mitogen-activated protein kinase kinase kinase isoform X1

LOCUS       XP_016994712            1211 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016994712
VERSION     XP_016994712.3
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017139223.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XP_016994712.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1211
                     /product="mitogen-activated protein kinase kinase kinase
                     isoform X1"
                     /calculated_mol_wt=134227
     Region          46..103
                     /region_name="SH3_MLK"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases;
                     cd11876"
                     /db_xref="CDD:212809"
     Site            order(51,53,56,60,83..84,97,99..100)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212809"
     Region          133..388
                     /region_name="STKc_MLK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mixed Lineage Kinases; cd14061"
                     /db_xref="CDD:270963"
     Site            order(134..138,142,153,155,188,203..206,210,212,250,252,
                     254..255,257,276,279,293..296)
                     /site_type="active"
                     /db_xref="CDD:270963"
     Site            order(134..138,142,153,155,188,203..206,210,250,252,
                     254..255,257,276)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270963"
     Site            order(138,210,212,250,252,254,279,293..296)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270963"
     Site            275..296
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270963"
     CDS             1..1211
                     /gene="slpr"
                     /coded_by="XM_017139223.3:693..4328"
                     /db_xref="GeneID:108055742"
ORIGIN      
        1 mlpiseeqqq qqqqrqleql hhqqipeipi sgdleqvepq vgdgslwtal ydyeaqgede
       61 ltlrrgeivv vlstdsevsg dvgwwtgkig dkvgvfpkdf vtdedplqln vssaigdiqp
      121 heieyseldi kevigsggfc kvhrgyydge evaikiahqt geddmqrmrd nvlqeaklfw
      181 alkheniaal rgvclntklc lvmeyarggs lnrilagkip pdvlvnwaiq iargmnylhn
      241 eapmsiihrd lkssnvliye aiegnqlqqk tlkitdfgla remyntqrms aagtyawmpp
      301 evisvstysk ssdvwsygvl lwelitgetp ykgfdplsva ygvavntltl pipktcpetw
      361 galmkscwqt dphkrpgfke ilkqlesiac skftltpqes fhymqecwkk eiaevlhdlr
      421 ekekrfqtie eelrnkeeql lrvqneqrek atllkiqeqi lreremvlie relvmmqpvp
      481 skrkpkkgkk nkplqislpt gfrhtitavr dkaeqpgsps fsglrivalt dghkgktwgp
      541 stmhqrersl lppqlgggqp ewpaqtsths sfsksapnld kkqqqqqqnq qqqvasltpp
      601 pglgalggsg sggvggtpat pllytgyqgh skmddwrpga tnmpimspsp yllsrftsnv
      661 plptlyagds arkpklsvie lllynmasll agvaagydvr msnvspvhpt llsevpalka
      721 apkavasite dqdkivelev eappkqqede qqqeirestp rkmvsqtrfs gmeapvsksq
      781 ptslarrigg sqpyytpvqr tpqhqlhhpq qhhqhhqpqa vpsavvttva asqppvsaly
      841 agtqpptpsp rrklsnssfg npnpqpeafe efrvgggigp pplyapadyl rngpsysndg
      901 gnyrngyfgs nyfpyrpeln ysyerdcksy pdysydynhr lpdyydyqye apvvpvpvpv
      961 tvpcpvsqtr tppprvpqmg vsaaghrrtp stvsnnsnvl leheellcyd ynnlnlnady
     1021 erererereq vppptkqely agspkllnrl ihsplpmtks kyataavtrp aslpfeqhal
     1081 slgyqqvgsl paplasgqsk lrsslkkyng ggggggngst ssqqgtptnp tppdsltsdd
     1141 ssylsakegs igsqhsrvrf speayldanp lptlgrrmta pamqlphqqq qqrrqrqass
     1201 gstpspsass s