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PREDICTED: Drosophila takahashii GTPase regulator associated with


LOCUS       XM_017140657            3969 bp    mRNA    linear   INV 09-DEC-2024
            FAK (Graf), transcript variant X4, mRNA.
ACCESSION   XM_017140657
VERSION     XM_017140657.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017140657.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3969
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..3969
                     /gene="Graf"
                     /note="GTPase regulator associated with FAK; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 Proteins"
                     /db_xref="GeneID:108056722"
     CDS             446..3478
                     /gene="Graf"
                     /codon_start=1
                     /product="rho GTPase-activating protein Graf isoform X2"
                     /protein_id="XP_016996146.2"
                     /db_xref="GeneID:108056722"
                     /translation="MGGGKNIRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQI
                     KRIIKEVKDLMSAAKMLSTRMKQLAILLTDFNFECIGTAQTDDENVICESLKRFGAII
                     GNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMS
                     TKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVF
                     YHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRG
                     YLFLMEKKPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKLTLFSCQR
                     RASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEA
                     YHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLSLGLNQKETDDVFVDD
                     KYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKL
                     PQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNN
                     IVINILIDNYERIFKNKPSADVKLPVEAAKAPSIMYPARSSPPTRMPRASQIGKAAST
                     GAMGSTSSTAAAAAAAGNPMFLNQQKIYRVVSKSNCTEPTMSSSLQNIPNGDNYASGG
                     AGCISLSPPMHMLNGILSPTIGSINNLHTISKNETTVGTTTAAGTRRYVPNDTAEVAT
                     DYGIIGANNGGVTLQSHHAIPVSSTTNFRHPEYLVTQSGSTNHLYTNSSSSVAGAAAT
                     SGNRISLNNVSPPNTAMRKERFLGSTGSGPQQHPPVQRGLHSYGQTKQQQQQHYSPLM
                     PTSTSSSNDSVCDSLSSNNGQHLGARNSNDYAMLTSQNSSLSPHLGHGSACDEVVTAT
                     TVSCGGSANESSEYPPSKMHRNRDINQIKRDLSTGTARVRTLYACMGESEGELSFEPN
                     QIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH"
     misc_feature    524..1144
                     /gene="Graf"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of
                     Oligophrenin1-like Rho GTPase Activating Proteins; Region:
                     BAR_RhoGAP_OPHN1-like; cd07602"
                     /db_xref="CDD:153286"
     misc_feature    order(551..553,560..565,575..577,581..586,593..598,
                     602..607,614..619,623..628,635..640,644..649,656..658,
                     737..739,746..751,1025..1027,1034..1039,1043..1045,
                     1058..1060,1067..1072,1076..1081,1091..1096,1103..1108,
                     1112..1117,1121..1126,1130..1135)
                     /gene="Graf"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153286"
     misc_feature    1262..1588
                     /gene="Graf"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; Region:
                     BAR-PH_GRAF_family; cd01249"
                     /db_xref="CDD:269953"
     misc_feature    1565..2170
                     /gene="Graf"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; Region:
                     RhoGAP; cl02570"
                     /db_xref="CDD:470621"
     misc_feature    order(1709..1711,1841..1843,1853..1855,2060..2062,
                     2069..2074,2141..2143)
                     /gene="Graf"
                     /note="GTPase interaction site; other site"
                     /db_xref="CDD:238090"
     misc_feature    1709..1711
                     /gene="Graf"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     misc_feature    3299..3460
                     /gene="Graf"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase and similar
                     proteins; Region: SH3_GRAF-like; cd11882"
                     /db_xref="CDD:212815"
     misc_feature    order(3314..3316,3320..3322,3329..3331,3341..3343,
                     3398..3403,3440..3442,3446..3451)
                     /gene="Graf"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212815"
     polyA_site      3969
                     /gene="Graf"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 attaattttt ttttttctaa tcgaagattt aacagccaaa gtaatatata tattgtggtg
       61 catttagaat acaattgagt gaaatgtgca attgatattg atgctgaata atatccgctg
      121 gaaatccgca aagcgcgacg cggtcgactg gcgttattcg agcagggcga cattagatat
      181 tgggaaatta ctcatacact aatgtttact ctgaatattt caatatgcat cgtccaccta
      241 ctgaaaaaca gtatttacat tgaaacgtaa atatttaaaa ggagccagag ccactcttcc
      301 tgtaaatgtt tcaaacacca cagcttcaac gcctgaatac aaatatacac catacattag
      361 ccaccgcgga agaacgcagc ctgaaataac ctaaagcagc tgggcccgaa aatcttcaat
      421 atttttgaaa ccaaaagcaa acacaatggg cggcggcaaa aatatacgcc gcggcttgga
      481 gccactggag ttcgaggaat gcatcgtcga cagtccggac tttcgcgaaa atctaaaccg
      541 acatgaaaag gagctggacc acactagtca tcaaataaaa cgaataatca aagaggtcaa
      601 ggatctaatg agtgcggcaa agatgctgtc cactagaatg aaacaattgg ccattttact
      661 taccgacttt aactttgagt gcataggcac tgctcagacc gacgacgaga atgtcatttg
      721 cgaaagccta aaacgctttg gtgctatcat tggcaatatc gaagatgagc gcgagaaaat
      781 gctaacgctc gctgacaaac atattattga gtcgctggag gattttcgaa aaaagcaaat
      841 tggcggcgtc aaagaaaaca aaaagaaatt cgataagaaa acggagaaat tctgtcagtc
      901 gcaggagcgt tttctcaata tgtcaactaa aaagcccgag aacacaatac aggaggctga
      961 tgctagcttg ggcatgcacg aacgcgagta tatccaggag tcgctgagct atgtcctgcg
     1021 gatacaggaa gtgcaggaac gaatcaaatt cgagttcgtc gagatactgc tcgcatttat
     1081 ttctggctgg ttggtgttct atcacacagc ccacgaacag gcggaagatc atcgcgacta
     1141 cctgcaggat ttgaggcaca aggtgcagaa gactcgcgaa aatttcgaag aggctcgcga
     1201 aaaggttact gagttgaaaa caaagtacat ggaaaaacgc acaaagcccg aggagatttt
     1261 cacaaagcgg ggctacctat ttttaatgga aaaaaagcca ttcaaagcga cgtggacgaa
     1321 atactattgt acattcaaga agcaaaagcg cgagttcacg atgctgcagt tcaatcaaat
     1381 gaatcacaat ttcaccaggc cggaggcacg cgatgacgag aagctgacgc tcttctcgtg
     1441 ccagcgaaga gcctcggagt tcgagaagcg cttctgcttc gatttgacct tcaaggagaa
     1501 gccgggcgtc gtctatacct ttcaggcgct aagcgaaaag gatcatcgct actggattag
     1561 cgctatggat ggcacggagc cgacttatct ggcgcctggt aaaatcaaag tcagcgaggc
     1621 ataccatctg gatgaggccg gcttcatgtt catccgccgc tgcattcaag tattagagat
     1681 ccgtggtctg gaggacgagg ggatttaccg gaagagcggt gtgggtacca aaatcagcaa
     1741 gctgctctcg ctgggcctga atcaaaagga aaccgacgac gtcttcgtgg acgacaagta
     1801 ccgggattta atggagagca acaccattgc cagtgccctg aaaatgtatc tgcgaaatct
     1861 aaatgagccc ttgatgacct atcaatacca cagtgatttt attgaggcag ccaagcaaga
     1921 aaccctgaat caacgcgtga acgaggtgca caagctggtc tacaaattgc cacagcctaa
     1981 ttttcagatg ctggacatgg ttatttgcca tttgacagac gtttcacgaa agtacgagaa
     2041 gaacaagatg tccgtattca atctgggcgt ggttttcgga cccactttgc tgcgacctcg
     2101 cgaggaatcg gtggccgcca tactggatat taaattcaac aatatcgtca ttaacattct
     2161 gattgataac tacgagcgga tcttcaagaa caagcccagc gccgatgtaa agctgcctgt
     2221 ggaggccgcc aaggcgccga gcattatgta tcccgcacgc agcagtccac ccacgcgaat
     2281 gccgcgtgcc tctcaaatag gaaaggccgc ttcgactggt gccatgggca gtacgagcag
     2341 cactgcggcg gcggcggcag cggcggggaa tccgatgttc ctcaatcagc agaagatcta
     2401 ccgcgtggtc agcaaatcca attgtacaga gcccaccatg tcgtccagcc tgcagaatat
     2461 tccgaatggc gataactatg cttcgggcgg tgccggctgc atttccctgt cgccgcccat
     2521 gcatatgctg aatggcatac tctcgccgac catcggcagc atcaacaatc tgcacacaat
     2581 atcgaagaac gagacgacgg taggaacgac aacggcggcg ggcacacggc gatacgttcc
     2641 caacgacacg gctgaggtcg cgaccgatta tggtattata ggtgccaaca atggcggcgt
     2701 gacgctgcag tcgcatcatg ccatacccgt cagcagcacg accaatttcc ggcatcccga
     2761 gtacctagtg acccagtcgg ggtcgactaa tcacctatat acgaacagta gctctagtgt
     2821 cgctggtgcc gccgctacct caggcaatcg gattagtctg aacaacgttt ccccgccaaa
     2881 tacagcgatg cgaaaggaga gatttctcgg tagcaccggc agcgggccgc agcagcatcc
     2941 gcccgtccaa cggggcctcc actcgtacgg ccaaacgaag cagcagcagc agcagcacta
     3001 ctcacccctg atgcccacgt caacgtcgag ctccaacgac agcgtatgtg attcactttc
     3061 ttccaataac ggccagcatt tgggcgcacg caactctaat gattatgcca tgctaacgtc
     3121 acagaactca tcgctgtcgc cgcatcttgg acacggatcc gcctgcgatg aggtcgtcac
     3181 ggccaccacc gtcagctgcg gcggctccgc caacgagagt tccgagtatc cgcccagcaa
     3241 aatgcatcgt aatcgtgaca ttaaccaaat aaaacgtgat ttgtcaacgg gcacagctcg
     3301 agtgcgcaca ctctatgctt gcatgggcga gagcgagggg gagctttcgt ttgagcccaa
     3361 tcaaataata accaatgttc ggtattccca cgagcccggc tggttgcagg gcacactaaa
     3421 tggaaaaaca ggactcattc cggagaacta tgtggaacac ttgaagcccc accattagat
     3481 tacgctttgg ttcggcttgg gagttcgaat gttccctcgt attttttgca ttcgtcgtta
     3541 gataaaatta aaaaaaaaac aaaaacaaaa caaaaaaatg aaatattagg aaatcgaaaa
     3601 atgatcgttg tgtaaaaaaa actaaaacta atttttgagt atgtgccctt ggggttgttt
     3661 tacatgaaat gcattttatt ttatgctgga aaccaggaaa ccacaatctt accttataac
     3721 tatgttaacc tttataatac catgaccata caatgtactt atttttaatt atttaataag
     3781 gagtataaac tcagtgcaac tgcaaagatt tatttactaa ttgttacgct cttcatttgt
     3841 tgcttattta tacataattc acgtaatttg tgcaaaaatg aattacatcg tatctaatat
     3901 ctactacata tacaattgta taaaaataaa tagcagtgct tcgaacactt ttaaaatgta
     3961 aactttaaa