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tyrosine-protein kinase hopscotch [Stomoxys calcitrans].


LOCUS       XP_013112402            1186 aa            linear   INV 02-SEP-2023
ACCESSION   XP_013112402
VERSION     XP_013112402.1
DBLINK      BioProject: PRJNA1009844
DBSOURCE    REFSEQ: accession XM_013256948.2
KEYWORDS    RefSeq.
SOURCE      Stomoxys calcitrans (stable fly)
  ORGANISM  Stomoxys calcitrans
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Muscoidea; Muscidae; Stomoxys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_081555) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_963082655.1-RS_2023_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/29/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Stomoxys calcitrans"
                     /db_xref="taxon:35570"
                     /chromosome="4"
     Protein         1..1186
                     /product="tyrosine-protein kinase hopscotch"
                     /calculated_mol_wt=136490
     Region          82..285
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          412..527
                     /region_name="SH2_Jak_family"
                     /note="Src homology 2 (SH2) domain in the Janus kinase
                     (Jak) family; cd09921"
                     /db_xref="CDD:198177"
     Site            order(432,452,483,485)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198177"
     Site            order(484,526)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198177"
     Region          604..837
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          898..1158
                     /region_name="TyrKc"
                     /note="Tyrosine kinase, catalytic domain; smart00219"
                     /db_xref="CDD:197581"
     Site            order(904..908,912,929,931,975..978,981..982,1022,
                     1026..1027,1029,1039,1057..1061,1070,1109)
                     /site_type="active"
                     /db_xref="CDD:270623"
     Site            order(904..905,907..908,912,929,931,975..978,981..982,
                     1026..1027,1029,1039)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270623"
     Site            order(1022,1026,1057..1061,1070,1109)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270623"
     Site            order(1038..1045,1057..1063)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270623"
     CDS             1..1186
                     /gene="LOC106090670"
                     /coded_by="XM_013256948.2:358..3918"
                     /db_xref="GeneID:106090670"
ORIGIN      
        1 mnqcsntsgt thttitvled sgssigsasi sglsngihnl dleqsnerdh dttsnttasq
       61 nsqcytermr qinlpleaet tthriycyrk rifiefehlt ntaseeicie isrrmgilpn
      121 trllfglkvy edsnqeewcl pgqplrpgvk ycfrmrfkmp pldgqlqsmd pnayeylynq
      181 mrhdmvhdci psiryplkkd nvmglgavdm yidslehrep vdriesnykr ylprplvkah
      241 kifikrkicn sfrllrekki elarvkwnyv lqlnnlapdy lletfkgvvd fipgdistsv
      301 pvdgggslan pttanvfikl dlydtpepgl kvarrtskdk lewalvskle niyavytrgv
      361 spntlscrle itgmpngyri qfeskiqlea fisylsgymr lttkwmvnlc lqystpslee
      421 lialhchgpi ggafsfakir eqgnkcgsyi irqcekeydt yyidintksi ceglqpekfk
      481 tetfkitkev nmafknqivv ktimwklhln gtievfdkln klanflqtes erktrlspsd
      541 ndksplllic lpknvqskkt ekelseaelq rkrvqildla kdlqwyhnss rncdnskmte
      601 ikadwiqdgg fkdvtvtlkv lkfeedfkef rslastwsri qsphiiklfg ltleppftmv
      661 meyckfgpls eflrhnktkv slrqlidvvh glvrgivylr nhhiihgyir canlyvtkfd
      721 tktqileaki sdsgfprayr rddlpwipfe yhnnlraakk epdvdvwafa ttvweifsrg
      781 epiglvttem lrqnysrdgg ilpmpddcpp eiaeiimdgw ntdpektfnh mqiierlsci
      841 keshstdstt rdvsenifen leddralhng fteqsdifsf psyfnatnsv leiprgkvif
      901 kkkigeghyg tvhlgevryn dsntreyvai ktlksaratq lsndfmreie imeslshrni
      961 vkikhwiqrp fciimeyles gsflvyltsk kpnltnpill gfaldiargm dylagqniih
     1021 rdlaarnilv drdsvkisdf glaqradsdg yyvphssrei pikwyapeai kkdakfssqs
     1081 dvwsygvtlf emfsrgespn lepnvelsqe eflmrldrgd rlrkptlced hiynrlmkpc
     1141 whgnpkmrpn fgeiigiiqs irnedintip ksdfnisppt sptsmn