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PREDICTED: Drosophila takahashii Tousled-like kinase (Tlk),


LOCUS       XM_044396108            6848 bp    mRNA    linear   INV 09-DEC-2024
            transcript variant X5, mRNA.
ACCESSION   XM_044396108
VERSION     XM_044396108.2
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_044396108.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6848
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..6848
                     /gene="Tlk"
                     /note="Tousled-like kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     Proteins"
                     /db_xref="GeneID:108054955"
     CDS             627..4481
                     /gene="Tlk"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 1
                     isoform X5"
                     /protein_id="XP_044252043.1"
                     /db_xref="GeneID:108054955"
                     /translation="MCVQKNMRRLKKMSAGAQLQMAPQTTSALSHHHPNQQQQLQPPQ
                     QQQAQPPPPQQQQHFANHHSAQQQSQQQQEQQNPQQAQQQQAQQQQILPQPHLQHLHK
                     HPHQLQLHQQQQQLHQQQQHFHQQQQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDML
                     SGGGAAPGVAAAAAIQQQHPAFAPALGMQQPPPPPPQHSNNGGEMGYLTAGTTTTASV
                     TAVGKPRTPAERKRKRKMPQTSADEAGSGGGSGGAGAAVVNNSSLKGKSLAFRDMPKV
                     NMSLNLGDRLGGSAGSGGGAGGAGSGGSGAGSGSGSGGGKSARIMLPVSDNKKINDYF
                     NKQQTGVGVGVPGGGGAGGNTAGLRGSHTGGGSKSPSSAQQQQQTTQQQQQQASGVAT
                     GGGAGGAAANQQVQVQTSSAYALYPPASPQTQTPQQQQQQQPGADFHYVNSSKAQQQQ
                     QQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQQQTPLSQQQQQQQQQQQQQQQ
                     QLGPPTTSTASVVSTHPHQLGSLGVVGMVGVGVGVGVNVGVGPPLPPPPPMAMPAAII
                     TYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKCQIVGNQKTIDQHKSHIA
                     KCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELS
                     RRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQQHQQQQQQQNS
                     NSNDSSQLTGGVVTGPGSDRLGGAAGGVSVDSGLGGNNAGAIGGGAVGGGVGGGGVGS
                     GGVGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGL
                     GGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLE
                     RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVA
                     CKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYC
                     DGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNV
                     CGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVD
                     VWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGC
                     LAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQA
                     NSTGQTSFSAHMFGNMNQSSSS"
     misc_feature    <2334..>2744
                     /gene="Tlk"
                     /note="Family of unknown function (DUF5401); Region:
                     DUF5401; pfam17380"
                     /db_xref="CDD:375164"
     misc_feature    3492..4295
                     /gene="Tlk"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; Region: STKc_TLK; cd13990"
                     /db_xref="CDD:270892"
     misc_feature    order(3501..3503,3540..3542,3546..3548,3654..3656,
                     3705..3716,3726..3728,3732..3734,3849..3851,3855..3857,
                     3861..3866,3870..3872,3912..3914,3921..3923,3990..4001)
                     /gene="Tlk"
                     /note="active site"
                     /db_xref="CDD:270892"
     misc_feature    order(3726..3728,3732..3734,3849..3851,3855..3857,
                     3861..3863,3921..3923,3990..4001)
                     /gene="Tlk"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270892"
     misc_feature    order(3909..3947,3960..4001)
                     /gene="Tlk"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270892"
     polyA_site      6848
                     /gene="Tlk"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ggcggcgtgt gtagtttgct ttcgctgttg tttttaaacg aacgcgcgcg cggaagttgc
       61 gcacaaaatt atttatcaac caaaaagaca aaaacgagaa gaaactaaga ccccagcacc
      121 aagtagagta aagagaggaa ggcccgagaa gaagcaatcg gataaatttt ttagtgtact
      181 tctgcccgtt tctcgcttcg gtttcttttt ttcgttgccg tttttgcaaa aatgagcgaa
      241 tagttccact cgctcttttg ctcgctctcc ctctcgccgc tctctgtctt cttcttcctc
      301 ttggcttgct aactctctgt gtttgcacct tcttctttct ttcgctccgc tcgttaccat
      361 tttacaaaca cacacgcgca cgatgagagc gactgcaaaa aaatcggaat aaacacagtt
      421 ataatatatg tgtacaaata aacgatatat atatattttt atgtaaatat atgggagagc
      481 accaaggcaa atgtgaaaat tagtgtaaac tacgggaaaa agctgaagaa aaaacggaaa
      541 accaaatgtg ataatattgt aatagaatgt gaaaagccaa acacgcacac tcccatacac
      601 acacacacgc gcgcccgcag ccacgtatgt gtgtgcagaa aaatatgcgg cgcttaaaaa
      661 agatgtccgc cggcgcacag ttgcagatgg ccccgcagac cacttcggcc ctaagtcacc
      721 accatcccaa tcagcagcag cagctgcagc cgccgcagca acagcaggca cagcccccgc
      781 ctccgcaaca gcagcagcac tttgccaacc atcacagcgc ccagcagcag tcgcagcaac
      841 agcaggagca acagaatccc cagcaggcgc aacagcagca ggcgcagcag cagcagatcc
      901 tcccgcagcc gcatctgcag cacctgcaca agcatccgca ccagctgcaa ctgcaccagc
      961 agcagcagca gctccaccag cagcagcaac acttccacca gcagcagcaa cagtcgctgc
     1021 aggggctgca ccagggcagc agcaatccgg attcgaatat gagcactggc tcctcgcaca
     1081 gcgagaagga tgtcaacgat atgctgagtg gcggcggagc agcgcccgga gtagctgccg
     1141 cggcagccat tcaacagcaa catcccgcct ttgcgcccgc cctgggaatg cagcagccac
     1201 cgccgccgcc gccgcagcac tccaataacg ggggcgagat gggctacttg acggcgggca
     1261 cgaccacgac ggcctcggtg acggcggtgg gcaagcccag gacgccggcg gagcggaagc
     1321 ggaagaggaa aatgccgcag accagtgcgg acgaggcggg gagtggcggt gggtccggcg
     1381 gagctggagc agccgtggtg aacaacagca gcctgaaggg caaatccctg gcctttcgtg
     1441 atatgcccaa ggtgaacatg agcctgaatc tgggcgatcg tctgggcggt tcggccggca
     1501 gtggcggcgg agccggaggc gccggcagcg gagggagtgg cgccggttcc ggttccggca
     1561 gtggcggcgg caagagtgcc cgcatcatgc tgcccgtcag cgacaacaag aagatcaacg
     1621 actacttcaa caagcagcaa acgggcgtgg gcgtcggtgt gccaggtgga ggtggtgcgg
     1681 gaggcaatac cgccggtctc cgaggatccc acacgggtgg cggcagcaag tcgccctcat
     1741 ccgcccagca gcagcagcag acgacccaac agcagcagca gcaggcgagc ggagtggcga
     1801 cgggcggtgg ggcaggagga gccgccgcca accagcaggt gcaggtgcag acgagcagcg
     1861 cctacgccct gtatccacca gctagtcccc aaacgcagac gccgcagcaa cagcagcagc
     1921 agcagccggg agccgacttc cactacgtca actccagcaa ggcgcagcag cagcagcaac
     1981 agcagcagca gcgccagcag caacagactt ccaatcaaat ggttcctcca cacgtggtcg
     2041 tcggcctggg tggtcatccc ctgagcctcg cgtccatcca gcagcagcag cagacgcccc
     2101 tctcccagca gcagcagcag cagcagcaac aacagcagca gcaacagcag caactgggac
     2161 cgccgaccac atcgacggcc tctgtcgtgt ccacgcatcc gcaccagctc ggctccctgg
     2221 gagttgtggg catggtcggt gtgggcgtcg gcgttggggt aaatgtgggc gtgggaccgc
     2281 cactgcctcc gccaccgccg atggcgatgc cggcggccat tatcacatac agcaaggcca
     2341 cccaaacgga ggtctcgctg cacgagctgc aggaacgcga ggcggagcac gagtcgggca
     2401 aggtgaagct ggacgagatg acgcggctgt ccgacgagca aaagtgccag attgtcggca
     2461 accagaagac gatcgaccag cacaagtcgc acattgccaa gtgcattgat gtggtcaaga
     2521 agctgctgaa ggaaaagagc agcatcgaga agaaggaggc gcgacagaag tgcatgcaga
     2581 accgcctgag actcggccag tttgtgaccc agcgagtggg cgccacattc caggagaact
     2641 ggacggacgg ctatgcgttc caggagctga gtcggcggca ggaggagata accgccgagc
     2701 gcgaggagat cgaccggcag aagaagcagc tgatgaagaa gcgtccggcg gagtccggac
     2761 gcaagcgcaa caacaacagc aaccagaaca accagcagca gcagcagcaa cagcagcacc
     2821 aacagcagca gcagcagcag aattccaact cgaacgattc ctcgcagctg acgggcggcg
     2881 ttgtcaccgg accgggcagc gatcgcctgg gcggcgcggc aggcggcgtt agcgtcgaca
     2941 gcggattggg tggcaacaat gcgggcgcaa tcggtggcgg agctgtgggc ggtggcgttg
     3001 gaggcggcgg cgtcggaagc ggcggcgttg gcggtgtcgg cggcggcgga ggacgtggtc
     3061 tatcgcgcag caactcgacg caggccaatc aggctcaact gctgcacaat ggcggcggcg
     3121 gatcgggggg caatgtgggc aactcgggcg gcgtcggcga tcgactgtcg gatcgaggag
     3181 gaggcggcgg cctcgggggc aacgacagcg gcagctgctc ggactcgggc acgttcctca
     3241 agccggatcc cgtttcgggg gcatataccg cgcaggagta ctacgagtac gatgagatcc
     3301 tcaagctgcg ccagaatgcc ctcaagaagg aggacgccga cctgcagctg gagatggaga
     3361 agctggagcg ggagcgcaat ctgcacatcc gagagctcaa gcggatactc aacgaggatc
     3421 agtcccgctt caacaaccat cccgtgctga atgatcgcta ccttctgctg atgctgctgg
     3481 gcaagggcgg cttctcagag gtccacaagg ccttcgacct caaggagcaa cgctatgtcg
     3541 catgtaaggt gcaccaatta aacaaggatt ggaaggagga taagaaagct aattatatca
     3601 aacacgcttt gcgggaatac aacatccaca aggcgctgga tcatccgcgg gtcgtcaagc
     3661 tctacgacgt cttcgagatc gatgcgaatt ccttttgcac agtgctcgaa tactgtgatg
     3721 gccacgatct ggacttctat ttgaagcaac ataagactat acccgagcgt gaagcgcgct
     3781 cgataataat gcaggttgta tctgcactca agtatctaaa tgagattaag cctccagtta
     3841 tccactacga tctgaagccc ggcaacattc tgctcaccga gggcaatgtc tgcggcgaga
     3901 tcaagatcac cgactttggt ctgtcgaagg tgatggacga cgagaactac aatcccgatc
     3961 acggcatgga tctgacctcc cagggagccg gcacttattg gtatctgcca cccgagtgct
     4021 ttgtggtggg caaaaatccg cccaagatct cctccaaggt ggacgtgtgg agtgtgggcg
     4081 tgatctttta ccagtgtctg tacggcaaga agcccttcgg tcataaccaa tcgcaggcca
     4141 cgattctcga ggagaacacg atcctgaagg ccaccgaagt gcagttctcc aacaagccaa
     4201 ccgtttccaa tgaggcaaag agcttcattc ggggctgctt ggcatatcgc aaggaggatc
     4261 gcatggatgt gttcgcgctg gccaggcacg agtacatcca gccgccgata ccgaagcacg
     4321 gccgaggctc gctcaaccag cagcagcagg cgcagcaaca gcagcagcaa caacagcagc
     4381 agcagcagca acagtcgtcg acgtcgcagg ccaattccac cggccagact tcgttctctg
     4441 cccacatgtt tggcaatatg aatcagtcga gttcgtccta gctgccaacc aagcgtaatt
     4501 ccaactcata attcgccgcc gccgcagtag cagcagcaac ttcagctgcc agccaacagc
     4561 aacaccaaca gcagcagcag cagcaacatc agcagcagca tcttcaactc cagcaatacc
     4621 agccgaatca gcagctccat ttgcaaaaca gtagcagcaa ctatgcggcc acgcttctcg
     4681 atgcagcggc cttttgctac gaaaccgtga tggatgcagc ccacttccac aacaataaca
     4741 acaacagcac catcatcaac aacaatatgc agacaatgcc ggcgaatgct gtcaatgctg
     4801 ctgctgccgg aggaggagga gcaggaggag cagcaggagg agggggaaca ccgacctacc
     4861 aagggaaata caagcgctgg cagcagcaac agttgcaaca gcaggcgcaa ctgcaacagc
     4921 agcaacacaa gctactgctg caacaagagc tgctgtagag taagaaaaaa aatacaaggg
     4981 tgatgatgat ttacgacgga ataatgacaa gggagtttga gagaaggagg agagctgcct
     5041 gcaacactgc cgccaagcca agctaatgtt gctgctgcaa cagcaacacc gtcagcaaca
     5101 acaacaacaa cagtaacaac accccaagaa tttccgcagc gagtcgcaaa acaacaacaa
     5161 aaacttaaat taatgaaact atatataaat atatatatgc atatatatat taaatgtgat
     5221 aaacaagcgt aaagcaaaaa aaaaaataca aaacaagaaa ggaaagcagc aaatacagca
     5281 ggagaaagac gaacaaccaa gggggaaaaa cccggaagat agggaaaagc aaagctgcag
     5341 caaaaaacca gaagagaaga gcatagaaag agggagcaga agaaaagcag aaagttgaaa
     5401 gctgagatga attgccgagg agaaagcttg agaaattgtt tataaaggct gctataaaca
     5461 cacacttttt tttttttgtt aactataaat accaagcaga ataattaatc taaaataaat
     5521 aataattaaa tgctaaatgt aaattagtaa gtagggtggc atctaaaaac aagagaagaa
     5581 cgcaaagaac acgattccca agaacgcgaa aaggcacata atattttttc tttgtattaa
     5641 aaataataat ggtaccataa agaaaacgta gcaaattagc gtaggctaaa tagcacagta
     5701 taaaaactga aactaaaaaa acagtaaaag cagcagaaaa atagaaatga ttgtaaacac
     5761 gcagagcaga ggaaacattt gcaatgggaa attacaaatt gttgcattgt tttttgggtt
     5821 atgtttgttt gtagttcaaa cattaaaata acactcatac acacaacaca acacaacaca
     5881 gcacagcaca cagacactgc agactacttt tgccttacaa gaagtgaaaa aaacactaat
     5941 tttaattgcc aatttccatt ttgtatacat gcatattcaa tattgtgtac tcgcatatat
     6001 acacacatat atatatttat cattttctac ccgcgaatct ttctttttat ttttttaacg
     6061 tatgcaccaa cgaacattta attttaacgc ttttaaacga agttaaaacc aacttatacc
     6121 ctatcttaat tttgaaatgg aaaagaaatc attctttgtt tgttttgtat caaaatccaa
     6181 aagaaattta atttaaaaat aaaattaaaa aataccatca atcacacacc gcacacacat
     6241 atacatttgt atatactcgt atctgaacga caaacaaaaa accgaagcga taaaaactaa
     6301 aaacttaatc aaacgaaatg caattccaaa atatccaaga gaaaaagaat cagataacca
     6361 ttttttttat atgccacaag aaaaacgcta agaacatgag aaacggcgag aaaaatcgat
     6421 ggaaggggaa aagctagaga tcaggttctc agatcggatc agaaaatcgg cagaaaaata
     6481 aacccatttg aagtaatcta cttctaatta catagtaaac taatgtaata gtttttatta
     6541 aatatatata tatatatgta tcgatatata tatacataca tgtttttttt ttaattttaa
     6601 aactatattt gtaatgcact atgcgtaaca ttgtattaaa tattaatatc caaggcatat
     6661 taatagaaat atatatataa acataaaaaa ccagaaaaaa gaacatgaac taccaaccta
     6721 aatgtttcaa taatatatag atctatatgt atgtaaaacc gatatgaaat ctgcctaatg
     6781 ccagacaaaa aaaaacccta caagagaaag ttgaaagctc cgaagagtga aagagtgaaa
     6841 gagatgga