pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

LOCUS       XP_016993366             437 aa            linear   INV 09-DEC-2024
            isoform X1 [Drosophila takahashii].
ACCESSION   XP_016993366
VERSION     XP_016993366.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017137877.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016993366.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..437
                     /product="pyruvate dehydrogenase E1 component subunit
                     alpha, mitochondrial isoform X1"
                     /calculated_mol_wt=48163
     Region          72..420
                     /region_name="TPP_enzymes"
                     /note="Thiamine pyrophosphate (TPP) enzyme family,
                     TPP-binding module; found in many key metabolic enzymes
                     which use TPP (also known as thiamine diphosphate) as a
                     cofactor. These enzymes include, among others, the E1
                     components of the pyruvate, the acetoin and...; cl01629"
                     /db_xref="CDD:470272"
     Site            order(130,182,207..208,239,241..244,247,251,255,270..273,
                     287,337,341)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(160..161,207,209,237..240,267,269,333)
                     /site_type="other"
                     /note="TPP-binding site [chemical binding]"
                     /db_xref="CDD:238958"
     Site            order(202,204,206,211,214..215,218..219,221..222,225,
                     244..245,251..252,255)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:238958"
     Site            order(328..334,336..346,355..357)
                     /site_type="phosphorylation"
                     /note="phosphorylation loop region [posttranslational
                     modification]"
                     /db_xref="CDD:238958"
     CDS             1..437
                     /gene="Pdha"
                     /coded_by="XM_017137877.3:232..1545"
                     /db_xref="GeneID:108054803"
ORIGIN      
        1 mlrtlsrvse lpiivkqlqk rchnnnnnsg wriysnnnnn neiigngrys ssffglfqna
       61 aqagvsktnn yateatiqvn rpfklhrlde gpatevkltk dqalkyytqm qtirrletaa
      121 gnlykekiir gfchlysgqe acavgmkaam rdvdniisay rvhgwtylmg vspsgvlael
      181 tgvqggcarg kggsmhmyap nfyggngivg aqvplgagvg lackykgngg mclalygdga
      241 anqgqvfeay nmaylwklpv ifvcennnyg mgtsserasc ntdyytrgda lpgiwvdgmd
      301 vlavrsatef ainyvnthgp lvletntyry sghsmsdpgt syrtreeiqe vrqkrdpits
      361 fkelcielgl ittdevkaid lkvrkevdea tafaksdael gvshlwtdvy snnlepklrg
      421 tiaydidhiq erkgvnh