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PREDICTED: Drosophila takahashii Tousled-like kinase (Tlk),


LOCUS       XM_017138082            6753 bp    mRNA    linear   INV 09-DEC-2024
            transcript variant X2, mRNA.
ACCESSION   XM_017138082
VERSION     XM_017138082.3
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 9, 2024 this sequence version replaced XM_017138082.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6753
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..6753
                     /gene="Tlk"
                     /note="Tousled-like kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     Proteins"
                     /db_xref="GeneID:108054955"
     CDS             496..4386
                     /gene="Tlk"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 1
                     isoform X2"
                     /protein_id="XP_016993571.2"
                     /db_xref="GeneID:108054955"
                     /translation="MDQFQTSLNPRKQELLEARFIGVRMSAGAQLQMAPQTTSALSHH
                     HPNQQQQLQPPQQQQAQPPPPQQQQHFANHHSAQQQSQQQQEQQNPQQAQQQQAQQQQ
                     ILPQPHLQHLHKHPHQLQLHQQQQQLHQQQQHFHQQQQQSLQGLHQGSSNPDSNMSTG
                     SSHSEKDVNDMLSGGGAAPGVAAAAAIQQQHPAFAPALGMQQPPPPPPQHSNNGGEMG
                     YLTAGTTTTASVTAVGKPRTPAERKRKRKMPQTSADEAGSGGGSGGAGAAVVNNSSLK
                     GKSLAFRDMPKVNMSLNLGDRLGGSAGSGGGAGGAGSGGSGAGSGSGSGGGKSARIML
                     PVSDNKKINDYFNKQQTGVGVGVPGGGGAGGNTAGLRGSHTGGGSKSPSSAQQQQQTT
                     QQQQQQASGVATGGGAGGAAANQQVQVQTSSAYALYPPASPQTQTPQQQQQQQPGADF
                     HYVNSSKAQQQQQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQQQTPLSQQQ
                     QQQQQQQQQQQQQLGPPTTSTASVVSTHPHQLGSLGVVGMVGVGVGVGVNVGVGPPLP
                     PPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKCQIVGN
                     QKTIDQHKSHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQE
                     NWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQ
                     QQHQQQQQQQNSNSNDSSQLTGGVVTGPGSDRLGGAAGGVSVDSGLGGNNAGAIGGGA
                     VGGGVGGGGVGSGGVGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVG
                     DRLSDRGGGGGLGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKE
                     DADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVH
                     KAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEI
                     DANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDL
                     KPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVV
                     GKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPT
                     VSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQ
                     QQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS"
     misc_feature    <2239..>2649
                     /gene="Tlk"
                     /note="Family of unknown function (DUF5401); Region:
                     DUF5401; pfam17380"
                     /db_xref="CDD:375164"
     misc_feature    3397..4200
                     /gene="Tlk"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; Region: STKc_TLK; cd13990"
                     /db_xref="CDD:270892"
     misc_feature    order(3406..3408,3445..3447,3451..3453,3559..3561,
                     3610..3621,3631..3633,3637..3639,3754..3756,3760..3762,
                     3766..3771,3775..3777,3817..3819,3826..3828,3895..3906)
                     /gene="Tlk"
                     /note="active site"
                     /db_xref="CDD:270892"
     misc_feature    order(3631..3633,3637..3639,3754..3756,3760..3762,
                     3766..3768,3826..3828,3895..3906)
                     /gene="Tlk"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270892"
     misc_feature    order(3814..3852,3865..3906)
                     /gene="Tlk"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270892"
     polyA_site      6753
                     /gene="Tlk"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 atatttttag cccatttctg cgtgtgtgcg ttcgtgtgaa tattgtgaat atttttttac
       61 tgtgacaaaa tagacgaaaa tcggctgtgg aaaaccgaag taaacacatt tagggatcat
      121 ggcgattggc ccttaaccct tgagtgccgt gccggcagtg ccacgccaca aaaattccaa
      181 tacaaatcga aatcgcagaa aaaaacaaca aaaacgccaa gtttatgtct ttaactttaa
      241 agtttgggac aatccgatcc gatcggaagc ggaacatata ggctggctat actatatggt
      301 atgatgaatt tgctatttta ttgctatggc tctgacaaat cttgtcgcat taattgccga
      361 catttgcaat cgatcataaa atcaatccta aaatgttaaa taagtaaaac attcaaagac
      421 caaacaaaat ctcagaaaaa actatcatat ctataaacaa ataaaattcg cattggaaaa
      481 aacaatcata ttgcaatgga tcaatttcaa acttcgctga atccacgaaa acaggagctt
      541 ttggaggctc gatttattgg agtgaggatg tccgccggcg cacagttgca gatggccccg
      601 cagaccactt cggccctaag tcaccaccat cccaatcagc agcagcagct gcagccgccg
      661 cagcaacagc aggcacagcc cccgcctccg caacagcagc agcactttgc caaccatcac
      721 agcgcccagc agcagtcgca gcaacagcag gagcaacaga atccccagca ggcgcaacag
      781 cagcaggcgc agcagcagca gatcctcccg cagccgcatc tgcagcacct gcacaagcat
      841 ccgcaccagc tgcaactgca ccagcagcag cagcagctcc accagcagca gcaacacttc
      901 caccagcagc agcaacagtc gctgcagggg ctgcaccagg gcagcagcaa tccggattcg
      961 aatatgagca ctggctcctc gcacagcgag aaggatgtca acgatatgct gagtggcggc
     1021 ggagcagcgc ccggagtagc tgccgcggca gccattcaac agcaacatcc cgcctttgcg
     1081 cccgccctgg gaatgcagca gccaccgccg ccgccgccgc agcactccaa taacgggggc
     1141 gagatgggct acttgacggc gggcacgacc acgacggcct cggtgacggc ggtgggcaag
     1201 cccaggacgc cggcggagcg gaagcggaag aggaaaatgc cgcagaccag tgcggacgag
     1261 gcggggagtg gcggtgggtc cggcggagct ggagcagccg tggtgaacaa cagcagcctg
     1321 aagggcaaat ccctggcctt tcgtgatatg cccaaggtga acatgagcct gaatctgggc
     1381 gatcgtctgg gcggttcggc cggcagtggc ggcggagccg gaggcgccgg cagcggaggg
     1441 agtggcgccg gttccggttc cggcagtggc ggcggcaaga gtgcccgcat catgctgccc
     1501 gtcagcgaca acaagaagat caacgactac ttcaacaagc agcaaacggg cgtgggcgtc
     1561 ggtgtgccag gtggaggtgg tgcgggaggc aataccgccg gtctccgagg atcccacacg
     1621 ggtggcggca gcaagtcgcc ctcatccgcc cagcagcagc agcagacgac ccaacagcag
     1681 cagcagcagg cgagcggagt ggcgacgggc ggtggggcag gaggagccgc cgccaaccag
     1741 caggtgcagg tgcagacgag cagcgcctac gccctgtatc caccagctag tccccaaacg
     1801 cagacgccgc agcaacagca gcagcagcag ccgggagccg acttccacta cgtcaactcc
     1861 agcaaggcgc agcagcagca gcaacagcag cagcagcgcc agcagcaaca gacttccaat
     1921 caaatggttc ctccacacgt ggtcgtcggc ctgggtggtc atcccctgag cctcgcgtcc
     1981 atccagcagc agcagcagac gcccctctcc cagcagcagc agcagcagca gcaacaacag
     2041 cagcagcaac agcagcaact gggaccgccg accacatcga cggcctctgt cgtgtccacg
     2101 catccgcacc agctcggctc cctgggagtt gtgggcatgg tcggtgtggg cgtcggcgtt
     2161 ggggtaaatg tgggcgtggg accgccactg cctccgccac cgccgatggc gatgccggcg
     2221 gccattatca catacagcaa ggccacccaa acggaggtct cgctgcacga gctgcaggaa
     2281 cgcgaggcgg agcacgagtc gggcaaggtg aagctggacg agatgacgcg gctgtccgac
     2341 gagcaaaagt gccagattgt cggcaaccag aagacgatcg accagcacaa gtcgcacatt
     2401 gccaagtgca ttgatgtggt caagaagctg ctgaaggaaa agagcagcat cgagaagaag
     2461 gaggcgcgac agaagtgcat gcagaaccgc ctgagactcg gccagtttgt gacccagcga
     2521 gtgggcgcca cattccagga gaactggacg gacggctatg cgttccagga gctgagtcgg
     2581 cggcaggagg agataaccgc cgagcgcgag gagatcgacc ggcagaagaa gcagctgatg
     2641 aagaagcgtc cggcggagtc cggacgcaag cgcaacaaca acagcaacca gaacaaccag
     2701 cagcagcagc agcaacagca gcaccaacag cagcagcagc agcagaattc caactcgaac
     2761 gattcctcgc agctgacggg cggcgttgtc accggaccgg gcagcgatcg cctgggcggc
     2821 gcggcaggcg gcgttagcgt cgacagcgga ttgggtggca acaatgcggg cgcaatcggt
     2881 ggcggagctg tgggcggtgg cgttggaggc ggcggcgtcg gaagcggcgg cgttggcggt
     2941 gtcggcggcg gcggaggacg tggtctatcg cgcagcaact cgacgcaggc caatcaggct
     3001 caactgctgc acaatggcgg cggcggatcg gggggcaatg tgggcaactc gggcggcgtc
     3061 ggcgatcgac tgtcggatcg aggaggaggc ggcggcctcg ggggcaacga cagcggcagc
     3121 tgctcggact cgggcacgtt cctcaagccg gatcccgttt cgggggcata taccgcgcag
     3181 gagtactacg agtacgatga gatcctcaag ctgcgccaga atgccctcaa gaaggaggac
     3241 gccgacctgc agctggagat ggagaagctg gagcgggagc gcaatctgca catccgagag
     3301 ctcaagcgga tactcaacga ggatcagtcc cgcttcaaca accatcccgt gctgaatgat
     3361 cgctaccttc tgctgatgct gctgggcaag ggcggcttct cagaggtcca caaggccttc
     3421 gacctcaagg agcaacgcta tgtcgcatgt aaggtgcacc aattaaacaa ggattggaag
     3481 gaggataaga aagctaatta tatcaaacac gctttgcggg aatacaacat ccacaaggcg
     3541 ctggatcatc cgcgggtcgt caagctctac gacgtcttcg agatcgatgc gaattccttt
     3601 tgcacagtgc tcgaatactg tgatggccac gatctggact tctatttgaa gcaacataag
     3661 actatacccg agcgtgaagc gcgctcgata ataatgcagg ttgtatctgc actcaagtat
     3721 ctaaatgaga ttaagcctcc agttatccac tacgatctga agcccggcaa cattctgctc
     3781 accgagggca atgtctgcgg cgagatcaag atcaccgact ttggtctgtc gaaggtgatg
     3841 gacgacgaga actacaatcc cgatcacggc atggatctga cctcccaggg agccggcact
     3901 tattggtatc tgccacccga gtgctttgtg gtgggcaaaa atccgcccaa gatctcctcc
     3961 aaggtggacg tgtggagtgt gggcgtgatc ttttaccagt gtctgtacgg caagaagccc
     4021 ttcggtcata accaatcgca ggccacgatt ctcgaggaga acacgatcct gaaggccacc
     4081 gaagtgcagt tctccaacaa gccaaccgtt tccaatgagg caaagagctt cattcggggc
     4141 tgcttggcat atcgcaagga ggatcgcatg gatgtgttcg cgctggccag gcacgagtac
     4201 atccagccgc cgataccgaa gcacggccga ggctcgctca accagcagca gcaggcgcag
     4261 caacagcagc agcaacaaca gcagcagcag cagcaacagt cgtcgacgtc gcaggccaat
     4321 tccaccggcc agacttcgtt ctctgcccac atgtttggca atatgaatca gtcgagttcg
     4381 tcctagctgc caaccaagcg taattccaac tcataattcg ccgccgccgc agtagcagca
     4441 gcaacttcag ctgccagcca acagcaacac caacagcagc agcagcagca acatcagcag
     4501 cagcatcttc aactccagca ataccagccg aatcagcagc tccatttgca aaacagtagc
     4561 agcaactatg cggccacgct tctcgatgca gcggcctttt gctacgaaac cgtgatggat
     4621 gcagcccact tccacaacaa taacaacaac agcaccatca tcaacaacaa tatgcagaca
     4681 atgccggcga atgctgtcaa tgctgctgct gccggaggag gaggagcagg aggagcagca
     4741 ggaggagggg gaacaccgac ctaccaaggg aaatacaagc gctggcagca gcaacagttg
     4801 caacagcagg cgcaactgca acagcagcaa cacaagctac tgctgcaaca agagctgctg
     4861 tagagtaaga aaaaaaatac aagggtgatg atgatttacg acggaataat gacaagggag
     4921 tttgagagaa ggaggagagc tgcctgcaac actgccgcca agccaagcta atgttgctgc
     4981 tgcaacagca acaccgtcag caacaacaac aacaacagta acaacacccc aagaatttcc
     5041 gcagcgagtc gcaaaacaac aacaaaaact taaattaatg aaactatata taaatatata
     5101 tatgcatata tatattaaat gtgataaaca agcgtaaagc aaaaaaaaaa atacaaaaca
     5161 agaaaggaaa gcagcaaata cagcaggaga aagacgaaca accaaggggg aaaaacccgg
     5221 aagataggga aaagcaaagc tgcagcaaaa aaccagaaga gaagagcata gaaagaggga
     5281 gcagaagaaa agcagaaagt tgaaagctga gatgaattgc cgaggagaaa gcttgagaaa
     5341 ttgtttataa aggctgctat aaacacacac tttttttttt ttgttaacta taaataccaa
     5401 gcagaataat taatctaaaa taaataataa ttaaatgcta aatgtaaatt agtaagtagg
     5461 gtggcatcta aaaacaagag aagaacgcaa agaacacgat tcccaagaac gcgaaaaggc
     5521 acataatatt ttttctttgt attaaaaata ataatggtac cataaagaaa acgtagcaaa
     5581 ttagcgtagg ctaaatagca cagtataaaa actgaaacta aaaaaacagt aaaagcagca
     5641 gaaaaataga aatgattgta aacacgcaga gcagaggaaa catttgcaat gggaaattac
     5701 aaattgttgc attgtttttt gggttatgtt tgtttgtagt tcaaacatta aaataacact
     5761 catacacaca acacaacaca acacagcaca gcacacagac actgcagact acttttgcct
     5821 tacaagaagt gaaaaaaaca ctaattttaa ttgccaattt ccattttgta tacatgcata
     5881 ttcaatattg tgtactcgca tatatacaca catatatata tttatcattt tctacccgcg
     5941 aatctttctt tttatttttt taacgtatgc accaacgaac atttaatttt aacgctttta
     6001 aacgaagtta aaaccaactt ataccctatc ttaattttga aatggaaaag aaatcattct
     6061 ttgtttgttt tgtatcaaaa tccaaaagaa atttaattta aaaataaaat taaaaaatac
     6121 catcaatcac acaccgcaca cacatataca tttgtatata ctcgtatctg aacgacaaac
     6181 aaaaaaccga agcgataaaa actaaaaact taatcaaacg aaatgcaatt ccaaaatatc
     6241 caagagaaaa agaatcagat aaccattttt tttatatgcc acaagaaaaa cgctaagaac
     6301 atgagaaacg gcgagaaaaa tcgatggaag gggaaaagct agagatcagg ttctcagatc
     6361 ggatcagaaa atcggcagaa aaataaaccc atttgaagta atctacttct aattacatag
     6421 taaactaatg taatagtttt tattaaatat atatatatat atgtatcgat atatatatac
     6481 atacatgttt tttttttaat tttaaaacta tatttgtaat gcactatgcg taacattgta
     6541 ttaaatatta atatccaagg catattaata gaaatatata tataaacata aaaaaccaga
     6601 aaaaagaaca tgaactacca acctaaatgt ttcaataata tatagatcta tatgtatgta
     6661 aaaccgatat gaaatctgcc taatgccaga caaaaaaaaa ccctacaaga gaaagttgaa
     6721 agctccgaag agtgaaagag tgaaagagat gga