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LOCUS XM_017150641 1773 bp mRNA linear INV 09-DEC-2024 kinase 1 (Dsor1), transcript variant X1, mRNA. ACCESSION XM_017150641 VERSION XM_017150641.3 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_017150641.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1773 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..1773 /gene="Dsor1" /note="mitogen-activated protein kinase kinase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 3 Proteins" /db_xref="GeneID:108063521" CDS 407..1597 /gene="Dsor1" /codon_start=1 /product="dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1" /protein_id="XP_017006130.1" /db_xref="GeneID:108063521" /translation="MSKNKLNLVLPPVNTEATVAAATVAPTPPFKTPSGTDTHSLLGK PKTSIDALTETLEGLDMDDTERKRIKVFLSQKEKIGELSDEDLEKLGELGSGNGGVVM KVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISI CMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDKHAIIHRDVKPSNILVN SSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMA IGMYPIPPPNTATLESIFADNAEDGGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFS TEFKDFVDICLKKQPDERADLKTLLSHPWIRKAEVEEVDISGWVCKTMDLPPSTPKRN TSPN" misc_feature 659..1552 /gene="Dsor1" /note="Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; Region: PKc_MEK; cd06615" /db_xref="CDD:132946" misc_feature order(683..697,707..709,746..748,752..754,842..844, 890..901,908..913,920..922,1031..1033,1037..1048, 1052..1054,1082..1087,1094..1096,1130..1141,1145..1147, 1226..1228,1253..1255) /gene="Dsor1" /note="active site" /db_xref="CDD:132946" misc_feature order(683..697,701..703,707..709,746..748,752..754, 842..844,890..901,908..913,917..922,1037..1039,1043..1048, 1052..1054,1085..1087) /gene="Dsor1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:132946" misc_feature order(692..697,1031..1033,1037..1045,1094..1096, 1130..1141,1145..1147,1226..1228,1253..1255) /gene="Dsor1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:132946" misc_feature order(695..697,752..754,806..808,815..817,842..844, 884..886,890..892,1085..1099,1106..1108,1118..1120) /gene="Dsor1" /note="noncompetitive inhibitor binding site [chemical binding]; other site" /db_xref="CDD:132946" misc_feature order(704..706,764..769,872..874,1151..1153,1163..1174, 1346..1348,1355..1360,1367..1372) /gene="Dsor1" /note="homodimer interface [polypeptide binding]; other site" /db_xref="CDD:132946" misc_feature 1082..1147 /gene="Dsor1" /note="activation loop (A-loop); other site" /db_xref="CDD:132946" polyA_site 1773 /gene="Dsor1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 ggtcacactg aatctgcaaa cgaaaaaaaa aaccaaaaag tcggcaaatt ttgcacccgc 61 agtttttgca aaaatatcac cgactttccg tttcttattg ttgttagaaa ttaacgctat 121 atcgagtgtg cacaaaaaga aacaagaaac agtgccaatt tacaagcggc tggcgaagaa 181 aacggaactt ttgcactggg ccaccgcttc attccccctc gtcgacgccc ctcgcccctc 241 atcctcctct cttcggacgc cgctgctcgt cgtgcatttt gttgttgttg tttcactgga 301 aacgaatcga agactttgtg ttttatttat ttttttatta ttgtttttgt tgttattgta 361 atctataact tatcggttaa ccgcgatata tagcgatatc gggaaaatgt cgaagaacaa 421 gctgaatttg gtgctgccgc cggtaaatac ggaggcaact gttgccgccg ccacagtggc 481 gccgacgccg ccgttcaaaa ccccctcggg cacagacaca cacagtttgc tggggaagcc 541 gaagacgagc atcgatgcgc tgacggagac gctggagggc ctggacatgg acgacacgga 601 gcggaagcgg atcaaggtgt tcctcagcca gaaggagaag atcggcgagc tgtccgatga 661 ggatctggag aagctgggcg agctgggttc gggcaatggc ggcgtggtga tgaaggtccg 721 gcacacgcac acacacctca tcatggccag gaaactgatc catctggagg tgaagccggc 781 gatcaagaaa cagatcctgc gcgaactgaa agtcctgcac gaatgcaatt tcccgcacat 841 cgttggcttc tacggcgcct tctacagcga cggagagatc agcatttgca tggagtacat 901 ggatggcggt tcgctggatt tgattctcaa gcgggctggt cgaataccgg agtccattct 961 cggccggatc acgctggccg tgctgaaggg cctgagttac ctgcgcgaca agcatgccat 1021 catccaccgg gacgtaaagc cgagcaatat actcgtcaac agcagcggcg agatcaagat 1081 ctgtgatttc ggtgtctctg gccagctgat cgactcgatg gccaactcat tcgtgggcac 1141 ccgcagctat atgtcgccgg agcgactgca gggcacgcac tactcggtgc agtcggacat 1201 ctggtcgctg ggcctgtcgc tggtggagat ggccatcggc atgtacccca tcccgccgcc 1261 gaacaccgcc accttggagt cgatattcgc ggacaacgcg gaggatggcg gacagccgac 1321 ggacgaaccg agggcaatgg ccatcttcga gctgctcgat tatattgtga acgaaccgcc 1381 gccgaagctc gagcacaaga tcttctccac cgagttcaag gactttgtgg acatctgcct 1441 gaagaagcag cccgacgagc gggccgatct caagaccctg ctgagtcacc cgtggatacg 1501 caaggcggaa gtggaggagg tggatatatc cggctgggtg tgcaagacaa tggatctgcc 1561 gccgtcgacg ccaaagcgga atacgtcgcc caactagatg caactacgat gcagatgcag 1621 atgcagctgc atctcggccc tcgatcttct ctcccctccc atatccgcat ttgctctttg 1681 ttcaacatct cgttgacgcc gggcagaaca acaactgaac tattattatt attattatta 1741 aatcgaaaat aaagaaatcg aagtcatacc atg