rho GTPase-activating protein Graf isoform X2 [Drosophila

LOCUS       XP_016996146            1010 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_016996146
VERSION     XP_016996146.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017140657.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016996146.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1010
                     /product="rho GTPase-activating protein Graf isoform X2"
                     /calculated_mol_wt=113795
     Region          27..233
                     /region_name="BAR_RhoGAP_OPHN1-like"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of
                     Oligophrenin1-like Rho GTPase Activating Proteins;
                     cd07602"
                     /db_xref="CDD:153286"
     Site            order(36,39..40,44,46..47,50..51,53..54,57..58,60..61,
                     64..65,67..68,71,98,101..102,194,197..198,200,205,
                     208..209,211..212,216..217,220..221,223..224,226..227,
                     229..230)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153286"
     Region          273..381
                     /region_name="BAR-PH_GRAF_family"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; cd01249"
                     /db_xref="CDD:269953"
     Region          374..575
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(422,466,470,539,542..543,566)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            422
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     Region          952..1005
                     /region_name="SH3_GRAF-like"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase and similar
                     proteins; cd11882"
                     /db_xref="CDD:212815"
     Site            order(957,959,962,966,985..986,999,1001..1002)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212815"
     CDS             1..1010
                     /gene="Graf"
                     /coded_by="XM_017140657.3:446..3478"
                     /db_xref="GeneID:108056722"
ORIGIN      
        1 mgggknirrg leplefeeci vdspdfrenl nrhekeldht shqikriike vkdlmsaakm
       61 lstrmkqlai lltdfnfeci gtaqtddenv iceslkrfga iigniedere kmltladkhi
      121 iesledfrkk qiggvkenkk kfdkktekfc qsqerflnms tkkpentiqe adaslgmher
      181 eyiqeslsyv lriqevqeri kfefveilla fisgwlvfyh taheqaedhr dylqdlrhkv
      241 qktrenfeea rekvtelktk ymekrtkpee iftkrgylfl mekkpfkatw tkyyctfkkq
      301 kreftmlqfn qmnhnftrpe arddekltlf scqrrasefe krfcfdltfk ekpgvvytfq
      361 alsekdhryw isamdgtept ylapgkikvs eayhldeagf mfirrciqvl eirgledegi
      421 yrksgvgtki skllslglnq ketddvfvdd kyrdlmesnt iasalkmylr nlneplmtyq
      481 yhsdfieaak qetlnqrvne vhklvyklpq pnfqmldmvi chltdvsrky eknkmsvfnl
      541 gvvfgptllr preesvaail dikfnnivin ilidnyerif knkpsadvkl pveaakapsi
      601 myparssppt rmprasqigk aastgamgst sstaaaaaaa gnpmflnqqk iyrvvsksnc
      661 teptmssslq nipngdnyas ggagcislsp pmhmlngils ptigsinnlh tisknettvg
      721 tttaagtrry vpndtaevat dygiiganng gvtlqshhai pvssttnfrh peylvtqsgs
      781 tnhlytnsss svagaaatsg nrislnnvsp pntamrkerf lgstgsgpqq hppvqrglhs
      841 ygqtkqqqqq hysplmptst sssndsvcds lssnngqhlg arnsndyaml tsqnsslsph
      901 lghgsacdev vtattvscgg sanesseypp skmhrnrdin qikrdlstgt arvrtlyacm
      961 gesegelsfe pnqiitnvry shepgwlqgt lngktglipe nyvehlkphh