ras GTPase-activating protein 1 [Drosophila takahashii].

LOCUS       XP_016995245             954 aa            linear   INV 09-DEC-2024
ACCESSION   XP_016995245
VERSION     XP_016995245.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017139756.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..954
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..954
                     /product="ras GTPase-activating protein 1"
                     /calculated_mol_wt=107798
     Region          64..166
                     /region_name="SH2_Nterm_RasGAP"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10353"
                     /db_xref="CDD:198216"
     Site            order(91,110,131,133)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198216"
     Site            order(132,158)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198216"
     Region          183..241
                     /region_name="SH3_RasGAP"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; cd11788"
                     /db_xref="CDD:212722"
     Region          252..326
                     /region_name="SH2_Cterm_RasGAP"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10354"
                     /db_xref="CDD:198217"
     Site            order(260,278,299,301)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198217"
     Site            order(300,326)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198217"
     Region          379..484
                     /region_name="PH_RASA1"
                     /note="RAS p21 protein activator (GTPase activating
                     protein) 1 Pleckstrin homology (PH) domain; cd13260"
                     /db_xref="CDD:270080"
     Region          499..622
                     /region_name="C2_Ras_p21A1"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); cd08400"
                     /db_xref="CDD:176045"
     Region          620..954
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Site            order(655,691,693,695..696,698,701,705,800,808..809,
                     812..813,816,837,840..841,844,848,850,855..856)
                     /site_type="other"
                     /note="RAS interface [polypeptide binding]"
                     /db_xref="CDD:213340"
     CDS             1..954
                     /gene="vap"
                     /coded_by="XM_017139756.3:301..3165"
                     /db_xref="GeneID:108056092"
ORIGIN      
        1 madlihlgni dvviqkdkpg sptgcsddgn laglggmsgl ggmmaaggid lgdlaqeldh
       61 defdgphmln gerpaiiapp esewyhgrld rysaesrlrg ssklgsylvr esdrkpgsyv
      121 lsyygrtgin hfritavcgd fyiggrqfis lsdlvgyyts csdllkrerl aipvappepv
      181 ndkkrvvail pytkmpetde lsfqkgdiff vhndmgdgwl wvtahrtgeq gmifrelvdd
      241 ldvsidpntv fpwfhpnctk neavdmlvka gpgsflvrps dnspgdyslf fhinnqiqrf
      301 riekkgvryl mggrtfecld avinryrkeq iveghslnhp vvngiqpefn qqyvvekaae
      361 kiyatlrecr dqiglkkikg ikhhghlnkk sdkttkwkql yfalindgse tqlcfydnpk
      421 ktkpkglidl scaylyqchd slwerpycfq iveralpcla tvtylcapsq esyvewinsl
      481 kaqcdsqlsr aqkkvsrlre lrclnlhvle ahrlpfklvp hpycsislnq vkvgktrvki
      541 apepvweeef vlddvppdvv sltitlisrg krgkdsevae ltidlsslkn gqetegwyql
      601 tgmtpmgewg slrlrmryld dlimpceeys plqqlllese lyavkalael chndrvplat
      661 allrvfrqek retelirmlc qaevtrenet ttlfrgasla ttlmdlymrt ecsgflqsav
      721 setvqriles kqsaelnptk mdvnddactn aefllqildl vtqsiftspd acprnvrfic
      781 sclqkavmak wpterlvrtr vvsgfiflrl lcpallnprq fglvsetppm aatrslvmva
      841 kclqnlanli efggkeqyme vvnpfilknk ermivfldql ssvndpnqpl gmfveqstnl
      901 nsqdtgrela tlhhicvshs qelhelsnil sikklvtvtd mltkhklkyr emis