcgat tcgcatccct cgaaattgtt 6301 gcgccactgt gccgccaaac tgctgcagat cttggccgtg ggcacgggac tacacggtgc 6361 ccagctggac aagcatgcgc tgcgcgggat gaccagcatg ttccgagcca tcatctaccc 6421 caagccaacc atgtctaata tctctcattc gctgggctgg ctgaatctcg gctttattcg 6481 ggctatttcg ggtgactgcc cacgcctttg cctggagctc agcaccccca actggctgag 6541 ccactacctt tcgctgctgg agcagccggc gggcagcgag gcgggtgtct accggcagct 6601 ccactgcctg cgcctgctgc agttcatcct ggccatgtgg ggcgtcgagg aggagccgcg 6661 aatgcctgcc ctagtgcatc aactatttgc caccctcggg cgcattgcac tccattgtcc 6721 cggcgatgcc agtctgctgc ccacttcgga gggcaaggcc cgcgtcctgc tgaccgcctc 6781 gcattcgggc agcgtggcgg aggaactggt tgccctgctg cgtcgcctgc acacgctgcc 6841 cacctggaat ccggtgatta actcgtttct cgcccagaaa ctctgcgtgg ccgccgaact 6901 gctggcggag caatcgccgc tggacagcga acaggttttc gtgctcggag tccttggtgc 6961 catgggtggc catgatttgc ggccgcgtgt aggactccat tgcttccacg agggcagcca 7021 catggtgata gccagcttca cgcccaaggg acgttgtttg ctggcgccag gaggcgttgg 7081 ttcatcgggc ttgggattcg tgaaggtgcc gctccccgcg ctaatgcccc atttggatca 7141 cagcgtcttc agtttgagcc gcctgccgat gaatgagatg ctgctgaacg cctggacggt 7201 gttgctctat ggtccagccc aggaactccg ggatctgccc agtagtcccg atggtcgctt 7261 ggatttaacc ctattgcggg cgcagcaact gcagctggct gtgctgcaca cgaatggagt 7321 actatatcgc caccaggtgg ccctgcgtcg aattctcaag caaagggctc cggggatgat 7381 ttatgcagcc ggcgaggagc agcagaagtc ggaatcccag gagcaggaac cgcaggaaca 7441 acagctttcg gctgcccagg aatcgcagct actgatacag tgcatcctct tgcgagccac 7501 tcaggcatca ccagtaaaag cctgctatag ctacatggat ttggccacgg ctgccctgaa 7561 ttgcatccaa tcgctggcca cccaggcgca tcaggagatc agcgagggaa gctgcaatct 7621 accctctaat ccacatccca tggctacacc accgcaaccc acgatggttc acggcgttcc 7681 cgtttacaat gtggccaaga aggagcagaa accattggat cccccagcgg aaaccaaatc 7741 caagtggccg gcggcagcca cagatgctca gctcatcaac cagataatgg aaatgggctt 7801 cacccgtcgc accgtggagt ttgccctcaa gcagctgtcg ctgcaggcgg agattatgcc 7861 caccccagag caaatagtcc aatggatact cgagcatccg gatgtgtgtg cgaatacgat 7921 tgaagaggat gctccctcgc atgatcccga agcggattcg gattgtgatt gccccagttc 7981 cgagtccagc agctcctcct ccgcctcctc ggacaccgtg gagggtgcac cagtggccac 8041 cccacctgtg aaattcgaat ctcgcaagga tttccagacc gccgatctct atgccttata 8101 tgtacgcggt ttagtgcgtc ctgggatgac ggtgcgctgc tgccgcgact tcgaggagat 8161 caagcagggc gacatgggca ccgtgctcat cgtggacacc gagggtctgc acgatctcaa 8221 tgtgcaggtg gactggcgca atcacggcag cacctattgg gtttgcttcg tgcacattga 8281 actggtggag gcggcacagg ctgcccatca gccacgccca ccgccaattg cggtgggagc 8341 gagggtcaag ctacgcacct cctcgctgcg ctacggaatg ctctgccaga tgcgaaggaa 8401 tcagggagcg gccactggag tggtgacctc ggtgaggagc aagcagctca cggtggattt 8461 tcccgaactg cttaattggc agggtcacat caacgaggtg gaactggtta cccctttgat 8521 ggccacgaat ctcgctcctt tgggagctgc agaatcaccc agcgatctta tcgaggactg 8581 gtcccgctgc atccgctcgc tgaccgtcag ttccaacgag gcggcggcca agcatctcct 8641 aaacggaagc aatcagcctt ggcagagctg ctccacggga ccctgtcgcc attggatacg 8701 cctggagctg cacgaccgca tcctggttca tagtctcacc ctaaaagtca gtcccgagga 8761 tcactcgcac atgccgtcgc tgctggagat tcgcgtgggt gagtgtgtgg atagtttgaa 8821 ggaatacacc tggatcccag tgccagcggg cgccagtaaa gtgctcctca tgcagcaggt 8881 gcccacctac tatccctggg tggaggtggt ggtcaagcag tgccagaaca acggcatcca 8941 gtgcaagatt catggcctga agttcgtggg acgccgccag cagccggatc ttcagcatat 9001 cctggccaac gcacagtttc tggccagtga atatagtgga ggagcagctg gaacagcggg 9061 atccctaagc aatcataatt tagagcccgc tgaacaggat ctgccctgca ccgtgatggt 9121 ctggggcctc aacgacaagg agcagctggg cgggctgaag ggatccaagg tcaaagtgcc 9181 caccttctcg cagaccatca gtcgtttgcg acccatccac atagctgggg gatccaaaag 9241 cctcttcatc gtgagccagg atggcaaggt ctatgcctgc ggcgagggaa ccaatggacg 9301 tctgggcctg ggagtcaccc acaatgttcc actgcctcac cagctgccgg tgctgcatca 9361 gtatgtggtt aagaaggtgg ctgtgcactc gggaggcaag catgccctcg ccttgaccct 9421 ggatggaaag gtcttctcgt ggggcgaggg cgaggatggc aagctgggcc acggcaatcg 9481 gacgacgctg gacaagccac gcctcgtgga atccctgcga gccaagaaaa tccgcgatgt 9541 ggcctgcggc tcctcgcatt cggcggccat cagcagccag ggagagctct acacctgggg 9601 attgggtgag tacggtcgtc tgggacatgg agacaatgcc acccagttga aacccaagtt 9661 agtggctgcc ctcgcgggac gtcgcgtcat ccaggtggcc tgcggcagtc gggatgctca 9721 gactttggcc ctaactgaag atggagctgt gtactcctgg ggagatggcg actttggcaa 9781 gctgggacgc ggcggcagcg agggatcgga cactccacac gagatagaaa ggctctcggg 9841 gatcggcgtg gtgcagatcg agtgcggagc ccagtttagc ttggctttga cgcgagctgg 9901 agaggtttgg acctggggca agggcgacta ctatcgcttg ggacacggcg gagatcagca 9961 tgtgcgcaag ccgcaaccca ttggaggatt aagaggcagg agagtcatcc acgtggccgt 10021 gggagccctc cattgcctgg ctgtcacgga tgccggacag gtttacgcct ggggcgacaa 10081 cgatcacgga cagcagggca gcggaaatac gtttgtgaac aagaagcccg ccttggtcat 10141 cggactagat gcagttttcg tgaaccgcgt ggcctgcggg agctcgcatt ccatcgcctg 10201 gggtctgccg aatgcctcgc tggatgagga gaagcgcgga ccagtgccct ttggcagcac 10261 aagggatcct ctcggaggaa gcagcctggg aatctacgag gcggaaactg tccaggcggt 10321 aaaacaggag gggaagcccc tgaatctctg cagcctgagt gagagcctcg ccttggagac 10381 gcctgctgcc aggcaggctg ctttgggtca tgtcctgcgc gccatgagca tcctgcaggc 10441 gcgacagctc atcgtggctg cgttgaccag tcacagcaag gtgaactaca aggaaagagg 10501 aggaggggga gtcccaggag cagaggaaga tcaactaggc ggcggagcag ccatcgtagg 10561 aggagcagct ctccaggagg gaggcggtga agcgcccgct gatgccgcag atgctgccct 10621 ccaagagcaa agtcccgagg cggcgataga agcaccagga ttacccaccc tacccgccgg 10681 gccactgagc gccttccaga gcttgacggg atccctgtcc atttcaggat ccctttcgag 10741 cagcgccttg ccacagcaca agcactcgag gatgtcggcc agcgccatgt ccgtgatggc 10801 ggccaccatg acgcagcagg aggagatgct cagccatcac tgccatggcc tggatgactt 10861 tggcgggctg ctgggcgagc cggaggccaa gagcctggtg gagctgctta aactagcagt 10921 gtgtggaaga tgtggacctc ccagcaccgc tcagacgata ggcgatacac tgatctccct 10981 gggcgctgga gcaccgcctg tagcagccat gctgctggaa acctgcatca cggaactgga 11041 ggatctctgc acctcgagac attgcctggg caagctaccc aaaccggtga tgcaggagag 11101 cagccatccg tatgtggata atgtgaatgt cacgggagtg gttcgcatac caggagccga 11161 gatgctgcgc ctggaattcg acagccagtg cagcacggag aagcgcaacg atccgttggt 11221 catcatggat ggaactggaa gagtgctggc catgcgatct ggacgggagt ttgcccactg 11281 ggcgccggaa attcgagtgc ctggcgacga gctgcgctgg aagttctcat cggacagctc 11341 ggtgaacgga tggggctggc gcttctgggt gcacgccatc atgccggcgg cgacgctggg 11401 cgagagtggc tcggataggg cagtcttatc ccaaccctcg atggcgctgg tcatgtcgct 11461 tttggattcc cgcctggctc ctcgccaacc gagtgtttta ctccgattag cctccgcttt 11521 ggccgcctgc tcgcaactgg gagctttgac cacggctcag aggatctggt cgctgcgcaa 11581 gctgcatggt gtgctgctcc tggaacaggc acctcgtccg caggatcccg cgctctcctc 11641 gctcctccaa ccgctcatcc cggagctgct gcggcagtac gagtacgagg agccgcaggt 11701 gcgcggcggc attcacctga tgcactcgga ttacttcaaa accctggccg ccttggcctg 11761 cgacatgcag ctggatgttg ggctgcccaa ctcctcctcc gctggagcca ccggagatgt 11821 gcacaagtgg gcctggttca agaggtactg cattgccgtg cgagtggccc aatccctcat 11881 ccggagaact gatttaccaa gagccttttg cctggaggtg cgcaagaaat tcgccgaaat 11941 gctgcccaat cataatcccc atacgggtgg ccaatccccg ggagcctcca tgctcaactc 12001 ggccacctcg ctgtcctcca gcacggcgag caatgtgtcg ccgccaccga gtgaccagca 12061 ggagctgcac tgccagttgg agtccgccag cacccttctc cacgaggatc actccctgtt 12121 ccaggcgccg cacgacgccc agctgctgca gtggctcaat aggaggcccg atgattgggc 12181 tctcagctgg ggaggagcca gcaccatcta cggatggggc cacaaccatc gcggccagct 12241 gggcggactg gagggcagta ggattaaaac gcccacgccc tgcgaggcgc tcagcctgct 12301 gcgtcctgtc cagctggctg gaggagaaca gtccctgttt gcggtgacac cagatggaaa 12361 gctctttgcc acgggctacg gatccggcgg acgactgggc gtcgggggaa gcgacagctg 12421 ggcgataccc actctgctag gatcccttca gcatgttttc gtcaagaagg tggccgtgaa 12481 ttcaggcggc aagcattgtt tggccttaac caccgaggga gaggtttatg cctggggcga 12541 aggcgaagat ggcaagctcg gacatggcaa ccggatgagc tacgatcgcc cgaagctagt 12601 ggagcatctc aatggcatga gcgtggcgga tattgcctgt ggcagtgccc attcggcggc 12661 catcaccgcc agcggtcatg tgctcacctg gggcaaggga cgctacggtc gcctgggaca 12721 cggtgactcg gaggatcaac tgaggcccaa actggtggaa gccttgctag gctatcgagc 12781 catcgatata gcctgtggtt caggcgacgc ccagacgctg tgcatcacgg acgacgacaa 12841 cgtttggagc tggggcgacg gcgactacgg gaagctggga cgcggcggca gcgatggctg 12901 caagttgccc tacaagattg agagtctcgc tgggctagga gtagtcaaag tggagtgcgg 12961 ctcgcagttc tcggtggccc tgaccaaatc cggagctgtg tacacctggg gcaagggcga 13021 cttccatcgg ctgggccacg gatccgttga ccatgtgcgg cggcccaaga aggtggccgc 13081 gctgcagggc aagaagatca tctcgatagc caccggttcg ctgcactgcg tcgcctgcag 13141 tgattccggg gaggtgtaca cctggggcga caacgacgag ggacaactgg gcgatggcac 13201 cgtgacggcc atccaaagac caagactagt ggccgccctg cagggcaagc acattgtgaa 13261 ggtcacctgc ggatcggcgc atacgttggc cttgtccact tcgcagctca gcgagcgact 13321 gcgtccgctg cccaatcctc cgctggaata tgatttggta agggatctgg cgccggaggc 13381 cctgcacgcc cgcctcatcc tgctgcatca cttctccgag ttggtttgcc cctgcctggc 13441 catgctgccc attgccgggg atttgagttt gggcgctctc aaggatgtgc tggtctacaa 13501 catcaaggag gcggccttcc gcaaggtcat ccagacgaca atggtgcggg acaagcagca 13561 tggaccggtg atcgagctga atcgcatcca ggtgaagcga tcgcgcagca gatgcaatgg 13621 attggccggc gtggatggga tgaagagcgt cttcgggcag atggtgcaga agctgccgct 13681 gctcacccag gaggcacttg ctctaccgca tcgcgtgtgg aaggtcaagt ttgtgggcga 13741 gagcgtggac gattgtggcg gcgggtacag cgaatccatc gccgagatgt gcgatgagct 13801 gcagaacgga agtgtgccgc tgctgatcaa cacgcccaat ggacgcggcg aggcgggcgc 13861 caatcgcgac tgcttcctgc tggatcccac cttgtcctcg gtgctccaga tgaacatgtt 13921 ccgcttcctg ggcgtcctca tgggcatcgc cgtgcgcacc ggatcgccgc tgagcatcaa 13981 cttggcggag cccgtttggc gtcagctgac cggcgagatc ctgcggccca ccgatctcac 14041 cgaggtcgat cgtgactatg tggccggttt gctctgcatc cgcaacatgg acgacgaccc 14101 caagctgttc aacactttgg agctgccctt ctccacgtcc tcggcccgcg gccacgaggt 14161 gccgctgtcc acgcgctaca cgcacatctc gcccagaaat cgatcggagt acgtccggct 14221 ggccctcggc tttcggctgc acgagttcga cgagcaggtg aaggccgtgc gggatggtat 14281 gtccaaggtg attccagtgc ctttgctatc gctcttctcc gccgccgagc tgcaggcgat 14341 ggtctgcggc tcgccggaca ttccgctggg cctgctcaag tcggtggcca cctacaaggg 14401 cttcgatcct agctccgccc tggtcacctg gttctgggag gtgatggagg agttcacgaa 14461 tcaggagcgc tccctattcc tacgcttcgt ctggggtcgc acccgcttgc cgcgcaccat 14521 tgccgacttc cgaggccgcg actttgtgct gcaagtgctc gagaagaatc cgcctgacca 14581 cttcctgccc gagagctaca cctgcttctt tctgcttaag atgccccgct actcgtgcaa 14641 gctcgtgctt ctggagaagc tcaagtatgc cattcacttc tgcaagagca ttgacaccga 14701 cgagtatgca cgcgtggcca tgggcgaacc caccgaggcg accggcagcg aggacaacag 14761 cgacctggag tcggtggcca gccacgaggg ctgaaccgag cccactgtcc aaggagccca 14821 tcctgcctga cctgaacaac tggaggaact ggagtaaatg gaacaactga gtaaccgaac 14881 aaacgaagca agaaaactgg cgaatctccc agcagtttat gatcctcacc cactagaata 14941 acacgaagat ttcaagttaa acccactcac gcgacacgta cacatatata cacgtataaa 15001 catatatttt aaattagcac ttgaatctga gcaggacgac gaatcgagcg aaaaagagag 15061 agagggcatg tgaggcggag aaagagagag agatagaaag atagagttag aagtagatag 15121 acggcgagcg aacgaaagga ataacgatcg gtcgatcgcg taatgaaacc aaaaagcaaa 15181 gcgttaaagt tatttccata atatattata tatacatata aatttaaata taaatgttag 15241 ttgaagtcca ctcataatta tacacaaggc ttaaacgtta gacgcaatcc aatccaatcc 15301 attcccatcc atcccgagtc caaaaccctg cccaaaaaaa cagttaataa gctaattgat 15361 attgataacc ccccagaaac acaaaggggc tgaattcgtt tctaatgatg atctattcaa 15421 aagttagatg cgccctccaa gcgccgcaaa gaaagctatc tgaactaaac tgaagctaaa 15481 taaaatacta tgaaaagcaa atggcgtgac ttattaattc aaagtgaagt ccaccc