mitogen-activated protein kinase kinase kinase isoform X2

LOCUS       XP_016994713            1135 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016994713
VERSION     XP_016994713.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017139224.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016994713.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1135
                     /product="mitogen-activated protein kinase kinase kinase
                     isoform X2"
                     /calculated_mol_wt=125801
     Region          46..103
                     /region_name="SH3_MLK"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases;
                     cd11876"
                     /db_xref="CDD:212809"
     Site            order(51,53,56,60,83..84,97,99..100)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212809"
     Region          133..388
                     /region_name="STKc_MLK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mixed Lineage Kinases; cd14061"
                     /db_xref="CDD:270963"
     Site            order(134..138,142,153,155,188,203..206,210,212,250,252,
                     254..255,257,276,279,293..296)
                     /site_type="active"
                     /db_xref="CDD:270963"
     Site            order(134..138,142,153,155,188,203..206,210,250,252,
                     254..255,257,276)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270963"
     Site            order(138,210,212,250,252,254,279,293..296)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270963"
     Site            275..296
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270963"
     CDS             1..1135
                     /gene="slpr"
                     /coded_by="XM_017139224.3:693..4100"
                     /db_xref="GeneID:108055742"
ORIGIN      
        1 mlpiseeqqq qqqqrqleql hhqqipeipi sgdleqvepq vgdgslwtal ydyeaqgede
       61 ltlrrgeivv vlstdsevsg dvgwwtgkig dkvgvfpkdf vtdedplqln vssaigdiqp
      121 heieyseldi kevigsggfc kvhrgyydge evaikiahqt geddmqrmrd nvlqeaklfw
      181 alkheniaal rgvclntklc lvmeyarggs lnrilagkip pdvlvnwaiq iargmnylhn
      241 eapmsiihrd lkssnvliye aiegnqlqqk tlkitdfgla remyntqrms aagtyawmpp
      301 evisvstysk ssdvwsygvl lwelitgetp ykgfdplsva ygvavntltl pipktcpetw
      361 galmkscwqt dphkrpgfke ilkqlesiac skftltpqes fhymqecwkk eiaevlhdlr
      421 ekekelrnke eqllrvqneq rekatllkiq eqilreremv lierelvmmq pvpskrkpkk
      481 gkknkplqis lptgfrhtit avrdkaeqpg spsfsglriv altdghkgkt wgpstmhqre
      541 rsllppqlgg gqpewpaqts thssfsksap nldkkqqqqq qnqqqqvasl tpppglgalg
      601 gsgsggvggt patpllytgi pylltrpnni gsckaittit ttnntttttt ttnnnnnsis
      661 annnsnqlnn nstsnsnnns qtnptsqqng rsnsnsstsq spiakmyhra rsqeygldyp
      721 pppplylvtd dssetdtvas ptgcfhflks ghsssvsnqv sgasvhlhrf ggslgnspav
      781 grkkhsldss ghppppvnns islalpnqlt lpsednntyd hafyrdvikk msmasservn
      841 skssgdltmy nsstpltarn cddadeeeac eggrfqrnfs gsqfprhcff trqendleae
      901 aeadeaevee dsledegqvp vnqmrqnstt srkssvtfqs vsfeeptpat tarsdlytss
      961 asisfatyrs aspslsssst tasasasias sggemiqgea wtarrmvnvq phsdvikmke
     1021 dlqrqhsknq rkhrpkhitk sksveapveg qnlnqhqhph hhhhhhhskf rsllnlftrs
     1081 rkkysklaeh nlmggsdfsa idpfqtdlai ggssrslkrk gkkpqtqsce qlerc