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LOCUS XM_017157796 1954 bp mRNA linear INV 09-DEC-2024 protein kinase kinase lic (lic), mRNA. ACCESSION XM_017157796 VERSION XM_017157796.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017157796.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1954 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..1954 /gene="lic" /note="dual specificity mitogen-activated protein kinase kinase lic; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 5 Proteins" /db_xref="GeneID:108068310" CDS 370..1374 /gene="lic" /codon_start=1 /product="dual specificity mitogen-activated protein kinase kinase 6" /protein_id="XP_017013285.1" /db_xref="GeneID:108068310" /translation="MSRRPRLSPFSISKEPEPAIVPPRNLDSRATIQIGEQTFDIDAD SLEKICDLGRGAYGIVEKMRHRQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDC PYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFRHDLRMEESVLGKIAMSVVSALH YLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERI DPQGNPAQYDIRSDVWSLGISMIEMATGRYPYDNWRTPFEQLRQVVEDDPPRLPAGTF SPEFEDFIAVSLQKEYMERPNYEQLLKHSFIVEHLQRNTDISEFVARILDLPDNQPAQ " misc_feature 499..1347 /gene="lic" /note="Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; Region: PKc_MKK3_6; cd06617" /db_xref="CDD:173729" misc_feature order(511..513,517..519,523..546,550..552,556..558, 592..597,601..609,703..705,709..714,718..720,724..726, 739..753,772..774,895..900,904..906,934..936,949..951, 958..969,1342..1347) /gene="lic" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:173729" misc_feature order(523..537,547..549,586..588,592..594,685..687, 733..744,748..753,760..762,883..885,889..900,904..906, 934..939,946..948,985..996,1000..1002,1093..1095, 1120..1122) /gene="lic" /note="active site" /db_xref="CDD:173729" misc_feature order(523..537,541..543,547..549,586..588,592..594, 685..687,733..744,748..753,757..762,889..891,895..900, 904..906,937..939) /gene="lic" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173729" misc_feature order(532..537,883..885,889..897,946..948,985..996, 1000..1002,1093..1095,1120..1122) /gene="lic" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:173729" misc_feature order(934..981,985..1002) /gene="lic" /note="activation loop (A-loop); other site" /db_xref="CDD:173729" polyA_site 1954 /gene="lic" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 tgatttacct cttacatccc tggcaaaagc gagaaaaacg aaaaagcgga aaaaggcgat 61 cggcaaacag tgcgaaaaaa aaagttgggc ggcaaaaagc gggccaccag gcagaggcaa 121 agcgaagagg cgaagaaccc agtcgaaggg gccacaaaat aggcgattcc aaatccccaa 181 ctggccggac caaatgcgat aaaaatagcc gcatccagag cttcttgcag aatccgcaga 241 acgaaacgaa gaattcttcg cagagaacgg aacgccggga gaaagtggcg tagaggagag 301 gagaggagag gaggaggatc tatgatatat gatatatata ggttatagga tatataagga 361 tagctcagaa tgtcgcgacg tccgcgcctc tcgccctttt ccatttccaa ggaaccggag 421 ccagccatag tgccgccacg caacctggac tcgcgggcca ccatccagat cggcgagcag 481 accttcgaca tcgacgccga cagcctggag aagatctgcg atctgggacg cggcgcctat 541 gggattgtgg agaagatgcg ccaccggcag accgacacgg tgctcgccgt caagcgaatc 601 ccaatgacgg tgaacatacg cgaacagcat cgcctcgtca tggatctgga catctcgatg 661 aggtccagcg actgtcctta tacggtgcat ttctatgggg ccatgtaccg cgagggcgac 721 gtctggatct gcatggaggt gatgagcacc agcctggaca agttctatcc gaaggtcttc 781 cgccacgatc tccgcatgga ggagagcgtc ctgggcaaga tcgccatgag cgtggtcagt 841 gcgctgcact atctgcacgc ccagctgaag gtcatccatc gggacgtgaa gccctcgaac 901 atactgatca accgggccgg ccaggtcaag atctgtgact ttggcatctc aggctacctg 961 gtggactcca ttgccaagac catcgatgcc ggctgcaagc cttacatggc acccgaacgc 1021 atcgatccac aaggaaatcc ggcgcagtat gacatccggt cggatgtttg gtcgctgggc 1081 atcagcatga tcgaaatggc caccggccgc tacccgtacg acaattggcg gacgcccttc 1141 gagcagctgc gccaggtggt tgaggacgat ccgccgcgtc tgccggcggg cacgttctcg 1201 ccggagttcg aggacttcat cgccgtcagc ctgcagaagg agtacatgga gcggcccaac 1261 tacgagcagc tgctcaagca cagcttcatt gtggagcacc tgcagcgcaa cacggacatc 1321 tcggagttcg tggccaggat actggatttg cccgacaacc agccggcgca gtaggcgaat 1381 ggttaatggt taacccatgg cgccccctta acccccttga gccgtgcccg tgtaaattgc 1441 cgccgtcttc ttctagcatg catttcgtac atgttgtgtg tgtctgtgtc cccgtctgcg 1501 tgccagcaaa aaacaaagga aaacaaatca aatatatata tgaaggaaaa gcaacagcaa 1561 cagcaatcta aagattcaac aaatggaaac agcataatta ttaatttaag tgagaagcaa 1621 acaagataac cgatactagc aaacctgcaa catgctaact tcgccttgca acgctcaaaa 1681 atggataacc gaaccgtgcc tccccagctg gcgatgcgat gctgctgtct taagaaaata 1741 ataataccat tttaatatat atttttaaaa aataatagct tagtcaacga gaaacaagaa 1801 cagaaccgaa cagaacagca agcaaacaat gaatgtaaaa acgtactaaa cttaaatcat 1861 aaattgtaaa ctttttgaac accaaaatag ccgaacagaa agtgtaatgg taattataat 1921 tgtttaacaa atatatatta cgtgaaatag ctaa