pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

LOCUS       XP_016993368             399 aa            linear   INV 09-DEC-2024
            isoform X2 [Drosophila takahashii].
ACCESSION   XP_016993368
VERSION     XP_016993368.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017137879.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..399
                     /product="pyruvate dehydrogenase E1 component subunit
                     alpha, mitochondrial isoform X2"
                     /calculated_mol_wt=43757
     Region          34..382
                     /region_name="TPP_enzymes"
                     /note="Thiamine pyrophosphate (TPP) enzyme family,
                     TPP-binding module; found in many key metabolic enzymes
                     which use TPP (also known as thiamine diphosphate) as a
                     cofactor. These enzymes include, among others, the E1
                     components of the pyruvate, the acetoin and...; cl01629"
                     /db_xref="CDD:470272"
     Site            order(92,144,169..170,201,203..206,209,213,217,232..235,
                     249,299,303)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(122..123,169,171,199..202,229,231,295)
                     /site_type="other"
                     /note="TPP-binding site [chemical binding]"
                     /db_xref="CDD:238958"
     Site            order(164,166,168,173,176..177,180..181,183..184,187,
                     206..207,213..214,217)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(290..296,298..308,317..319)
                     /site_type="phosphorylation"
                     /note="phosphorylation loop region [posttranslational
                     modification]"
                     /db_xref="CDD:238958"
     CDS             1..399
                     /gene="Pdha"
                     /coded_by="XM_017137879.3:229..1428"
                     /db_xref="GeneID:108054803"
ORIGIN      
        1 mlrtlsrvse lpiivkqlqk naaqagvskt nnyateatiq vnrpfklhrl degpatevkl
       61 tkdqalkyyt qmqtirrlet aagnlykeki irgfchlysg qeacavgmka amrdvdniis
      121 ayrvhgwtyl mgvspsgvla eltgvqggca rgkggsmhmy apnfyggngi vgaqvplgag
      181 vglackykgn ggmclalygd gaanqgqvfe aynmaylwkl pvifvcennn ygmgtssera
      241 scntdyytrg dalpgiwvdg mdvlavrsat efainyvnth gplvletnty rysghsmsdp
      301 gtsyrtreei qevrqkrdpi tsfkelciel glittdevka idlkvrkevd eatafaksda
      361 elgvshlwtd vysnnlepkl rgtiaydidh iqerkgvnh