serine/threonine-protein kinase tousled-like 1 isoform X4

LOCUS       XP_016993573            1285 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_016993573
VERSION     XP_016993573.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017138084.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016993573.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1285
                     /product="serine/threonine-protein kinase tousled-like 1
                     isoform X4"
                     /calculated_mol_wt=138301
     Region          <571..>707
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          957..1224
                     /region_name="STKc_TLK"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; cd13990"
                     /db_xref="CDD:270892"
     Site            order(960,973,975,1011,1028..1031,1035,1037,1076,1078,
                     1080..1081,1083,1097,1100,1123..1126)
                     /site_type="active"
                     /db_xref="CDD:270892"
     Site            order(1035,1037,1076,1078,1080,1100,1123..1126)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270892"
     Site            order(1096..1108,1113..1126)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270892"
     CDS             1..1285
                     /gene="Tlk"
                     /coded_by="XM_017138084.3:269..4126"
                     /db_xref="GeneID:108054955"
ORIGIN      
        1 mpvvkqrkms rfkmsagaql qmapqttsal shhhpnqqqq lqppqqqqaq ppppqqqqhf
       61 anhhsaqqqs qqqqeqqnpq qaqqqqaqqq qilpqphlqh lhkhphqlql hqqqqqlhqq
      121 qqhfhqqqqq slqglhqgss npdsnmstgs shsekdvndm lsgggaapgv aaaaaiqqqh
      181 pafapalgmq qppppppqhs nnggemgylt agttttasvt avgkprtpae rkrkrkmpqt
      241 sadeagsggg sggagaavvn nsslkgksla frdmpkvnms lnlgdrlggs agsgggagga
      301 gsggsgagsg sgsgggksar imlpvsdnkk indyfnkqqt gvgvgvpggg gaggntaglr
      361 gshtgggsks pssaqqqqqt tqqqqqqasg vatgggagga aanqqvqvqt ssayalyppa
      421 spqtqtpqqq qqqqpgadfh yvnsskaqqq qqqqqqrqqq qtsnqmvpph vvvglgghpl
      481 slasiqqqqq tplsqqqqqq qqqqqqqqqq lgppttstas vvsthphqlg slgvvgmvgv
      541 gvgvgvnvgv gpplpppppm ampaaiitys katqtevslh elqereaehe sgkvkldemt
      601 rlsdeqkcqi vgnqktidqh kshiakcidv vkkllkekss iekkearqkc mqnrlrlgqf
      661 vtqrvgatfq enwtdgyafq elsrrqeeit aereeidrqk kqlmkkrpae sgrkrnnnsn
      721 qnnqqqqqqq qhqqqqqqqn snsndssqlt ggvvtgpgsd rlggaaggvs vdsglggnna
      781 gaigggavgg gvggggvgsg gvggvggggg rglsrsnstq anqaqllhng gggsggnvgn
      841 sggvgdrlsd rggggglggn dsgscsdsgt flkpdpvsga ytaqeyyeyd eilklrqnal
      901 kkedadlqle meklerernl hirelkriln edqsrfnnhp vlndrylllm llgkggfsev
      961 hkafdlkeqr yvackvhqln kdwkedkkan yikhalreyn ihkaldhprv vklydvfeid
     1021 ansfctvley cdghdldfyl kqhktipere arsiimqvvs alkylneikp pvihydlkpg
     1081 nilltegnvc geikitdfgl skvmddenyn pdhgmdltsq gagtywylpp ecfvvgknpp
     1141 kisskvdvws vgvifyqcly gkkpfghnqs qatileenti lkatevqfsn kptvsneaks
     1201 firgclayrk edrmdvfala rheyiqppip khgrgslnqq qqaqqqqqqq qqqqqqqsst
     1261 sqanstgqts fsahmfgnmn qssss