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LOCUS XP_016996240 895 aa linear INV 09-DEC-2024 ACCESSION XP_016996240 VERSION XP_016996240.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_017140751.3 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..895 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..895 /product="alpha-actinin, sarcomeric isoform X2" /calculated_mol_wt=103697 Region 31..135 /region_name="CH_ACTN_rpt1" /note="first calponin homology (CH) domain found in the alpha-actinin family; cd21214" /db_xref="CDD:409063" Site order(36,40,84,88..90,93..94,109..117,125,127..128, 131..132,134..135) /site_type="other" /note="actin binding site [polypeptide binding]" /db_xref="CDD:409063" Site order(51,53,77..79) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:409063" Region 139..252 /region_name="CH_ACTN_rpt2" /note="second calponin homology (CH) domain found in the alpha-actinin family; cd21216" /db_xref="CDD:409065" Site order(149,153,200..202,205..206,221..229,240,242..243, 246..247,249..250) /site_type="other" /note="putative actin binding site [polypeptide binding]" /db_xref="CDD:409065" Region 280..503 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Region 398..625 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 398..403 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Site 503..508 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 516..738 /region_name="SPEC" /note="Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; cd00176" /db_xref="CDD:238103" Site 624..629 /site_type="active" /note="linker region [active]" /db_xref="CDD:238103" Region 753..820 /region_name="EFh" /note="EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051" /db_xref="CDD:238008" Site order(762,764,766,773,803,805,807,814) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238008" Region 825..891 /region_name="EFhand_Ca_insen" /note="Ca2+ insensitive EF hand; pfam08726" /db_xref="CDD:430177" CDS 1..895 /gene="Actn" /coded_by="XM_017140751.3:220..2907" /db_xref="GeneID:108056774" ORIGIN 1 mmmenglsme ygdgymeqee ewereglldp awekqqkktf tawcnshlrk agtaidniee 61 dfrnglklml llevisgetl pkpdrgkmrf hkianvnkal dfiaskgvhl vsigaeeivd 121 gnlkmtlgmi wtiilrfaiq disveemtak eglllwcqrk tapyknvnvq nfhlsfkdgl 181 afcalihrhr pdlidyakls kdnplenlnt afdvaekyld iprmldpddl intpkpdera 241 imtyvscyyh afqgaqqaet aanrickvlk vnqenerlme eyerlasdll ewirrtmpwl 301 nsrqadnsla gvqkkleeyr tyrrkhkppr veqkakletn fntlqtklrl snrpaylpte 361 gktvsdisns wkglelaeka feewllaetm rlerlehlaq kfkhkadahe dwtrgkeeml 421 qsqdfrqckl nelkalkkkh eafesdlaah qdrveqiaai aqelntleyh dcvsvnarcq 481 ricdqwdrlg altqrrrtal deaerileki dilhlefakr aapfnnwldg tredlvdmfi 541 vhtmeeiqgl iqahdqfkat lgeadkefnl ivnlvreves ivkqhqipgg lenpyttlta 601 ndmtrkwsdv rqlvpqrdqt lanelrkqqn nemlrrqfae kanivgpwie rqmdavtaig 661 mglqgsledq lhrlkeyeqa vyaykpniee lekihqavqe smifenrytn ytmetlrvgw 721 eqlltsinrn inevenqilt rdskgisqeq lnefrssfnh fdknrtgrls peefksclvs 781 lgysigkdrq gdldfqrila vvdpnntgyv hfdafldfmt restdtdtae qvidsfrila 841 adkpyilpde lrrelppdqa eyciqrmppy kgpngvpgal dymsfstaly getdl