active breakpoint cluster region-related protein isoform X1

LOCUS       XP_016994810            1414 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016994810
VERSION     XP_016994810.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017139321.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016994810.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1414
                     /product="active breakpoint cluster region-related protein
                     isoform X1"
                     /calculated_mol_wt=154435
     Region          685..867
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(688,692,789,818..819,822..823,825..826,829..830,
                     833..834,837,863,867)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          861..1047
                     /region_name="PH_BCR_arthropod"
                     /note="Breakpoint Cluster Region-related pleckstrin
                     homology (PH) domain; cd13368"
                     /db_xref="CDD:270174"
     Region          1089..>1154
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          1213..1408
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(1251,1290,1294,1366,1369..1370,1400)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            1251
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     CDS             1..1414
                     /gene="RhoGAP1A"
                     /coded_by="XM_017139321.3:357..4601"
                     /db_xref="GeneID:108055801"
ORIGIN      
        1 msvfddfqrl wmqrfpqssl sdaweqdvra slerhklril eltkeleqet lyveylerll
       61 sdvekyrasg gdptalfeaa sgsggtnngg ttngappggg ttnvdkefks slnlressts
      121 sggkdkdrls lntdnkytth tnaagsgsgg gtaagagags tsgplhsapp tgkriaelnf
      181 ereerdkdsg nekdtngalq qcitelaasi kaqpdngass tggggaggag gstdggdkek
      241 qplrkstsqy vtviqvkeak ekegddggas dpqqsqqptp pstfaryaea sapplspslt
      301 syaahveakk kmpprpppkn irrvepptip sqqqqqlsss pkretpfvgs smplpsssgg
      361 slssdspgns lernikpsdi lrqkssenld skyaanrktt pelgkfvnvn npelmeelgr
      421 kmvgktdsle qakrndssps gggslgrtas tpgrsltpgr tgvgasptgs lnktaklaaa
      481 dssstsslek ksrnclqasd aeggtgtnqr svgskeslas qgiseviksy esvsslsses
      541 akaaataaas qqsaadnepy ydsvpldngd geyvfikpgr tgssssrddl stpgsstlpl
      601 anpadpespg rtsnyvnidy flqqsnetrs ssldsdgeye gppilrtish deqttsqttp
      661 galrknlvsa ilvsgnarga kirsilssii qsetiyvecl nkmmqykkai hatlntsqpv
      721 ikeeeentif fkidelhdlh taflsdlkti vsheggdvli gepfrrladm fdlysaflhn
      781 yknaietvkk csannpqfkk ivstivvnlq teqsltledl lhkpvarvqi nalvfndllr
      841 etpmahpdhq plrqaqkiiq mflnqfnvvn qrlpsesnrn lrrmvrnsfi velvdghrkl
      901 rhlflfndvi acakykalgr dridyelkwf iplkeisiie eadpaaelke sspanisqvk
      961 rnlrsvrdql amevansggg gvrsgdkyrr kladlesqlv latpnlvlrl ankannktmt
     1021 fflssdfert qwidsitslk qkcnlpgant inslevtafi vamqkgmkte mgsylmrntn
     1081 desllvgdlh mavqglggle qaadlyicie vdsyghyfrk attkmvcrsq tplwnesfml
     1141 elegsqnvri llyeakerpl lrakhilkls lswltettqp rtiklsetle lgcsfrfvpg
     1201 elcrattkpg alfgakmsqv lkrekrdipf iisacireve rrgmlevgcy rvsgsasdla
     1261 klkkafesda yeaeqllrev dihsvtgilk tflrelpeal ftdqlyprff dtfsafsnnn
     1321 estrinellk vfeelpqvnk asinsildhl irvheketdn kmslhnlamv fgptllrpgq
     1381 tqvkqkdpla astvdvmaqa gilycflqar ikkd