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LOCUS XM_017157408 11532 bp mRNA linear INV 09-DEC-2024 ACCESSION XM_017157408 VERSION XM_017157408.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017157408.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..11532 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..11532 /gene="Cubn" /note="Cubilin; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 Protein" /db_xref="GeneID:108068043" CDS 87..11399 /gene="Cubn" /codon_start=1 /product="cubilin homolog" /protein_id="XP_017012897.2" /db_xref="GeneID:108068043" /translation="MKGSARSRLLLCLAIFIITDIWPFAEGFVNSPKIISKDGNLIFE SGANRNISFRLSGNSRLTINEEFDVMELLMATGGGKKRPNGPKDEWNTGEDFVDVREL ADQMADFKRRVFGVNGLDATLRLQTNRTRGSLALMRRFQTRLRAVENKVDRMKTQLET NSCASGPCENGGTCYNTFNGFRCQCRAAFEGTKCEVDVNECALYEGTDLGCQNGGQCQ NQFGSYSCLCQPGWHGMHCSQRKADCSQSSAWELCGHGSCIPSADSAGYRCLCEPGWK SNGVTPVCGEDVDECSDSAAYRPCSTKCINLPGSFTCAPCAAGLTGNGISCRDLDECQ TNNGGCSLSPKVDCINTYGSYHCGECPLGWTGDGRKCERSAEDFDIQTGQRPRSCPAS NNPCYPTASCFLISGTATCRCPVGMVGSGYGPSGCVNGTTTNCAGNPCLNDGICLDAG PSNFTCLCPSGFKQPICEPMASPCDLHPCKNGGRCRPTVGATGDGFVCQCMPGYRGRL CDTRFSSCNGMLAAPSGRLKYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNSFDVEDS TECRFDWLQINDGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAREGFD LSWNSMQPQCGGRLEFETHGTLASPGSPGNYPKNRDCRWQLVAPTNKRIKLTFFSLQL EQHDSCNFDYVKIKDTISGRELAQYCTSGAPAPLLLATHLAEIHFHSDADGGDTGFQL HYSVEERVPGCGGVYTAKQGTISESSTANSEPGGVSCEYEIHLAVGEQIAIQFVRLQL EPQDCLEVLDVTDEGASSLQEKICGSDAARLNPPAFTSQFNRLKIKFYARSGAFQLNY RMACDLKLDSAEGTLTSPGYPNLSRSDRLCTYTIRTASNTVINLKRIDFQLNDGESLD DDPGCPTTNLRINDGLNRQILGPFCGKNQPAEIFVSQTNFLQFHLTTDADSSGRGFKF EYQSVSAGSDKCGGVHTLSGEHIRLPESSAGHYADDANCYWVIMAPANKAIRLHWLSF DLEESLDCSFDFVEIYDSLSAQQNDEKAKPLAKLCGSHLPEDLVSHSRQLVIKFVSDY SESDGGFELSYSFEERGNCGGHIHASSGELTSPDYPANYSSGLDCDWHLTGTLGHLLE IQLENFALEESSNCSADYLEIRNGGADTSPLIGRFCGGNIPARIPSFSHEMRLHLHTD SAINGRGFRLRWRVAAFGCGGNLRSNMGAISSPRYPNSYPHLSHCEWRISVHPGSAVS LLVDDMDVEGLSSCYYDSVKIYAGIKQPNQTPDKVMCGSDQKNQLIQLETSEATVAFD TDSSNAGRGFRISFKANCVRNLTATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRI RLEVSHLERHEAEQHMPSTQMPGGLYIMDGKNIESIIAPGALNASGEVLTVVHNASFV NFQLDYRIDGCLQELRGESGSFDSPNRPHMYPNDLECYWLITVQRDSIIELTIFNMDL EESVNCTKDALTVSNHKYSVADHERHCGSTDKLVITSAGHRLHVRFQSDGSHNGLGFS ATYKTVKATCGGKISARNGVIESPNYPQSYPVSSHCEWQVEVSPHHQIVFEMQNLDLE SGYDCNWDYLEGYDLAEDDTEGQQLFKVCGDEEQDTAIRKSATNLAVVRFISDDSVSR KGFRLHFHESCGQTVTIDDTDFEYVEMSRQAPRNETCLFVFQSQEPNKHIIFTPTHVK LREEAESRYPTEGDCLQMGVKIYEGTEAKGTPRLQFCRSHPPALISNGQALAISVPLL LVEEFAGHYMTMDTACGSLYNALSGRFTSPYYPASYPPNIECTWLLEASAGNSISLAL LSMDLEKSDGCNRDYLEVREETENGKLIGVYCGNEVPGVIHSSGSIWMKFKSDDDNVG EGFMASYNYEHHNELNGTDGAIESPHYPSKFQDTDPYSWRITVEKEYVVAISVDHLRD VDQPHLRFYDGYSDIGARIEMMGLEEPILSSTNVVYLTASRGPFRLTWERLSKEALRS NRTAEEQTRLCGGRQLITIDRSAIGFHSPGYPNGYDNGLKCSWTLVPSDPAVHAIFTL SHLDLEVFGGPNDCIADYVRISSGGDLQNWSELARLCTLPTAPNERIFHGKPYLRVEF TTDPSVNRTGFNGLVRTGCGSEITATQGQVNITEVLRLNPRVNQDCVWTIKVRQGRRI KIDFPDFQLQNSAANDCRNFLMLRNGNDEDSPFLGRGKYCEDVANEILNTTSNRAYVK FHYASPPRFLMTFRFEELGHACSGRIQLTSSSDEKIISTPYYPHLPHPHSECIWIVQA PPEHRIVLHFQGGFDLVEADGETRECQREYVLVNDGSTELKHEIGRYCGNRKPDSIYS TGNQLRIRYYTDVSEPHMGFNASLKLARCGGSFHGSEGVIASPPRDLLQIHHGQEEGK QLEECVYTIELEKGSTIELETEFMQIPRLANGSCSQRNHLRLEEMDAFAGSDGEEQEE KVVDDLTVCGNEKHRLLSETNKIVFRYRFMDGIPAENQGFRFTYKSLGSRCGETINAN VGVLQTPGYPMGVDHPMHCVWHVEVAKGRRVRLEILDFNMGNRNVSEGWRTPMAYGFG HFRGRLTVANDFKMQSILGRYTADPPAEVMSSDNTMGIDAFLLPTGQTRGIKLRFSAS GFSRCQQFGIQRDVTTEIVFQPVNVSIPIHCSYKIEPLVNSTIMIQVKQYNSSSVMMR NTHLCSLLSPLRINRVDQVEHLMQRILCNYQAPTPGKPLPSIRVPFPIQLVVSSNNRN SLSSLVLSYNMQSCGGVYILEPGDNMTLSQPTGMAEIQGPIDCAWAIGSYADAVNDDE VVPQDIQLEVTVRGVNLPTPPLAPGSTEEACQHHYLKVYNGPDQNSPSLGLFCNQPAA VNVVVERGLFFEYHSDSFAPNATFNVSVKYGSGCGGKLTYPYRAIDFSEQYKNNVECI WEVEAASGYHIGLTFQGRFYIEDSAGCAKDYLLVQQRNESSGNWTDLQRICGRVAPEM INTTSPYLRLIFRSDGDVVGDGFLAKFERNCGGLLYADDEERNLSSPGFPVSYEKDLQ CNWTIVPRDPLSGGVLVSFLQFDLEQAPISVCLFDNVTVVTKDKDRDPEQVIICGVKH NHEYRAKESISLIFKTDSSYSGRGFQVRYSSRLCGGVISRTGVVQSPRQHTDNNLPPG SDCYWNLTAPVGYKFIVKFELLDFEPHTNCAYDGVEIFAGSIPDERQRRGRFCGRMNE ELPVISIPQERGIIHSYSDERDPSRGFRAFVRIMQNCDEKISLNGSTRYVYSKFYNPE GYDFGLDCHVVFRVNTDQQISVQFSHFHVQQSDDCSKDYVELRDGAGPFADIIGRFCG QDQPPTLSTSRHTLFLRFVTDTRVTDSGFEVTINAVPRLCGSSEIALSSERQEVTIDS PARTPGGNYANGVACFWRIKGDTPLRMNFVSFDLHGPDANGSCVEDYLKVYNSEDAEQ VEQGFGSELVFNGQTSGHNHFDFATEHVYCGNVRPDTYYANANEVYLRFRSKGLEQRS GFQVQVGLNSKSERHYDGLQGRVHLSQTDDCDITIRAPVNHTLSLYYTELIFGTYDCQ TEYMEVFDRQNKSLQRFCSFVDVGKSLFSYSDELRLHMKTGSFLTSLDLTYLASPVEK GPGCGGQFYNTEGIFANPFYPANVRNNSECQWIVRVPSNNKVFLNFEVFNLGSKTTCH TDYLQVLEKDEAGEEVEVRRFCGEDNPKYYKSQRSQVVVRFHKTVNYDGVGWVIRFNG VYSNYQIPRYLLGG" misc_feature 144..548 /gene="Cubn" /note="N-terminal domain of cubilin and similar proteins; Region: cubilin_NTD; cd22201" /db_xref="CDD:412063" misc_feature order(180..182,186..188,192..194,198..227,231..257, 261..278,291..293,300..305,309..314,321..326,330..335, 342..347,429..434,441..443,450..455,462..464,471..476, 483..485) /gene="Cubn" /note="trimer interface [polypeptide binding]; other site" /db_xref="CDD:412063" misc_feature 180..194 /gene="Cubn" /note="tetramer interface [polypeptide binding]; other site" /db_xref="CDD:412063" misc_feature 567..671 /gene="Cubn" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 675..797 /gene="Cubn" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature order(675..677,684..686,741..743) /gene="Cubn" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 945..1067 /gene="Cubn" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(945..947,954..956,1002..1004) /gene="Cubn" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 1071..1202 /gene="Cubn" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(1071..1073,1080..1082,1134..1136) /gene="Cubn" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 1389..1490 /gene="Cubn" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature <1515..1613 /gene="Cubn" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 1632..1973 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(1656..1658,1662..1664,1668..1670,1749..1751, 1764..1766,1884..1886,1956..1958,1962..1964,1968..1973) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 1986..2318 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(2013..2015,2019..2021,2025..2027,2106..2108, 2121..2123,2229..2231,2301..2303,2307..2309,2313..2318) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 2337..2654 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(2361..2363,2367..2369,2373..2375,2454..2456, 2469..2471,2583..2585,2643..2645,2649..2651,2655..2657) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 2679..3014 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(2688..2690,2694..2696,2700..2702,2781..2783, 2796..2798,2922..2924,2997..2999,3003..3005,3009..3014) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 3036..3389 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(3063..3065,3066..3068,3072..3074,3156..3158, 3171..3173,3300..3302,3372..3374,3378..3380,3384..3389) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 3405..3740 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(3429..3431,3435..3437,3441..3443,3522..3524, 3537..3539,3651..3653,3723..3725,3729..3731,3735..3740) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 3753..4094 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(3783..3785,3789..3791,3870..3872,3885..3887, 4005..4007,4077..4079,4083..4085,4089..4094) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 4446..4751 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(4449..4451,4455..4457,4461..4463,4542..4544, 4557..4559,4668..4670,4740..4742,4746..4748) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 4770..5111 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(4794..4796,4800..4802,4806..4808,4887..4889, 4902..4904,5022..5024,5100..5102,5106..5108) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 5484..5807 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(5508..5510,5514..5516,5520..5522,5601..5603, 5616..5618,5727..5729,5796..5798,5802..5804) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 5808..6107 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(5832..5834,5838..5840,5853..5855,5934..5936, 5949..5951,6039..6041,6093..6095,6099..6101,6105..6107) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 6165..6518 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature 6537..6875 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(6564..6566,6570..6572,6576..6578,6657..6659, 6672..6674,6795..6797,6858..6860,6864..6866,6870..6875) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 6894..7247 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(6921..6923,6936..6938,6942..6944,7023..7025, 7038..7040,7167..7169,7239..7241,7245..7247) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 7263..7664 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(7287..7289,7293..7295,7299..7301,7404..7406, 7419..7421,7569..7571,7647..7649,7653..7655,7659..7664) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 7677..8045 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(7707..7709,7713..7715,7794..7796,7809..7811, 7956..7958,8028..8030,8034..8036,8040..8045) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature <8652..8825 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature 8844..9176 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(8871..8873,8877..8879,8952..8954,8970..8972, 9090..9092,9162..9164,9168..9170,9174..9176) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 9183..9533 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(9213..9215,9219..9221,9225..9227,9312..9314, 9327..9329,9447..9449,9516..9518,9522..9524,9528..9533) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 9540..9875 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature 9912..10241 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(9930..9932,9936..9938,9942..9944,10023..10025, 10038..10040,10152..10154,10224..10226,10230..10232, 10236..10241) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 10254..10673 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(10281..10283,10299..10301,10305..10307,10386..10388, 10401..10403,10593..10595,10665..10667,10671..10673) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 10746..10952 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature 11016..11348 /gene="Cubn" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(11040..11042,11046..11048,11052..11054,11133..11135, 11148..11150,11265..11267,11337..11339,11343..11345) /gene="Cubn" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" polyA_site 11532 /gene="Cubn" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 ttccatcgga acggatcttt tttttttata gtgattatta aatgttttaa tttttgttcg 61 gtgaaattgt ttggtaaagt gacaaaatga aaggatctgc gagaagcaga ctcctgttgt 121 gtttggccat ctttattatt acggatattt ggccttttgc cgagggtttt gtcaactcgc 181 caaaaattat aagcaaagat ggcaatttga tatttgagtc gggagcgaat cgcaatatta 241 gttttcggtt gagcggaaat tcgcggctta ccatcaacga ggagttcgat gtgatggagc 301 tcctgatggc caccggtggc ggcaagaagc ggccgaatgg cccgaaggat gaatggaaca 361 ccggcgagga tttcgtggat gtgcgggagc tggcagatca gatggctgat ttcaagagaa 421 gggtcttcgg ggtcaacggc ttggatgcca cgctgcgact gcagacgaac agaactcgcg 481 gatccttggc cctaatgcgt cgcttccaga cccgactgag ggcagtggag aacaaggtgg 541 atcggatgaa gacccagttg gagacgaata gctgtgccag tggaccctgc gagaacggag 601 gaacctgcta caacaccttc aacggctttc gatgccagtg ccgcgcggcc ttcgagggca 661 ccaagtgcga ggtggacgtc aacgagtgcg ccctgtacga gggcaccgac ctgggctgcc 721 agaacggagg acagtgccag aatcagttcg gatcctacag ctgcctgtgc cagccgggct 781 ggcatgggat gcactgcagc cagcgcaagg cggactgctc gcagtcgagt gcctgggagc 841 tgtgtggcca cggatcctgc attccgagtg ccgatagcgc cggttatcgg tgcctctgtg 901 agcctggctg gaagtccaat ggcgtgacgc ccgtttgtgg cgaggatgtg gacgagtgca 961 gcgattcggc ggcctacagg ccgtgctcca ccaagtgcat caatctgccg ggcagcttca 1021 cctgcgcccc ctgtgccgcc ggcctcacgg gaaacgggat cagttgccgg gatctggacg 1081 agtgccagac gaacaacggc ggctgcagcc tcagtccgaa ggtggactgc ataaatacct 1141 atggatcgta tcactgcggc gagtgtccgc tgggttggac gggcgatggc cggaagtgcg 1201 agcggagtgc cgaggatttc gatatccaga ccggccagcg gcccagaagt tgtccggcga 1261 gcaacaatcc ctgctacccg acagccagct gcttcctgat ctccggcacc gccacctgca 1321 gatgtccggt gggcatggtg ggttcgggat acggtccaag tggctgcgtc aatggaacga 1381 ccacgaattg cgctggaaat ccctgcctga acgatggcat ttgcctggac gccggaccct 1441 cgaacttcac ctgcctgtgt cccagtggct tcaagcagcc gatctgcgag ccgatggcca 1501 gtccctgcga cctgcatccc tgcaagaacg gcggacgctg ccggccgacg gtgggggcca 1561 ctggcgatgg cttcgtctgc cagtgcatgc cgggctaccg gggtcgcctg tgcgacacgc 1621 gattcagcag ctgcaacgga atgctggcgg cgcccagcgg acgtctgaaa tatccgccgg 1681 agggcactgg atacgagcac aatgcccagt gcgcctgggt cattcgcacc aacgaatcgc 1741 tggtggtcaa tgtcaccttc aatagcttcg atgtggagga ctcgacggag tgccgcttcg 1801 attggctgca gatcaacgat ggccgctcgg cggctgccca gataatcgga cgctattgtg 1861 gcaaccatct gccgcacggc gggaatatcg tctcttcagg gaatcaactg tatctttggt 1921 tccgatccga caactcgacg gccagggagg gcttcgatct cagctggaat tcaatgcagc 1981 cgcagtgcgg cggtcggctg gaatttgaga cccatggaac cctcgcctcg ccgggatcac 2041 cgggcaatta tccaaagaac cgcgactgcc gctggcaact ggtggccccg accaacaagc 2101 gcatcaagct caccttcttc tctctccagc tggagcagca cgacagctgc aatttcgatt 2161 atgtgaagat caaggacacc atttccggcc gcgaactggc ccagtactgc accagcggag 2221 ctccggcacc gctgctcctg gccacccacc tggccgagat ccacttccac tcggacgccg 2281 atggcggcga cacgggcttc cagctgcact attcggtcga ggagcgggtg cccggctgcg 2341 gtggcgtcta caccgccaag cagggcacca tttccgaatc ctccacagcc aattcggaac 2401 ccggtggagt ttcctgcgaa tacgaaatcc atttggccgt gggcgagcag atagccattc 2461 agtttgtgcg cctgcagctg gagccgcagg actgcctcga agtgctggac gtgacggacg 2521 agggcgccag tagtttgcag gagaagatct gcggttcgga cgcggcccgc ttgaatccgc 2581 ccgccttcac atcgcagttc aatcgcctca aaatcaagtt ctatgcccgc tcgggtgcct 2641 tccagctgaa ctatcggatg gcctgtgacc tcaaactgga cagtgccgag ggcacactca 2701 cctcaccggg ctatccaaac ctgtccagga gcgaccggct gtgcacctat acgattcgaa 2761 cggcctccaa tacggttatc aacttgaaga ggattgattt tcaactgaac gacggcgaga 2821 gtctagacga tgatcctggc tgtccaacca ccaatttgag gatcaacgat ggcctgaacc 2881 gccagatcct tggacccttc tgtggcaaga accagccggc ggagatcttt gtcagccaga 2941 ccaacttcct gcagttccac ctgaccacgg atgcggacag ttcgggtcgt ggcttcaagt 3001 tcgagtacca gtcggtgtcg gcgggaagcg acaagtgtgg tggagtccac actctttccg 3061 gtgagcacat ccgcctgccg gaatcctcgg cgggtcacta tgccgatgat gcgaactgct 3121 actgggtgat aatggcgccg gccaacaagg ccatccggct gcactggctg agcttcgatc 3181 tggaggaatc gttggactgc agctttgact ttgtggagat ctacgatagc ctttccgccc 3241 agcagaacga tgagaaggcc aagccgctgg ctaagctatg tggctcccat ttgcccgagg 3301 atctggtcag tcactcgcgt cagttggtca tcaaattcgt ctcggactac agcgaatcgg 3361 acggcggctt cgaattgagc tactcgttcg aggaacgcgg caattgcggt ggtcacattc 3421 atgcatccag tggtgagctc acctcaccgg attatcccgc caattattcc agcggtttgg 3481 attgcgattg gcatttgacg gggacattgg gtcatctgct cgagattcag ctggagaact 3541 ttgccctcga ggagtcgtcg aactgctcgg cggattattt ggagataagg aacggcggtg 3601 ccgacacatc gccgctgata ggaaggtttt gtggagggaa tataccggcg aggataccca 3661 gttttagcca cgagatgcga ctgcatctgc acacggattc ggcaattaat ggtcgaggct 3721 tccgcctacg ttggcgcgtc gccgcctttg gatgcggcgg gaatctgcgc tccaatatgg 3781 gagccatctc ctcgccccgc taccccaact cgtatcccca cctgtcgcac tgcgagtggc 3841 ggattagtgt gcatcccggc tccgcagtct ccctgctcgt cgatgacatg gatgtggagg 3901 gcttgagtag ctgctactac gacagcgtga agatctacgc gggcatcaag caacccaatc 3961 agacgcccga caaggtgatg tgcggatcgg atcagaagaa tcaattgatt cagctggaga 4021 cgagtgaggc gacggtggcc ttcgatacgg attcctcaaa tgctggaaga ggttttcgta 4081 tatccttcaa ggcgaattgc gttagaaatc tgacggccac cacgggaacc atcgagagtc 4141 tgaactacat ggagcccttc tgggagacga taccgatcaa ttgcagctgg accattcggg 4201 cgcccaaagg caatcgcatt cgcctggaag tctcccattt ggagcgacac gaggcggagc 4261 agcatatgcc gagtacccag atgcccggtg gtctgtatat catggatggg aaaaatatag 4321 agagcattat tgccccagga gcactgaatg ccagtggcga agtgctgacc gtcgtccaca 4381 atgccagctt tgtgaacttc cagctggact accgcatcga tggctgcctc caggagctgc 4441 gcggcgaaag tggatccttc gattcgccaa atagaccgca catgtatccc aacgacctgg 4501 agtgctactg gctcatcacc gtccagcgcg acagcatcat cgagctgacc atcttcaata 4561 tggatctcga ggagagcgtc aattgcacca aggatgcgct gacggtgtcc aaccacaagt 4621 actctgtggc ggaccacgaa cgccactgtg gatccacgga caagctggtc atcaccagtg 4681 ccgggcacag gttgcatgtg cgattccaat cggatggttc gcacaatgga ctgggattct 4741 ctgccaccta taaaactgtg aaagcaactt gcggtggcaa aatctcggcc cgcaacggag 4801 tgatcgagtc tcccaactac ccgcaatcat atcccgtcag cagtcactgc gaatggcagg 4861 tggaggtgtc gccgcaccac cagatcgtct tcgaaatgca gaaccttgat ctcgagtcgg 4921 gctacgattg caactgggac tatttggaag gctacgatct ggccgaggac gacaccgagg 4981 gtcagcagct gttcaaggtc tgcggcgatg aggagcaaga taccgccatt cgaaagtccg 5041 ccaccaattt ggcggtggtg cgattcatca gcgatgactc cgtctcgagg aagggcttcc 5101 ggctgcactt ccacgagtcg tgtggccaaa cggtgaccat cgacgatacc gacttcgaat 5161 acgtggagat gtcgcgtcag gcgccgcgga acgagacctg tctgtttgtc ttccagtcgc 5221 aggagcccaa caagcacatc atcttcacgc ccacccatgt gaagttgcgc gaggaggccg 5281 agagccgata tcccaccgag ggcgactgcc tccaaatggg cgtgaagatc tacgagggca 5341 cggaggccaa gggaacgccg cgcctccagt tctgccgctc gcatccgccg gcgttgatct 5401 ccaacggcca ggcgctggcc atcagtgtgc ccctgctgct ggtcgaggag ttcgccggcc 5461 actacatgac catggacacg gcctgcggca gcctgtacaa cgctctgtcc ggccggttca 5521 cttcgcccta ctatcccgcc tcctatccac cgaacatcga gtgcacctgg ctgctggaag 5581 cctccgcggg caattccatc agcctggcgc tgctatcgat ggacctagag aagtcggatg 5641 gctgcaatcg ggattatctg gaggtgcgcg aggagacgga gaacggtaaa ctgatcggag 5701 tctattgcgg caacgaggtg cccggggtga ttcactcgag cggttcgatc tggatgaagt 5761 tcaagagcga cgatgacaat gtgggcgagg gattcatggc ctcttataac tatgaacacc 5821 acaacgagct gaatggcact gacggcgcca tcgagtcgcc gcactatccg agcaaattcc 5881 aggacaccga tccgtacagc tggcgcataa cggtggaaaa ggagtatgtg gtggcgatat 5941 cggtggacca tttgagggat gtcgaccagc cacatttgcg tttctacgat ggctattcgg 6001 acattggagc ccgcatcgag atgatgggtc tagaagagcc gatcctttcc agcaccaatg 6061 tggtctattt gacggccagc cggggtccct tccgtttgac ctgggagcgt ctctccaagg 6121 aggctcttcg ctcgaatcgc acggccgagg agcagacgcg cctgtgcggc ggccgtcagt 6181 taatcaccat cgatcgttcg gccattggat tccattcgcc gggctatccg aatggctacg 6241 acaatgggtt gaagtgctcg tggactttgg tgccctcgga tccggctgtg catgccatct 6301 tcacgctgag tcacctggat ttggaggtct ttggcgggcc caacgattgc atagcggact 6361 atgtgaggat ttcgagtgga ggtgatctgc agaactggtc ggaattggct agattgtgca 6421 cgctgcccac tgctcctaat gagagaatct tccatgggaa accctatctt cgagtggagt 6481 tcactacgga tcctagtgtc aatagaacgg gctttaatgg gcttgtacga acgggctgtg 6541 gttccgagat tacggccacc caaggtcagg tgaacatcac cgaggttttg agactgaatc 6601 cccgcgtgaa tcaggattgt gtgtggacta taaaggtgcg tcagggtcgc aggatcaaga 6661 tcgatttccc cgactttcag ttacaaaaca gtgccgcaaa tgattgtcgc aatttcctaa 6721 tgctacgcaa tggcaacgat gaggattcac cctttttggg ccgtggaaaa tactgtgagg 6781 atgtggcgaa tgagatccta aacaccacct ccaatcgggc gtatgtcaag ttccactatg 6841 cgagtcctcc ccgcttcctg atgaccttcc gcttcgagga actaggccac gcctgctcgg 6901 gtcgcattca attgaccagc agctccgatg agaagatcat cagtacaccg tattatccac 6961 atctgccgca tccccattcc gaatgcattt ggattgtaca ggcgccgccg gaacatcgga 7021 tagtgctgca ttttcagggc ggattcgatc tggtcgaagc ggatggggag acgagggagt 7081 gccaaaggga gtacgtcctg gtcaacgatg gcagcacgga gctgaagcac gagatcggtc 7141 gctattgtgg caatcgcaaa ccggattcga tttactccac tggcaatcag ctgaggattc 7201 gctactacac agatgtctcg gagccgcaca tgggtttcaa tgccagcctg aagttggccc 7261 gttgcggtgg ctctttccat ggcagcgagg gcgtcatagc ctcaccaccg cgcgatctcc 7321 tccagattca ccatggccag gaggaaggca agcagctgga ggagtgtgtg tacaccattg 7381 agctggaaaa gggcagcacc atcgagctgg aaacggaatt tatgcagatc ccacggctgg 7441 cgaatggcag ctgctcgcag cggaatcatc tgcggctgga ggagatggat gccttcgcag 7501 gatcggatgg tgaagagcag gaggagaagg tcgtggatga tctgaccgtg tgcggcaacg 7561 agaaacatcg cctgttgagc gagaccaaca agattgtgtt ccgctatcgg tttatggatg 7621 gaattcccgc cgagaatcag ggcttccggt ttacttataa atccctgggc tcccgctgcg 7681 gtgagaccat caacgccaat gtgggagtcc tccagacgcc tggctatccc atgggtgtcg 7741 accatccgat gcactgcgtc tggcacgtgg aggtggccaa gggacggcga gttcgcctcg 7801 agatcctcga ctttaatatg ggcaatcgga atgtgagcga aggttggaga accccaatgg 7861 cctatggctt tggtcacttc cgtggacgtc tcaccgtggc caatgacttc aaaatgcagt 7921 cgatcctggg cagatacacc gccgatccgc ctgccgaggt gatgtcctcg gacaatacca 7981 tgggcatcga tgccttcctg ctgcccaccg gccagacgcg cggcattaag ctgcgattca 8041 gtgcctcggg attcagcaga tgccagcagt tcggcatcca aagggatgtc accacggaga 8101 ttgtgtttca gccggttaat gtcagcattc cgattcactg cagctacaaa attgagccgc 8161 tggttaatag caccatcatg attcaggtga agcagtacaa ctcgagctct gtgatgatgc 8221 gtaacacgca tctctgctcc ctcctctcgc cgcttaggat caaccgcgtc gaccaggtgg 8281 agcacctaat gcagcgcatc ctctgcaatt accaggcacc cacaccgggc aaacccctcc 8341 cctccatccg agtgcccttc cccatccaac tggttgtctc gtccaacaac cgcaactcgt 8401 tgtccagcct cgtcctgtcc tacaacatgc agtcctgcgg cggcgtctat atcctggagc 8461 cgggcgacaa tatgacgctg agccagccaa cgggaatggc ggagatacag ggacccatcg 8521 actgtgcctg ggccattgga tcctatgcgg atgccgtcaa cgacgacgag gtggttccgc 8581 aggacatcca gctggaggtg acggtgcgcg gtgtcaacct gccgacgcct ccgctggctc 8641 cgggatccac ggaagaggcc tgccagcatc actatcttaa agtgtacaat ggacccgacc 8701 agaactcacc ctcgctggga ttattctgca accagccggc ggctgtgaat gtggtggtgg 8761 agcgtggcct gttctttgaa taccactcgg atagcttcgc acccaatgcg acattcaatg 8821 tgtccgttaa atacggttcg ggatgcggcg gcaagctgac ctatccgtat cgagccatcg 8881 atttcagtga gcagtacaag aataatgtcg agtgcatttg ggaggtggag gctgcctcgg 8941 gctatcacat cggtctcacc ttccaagggc gtttctatat cgaggatagc gccggctgtg 9001 ccaaggacta tctgctcgtc cagcagcgca acgaatcctc gggcaattgg acggatctcc 9061 agaggatctg cggtcgtgtg gcccccgaaa tgatcaacac cacatcgccg tatctgcggc 9121 taatctttcg ctccgacggc gatgtcgtgg gcgatggttt cctggccaaa ttcgagcgga 9181 attgcggtgg ccttctctac gccgacgatg aggaaaggaa tctcagcagt ccgggctttc 9241 cagttagcta cgagaaggat ctgcaatgca actggacgat cgtgccgagg gatccgctat 9301 ccggtggcgt tctcgtgagc ttcctgcaat tcgatctgga acaggcaccc atatccgttt 9361 gcctctttga caatgtcacc gtggttacca aggacaagga tcgggacccg gagcaggtga 9421 tcatctgtgg cgtgaagcac aatcacgagt acagggccaa ggagtccata agtttgattt 9481 tcaaaacgga tagcagctat tcgggccgag gattccaggt gcgttactcg agtcgccttt 9541 gcggtggagt aatcagccga acgggagtgg ttcaatcacc caggcagcac acggataaca 9601 acctcccgcc gggcagcgat tgctattgga atctcacggc accggtgggc tacaagttca 9661 ttgtaaagtt cgaactcctt gactttgaac cgcacacgaa ttgtgcttat gatggggtgg 9721 aaatctttgc gggttccatt cccgatgaac gacagcgaag gggacgcttc tgcgggcgga 9781 tgaacgaaga gctcccggtg attagcattc cgcaggagcg gggcatcata cacagctact 9841 cggatgagcg ggatccgtcg cggggattcc gtgccttcgt tcgcatcatg cagaattgcg 9901 atgagaagat ctcgctaaat ggatccacgc gttatgtgta cagcaagttc tacaatcccg 9961 agggctatga cttcggtctc gactgccatg tcgttttccg ggtgaacacg gatcagcaga 10021 tcagcgtgca gttcagtcac ttccacgttc agcagtcgga tgactgttcc aaggattatg 10081 tggagttgcg cgatggcgcc ggtccctttg ccgatatcat tggacgcttc tgtggccagg 10141 atcagccgcc cacgctgagc acctcgcggc acacgctctt cctgcgcttc gtcaccgata 10201 cgagggtcac cgattccggt ttcgaggtca ccatcaacgc cgtgccccgt ctgtgcggca 10261 gttcggagat cgcgttgagt tcggagcggc aggaggtgac cattgactcg ccggccagga 10321 cgccgggcgg taactacgcc aacggggtgg cctgcttctg gcggatcaag ggcgatacgc 10381 cgctgcggat gaactttgtc agcttcgatc tacatggtcc cgatgccaat ggcagctgtg 10441 tggaggacta cctgaaggtc tacaacagtg aggatgccga acaggtggag cagggctttg 10501 gcagcgagct ggtcttcaat ggccagacct ccggacacaa tcactttgac tttgccacgg 10561 agcacgtcta ctgcggcaat gtgaggccgg acacctatta cgccaacgcc aacgaggtgt 10621 acctgcggtt ccgatcgaag ggcttggagc agcgctccgg attccaggtg caggtggggc 10681 tgaactccaa gtccgagcgg cactacgatg gtctgcaggg aagggtacat ctttcgcaga 10741 ccgacgattg cgatattacg atccgtgccc cggtcaatca cacgctgagt ttgtactaca 10801 cggaactgat tttcggcacc tacgactgcc agacggaata tatggaggtc ttcgacaggc 10861 aaaataaatc gctgcaacgc ttctgctcct ttgtggacgt cggcaagagc ctgttcagct 10921 attcggatga actgcgactg cacatgaaga ccgggtcgtt tttgacctcg ctggatctca 10981 cctatctggc cagtcccgtg gagaaggggc ccggatgcgg cggtcagttc tacaacaccg 11041 agggcatctt cgccaatccc ttttatccgg ccaatgtgcg gaataactcc gagtgccagt 11101 ggattgtccg ggtgccgagc aacaataaag ttttcctcaa tttcgaagtt ttcaatctgg 11161 gctccaagac cacctgtcac accgactacc ttcaggtcct ggaaaaggac gaggctggcg 11221 aggaagtaga agtgaggcgc ttctgtggcg aggacaatcc gaaatactac aagagccagc 11281 gcagccaagt ggtcgtccgc ttccacaaga cggtcaacta cgatggcgtc ggctgggtga 11341 tacgcttcaa tggggtgtac tccaactacc agatacccag atacttgctg ggcggttgaa 11401 tccaaccctt gatcttgaaa ataatatgaa ataataattt ttattgtgaa gaatataata 11461 tttttgcagg cctaaaaaga gtttaaggcg taattttaaa gtaaagcaaa taaaaaataa 11521 aactttctta aa