raf homolog serine/threonine-protein kinase Raf [Drosophila

LOCUS       XP_016995777             744 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_016995777
VERSION     XP_016995777.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017140288.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016995777.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..744
                     /product="raf homolog serine/threonine-protein kinase Raf"
                     /calculated_mol_wt=84230
     Region          146..216
                     /region_name="RBD_RAF"
                     /note="Ras-binding domain (RBD) found in RAF family
                     serine/threonine kinases; cd01816"
                     /db_xref="CDD:340514"
     Site            order(146,148,153..158,160,173,177..179)
                     /site_type="other"
                     /note="RBD_Raf-Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:340514"
     Site            order(146,153,155..158,173,176..179)
                     /site_type="other"
                     /note="RBD_Raf-KRas interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:340514"
     Site            210
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:340514"
     Region          225..273
                     /region_name="C1_Raf"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the Raf (Rapidly Accelerated Fibrosarcoma) kinase
                     family; cd20811"
                     /db_xref="CDD:410361"
     Region          440..692
                     /region_name="STKc_Raf"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Raf (Rapidly Accelerated Fibrosarcoma) kinases; cd14062"
                     /db_xref="CDD:270964"
     Site            order(440..444,448,458,460,491,506..509,513,515,553,555,
                     557..558,560,571,574,592..595)
                     /site_type="active"
                     /db_xref="CDD:270964"
     Site            order(440..444,448,458,460,491,506..509,513,553,555,
                     557..558,560,571)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270964"
     Site            order(444,513,515,553,555,557,574,592..595)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270964"
     Site            order(452,454..455,482..488,492..494,539,542..543,
                     546..547,563,565,692)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270964"
     Site            order(570..583,589..595)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270964"
     CDS             1..744
                     /gene="Raf"
                     /coded_by="XM_017140288.3:637..2871"
                     /db_xref="GeneID:108056478"
ORIGIN      
        1 mssesstegd sdlydplaee lhnvqlvkhv trenidalna kfanlqeppa mylmeyqelt
       61 sklheleake qelierlnaq dqrqeqqqqq qqqeqeqphy qnqtqilqqq rqlarvhvhg
      121 sdltdslvss qpgsqcgtlt rqpkillrah lpnqqrtsve visgvrlcda lmkalklrql
      181 tpdmcevstt hagrhiipwh tdigtlhvee ifvrlldkfp irthikhqii rktffslvfc
      241 egcrrllftg fycsqcnfrf hqrcanrvpm lcqpfpmdsy yqlllaenpe tgvgfpgtrg
      301 tavrfnmssr srsrrcsssg ssssskppsa ssgnhrqgrp prisqddrsn sapnvcinni
      361 rsvtsevqrs limqarpplp ypctdhsnst qasptstlkh nrprarsade snknllsrda
      421 ksseenwnil aeeiligpri gsgsfgtvyr ahwhgpvavk tlnvktpspa qlqafkneva
      481 mlkktrhcni llfmgcvskp slaivtqwce gsslykhvhv setkfklntl idigrqvaqg
      541 mdylhaknii hrdlksnnif lhedlsvkig dfglataktr wsgekqanqp tgsilwmape
      601 virmqelnpy sfqsdvyafg ivmyellaec lpyghisnkd qilfmvgrgl lrpdmsqvrs
      661 dapqalkrla edcikytpkd rplfrpllnm lenmlrtlpk ihrsasepnl tqsqlqndef
      721 lylpspktpv nfnnfqffgs agni