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LOCUS NM_167193 11349 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_167193 VERSION NM_167193.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 11349) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 11349) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 11349) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 11349) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 11349) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 11349) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 11349) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 11349) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 11349) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 11349) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 11349) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 11349) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 11349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 11349) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 11349) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 11349) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 11349) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 11349) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 26, 2009 this sequence version replaced NM_167193.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on the 5' end. FEATURES Location/Qualifiers source 1..11349 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene <1..11349 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Cubilin" /map="8E7-8E10" /db_xref="FLYBASE:FBgn0052702" /db_xref="GeneID:326235" CDS 1..11253 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CG32702 gene product from transcript CG32702-RB; CG32702-PB; Cubn-PB; dCubilin; TMPRSS6 iron sensing; cubilin ortholog" /codon_start=1 /product="cubilin" /protein_id="NP_727348.2" /db_xref="FLYBASE:FBpp0271945" /db_xref="GeneID:326235" /db_xref="FLYBASE:FBgn0052702" /translation="MEGAARSRLLLCWTLLAIITDTWPIAEGFVNSPKIISKDGNLIF ESGANRNISFRLSGNSRLTINEELDVMELLLATSGSKKRSGGKDDDFVDARELADQLA DFNRRAFGANGLSAMLRVQQNRTRGSMALLRRFQTRLRALENRVDRMKTDLEANSCAS GPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGT YSCLCQPGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADDAGYRCICEPGWKTNGLT PICGEDVDECSDSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCRDLDECQTNNGG CSLSPKVDCINTYGSYHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCY PTASCFLISGTTSCRCPMGMVGTGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYT CLCPIGFRPPICEPQPSPCDQHPCKNGGRCRPTTSGDLFVCQCLPGYRGRLCETRFSS CNGMLSAQSGRLRYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNSFDVEDSTECRFDW LQINDGRSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSME PQCGGRLNFETHGTLASPGSPGNYPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCN FDYVLIKDSISGRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSVEER VPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAVGEQVVIQFARLELDPLDCLE VLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYK LNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECL TTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRALA TGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVD CIYDYLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGF DLTYTFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQVENFE LEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRG FRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLE LEGLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNT FRGFRISYKANCIRNLTATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSH LARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNFQLDYRI DGCMEELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTK DALTVSNHKNSVEVHERHCGSTTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKA TCGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCNWD YLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSKKGFRLHFH ESCGQTIIVDETMFDYIQMSRQAARNESCLWVFQAVEPNKRIIFTPTHVKLREDANQQ YPTEGDCLNVGVKIYEGTEPQGTPRLKFCRSHPPALISNGQALTVSVPLQLVEEFQGH YMTMDTSCGSIYNALSGKFTSPYYPASYPPNIECLWLLEASMGNSLSLTLESMDLEKS ESCNRDYLEVREESESGQLIGVYCGNEVPGVIHSRGAIWMKFKSDDDNVGEGFMASYN YEHHNELNGTEGTIESPHFPSKFQDPVPYSWRITVDKEYVVAISLLYLRDLDQPHLNF YDGYSDIGARIEVTDPDETIISSTNVVYFTSNRGPFKLNWNRLSKEALRSNRTAEERT RQCGNQLITIDRSVIGFHSPGYPNGYEQDLNCFWTLVPSNPAMHAVLTLSQIDLEIFS EDCIADYVKIFSGSDLQNWSELRTLCSLPTESSDRVFHGRPYLRVEFVTDPSVNKTGF NGIVRTACGSEITASKGLVNITEILKVLPRPNHDCVWTIKVRQGRRIKIDFPDFQLQN NMASGSSDCRNYLLLRNGNDEDSPFLGRGKYCEDVVHEVLNTSSNKAYIKFHFASPPR FLVSFRFEELRYTDSGRIRLSASGDEQFISSPYYPHLPHPHSECIWIVEAPPEHRIML HFQGAFDMLDATGEPEECQREFVLINDGSTELRPEIGRYCGNRKPDTIYSTGNQMRIR YFTDVSEPHMGFNASLSVARCGGSFHSPEGVIASPSRDLLLIHEEGKQLQECVYTIEL EKGSTIDLTSEYLQIPTLRNGSCSQRNHLMLEEMDAFGLDGEEKIVDTLMLCGMEAKH LISETNKIVFRYRFLDGIPAENQGFRLKYTSLGSRCGETIYASVGVLQTPGYPLGVPH PMHCKWQVQVPKGRRVRLEILDFNTGTNMDLRGRLGFRGRLTVANDFKMQSILGRYNV DPPAEVLSSDNTMGIDAFLLPIVQNHGIKLRFSAYGSSSCPGFTVMMNEVADIQFQRF NISRPLHCSYKVVPPSNSTLLIRVKEYNTTSVMMWNTHMCALLSPLKFNRLEQEEELM ERILCDYQSPAPGKPLPSIRLPFPIQLVVSASARNAMTNLVLSYSTQSCGGVIILEPG DNMTVHQPSGMVSAAGAIDCAWAIGPYTDASGEDEVLVPQDIQLEVSVYNVNLPAPSP SAQSPEAPCLHHYLKVYNGPDQNSPSLGLFCNQATAVNMVVERGLFLEYHSDSFSANA TFNVSIKYGSGCGGKLVYPYRAIDFAEQYKNNVECIWEVEATMGYHIGLTFQGRFYIE DSPGCTKDYLLVQQRNETTGNWTDLQRICGRVAPEMINTTSPYLRLIFRSDGDVVADG FLAKFERNCGGLLYADSTEQELASPGFPNGYEKYLQCNWTIVPRSPSMGGVLVSFVNF DLEQGPISVCLYDNLTVTTKDKGKDPQQTTLCGVKHNHEYRGKEYVNLLLRTDGSYSG RGFTLLYTSRLCGGIISRTSMVESPVQHTDNTLPPGSDCYWNLTAPAGYKFNIKFLFI DFEANSNCAYDGVEVFSGPIPDERYRWGRFCGRINEDLPLISIPQERGIIHSFSDDRD PSRGFRALVRVMPNCDEKISLNGSSRYVYSKFNNAGGYQNDLDCQIVFRVNPDQQISV EFSNFHVQDTDGCRSDYVELRDGGGTFADIIGRFCGQNQPPTLRTTRHTLYMRFVTDN KVTDTGFQVTINAIPRLCGSSEITLSADGTKEVTINSPARTPGGNYPNGVSCFWKIKG DSLLRVQFVNFDLHGPNQNGSCVDDYLKIYNSEDAPLLEQGLGTDLVFNGQTSSKNGF GFATEHVYCGNVKPDIYYGRSSEVYLKFRSKGLEQHGGFQLQVALNSNRERHYDGLQG RVHLSQSADCNIIIRAPPNYTLSLYYTELIFGTYDCEMENLEVFDRTNRSLQRVCSFV DMGKSLFSNANELRLQMKTGSYLTSLDLTYLASPVEKGPGCGGQFYNTEGIFSNPFYP NNVRNNSECQWIVRVPSNNVVFLTFEVFNLGSKTTCHTDYLQILEQDATGEEREMRRF CGEDNPKYYKSRRSQVLVRFHKTVNYDGIGWVIRFAGVYSDHQIPRHLLGGS" misc_feature 61..447 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="N-terminal domain of cubilin and similar proteins; Region: cubilin_NTD; cd22201" /db_xref="CDD:412063" misc_feature order(97..99,103..105,109..111,115..144,148..174,178..195, 208..210,217..222,226..231,238..243,247..252,259..264, 328..333,340..342,349..354,361..363,370..375,382..384) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="trimer interface [polypeptide binding]; other site" /db_xref="CDD:412063" misc_feature 97..111 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="tetramer interface [polypeptide binding]; other site" /db_xref="CDD:412063" misc_feature 466..570 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 574..699 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature order(574..576,583..585,640..642) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 844..966 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(844..846,853..855,901..903) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 970..1101 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(970..972,979..981,1033..1035) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 1288..1371 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 1405..1509 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 1525..1866 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(1549..1551,1555..1557,1561..1563,1642..1644, 1657..1659,1777..1779,1849..1851,1855..1857,1861..1866) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 1879..2211 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(1906..1908,1912..1914,1918..1920,1999..2001, 2014..2016,2122..2124,2194..2196,2200..2202,2206..2211) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 2230..2547 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(2254..2256,2260..2262,2266..2268,2347..2349, 2362..2364,2476..2478,2536..2538,2542..2544,2548..2550) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 2557..2910 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(2581..2583,2587..2589,2593..2595,2674..2676, 2689..2691,2818..2820,2893..2895,2899..2901,2905..2910) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 2932..3282 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(2956..2958,2962..2964,2968..2970,3049..3051, 3064..3066,3193..3195,3265..3267,3271..3273,3277..3282) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 3298..3633 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(3322..3324,3328..3330,3334..3336,3415..3417, 3430..3432,3544..3546,3616..3618,3622..3624,3628..3633) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 3646..3990 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(3676..3678,3682..3684,3763..3765,3778..3780, 3901..3903,3973..3975,3979..3981,3985..3990) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 4336..4647 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(4339..4341,4345..4347,4351..4353,4432..4434, 4447..4449,4558..4560,4630..4632,4636..4638,4642..4647) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 4660..5001 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(4684..4686,4690..4692,4696..4698,4777..4779, 4792..4794,4912..4914,4990..4992,4996..4998) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 5374..5697 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(5398..5400,5404..5406,5410..5412,5491..5493, 5506..5508,5617..5619,5686..5688,5692..5694) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 5728..5994 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature order(5731..5733,5737..5739,5743..5745,5824..5826, 5839..5841,5929..5931,5983..5985,5989..5991) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 6055..6399 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature 6418..6726 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature 6787..7137 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(6811..6813,6826..6828,6832..6834,6913..6915, 6931..6933,7057..7059,7129..7131,7135..7137) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 7153..7533 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(7177..7179,7183..7185,7189..7191,7285..7287, 7300..7302,7516..7518,7522..7524,7528..7533) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 7546..7890 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(7576..7578,7582..7584,7663..7665,7678..7680, 7801..7803,7873..7875,7879..7881,7885..7890) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature <8497..8676 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature 8692..9024 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(8719..8721,8725..8727,8800..8802,8818..8820, 8938..8940,9010..9012,9016..9018,9022..9024) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 9031..9381 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(9061..9063,9067..9069,9073..9075,9160..9162, 9175..9177,9295..9297,9364..9366,9370..9372,9376..9381) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 9388..9723 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature 9760..10089 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(9778..9780,9784..9786,9790..9792,9871..9873, 9886..9888,10000..10002,10072..10074,10078..10080, 10084..10089) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 10135..10524 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(10144..10146,10150..10152,10156..10158,10237..10239, 10252..10254,10444..10446,10516..10518,10522..10524) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" misc_feature 10591..10803 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049" /db_xref="CDD:412131" misc_feature 10867..11199 /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041" /db_xref="CDD:238001" misc_feature order(10891..10893,10897..10899,10903..10905,10984..10986, 10999..11001,11116..11118,11188..11190,11194..11196) /gene="Cubn" /locus_tag="Dmel_CG32702" /gene_synonym="CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like" /note="heterodimerization interface [polypeptide binding]; other site" /db_xref="CDD:238001" ORIGIN 1 atggaaggag ctgcgaggag cagactccta ttgtgttgga cactccttgc catcatcaca 61 gatacttggc ccattgccga gggttttgtc aactcgccaa aaattataag caaagatggc 121 aatttgattt ttgaatccgg tgcaaatcgc aatataagct ttcgattgag cggaaattcg 181 cggcttacca tcaacgagga attggatgtt atggagctct tgctggccac cagtggctcc 241 aaaaagcgtt ccggtggcaa ggatgatgat ttcgtagatg cgcgcgagct ggcggatcag 301 ttggctgatt tcaataggcg cgcctttgga gcgaatggct tgagtgcaat gctgcgagtg 361 cagcaaaata ggacccgagg atcgatggct ctgttgcggc gttttcagac acgactcaga 421 gcgctggaga atcgggtgga tcgaatgaag accgatttgg aggcaaacag ctgtgcaagt 481 ggaccctgcg agaatggagg cacctgctac aacacataca ccggattccg ttgccaatgt 541 cgatcggcat tcgagggtac caagtgcgag atggatgtca acgagtgcgc actgtacgag 601 ggcaccgatc tgggttgcca aaatggtgga caatgccaga atcatttcgg cacatacagt 661 tgcctttgcc agccgggttg gcatgggatg cactgcaccc agcgcaaggc ggattgctca 721 cagtccagtg catgggagct gtgtggccat ggatcttgtg tgcccagtgc agacgatgcc 781 ggctatcgat gcatctgcga accgggttgg aagacgaatg gcttgacacc catttgtggc 841 gaggatgtgg acgaatgcag cgattcggcc gcccacaagc cctgctccac cagctgcatt 901 aatctgcctg gcagcttcac ctgtgctccc tgtccagccg gcttgaccgg gaatggggtc 961 agttgccggg acttggacga atgccagacg aacaacggtg gatgcagtct tagtcccaag 1021 gtagattgca taaataccta tggttcatat cattgcggcg agtgtcccgt tggctggacc 1081 ggcgatgggc ggaagtgcga gagaagcccc caggacattg acatcccagc tggacagacg 1141 ccaagaactt gtccggcggg caacaatccc tgctatccga cggcgagctg ctttttgatc 1201 tccggcacca catcctgcag atgtccaatg ggcatggtgg gaacaggata cggtccgaat 1261 ggctgtgtca atggcacgac cacaaactgc aaggaaaatc cctgcctgaa tggtggcatt 1321 tgcctgttcg ccggaccctc gaattatacc tgcctgtgtc caattggctt ccgtccgccc 1381 atctgtgagc cacagccgag tccttgcgat cagcatccat gcaagaatgg aggacgttgc 1441 cgtcccacca ccagtgggga tctattcgtc tgccagtgtt tacctggcta ccggggacga 1501 ctttgcgaga cgcgcttcag cagctgcaat ggaatgctga gtgcccagag tggcaggctt 1561 aggtatccgc cggagggcac tggatacgag cacaatgccc agtgcgcttg ggttattcgc 1621 accaacgaat cgctggtggt aaatgtcacg ttcaatagct tcgatgtgga ggattccacg 1681 gaatgccgct tcgattggct gcagatcaac gatggccgtt cggcggctgc ccagataatt 1741 ggacgctatt gtggtaacca tttaccgcat ggcgggaata tcgtatcatc cggcaatcaa 1801 ctctatctat ggttccgatc cgataactcg acggctaaag agggattcga tctcacatgg 1861 aactcgatgg agccgcagtg tggcggtcgc ttgaatttcg agacacatgg cacacttgcg 1921 tcgccgggat cgcccggaaa ttatccgaag aatcgggact gccggtggca actggtggcg 1981 cccaccacca aacgcatcaa gctgaccttc ttcagtttgc agctggagca gcacgcaaat 2041 tgcaatttcg attatgtcct gatcaaggac agcatttccg gacgtgagct ggccaaatat 2101 tgcaccacgg gagcgccagc accgctgctc ttgcccaccc acctggccga gatccacttc 2161 cattcggatg ccgagggcag cgatactggc ttccagctgc actattccgt ggaggagcgt 2221 gtgcccggct gcggtggtgt ctacaccgcc aaggagggca ccatttctga atcatccaca 2281 gccaataccg aaccaggtgg tgtctcctgc gaatacgaaa tccatttggc cgtgggcgag 2341 caggttgtca ttcagtttgc gcgtctggag ctggatccac ttgactgcct ggaggtgctg 2401 gatatcacgg acgagggtgg tagcattttg caggagaaga tttgcggatc ggatgcgtcg 2461 cgtttgaatc ctcctacctt cacttcggaa ttcaatcggc tgaagattaa gttttatgcc 2521 cgtgccggca gcttccagtt gaactaccgg atggcctgcg attataaact gaataatgag 2581 cagggcacca ttacctcacc cggttatccc aatctaacaa gatcggatcg tatctgcacc 2641 tatacgatta gtacggccac caatacggtg attagtctga agaggatcga ctttcagttg 2701 accaatggcg agagcgacga tgatgataac gatgaatgtc tgacaaccaa cttgagaatc 2761 aacgatggat taaaccgaaa gatcctgggc ccctattgcg gcaagaatca gccggaggag 2821 aactttgtca gcgaaaccaa ctacctgcag ttgcacctgt ccaccgatgt ggacagcatg 2881 gggcgtggct ttaagttcga gtatcgagcc ctggccaccg gcaacgataa gtgcggtggc 2941 gttcataccc gttccggcga tcatatccgc ttgccggtgc acgacgactc atatgccggc 3001 gaagccacct gttactgggt gataatggcg ccggcaaaca aggccatccg cctccactgg 3061 aacagcttca gtttggaaaa tgcggtggac tgcatctatg actatttgga gatctatgat 3121 agtctgggtg cccaggtaaa tgacgagagg agcaagccgt tggccaaata ctgtggtaat 3181 agtgtgccag aggatctgct cagccattcg cgtcagcttg tcctcaagtt cgtgtcggac 3241 tacagcgaat cggatggagg ctttgattta acctacacct tcgaggatcg agccaagtgc 3301 ggcggtcaca ttcatgcgtc cagcggtgag ctaacctcac cggaatatcc ggccaactat 3361 tcggccggct tggactgcga ttggcatctg accggtacga ttgatcatct gctggagatt 3421 caggtggaga actttgaact ggagcaatcg ccgaactgtt cagccgatta tctggaagtg 3481 agaaatggag gcggcactga ttccccactg attgggcgct tctgcggacg ggatataccc 3541 gctcggatac caggctttag ccacgagatg aggttgatcc ttcatacgga ttcggcgatc 3601 aatggtcgtg gattccggct gcgctggcga atctttgcct tcggatgcgg cggaagtttg 3661 cgttcgaata tgggcgccat ttcgtcgccc agatatccga actcgtatcc caacatggcg 3721 cactgtgagt ggcgaattag cttgcatccg ggatcgggta tttcgcttct catcgaggac 3781 ttggaactgg agggtttgag caattgttac tacgacagcg tgaagatcta cacgggcatt 3841 aagctgccca atcagagccc ctgcaaagta ctctgcaagg acgatgatct gcataatccg 3901 ctcattcagc tggagaacaa taagggcacc attgtcttcg attctgatgc gtccaacaca 3961 ttccgtggct ttcgaatatc ctacaaggcg aattgcattc gaaaccttac ggccacgacg 4021 ggaaccattg agagtctgaa ctacatggaa ccattctggg agaccatacc catcaattgt 4081 agttggacta ttcgtgcgcc caagggcaat cgcgttctag tggaagtctc acatttggca 4141 cggcacgaac agcacgtccc gactgccacc atgcccggcg gattgtacat tgtggacggc 4201 aggaatgtcc aggaaatagt cacaccacaa gcgatgaaca tcagcggcga agtgctgacc 4261 gtcgtccaca atgccagcaa tgtgaacttt cagctggact atcgcatcga tggctgcatg 4321 gaggagctgc gcggcacgtt cggattcttt caatcgccca attatccaaa aatgtatccg 4381 aacaacctgg agtgctattg gctgatcacc gtcgagcagg atagcgccat cgagcttacg 4441 atcaacaaca tagatctcga ggacagtccc aattgtacca aggatgcgct gacggtttcc 4501 aatcataaga attcggtgga agtccacgaa cgacattgcg gttccacgac caaattggtg 4561 atcaccagtt cgggtcacag gctgcacgtg cgtttcatct cggacaattc gcacaatgga 4621 ctcggttttg aagccaccta tagaactgtg aaagcaactt gtggtggcaa attgacggcg 4681 cgaaacggag tgatcgaatc gccaaattat ccgctcaatt atccagctca cagtcgatgc 4741 gagtggcagg tggaggtctc ccagcaccac cagatcgttt tcgagatggc ggatcttaat 4801 cttgagtcgg gctacgactg caactgggat tatctggagg cctacgatct gacggaggac 4861 gacacggagg gtgaaagatt gttcaaggtc tgcggcgacg agacggaaga tgacaagctg 4921 ctttcttcct catccaatat ggctgtggtg cgatttatca gcgatgattc cgtttcgaaa 4981 aagggcttcc ggctgcactt ccacgagtcc tgtggccaaa cgataatcgt tgatgaaaca 5041 atgtttgatt acatccaaat gtccaggcag gcggcccgaa acgagagctg cttatgggta 5101 ttccaagccg tggagcccaa caaacgcatc atctttacgc ccacccatgt gaagctgcgc 5161 gaggatgcca accagcaata tcccacggag ggtgattgcc tcaatgtggg agttaagatc 5221 tacgagggta cagagccgca gggaacaccg cgtctcaagt tctgtcgctc gcatccgccg 5281 gccttgattt ccaatggcca ggctctgacc gtcagtgtgc cgctccagct ggtggaggag 5341 ttccaaggac actacatgac catggacacg tcctgcggca gtatttacaa tgctctgtcc 5401 ggaaagttca cttcacccta ttaccccgcc tcgtatccgc caaacattga atgcctgtgg 5461 ctgctggaag ccagcatggg taactccctc agtctcacgc tggagtcgat ggacttggag 5521 aagtcagaga gttgcaatcg ggattatctg gaagtgcgcg aggaatcgga gagcggccaa 5581 ctgatcggcg tttactgtgg caacgaagtg cccggcgtga ttcactcgcg cggtgccatc 5641 tggatgaagt tcaagagtga cgacgacaat gtgggcgagg gattcatggc ctcctataac 5701 tacgagcacc acaacgagct gaatggcact gaaggcacca ttgaatcgcc gcactttcca 5761 agcaaattcc aggatccggt gccgtacagc tggcgcatta cggtggacaa ggagtacgtg 5821 gtggcgatat ccctgctcta tctgagggat ctggaccaac cgcatttaaa tttctacgac 5881 ggctattcgg acattggagc tcgtatcgag gtgactgatc ccgacgaaac catcatctcc 5941 agcacgaatg tggtttactt cacgagcaat cgaggtcctt tcaagttaaa ttggaatcga 6001 ttatccaagg aggcgctacg ttcgaatcgt acggcagagg agcggacacg ccagtgtggc 6061 aatcagttga ttacaatcga tcgatcggtg atcggatttc attcgcctgg ctatcccaat 6121 ggctacgagc aggatctcaa ttgcttctgg actttggtgc cctcgaatcc ggctatgcat 6181 gccgtactca cactgtccca aatcgatctg gagatattta gcgaagattg cattgctgac 6241 tatgttaaga tttttagtgg gagcgatctg cagaactggt cggagctaag aacgttgtgc 6301 tccctgccca cggagtcgag tgaccgagtc tttcatggaa ggccctatct cagggtggaa 6361 ttcgtgacgg atccaagtgt gaataagacg ggattcaatg gcattgtgcg cacggcctgc 6421 ggttcggaaa tcactgcctc caagggactg gttaacatta cggagatcct gaaggtcctt 6481 ccgcggccaa accacgattg tgtgtggacc ataaaagtgc gccagggccg tagaatcaag 6541 atcgacttcc ccgacttcca gttgcagaac aacatggcct ccggatcgag tgattgccga 6601 aattatcttc tactccgcaa tggaaacgat gaagattcgc ccttcttggg acgtggcaag 6661 tactgtgagg atgtcgtgca cgaggtcctg aacacctcct cgaataaggc ctatataaag 6721 ttccactttg cgagtccacc ccgcttcctg gtgtccttcc gcttcgagga actgcgttac 6781 accgactctg gccgtatccg attgtccgcc tccggagatg agcagttcat tagctcaccg 6841 tattacccac atcttccgca tccccattcc gagtgcattt ggatcgttga agcaccacca 6901 gaacaccgca taatgctgca ctttcaaggc gcattcgata tgttggacgc caccggggaa 6961 ccggaggagt gccaacggga atttgttttg atcaacgatg gcagtacgga gctaagaccg 7021 gagatcggtc gctattgtgg caatcgtaag ccggatacga tctactccac cggtaaccag 7081 atgaggattc gctacttcac cgatgtctcg gagccacata tgggcttcaa tgccagtttg 7141 agtgtggccc gatgcggagg ctccttccat agtcccgagg gcgtgatagc ctcgccgtcg 7201 agggacctcc tgttgattca cgaggaaggc aagcagctgc aggaatgcgt ttacaccatc 7261 gaactggaga agggcagcac catcgatctg actagcgaat atctgcagat acccacgttg 7321 cggaatggta gctgctcgca gcgaaatcac ttgatgctcg aagagatgga tgcctttgga 7381 ttggacggtg aggagaagat cgtggacacc ctaatgctct gcggtatgga agccaagcac 7441 ctgataagtg agacgaacaa gatcgtgttc cgatatcgct tcctggatgg cattccggcg 7501 gagaatcagg gcttccgttt aaagtacacc tcgctgggct cacgatgcgg cgagaccatc 7561 tacgcatccg tgggagttct ccaaacaccc ggttatccct taggcgtacc ccatcccatg 7621 cactgcaagt ggcaggtgca agtgcccaag ggcagaaggg tgcgtctgga gattctcgac 7681 tttaacaccg gcacgaatat ggatctcaga ggaaggcttg gattccgtgg ccgccttacc 7741 gtggccaacg atttcaaaat gcaatccatc ctgggtcgct acaacgtcga tcctcctgcg 7801 gaggtgcttt cctcggacaa tacaatgggc atcgatgcct tcctactgcc cattgttcag 7861 aatcatggaa tcaagctgcg gttcagtgcc tatggctcca gtagctgtcc gggattcacg 7921 gtaatgatga atgaggtcgc agatattcag ttccagcggt tcaatatcag ccgtccgctt 7981 cactgcagct ataaagtcgt tccaccgtcc aatagtaccc tcctgattcg ggtgaaagag 8041 tacaacacca cgtccgtaat gatgtggaat acacatatgt gcgcattgct ctcgccgctt 8101 aagtttaacc gcttggagca ggaggaggag ctcatggagc gcattctctg cgattaccag 8161 tcacccgctc ctggcaagcc cctgccctcc atccggttgc ctttccccat tcaactggtc 8221 gtctcggcat ccgcccgcaa cgcaatgacc aatctcgtcc tgagctatag cacacagtcg 8281 tgcggcggag tcattatcct ggaaccgggt gataatatga cggtgcacca gccatcggga 8341 atggtgtcgg cggcgggcgc cattgactgt gcctgggcca ttggacccta tacggatgcc 8401 agtggcgagg acgaggtcct ggtgccgcag gacattcagc tggaggtgtc ggtatataac 8461 gtcaacctgc cagcaccgag cccgtccgca caatctccgg aagccccatg cctgcatcac 8521 tatcttaagg tatacaatgg acccgatcag aactcaccat cgttgggact gttttgcaat 8581 caggccacag ctgtgaacat ggtggtggag cgaggtctct tcctggaata tcactccgat 8641 agtttctcag ccaatgccac cttcaatgtg tccatcaagt atggatctgg atgcggtggc 8701 aagttggtat atccctatag agccatcgac tttgccgagc aatacaagaa caatgtggag 8761 tgcatctggg aggtcgaggc gacaatgggc taccacatcg gtctaacatt ccaaggacgc 8821 ttttatatcg aggatagccc cggttgcaca aaggattacc tgctcgtcca gcagcgcaac 8881 gagaccactg gcaattggac cgacctgcag aggatttgcg gtcgtgttgc gccggagatg 8941 ataaacacaa cttcaccgta tctccggcta atcttccgat ccgatggcga tgtggtggcc 9001 gatggttttt tggccaaatt cgaaaggaat tgcggtggcc tgctgtacgc cgacagcacg 9061 gaacaggagc tggccagtcc gggctttccg aatggctatg aaaagtactt gcaatgtaat 9121 tggacgatag tgcccaggag tccatcgatg ggcggtgtcc tggtcagctt tgtcaatttc 9181 gatctggaac agggacccat atccgtttgc ctctacgaca atctcacggt gaccacaaag 9241 gacaagggca aggatccgca acagaccact ctctgcggcg taaagcataa ccacgagtat 9301 cggggcaagg aatatgttaa tctactgctc cgaacggatg gcagttattc cggtcgcgga 9361 ttcacattac tctataccag ccgcctttgc ggtggaatta tctcgcgaac atcaatggtg 9421 gaatcacccg tacagcatac ggataacacc ctgccacctg gcagtgattg ctattggaat 9481 ctaaccgccc cggctggtta caagttcaac attaagttcc tattcattga ctttgaggcg 9541 aatagcaatt gtgcctacga tggcgtcgag gtattctccg gacccatccc ggacgagcga 9601 taccgatggg gacgcttctg cggtcgcatt aacgaggatc tgccactgat cagtattccc 9661 caagagcggg gcatcataca cagcttctcg gatgatcggg atccatcgag gggattccgt 9721 gccttggtgc gcgtaatgcc aaattgcgat gagaagatct cgctgaacgg atcgtcgcgt 9781 tatgtctata gcaaatttaa caacgctggc ggttatcaaa acgatttgga ctgtcaaata 9841 gtattccggg tgaatcctga tcagcagata agcgtggagt tcagtaattt ccatgtccaa 9901 gacacggacg gatgccgcag tgattatgtg gagttgcgcg atggtggcgg aacctttgcc 9961 gacattatcg gacgtttttg tggccagaat caaccgccca ccttgagaac aaccaggcat 10021 acgctctata tgcgctttgt caccgataat aaggtgacgg atacgggttt ccaggtgacc 10081 atcaatgcta ttccccgact atgcggcagt tcagagatta cgttgagtgc ggatggcacc 10141 aaggaggtca ccattaattc tccggcaagg acgccaggtg gcaattatcc caatggagtg 10201 tcgtgcttct ggaaaattaa gggcgattcc ctgctgaggg tgcagttcgt caactttgat 10261 ctccacggac cgaatcaaaa tggtagctgc gtggatgact atttgaaaat ctacaatagt 10321 gaggatgcac cgctgttgga gcagggattg ggcaccgacc tggtattcaa tggccagacc 10381 tccagtaaga acggtttcgg ctttgccacg gagcatgtgt actgcggcaa tgtgaagccg 10441 gacatctatt atggccggtc cagcgaggtg tatctgaagt tccggtcaaa gggattggag 10501 cagcatggtg gatttcagtt acaggtcgct ctgaactcca accgagagcg ccactacgat 10561 ggactgcagg gcagagtgca tttatcacag tcggccgatt gtaacatcat tattcgggcg 10621 ccaccaaatt acaccttaag tttgtactac accgaattga tattcggcac ctacgactgc 10681 gaaatggaga atttggaggt gttcgacagg acgaatcgat cgctgcagcg cgtctgctcc 10741 tttgtggaca tgggcaagag cctgttcagc aatgcgaatg aactgcggct acagatgaag 10801 actggctcgt acttgacctc gctggatctc acctatttgg ccagtccggt ggagaagggt 10861 cctggttgcg gtggtcaatt ctacaatacc gagggcatat tctcaaatcc cttctatccg 10921 aacaatgtgc gcaataactc agagtgtcag tggattgtcc gcgtgccgag caacaatgtt 10981 gtgttcctta catttgaagt cttcaatctg ggctcgaaga ccacctgtca cacggactac 11041 ctgcaaatcc tggaacagga cgcaaccggt gaggagcgcg aaatgagacg cttctgtggc 11101 gaggataacc caaagtacta caagagccgg cgcagccagg tgctcgtccg ctttcacaag 11161 accgtcaact acgatggtat cggttgggtg atccgctttg ccggtgtcta ctccgaccat 11221 cagataccca gacacctgtt gggcggttct taaccgcttg atttcttctt cagccgcaat 11281 ctgtattaag aagcttaaaa ttcctacaat taaatcattt ctattgcaat aaatacatct 11341 aaataaagg