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LOCUS NP_727348 3750 aa linear INV 26-DEC-2023 ACCESSION NP_727348 VERSION NP_727348.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_167193.2 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 3750) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 3750) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 3750) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 3750) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 3750) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 3750) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 3750) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 3750) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 3750) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 3750) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 3750) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 3750) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 3750) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 3750) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 3750) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 3750) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 3750) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 3750) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAF46505. On Jan 26, 2009 this sequence version replaced NP_727348.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..3750 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..3750 /product="cubilin" /name="CG32702 gene product from transcript CG32702-RB" /note="CG32702-PB; Cubn-PB; dCubilin; TMPRSS6 iron sensing; cubilin ortholog" /calculated_mol_wt=418051 Region 21..149 /region_name="cubilin_NTD" /note="N-terminal domain of cubilin and similar proteins; cd22201" /db_xref="CDD:412063" Site order(33,35,37,39..48,50..58,60..65,70,73..74,76..77, 80..81,83..84,87..88,110..111,114,117..118,121,124..125, 128) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:412063" Site 33..37 /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:412063" Region 156..190 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 192..233 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(192,195,214) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 282..322 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain; smart00179" /db_xref="CDD:214542" Site order(282,285,301) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 324..367 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain; smart00179" /db_xref="CDD:214542" Site order(324,327,345) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 430..457 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 469..503 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 509..622 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(517,519,521,548,553,593,617,619,621..622) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 627..737 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(636,638,640,667,672,708,732,734,736..737) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 744..849 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cl00049" /db_xref="CDD:412131" Site order(752,754,756,783,788,826,846,848,850) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 853..970 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(861,863,865,892,897,940,965,967,969..970) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 978..1094 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(986,988,990,1017,1022,1065,1089,1091,1093..1094) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1100..1211 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(1108,1110,1112,1139,1144,1182,1206,1208,1210..1211) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1216..1330 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(1226,1228,1255,1260,1301,1325,1327,1329..1330) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1446..1549 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(1447,1449,1451,1478,1483,1520,1544,1546,1548..1549) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1554..1667 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(1562,1564,1566,1593,1598,1638,1664,1666) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1792..1899 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(1800,1802,1804,1831,1836,1873,1896,1898) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 1910..1998 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cl00049" /db_xref="CDD:412131" Site order(1911,1913,1915,1942,1947,1977,1995,1997) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 2019..2133 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Region 2140..2242 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Region 2263..2379 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(2271,2276,2278,2305,2311,2353,2377,2379) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 2385..2511 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(2393,2395,2397,2429,2434,2506,2508,2510..2511) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 2516..2630 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(2526,2528,2555,2560,2601,2625,2627,2629..2630) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region <2833..2892 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cl00049" /db_xref="CDD:412131" Region 2898..3008 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(2907,2909,2934,2940,2980,3004,3006,3008) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 3011..3127 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(3021,3023,3025,3054,3059,3099,3122,3124,3126..3127) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 3130..3241 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Region 3254..3363 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(3260,3262,3264,3291,3296,3334,3358,3360,3362..3363) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 3379..3508 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(3382,3384,3386,3413,3418,3482,3506,3508) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" Region 3531..3601 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cl00049" /db_xref="CDD:412131" Region 3623..3733 /region_name="CUB" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; cd00041" /db_xref="CDD:238001" Site order(3631,3633,3635,3662,3667,3706,3730,3732) /site_type="other" /note="heterodimerization interface [polypeptide binding]" /db_xref="CDD:238001" CDS 1..3750 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /coded_by="NM_167193.2:1..11253" /db_xref="FLYBASE:FBpp0271945" /db_xref="GeneID:326235" /db_xref="FLYBASE:FBgn0052702" ORIGIN 1 megaarsrll lcwtllaiit dtwpiaegfv nspkiiskdg nlifesganr nisfrlsgns 61 rltineeldv melllatsgs kkrsggkddd fvdareladq ladfnrrafg anglsamlrv 121 qqnrtrgsma llrrfqtrlr alenrvdrmk tdleanscas gpcenggtcy ntytgfrcqc 181 rsafegtkce mdvnecalye gtdlgcqngg qcqnhfgtys clcqpgwhgm hctqrkadcs 241 qssawelcgh gscvpsadda gyrcicepgw ktngltpicg edvdecsdsa ahkpcstsci 301 nlpgsftcap cpagltgngv scrdldecqt nnggcslspk vdcintygsy hcgecpvgwt 361 gdgrkcersp qdidipagqt prtcpagnnp cyptascfli sgttscrcpm gmvgtgygpn 421 gcvngtttnc kenpclnggi clfagpsnyt clcpigfrpp icepqpspcd qhpcknggrc 481 rpttsgdlfv cqclpgyrgr lcetrfsscn gmlsaqsgrl ryppegtgye hnaqcawvir 541 tneslvvnvt fnsfdvedst ecrfdwlqin dgrsaaaqii grycgnhlph ggnivssgnq 601 lylwfrsdns takegfdltw nsmepqcggr lnfethgtla spgspgnypk nrdcrwqlva 661 pttkrikltf fslqleqhan cnfdyvlikd sisgrelaky cttgapapll lpthlaeihf 721 hsdaegsdtg fqlhysveer vpgcggvyta kegtisesst antepggvsc eyeihlavge 781 qvviqfarle ldpldclevl ditdeggsil qekicgsdas rlnpptftse fnrlkikfya 841 ragsfqlnyr macdyklnne qgtitspgyp nltrsdrict ytistatntv islkridfql 901 tngesddddn declttnlri ndglnrkilg pycgknqpee nfvsetnylq lhlstdvdsm 961 grgfkfeyra latgndkcgg vhtrsgdhir lpvhddsyag eatcywvima pankairlhw 1021 nsfslenavd ciydyleiyd slgaqvnder skplakycgn svpedllshs rqlvlkfvsd 1081 ysesdggfdl tytfedrakc gghihassge ltspeypany sagldcdwhl tgtidhllei 1141 qvenfeleqs pncsadylev rngggtdspl igrfcgrdip aripgfshem rlilhtdsai 1201 ngrgfrlrwr ifafgcggsl rsnmgaissp rypnsypnma hcewrislhp gsgisllied 1261 leleglsncy ydsvkiytgi klpnqspckv lckdddlhnp liqlennkgt ivfdsdasnt 1321 frgfrisyka ncirnltatt gtieslnyme pfwetipinc swtirapkgn rvlvevshla 1381 rheqhvptat mpgglyivdg rnvqeivtpq amnisgevlt vvhnasnvnf qldyridgcm 1441 eelrgtfgff qspnypkmyp nnlecywlit veqdsaielt innidledsp nctkdaltvs 1501 nhknsvevhe rhcgsttklv itssghrlhv rfisdnshng lgfeatyrtv katcggklta 1561 rngviespny plnypahsrc ewqvevsqhh qivfemadln lesgydcnwd yleaydlted 1621 dtegerlfkv cgdeteddkl lssssnmavv rfisddsvsk kgfrlhfhes cgqtiivdet 1681 mfdyiqmsrq aarnesclwv fqavepnkri iftpthvklr edanqqypte gdclnvgvki 1741 yegtepqgtp rlkfcrshpp alisngqalt vsvplqlvee fqghymtmdt scgsiynals 1801 gkftspyypa syppnieclw lleasmgnsl sltlesmdle ksescnrdyl evreesesgq 1861 ligvycgnev pgvihsrgai wmkfksdddn vgegfmasyn yehhnelngt egtiesphfp 1921 skfqdpvpys writvdkeyv vaisllylrd ldqphlnfyd gysdigarie vtdpdetiis 1981 stnvvyftsn rgpfklnwnr lskealrsnr taeertrqcg nqlitidrsv igfhspgypn 2041 gyeqdlncfw tlvpsnpamh avltlsqidl eifsedciad yvkifsgsdl qnwselrtlc 2101 slptessdrv fhgrpylrve fvtdpsvnkt gfngivrtac gseitaskgl vniteilkvl 2161 prpnhdcvwt ikvrqgrrik idfpdfqlqn nmasgssdcr nylllrngnd edspflgrgk 2221 ycedvvhevl ntssnkayik fhfaspprfl vsfrfeelry tdsgrirlsa sgdeqfissp 2281 yyphlphphs eciwiveapp ehrimlhfqg afdmldatge peecqrefvl indgstelrp 2341 eigrycgnrk pdtiystgnq mriryftdvs ephmgfnasl svarcggsfh spegviasps 2401 rdllliheeg kqlqecvyti elekgstidl tseylqiptl rngscsqrnh lmleemdafg 2461 ldgeekivdt lmlcgmeakh lisetnkivf ryrfldgipa enqgfrlkyt slgsrcgeti 2521 yasvgvlqtp gyplgvphpm hckwqvqvpk grrvrleild fntgtnmdlr grlgfrgrlt 2581 vandfkmqsi lgrynvdppa evlssdntmg idafllpivq nhgiklrfsa ygssscpgft 2641 vmmnevadiq fqrfnisrpl hcsykvvpps nstllirvke ynttsvmmwn thmcallspl 2701 kfnrleqeee lmerilcdyq spapgkplps irlpfpiqlv vsasarnamt nlvlsystqs 2761 cggviilepg dnmtvhqpsg mvsaagaidc awaigpytda sgedevlvpq diqlevsvyn 2821 vnlpapspsa qspeapclhh ylkvyngpdq nspslglfcn qatavnmvve rglfleyhsd 2881 sfsanatfnv sikygsgcgg klvypyraid faeqyknnve ciweveatmg yhigltfqgr 2941 fyiedspgct kdyllvqqrn ettgnwtdlq ricgrvapem inttspylrl ifrsdgdvva 3001 dgflakfern cggllyadst eqelaspgfp ngyekylqcn wtivprspsm ggvlvsfvnf 3061 dleqgpisvc lydnltvttk dkgkdpqqtt lcgvkhnhey rgkeyvnlll rtdgsysgrg 3121 ftllytsrlc ggiisrtsmv espvqhtdnt lppgsdcywn ltapagykfn ikflfidfea 3181 nsncaydgve vfsgpipder yrwgrfcgri nedlplisip qergiihsfs ddrdpsrgfr 3241 alvrvmpncd ekislngssr yvyskfnnag gyqndldcqi vfrvnpdqqi svefsnfhvq 3301 dtdgcrsdyv elrdgggtfa diigrfcgqn qpptlrttrh tlymrfvtdn kvtdtgfqvt 3361 inaiprlcgs seitlsadgt kevtinspar tpggnypngv scfwkikgds llrvqfvnfd 3421 lhgpnqngsc vddylkiyns edaplleqgl gtdlvfngqt sskngfgfat ehvycgnvkp 3481 diyygrssev ylkfrskgle qhggfqlqva lnsnrerhyd glqgrvhlsq sadcniiira 3541 ppnytlslyy telifgtydc emenlevfdr tnrslqrvcs fvdmgkslfs nanelrlqmk 3601 tgsyltsldl tylaspvekg pgcggqfynt egifsnpfyp nnvrnnsecq wivrvpsnnv 3661 vfltfevfnl gskttchtdy lqileqdatg eeremrrfcg ednpkyyksr rsqvlvrfhk 3721 tvnydgigwv irfagvysdh qiprhllggs