Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

PREDICTED: Drosophila takahashii RAS p21 protein activator vap


LOCUS       XM_017139756            3626 bp    mRNA    linear   INV 09-DEC-2024
            (vap), transcript variant X2, mRNA.
ACCESSION   XM_017139756
VERSION     XM_017139756.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017139756.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..3626
                     /gene="vap"
                     /note="RAS p21 protein activator vap; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     Proteins"
                     /db_xref="GeneID:108056092"
     CDS             301..3165
                     /gene="vap"
                     /codon_start=1
                     /product="ras GTPase-activating protein 1"
                     /protein_id="XP_016995245.1"
                     /db_xref="GeneID:108056092"
                     /translation="MADLIHLGNIDVVIQKDKPGSPTGCSDDGNLAGLGGMSGLGGMM
                     AAGGIDLGDLAQELDHDEFDGPHMLNGERPAIIAPPESEWYHGRLDRYSAESRLRGSS
                     KLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFYIGGRQFISLSDLVGYYTS
                     CSDLLKRERLAIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDG
                     WLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGPGSFL
                     VRPSDNSPGDYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEG
                     HSLNHPVVNGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKKSD
                     KTTKWKQLYFALINDGSETQLCFYDNPKKTKPKGLIDLSCAYLYQCHDSLWERPYCFQ
                     IVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCLNLHV
                     LEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDVVSLTITL
                     ISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLIM
                     PCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQA
                     EVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTK
                     MDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR
                     TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKE
                     QYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHH
                     ICVSHSQELHELSNILSIKKLVTVTDMLTKHKLKYREMIS"
     misc_feature    490..798
                     /gene="vap"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Nterm_RasGAP; cd10353"
                     /db_xref="CDD:198216"
     misc_feature    order(571..573,628..630,691..693,697..699)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198216"
     misc_feature    order(694..696,772..774)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198216"
     misc_feature    847..1023
                     /gene="vap"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; Region: SH3_RasGAP; cd11788"
                     /db_xref="CDD:212722"
     misc_feature    1054..1278
                     /gene="vap"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Cterm_RasGAP; cd10354"
                     /db_xref="CDD:198217"
     misc_feature    order(1078..1080,1132..1134,1195..1197,1201..1203)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198217"
     misc_feature    order(1198..1200,1276..1278)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198217"
     misc_feature    1435..1752
                     /gene="vap"
                     /note="RAS p21 protein activator (GTPase activating
                     protein) 1 Pleckstrin homology (PH) domain; Region:
                     PH_RASA1; cd13260"
                     /db_xref="CDD:270080"
     misc_feature    1795..2166
                     /gene="vap"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); Region: C2_Ras_p21A1; cd08400"
                     /db_xref="CDD:176045"
     misc_feature    2158..3162
                     /gene="vap"
                     /note="Ras GTPase Activating Domain; Region: RasGAP;
                     cl02569"
                     /db_xref="CDD:470620"
     misc_feature    order(2263..2265,2371..2373,2377..2379,2383..2388,
                     2392..2394,2401..2403,2413..2415,2698..2700,2722..2727,
                     2734..2739,2746..2748,2809..2811,2818..2823,2830..2832,
                     2842..2844,2848..2850,2863..2868)
                     /gene="vap"
                     /note="RAS interface [polypeptide binding]; other site"
                     /db_xref="CDD:213340"
     polyA_site      3626
                     /gene="vap"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 aaattactaa acaaaatttg ttagacccca aaagtccttg tcagaggaac tggacaatac
       61 tagtgaattt atcccagttg gttttgcgtg gttaccgcta ccgatatggc gaagattgtg
      121 tatttatgct tagcacataa tcatcacgga aaactgagta caatcaccaa agcttccgtt
      181 tttcctaagt aaacgcaaag acatcgttgc tatatgtggc ttttatcaaa gggaatttcg
      241 ctgaaagtta aatatagatt aagattccca ttcactgagc agagatcata aaggaagatc
      301 atggcggacc taattcactt gggaaacata gatgttgtca tccagaaaga taagcccggc
      361 tcgccgacgg gctgctcgga tgatggaaac ctggcaggtc tgggcggcat gagtggattg
      421 ggcgggatga tggccgccgg tggcattgat ctgggtgact tggcgcagga attggatcac
      481 gatgaattcg atggaccaca catgctaaat ggtgaacgtc cagcgattat tgctcctccc
      541 gaaagtgaat ggtaccacgg acgacttgat cgttactcag ctgaatcacg tctgcggggc
      601 agcagtaaac tgggaagcta cttagttcgt gaaagtgacc gcaagcctgg ctcctatgtt
      661 ctaagttatt atgggcgtac cggcataaac cattttcgga tcacggctgt gtgcggagac
      721 ttctatatcg gtggacgaca attcatatcg ttgagcgatc tggttggcta ctatacctca
      781 tgcagtgacc tactgaagcg cgaacgattg gccataccag tggctccgcc ggagccagtt
      841 aatgataaga agcgagtcgt tgccatcctg ccttatacaa aaatgccaga gaccgatgag
      901 ctgagcttcc agaaaggtga tattttcttc gtgcacaatg acatgggcga cggttggctg
      961 tgggtcactg cccatcgtac tggcgagcag ggaatgattt tccgagagct tgtggatgat
     1021 ctggatgtat ccatcgatcc gaataccgtc tttccgtggt ttcatccgaa ttgcaccaaa
     1081 aacgaagctg tcgatatgtt ggttaaagct ggacccggca gcttcttggt tcgccccagc
     1141 gacaactcac cgggcgatta ctccctcttt ttccatatta acaaccagat ccaacgattt
     1201 cgcatcgaga agaagggcgt gcgatatttg atgggtgggc ggacatttga atgcctcgat
     1261 gcggtgatta atcgttaccg caaggagcaa attgtcgagg gccattcgct caatcatccg
     1321 gttgtcaatg gcatacagcc agagttcaat cagcaatatg ttgtggaaaa ggctgcggaa
     1381 aagatatatg ccacactgcg cgagtgccgt gaccaaatcg gtctgaagaa gatcaaggga
     1441 atcaaacatc atgggcattt gaacaagaaa tcggacaaaa cgacgaaatg gaagcaacta
     1501 tatttcgctc taatcaacga tggctccgag acgcaacttt gcttctacga caatccgaag
     1561 aagaccaagc cgaagggtct gatcgatttg tcatgtgctt acctctatca atgtcacgat
     1621 tccctctggg agcgtcccta ttgctttcaa attgtggaaa gggctctgcc ctgtttggcc
     1681 actgtgacat atctgtgtgc tcctagtcag gaaagctacg tggagtggat caattcgctg
     1741 aaggcccaat gcgactccca gctaagtcgg gcccagaaga aggtctcacg gctacgcgag
     1801 cttcggtgtc tcaatctgca tgtgctagaa gctcatcgct taccatttaa attagtgcca
     1861 catccatact gcagtatttc actcaatcaa gtcaaagtgg gtaaaacacg tgtcaaaatt
     1921 gcacccgaac cggtttggga ggaggaattt gtactggatg acgttccccc agatgttgtc
     1981 tccctaacca ttacgttaat atcgcgcggt aaacgcggca aagattcgga agtggccgag
     2041 ctaacgatcg atttgtctag tctgaagaat ggccaagaga ctgagggctg gtaccagctc
     2101 accggaatga cgccgatggg cgaatggggc tcgctgcgtc tgcgtatgcg ttacctcgac
     2161 gatctgataa tgccctgcga ggagtacagt ccactgcagc aattgctact cgaatcggag
     2221 ctgtatgcgg tgaaggcgct ggcggagctc tgtcacaacg atcgagtgcc attggcgacg
     2281 gctctgttgc gagtctttcg gcaggagaag cgcgagacgg agctaattcg aatgctgtgc
     2341 caggcggagg tgacacgcga aaacgagacg acgacacttt tccggggcgc ctccttggcc
     2401 accacactaa tggatttgta tatgcgaacc gaatgcagtg gattcttgca gtcggcggtc
     2461 agcgaaaccg ttcagcgcat tttggagagc aagcagtcgg cggaattaaa tccaacgaaa
     2521 atggacgtca acgatgatgc ctgcacgaat gccgagtttc tgctgcaaat cctcgatctg
     2581 gtcacccagt cgatatttac ttcaccggac gcctgtcccc ggaatgtgcg cttcatttgc
     2641 agctgcctgc agaaggctgt gatggccaag tggccgacag agcggctggt tcgcacccga
     2701 gtcgtctccg ggttcatatt cttgcgcctc ctatgcccag ccctgctgaa tcctcgacaa
     2761 tttggcctgg tcagcgagac gcctccgatg gcggccactc gttctttggt catggtcgcc
     2821 aagtgtcttc aaaatttggc caacttgatt gagtttggcg gcaaggaaca atacatggag
     2881 gttgtcaatc cgtttatttt gaaaaacaag gaacgcatga ttgtcttctt ggatcaactg
     2941 tcctccgtca acgatccgaa tcaaccgctt ggaatgtttg tcgaacaaag tacaaatctg
     3001 aattcacaag acactgggcg cgagctggct accttacatc acatctgtgt atcgcattcg
     3061 caagagcttc acgagctatc caacatactt tcaattaaga agctggtcac agtaacggac
     3121 atgttgacca agcataaact gaagtaccgc gagatgatca gctaaaataa agataataaa
     3181 cgcgatgtct tcttatctac acaagtccct tcataccttt ttataacaaa tatttatatg
     3241 tgtatactat tagaatacat gataacaata agaactcata ataactggtt gaattgtatt
     3301 ggaatagtaa acagaagaat atcatttata aaaattattt atacgaaatg aaatattata
     3361 tttaactgac aggtatatgc atttatttat tattaaaaat tacttatata atacactagc
     3421 ttacacggag tactctccgt atagccgcaa aaaactcaga aattatacat ggttttgctt
     3481 ttgatattgt gttttaaatt tacagaaaca gaaaccactt ttatccaaaa tccatacatt
     3541 tttttcgaga caaataacgc ataaaatcga aataaattaa tgaatttata aaaaaaagag
     3601 tgcaaaagac ttcctctgaa aaaata