active breakpoint cluster region-related protein isoform X2

LOCUS       XP_016994812            1407 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016994812
VERSION     XP_016994812.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017139323.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016994812.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1407
                     /product="active breakpoint cluster region-related protein
                     isoform X2"
                     /calculated_mol_wt=153724
     Region          678..860
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(681,685,782,811..812,815..816,818..819,822..823,
                     826..827,830,856,860)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          854..1040
                     /region_name="PH_BCR_arthropod"
                     /note="Breakpoint Cluster Region-related pleckstrin
                     homology (PH) domain; cd13368"
                     /db_xref="CDD:270174"
     Region          1082..>1147
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          1206..1401
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(1244,1283,1287,1359,1362..1363,1393)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            1244
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     CDS             1..1407
                     /gene="RhoGAP1A"
                     /coded_by="XM_017139323.3:372..4595"
                     /db_xref="GeneID:108055801"
ORIGIN      
        1 msvfddfqrl wmqrfpqssl sdaweqdvra slerhklril eltkeleqet lyveylerll
       61 sdvekyrasg gdptalfeaa sgsggtnngg ttngappggg ttnvdkefks slnlressts
      121 sggkdkdrls lntdnkytth tnaagsgsgg gtaagagags tsgplhsapp tgkriaelnf
      181 ereerdkdsg nekdtngalq qcitelaasi kaqpdngass tggggaggag gstdggdkek
      241 qplrkstsqy vtviqvkeak ekegddggas dpqqsqqptp pstfaryaea sapplspslt
      301 syaahveakk kmpprpppkn irrvepptip sqqqqqlsss pkretpfvgs smplpsssgg
      361 slssdspgns lernikpsdi lrqkssenld skyaanrktt pelgkfvnvn npelmeelgr
      421 kmvgktdsle qakrndssps gggslgrtas tpgrsltpgr tgvgasptgs lnktaklaaa
      481 dssstsslek ksrnclqasd aeggtgtnqr svgskeslas qgiseviksy esvsslsses
      541 akaaataaas qqsaadnepy ydsvpldngd geyvfikpgr tgssssrddl stpgsstlpl
      601 anpadpespg rtsnyvnidy flqqsnetrs ssldsdgeye gppilrtish deqttsqttp
      661 galrkvsgna rgakirsils siiqsetiyv eclnkmmqyk kaihatlnts qpvikeeeen
      721 tiffkidelh dlhtaflsdl ktivsheggd vligepfrrl admfdlysaf lhnyknaiet
      781 vkkcsannpq fkkivstivv nlqteqsltl edllhkpvar vqinalvfnd llretpmahp
      841 dhqplrqaqk iiqmflnqfn vvnqrlpses nrnlrrmvrn sfivelvdgh rklrhlflfn
      901 dviacakyka lgrdridyel kwfiplkeis iieeadpaae lkesspanis qvkrnlrsvr
      961 dqlamevans ggggvrsgdk yrrkladles qlvlatpnlv lrlankannk tmtfflssdf
     1021 ertqwidsit slkqkcnlpg antinslevt afivamqkgm ktemgsylmr ntndesllvg
     1081 dlhmavqglg gleqaadlyi cievdsyghy frkattkmvc rsqtplwnes fmlelegsqn
     1141 vrillyeake rpllrakhil klslswltet tqprtiklse tlelgcsfrf vpgelcratt
     1201 kpgalfgakm sqvlkrekrd ipfiisacir everrgmlev gcyrvsgsas dlaklkkafe
     1261 sdayeaeqll revdihsvtg ilktflrelp ealftdqlyp rffdtfsafs nnnestrine
     1321 llkvfeelpq vnkasinsil dhlirvheke tdnkmslhnl amvfgptllr pgqtqvkqkd
     1381 plaastvdvm aqagilycfl qarikkd